Lessons learned — resolving the enigma of genetic factors in IBS

Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region

Lesch, K.-P., Bengel, D., Heils, A., Sabol, S. Z., Greenberg, B. D., Petri, S., Benjamin, J., Müller, C. R., Hamer, D. H., & Murphy, D. L. (1996) · Science · doi:10.1126/science.274.5292.1527 · Cited by 5,162 · see citing works

Functional Bowel Disorders

Longstreth, G. F., Thompson, W. G., Chey, W. D., Houghton, L. A., Mearin, F., & Spiller, R. C. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.11.061 · Cited by 4,856 · see citing works

A Systematic Method for Clinical Description and Classification of Personality Variants: A Proposal

Cloninger, C. R. (1987) · Archives of General Psychiatry · doi:10.1001/archpsyc.1987.01800180093014 · Cited by 3,678 · see citing works

Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse

McGowan, P. O., Sasaki, A., D'Alessio, A. C., Dymov, S., Labonté, B., Szyf, M., Turecki, G., & Meaney, M. J. (2009) · Nature Neuroscience · doi:10.1038/nn.2270 · Cited by 3,531 · see citing works

5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression

Pezawas, L., Meyer-Lindenberg, A., Drabant, E. M., Verchinski, B. A., Munoz, K. E., Kolachana, B. S., Egan, M. F., Mattay, V. S., Hariri, A. R., & Weinberger, D. R. (2005) · Nature Neuroscience · doi:10.1038/nn1463 · Cited by 1,980 · see citing works

Gut feelings: the emerging biology of gut-brain communication

Mayer, E. A. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3071 · Cited by 1,726 · see citing works

AGA technical review on irritable bowel syndrome.

Drossman, D. A., Camilleri, M., Mayer, E. A., & Whitehead, W. E. (2002) · Gastroenterology · doi:10.1053/gast.2002.37095 · Cited by 1,384 · see citing works

A tutorial on statistical methods for population association studies

Balding, D. J. (2006) · Nature Reviews Genetics · doi:10.1038/nrg1916 · Cited by 1,328 · see citing works

Efficacy and safety of alosetron in women with irritable bowel syndrome: a randomised, placebo-controlled trial

Camilleri, M., Northcutt, A. R., Kong, S., Dukes, G. E., McSorley, D., & Mangel, A. W. (2000) · The Lancet · doi:10.1016/s0140-6736(00)02033-x · Cited by 551 · see citing works

Basic statistical analysis in genetic case-control studies

Clarke, G. M., Anderson, C. A., Pettersson, F. H., Cardon, L. R., Morris, A. P., & Zondervan, K. T. (2011) · Nature Protocols · doi:10.1038/nprot.2010.182 · Cited by 507 · see citing works

Abnormal Intestinal Permeability in Subgroups of Diarrhea-Predominant Irritable Bowel Syndromes

Dunlop, S. P., Hebden, J., Campbell, E., Naesdal, J., Olbe, L., Perkins, A. C., & Spiller, R. C. (2006) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2006.00672.x · Cited by 476 · see citing works

Non-colonic features of irritable bowel syndrome.

Whorwell, P. J., McCallum, M., Creed, F. H., & Roberts, C. T. (1986) · Gut · doi:10.1136/gut.27.1.37 · Cited by 473 · see citing works

Irritable bowel syndrome in twins: Heredity and social learning both contribute to etiology

Levy, R. L., Jones, K. R., Whitehead, W. E., Feld, S. I., Talley, N. J., & Corey, L. A. (2001) · Gastroenterology · doi:10.1053/gast.2001.27995 · Cited by 458 · see citing works

Mechanisms of hypersensitivity in IBS and functional disorders

Azpiroz, F., Bouin, M., Camilleri, M., Mayer, E. A., Poitras, P., Serra, J., & Spiller, R. E. (2007) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2006.00875.x · Cited by 353 · see citing works

Postprandial plasma 5-hydroxytryptamine in diarrhoea predominant irritable bowel syndrome: a pilot study

