The interaction between gut microbiota and age-related changes in immune function and inflammation
Open accessAbstract
Intestinal microbiota and gut immune systems interact each other, maintaining a condition of homeostasis in the context of the intestinal habitat. However, both systems undergo modifications in elderly, thus accounting for a low grade inflammatory status which, in turn, may evolve toward more severe pathological conditions such as inflammatory bowel disease and colon rectal cancer. In addition, in western societies dietary habits may negatively influence the microbiota composition, also altering gut immune response which is per se impaired in elderly. In order to prevent the outcome of aged-related disease, supplementation of nutraceuticals able to correct abnormalities of both immune system and microbiota has become more frequent than in the past. In this respect, a better identification of components of the aged microbiota as well as a deeper analysis of gut mucosal immunity function should be pursued.
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Ageing and obesity are both associated with chronic low grade inflammation, immune impairment, and intestinal dysbiosis.
“ageing and obesity are both associated with chronic low grade inflammation, immune impairment, and intestinal dysbiosis.”
From Antioxidant, Immunomodulating, and Microbial‐Modulating Activities of the Sustainable and Ecofriendly <i>Spirulina</i> (2017) · cites this paper as [140]
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- Authors
- Magrone, T., & Jirillo, E.
- Affiliations
- University of Bari Aldo Moro (IT)
- Corresponding author
- Magrone, Thea
- Venue
- Immunity & Ageing
- Published
- 2013-08-05
- Volume
- 10
- Issue
- 1
- Pages
- 31-31
- ISSN
- 1742-4933 (ISSN-L)
- PMC
- PMC3848811
- OpenAlex
- W2111169314
- Cited by
- 124
- References
- 57
- Citations by year
- 2026: 2 · 2025: 11 · 2024: 4 · 2023: 7 · 2022: 10 · 2021: 7 · 2020: 13 · 2019: 7 · 2018: 24 · 2017: 11 · 2016: 11 · 2015: 11 · 2014: 6
- FWCI
- 4.18
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Immunity & Ageing (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Keywords
- gut microbiota, aging, immune function, low-grade inflammation, gut immune homeostasis, intestinal mucosal immunity, dietary habits, nutraceuticals, inflammatory bowel disease, colorectal cancer, older adults
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