Bearcroft, C. P., Perrett, D. I., & Farthing, M. J. G. (1998) · Gut · doi:10.1136/gut.42.1.42 · Cited by 303 · see citing works

Peripheral mechanisms in irritable bowel syndrome

Camilleri, M. (2012) · New England Journal of Medicine · doi:10.1056/nejmra1207068 · Cited by 300 · see citing works

Expression, Localization, and Functional Activity of TL1A, a Novel Th1-Polarizing Cytokine in Inflammatory Bowel Disease

Bamias, G., Martin, C. T., Marini, M., Hoang, S. B., Mishina, M., Ross, W. G., Sachedina, M. A., Friel, C. M., Mize, J., Bickston, S. J., et al. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.9.4868 · Cited by 299 · see citing works

Peripheral Mechanisms in Irritable Bowel Syndrome

Kassam, Z., Collins, S. M., & Moayyedi, P. (2013) · New England Journal of Medicine · doi:10.1056/nejmc1214185 · Cited by 285 · see citing works

Evidence of a Genetic Contribution to Functional Bowel Disorder

Morris‐Yates, A. D., Talley, N. J., Boyce, P. M., Nandurkar, S., & Andrews, G. (1998) · The American Journal of Gastroenterology · doi:10.1016/s0002-9270(98)00321-9 · Cited by 285 · see citing works

Serotonin-transporter polymorphism pharmacogenetics in diarrhea-predominant irritable bowel syndrome

Camilleri, M., Atanasova, E. A., Carlson, P. J., Ahmad, U. S., Kim, H. J., Viramontes, B. E., McKinzie, S., & Urrutia, R. A. (2002) · Gastroenterology · doi:10.1053/gast.2002.34780 · Cited by 285 · see citing works

Diarrhoea-predominant irritable bowel syndrome: an organic disorder with structural abnormalities in the jejunal epithelial barrier

Martínez, C., Lobo, B., Pigrau, M., Ramos, L., González-Castro, A. M., Alonso, C., Guilarte, M., Guilá, M., de Torres, I., Azpiroz, F., et al. (2013) · Gut · doi:10.1136/gutjnl-2012-302093 · Cited by 283 · see citing works

MicroRNA-29a regulates intestinal membrane permeability in patients with irritable bowel syndrome

Zhou, Q., Souba, W. W., Croce, C. M., & Verne, G. N. (2009) · Gut · doi:10.1136/gut.2009.181834 · Cited by 277 · see citing works

Interleukin 10 genotypes in irritable bowel syndrome: evidence for an inflammatory component?: Table 1

Gonsalkorale, W. M., Perrey, C., Pravica, V, Whorwell, P. J., & Hutchinson, I. V. (2003) · Gut · doi:10.1136/gut.52.1.91 · Cited by 273 · see citing works

Association between a functional polymorphism in the serotonin transporter gene and diarrhoea predominant irritable bowel syndrome in women

Yeo, A., Boyd, P., Lumsden, S., Saunders, T., Handley, A., Stubbins, M., Knaggs, A., Asquith, S., Taylor, I., Bahari, B., et al. (2004) · Gut · doi:10.1136/gut.2003.035451 · Cited by 260 · see citing works

A randomised trial of ondansetron for the treatment of irritable bowel syndrome with diarrhoea

Garsed, K., Chernova, J., Hastings, M., Lam, C., Marciani, L., Singh, G., Henry, A., Hall, I., Whorwell, P., & Spiller, R. (2014) · Gut · doi:10.1136/gutjnl-2013-305989 · Cited by 246 · see citing works

Genetic Risk Factors for Post-Infectious Irritable Bowel Syndrome Following a Waterborne Outbreak of Gastroenteritis

Villani, A., Lemire, M., Thabane, M., Belisle, A., Geneau, G., Garg, A. X., Clark, W. F., Moayyedi, P., Collins, S. M., Franchimont, D., et al. (2010) · Gastroenterology · doi:10.1053/j.gastro.2009.12.049 · Cited by 244 · see citing works

The Patient Health Questionnaire 12 Somatic Symptom scale as a predictor of symptom severity and consulting behaviour in patients with irritable bowel syndrome and symptomatic diverticular disease

Spiller, R. E., Humes, D. J., Campbell, E., Hastings, M. C., Neal, K. R., Dukes, G. E., & Whorwell, P. J. (2010) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2010.04402.x · Cited by 236 · see citing works

Evidence of a Genetic Contribution to Functional Bowel Disorder

Morris‐Yates, A. D., Talley, N. J., Boyce, P. M., Nandurkar, S., & Andrews, G. (1998) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.1998.440_j.x · Cited by 225 · see citing works

Increased Somatic Complaints and Health-Care Utilization in Children: Effects of Parent IBS Status and Parent Response to Gastrointestinal Symptoms

Levy, R. L., Whitehead, W. E., Walker, L. S., Korff, M. V., Feld, A. D., Garner, M. D., & Christie, D. L. (2004) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2004.40478.x · Cited by 223 · see citing works

TL1A–DR3 interaction regulates Th17 cell function and Th17-mediated autoimmune disease

Pappu, B. P., Borodovsky, A., Zheng, T. S., Yang, X. O., Wu, P., Dong, X., Weng, S., Browning, B., Scott, M. L., Ma, L., et al. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20071364 · Cited by 218 · see citing works

Role of Tumor Necrosis Factor-alpha and Interleukin-10 Gene Polymorphisms in Irritable Bowel Syndrome

van der Veek, P. P. J., van den Berg, M., de Kroon, Y. E., Verspaget, H. W., & Masclee, A. A. M. (2005) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2005.00257.x · Cited by 217 · see citing works

The Jejunum of Diarrhea-Predominant Irritable Bowel Syndrome Shows Molecular Alterations in the Tight Junction Signaling Pathway That Are Associated With Mucosal Pathobiology and Clinical Manifestations

Martínez, C., Vicario, M., Ramos, L., Lobo, B., Mosquera, J. L., Alonso, C., Sánchez, A., Guilarte, M., Antolín, M., de Torres, I., et al. (2012) · American Journal of Gastroenterology · doi:10.1038/ajg.2011.472 · Cited by 214 · see citing works

Stress and visceral pain: From animal models to clinical therapies

Larauche, M. H., Mulak, A., & Taché, Y. (2011) · Experimental Neurology · doi:10.1016/j.expneurol.2011.04.020 · Cited by 212 · see citing works

Familial Diarrhea Syndrome Caused by an Activating GUCY2C Mutation

Fiskerstrand, T., Arshad, N., Haukanes, B. I., Tronstad, R. R., Pham, K. D.-C., Johansson, S., Håvik, B., Tønder, S. L., Levy, S., Brackman, D., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1110132 · Cited by 206 · see citing works

Irritable bowel syndrome in twins: genes and environment

Bengtson, M.-B., Ronning, T., Vatn, M. H., & Harris, J. R. (2006) · Gut · doi:10.1136/gut.2006.097287 · Cited by 204 · see citing works

5-HT3 receptors: Role in disease and target of drugs

Walstab, J., Rappold, G., & Niesler, B. (2010) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2010.07.001 · Cited by 203 · see citing works

Childhood Trauma Is Associated With Hypothalamic-Pituitary-Adrenal Axis Responsiveness in Irritable Bowel Syndrome

Videlock, E. J., Adeyemo, M. A., Licudine, A., Hirano, M., Ohning, G., Mayer, M., Mayer, E. A., & Chang, L. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.08.058 · Cited by 198 · see citing works

Migraine, fibromyalgia, and depression among people with IBS: a prevalence study

Cole, J. A., Rothman, K. J., Cabral, H., Zhang, Y., & Farraye, F. A. (2006) · BMC Gastroenterology · doi:10.1186/1471-230x-6-26 · Cited by 196 · see citing works

First evidence for an association of a functional variant in the microRNA-510 target site of the serotonin receptor-type 3E gene with diarrhea predominant irritable bowel syndrome

Kapeller, J., Houghton, L. A., Mönnikes, H., Walstab, J., Möller, D., Bönisch, H., Burwinkel, B., Autschbach, F., Funke, B., Lasitschka, F., et al. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn195 · Cited by 193 · see citing works

Role of infection in irritable bowel syndrome

Spiller, R. C. (2007) · Journal of Gastroenterology · doi:10.1007/s00535-006-1925-8 · Cited by 187 · see citing works

Irritable bowel syndrome: Emerging paradigm in pathophysiology

Lee, Y. J. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i10.2456 · Cited by 186 · see citing works

Chenodeoxycholate in Females With Irritable Bowel Syndrome-Constipation: A Pharmacodynamic and Pharmacogenetic Analysis

Rao, A. S., Wong, B. S., Camilleri, M., Odunsi, S. T., McKinzie, S., Ryks, M. D., Burton, D. D., Carlson, P., Lamsam, J. L., Singh, R. J., et al. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.07.052 · Cited by 182 · see citing works

Crosstalk at the mucosal border: importance of the gut microenvironment in IBS

Öhman, L., Törnblom, H., & Simrén, M. (2014) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2014.200 · Cited by 181 · see citing works

MicroRNA 29 Targets Nuclear Factor-κB–Repressing Factor and Claudin 1 to Increase Intestinal Permeability

Zhou, Q., Costinean, S., Croce, C. M., Brasier, A. R., Merwat, S. N., Larson, S. A., Basra, S. S., & Verne, G. N. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.09.037 · Cited by 178 · see citing works

Association of distinct α2 adrenoceptor and serotonin transporter polymorphisms with constipation and somatic symptoms in functional gastrointestinal disorders

Kim, H. J., Camilleri, M., Carlson, P., Cremonini, F., Ferber, I., Stephens, D., Mckinzie, S., Zinsmeister, A., & Urrutia, R. (2004) · Gut · doi:10.1136/gut.2003.030882 · Cited by 168 · see citing works

Familial aggregation of irritable bowel syndrome: a prospective study

Kalantar, J. S., Locke, G. R., Zinsmeister, A. R., Beighley, C. M., & Talley, N. J. (2003) · Gut · doi:10.1136/gut.52.12.1703 · Cited by 168 · see citing works

Identifying and testing candidate genetic polymorphisms in the irritable bowel syndrome (IBS): association with TNFSF15 and TNFα

Swan, C., Duroudier, N. P., Campbell, E., Zaitoun, A., Hastings, M., Dukes, G. E., Cox, J., Kelly, F. M., Wilde, J., Lennon, M. G., et al. (2013) · Gut · doi:10.1136/gutjnl-2011-301213 · Cited by 165 · see citing works

Association Between Variants of PRDM1 and NDP52 and Crohn's Disease, Based on Exome Sequencing and Functional Studies

Ellinghaus, D., Zhang, H., Zeißig, S., Lipinski, S., Till, A., Jiang, T., Stade, B., Bromberg, Y., Ellinghaus, E., Keller, A., et al. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.04.040 · Cited by 156 · see citing works

The TNF-family cytokine TL1A promotes allergic immunopathology through group 2 innate lymphoid cells

Meylan, F., Hawley, E., Barron, L., Barlow, J. L., Penumetcha, P. M., Pelletier, M., Sciumè, G., Richard, A. C., Hayes, E. T., Gómez‐Rodríguez, J., et al. (2013) · Mucosal Immunology · doi:10.1038/mi.2013.114 · Cited by 150 · see citing works

Serotonin Transporter Gene Polymorphism in Irritable Bowel Syndrome

Pata, C., Erdal, E. M., Derici, E., Yazar, A., Kanık, A., & Ulu, O. (2002) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2002.05841.x · Cited by 146 · see citing works

Influence of genetics on irritable bowel syndrome, gastro‐oesophageal reflux and dyspepsia: a twin study

LEMBO, A., ZAMAN, M., Jones, M., & Talley, N. J. (2007) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2007.03326.x · Cited by 144 · see citing works

Loss-of-Function of the Voltage-Gated Sodium Channel NaV1.5 (Channelopathies) in Patients With Irritable Bowel Syndrome

Beyder, A., Mazzone, A., Strege, P. R., Tester, D. J., Saito, Y. A., Bernard, C. E., Enders, F. T., Ek, W. E., Schmidt, P. T., Dlugosz, A., et al. (2014) · Gastroenterology · doi:10.1053/j.gastro.2014.02.054 · Cited by 144 · see citing works

Decreased miR-199 augments visceral pain in patients with IBS through translational upregulation of TRPV1

Zhou, Q., Yang, L., Larson, S., Basra, S., Merwat, S. N., Tan, A., Croce, C. M., & Verne, G. N. (2015) · Gut · doi:10.1136/gutjnl-2013-306464 · Cited by 144 · see citing works

The Role of Genetics in IBS

Saito, Y. A. (2011) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2010.12.011 · Cited by 139 · see citing works

Sodium channel mutation in irritable bowel syndrome: evidence for an ion channelopathy

Saito, Y. A., Strege, P. R., Tester, D. J., Locke, G. R., Talley, N. J., Bernard, C. E., Rae, J. L., Makielski, J. C., Ackerman, M. J., & Farrugia, G. (2008) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.90571.2008 · Cited by 133 · see citing works

The Fundamentals of Modern Statistical Genetics

Laird, N. M., & Lange, C. (2010) · Statistics for biology and health · doi:10.1007/978-1-4419-7338-2 · Cited by 132 · see citing works

Exploring the genetics of irritable bowel syndrome: a GWA study in the general population and replication in multinational case-control cohorts

Ek, W. E., Reznichenko, A., Ripke, S., Niesler, B., Zucchelli, M., Rivera, N. V., Schmidt, P. T., Pedersen, N. L., Magnusson, P. K. E., Talley, N. J., et al. (2014) · Gut · doi:10.1136/gutjnl-2014-307997 · Cited by 132 · see citing works

Genomewide Association Analysis Followed by a Replication Study Implicates a Novel Candidate Gene for Neuroticism

van den Oord, E. J. C. G., Kuo, P., Hartmann, A. M., Webb, B. T., Möller, H., Hettema, J. M., Giegling, I., Bukszár, J., & Rujescu, D. (2008) · Archives of General Psychiatry · doi:10.1001/archpsyc.65.9.1062 · Cited by 131 · see citing works

Familial Aggregation of Irritable Bowel Syndrome: A Family Case–Control Study

Saito, Y. A., Petersen, G. M., Larson, J. J., Atkinson, E. J., Fridley, B. L., de Andrade, M., Locke, R. G., Zimmerman, J. M., Almazar, A. E., & Talley, N. J. (2010) · The American Journal of Gastroenterology · doi:10.1038/ajg.2010.116 · Cited by 130 · see citing works

Association of TNFSF15 polymorphism with irritable bowel syndrome

Zucchelli, M., Camilleri, M., Andréasson, A., Bresso, F., Dlugosz, A., Halfvarson, J., Törkvist, L., Schmidt, P. T., Karling, P., Ohlsson, B., et al. (2011) · Gut · doi:10.1136/gut.2011.241877 · Cited by 127 · see citing works

TL1A produced by lamina propria macrophages induces Th1 and Th17 immune responses in cooperation with IL-23 in patients with Crohn's disease

Kamada, N., Hisamatsu, T., Honda, H., Kobayashi, T., Chinen, H., Takayama, T., Kitazume, M. T., Okamoto, S., Koganei, K., Sugita, A., et al. (2009) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21124 · Cited by 126 · see citing works

Importance of epigenetic mechanisms in visceral pain induced by chronic water avoidance stress

Tran, L., Chaloner, A., Sawalha, A. H., & van-Meerveld, B. G. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.09.016 · Cited by 124 · see citing works

Effect of Increased Bile Acid Synthesis or Fecal Excretion in Irritable Bowel Syndrome-Diarrhea

Camilleri, M., Busciglio, I., Acosta, A., Shin, A., Carlson, P., Burton, D., Ryks, M., Rhoten, D., Lamsam, J., Lueke, A., et al. (2014) · American Journal of Gastroenterology · doi:10.1038/ajg.2014.215 · Cited by 114 · see citing works

New perspectives in the diagnosis and management of enteric neuropathies

Knowles, C. H., Lindberg, G., Panza, E., & GIORGIO, R. D. (2013) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2013.18 · Cited by 111 · see citing works

Genetic Approaches to Functional Gastrointestinal Disorders

Saito, Y. A., Mitra, N., & Mayer, E. A. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.02.037 · Cited by 104 · see citing works

The presentation of irritable bowel syndrome in the context of somatization disorder

North, C. S., Downs, D., Clouse, R. E., Alrakawi, A., Dokucu, M. E., Cox, J., Spitznagel, E. L., & Alpers, D. H. (2004) · Clinical Gastroenterology and Hepatology · doi:10.1016/s1542-3565(04)00350-7 · Cited by 102 · see citing works

Pharmacogenetic Trial of a Cannabinoid Agonist Shows Reduced Fasting Colonic Motility in Patients With Nonconstipated Irritable Bowel Syndrome

Wong, B. S., Camilleri, M., Busciglio, I., Carlson, P., Szarka, L. A., Burton, D., & Zinsmeister, A. R. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.07.036 · Cited by 100 · see citing works

Symptom overlap and comorbidity of irritable bowel syndrome with other conditions

Frissora, C. L., & Koch, K. L. (2005) · Current Gastroenterology Reports · doi:10.1007/s11894-005-0018-9 · Cited by 100 · see citing works

Effect of Ramosetron on Stool Consistency in Male Patients With Irritable Bowel Syndrome With Diarrhea

Fukudo, S., Ida, M., Akiho, H., Nakashima, Y., & Matsueda, K. (2013) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2013.11.024 · Cited by 95 · see citing works

Randomized pharmacodynamic and pharmacogenetic trial of dronabinol effects on colon transit in irritable bowel syndrome‐diarrhea

Wong, B. S., Camilleri, M., Eckert, D. J., Carlson, P., Ryks, M. D., Burton, D. D., & Zinsmeister, A. R. (2012) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2011.01874.x · Cited by 95 · see citing works

Genetic variation in endocannabinoid metabolism, gastrointestinal motility, and sensation

Camilleri, M., Carlson, P., McKinzie, S., Grudell, A., Busciglio, I. A., Burton, D. D., Baxter, K. L., Ryks, M. D., & Zinsmeister, A. R. (2007) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00371.2007 · Cited by 95 · see citing works

Meta‐analysis: a functional polymorphism in the gene encoding for activity of the serotonin transporter protein is not associated with the irritable bowel syndrome

van Kerkhoven, L. A. S., Laheij, R. J. F., & Jansen, J. B. �. �. (2007) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2007.03453.x · Cited by 93 · see citing works

Serotonin transporter gene polymorphism and irritable bowel syndrome

Park, J. M., Choi, M., Park, J., Oh, J. H., Cho, Y. K., Lee, I. S., Kim, S. W., Choi, K.-Y., & Chung, I. ‐. (2006) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2006.00829.x · Cited by 91 · see citing works

Elevated circulating miR-150 and miR-342-3p in patients with irritable bowel syndrome

Fourie, N. H., Peace, R. M., Abey, S. K., Sherwin, L. B., Rahim-Williams, B., Smyser, P. A., Wiley, J. W., & Henderson, W. A. (2014) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2014.04.009 · Cited by 91 · see citing works

IBS: an epigenetic perspective

Dinan, T. G., Cryan, J. F., Shanahan, F., Keeling, P. W. N., & Quigley, E. M. M. (2010) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2010.99 · Cited by 90 · see citing works

A Polymorphism in the Serotonin Receptor 3A (HTR3A) Gene and Its Association With Harm Avoidance in Women

Melke, J., Westberg, L., Nilsson, S., Landén, M., Söderström, H., Baghaei, F., Rosmond, R., Holm, G., Björntorp, P. A., Nilsson, L., et al. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.10.1017 · Cited by 89 · see citing works

Gene, environment, and brain‐gut interactions in irritable bowel syndrome

Fukudo, S., & Kanazawa, M. (2011) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2011.06631.x · Cited by 87 · see citing works

Distinguishable Haplotype Blocks in the HTR3A and HTR3B Region in the Japanese Reveal Evidence of Association of HTR3B with Female Major Depression

Yamada, K., Hattori, E., Iwayama, Y., Ohnishi, T., Ohba, H., Toyota, T., Takao, H., Minabe, Y., Nakatani, N., Higuchi, T., et al. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.11.008 · Cited by 86 · see citing works

Impact of serotonin transporter gene polymorphism on brain activation by colorectal distention

Fukudo, S., Kanazawa, M., Mizuno, T., Hamaguchi, T., Kano, M., Watanabe, S., Sagami, Y., Shoji, T., Endo, Y., Hongo, M., et al. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.04.083 · Cited by 84 · see citing works

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Functional Bowel Disorders: A Roadmap to Guide the Next Generation of Research

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Development, Diversity, and Neurogenic Capacity of Enteric Glia

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Hypoxic Environment Promotes Barrier Formation in Human Intestinal Epithelial Cells through Regulation of MicroRNA 320a Expression

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Guidelines on the management of irritable bowel syndrome

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The Role of Diet in the Treatment of Irritable Bowel Syndrome

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Irritable Bowel Syndrome: News from an Old Disorder

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Functional dyspepsia susceptibility is related to CD14, GNB3, MIF, and TRPV1 gene polymorphisms in the Greek population

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Serotonin-Related Gene Variants in Patients with Irritable Bowel Syndrome and Depressive or Anxiety Disorders

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Silencing interleukin 1α underlies a novel inhibitory role of miR‐181c‐5p in alleviating low‐grade inflammation of rats with irritable bowel syndrome

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Impact of Enteric Nervous Cells on Irritable Bowel Syndrome: Potential Treatment Options

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Effects of Ellagic Acid on Oxidative Stress Index, Inflammatory Markers and Quality of Life in Patients With Irritable Bowel Syndrome: Randomized Double-blind Clinical Trial

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Efficacy and safety of non-pharmacological interventions for irritable bowel syndrome in adults

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Gene Polymorphisms and Susceptibility to Functional Dyspepsia: A Systematic Review and Meta-Analysis

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Correlation between the neuroendocrine axis, microbial species, inflammatory response, and gastrointestinal symptoms in irritable bowel syndrome

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Subjective Taste and Smell Changes in Conjunction with Anxiety and Depression Are Associated with Symptoms in Patients with Functional Constipation and Irritable Bowel Syndrome

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Mass spectrometry-based metabolomics for irritable bowel syndrome biomarkers

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The serotonin receptor 3E variant is a risk factor for female IBS-D

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Hypnotherapy and IBS: Implicit, long-term stress memory in the ENS?

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Stress, microbiota, and the gut–brain axis in mental and digestive health

Santos, J., Maran, P. L., & Rodríguez‐Urrutia, A. (2025) · Medicina Clínica · doi:10.1016/j.medcli.2024.11.023 · Cited by 15 · see citing works

Pharmacogenetics and the Treatment of Functional Gastrointestinal Disorders

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High Rates of Non-Response Across Treatment Attempts in Chronic Irritable Bowel Syndrome: Results From a Follow-Up Study in Tertiary Care

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Identification of serum proteome signature of irritable bowel syndrome: Potential utility of the tool for early diagnosis and patient's stratification

Τσιγαρίδας, Α., Anagnostopoulos, A. K., Papadopoulou, A., Ioakeim, S., Vaiopoulou, A., Papanikolaou, I. S., Viazis, N., Karamanolis, G. P., Mantzaris, G. J., Tsangaris, G. T., et al. (2017) · Journal of Proteomics · doi:10.1016/j.jprot.2017.07.019 · Cited by 12 · see citing works

The alternative serotonin transporter promoter P2 impacts gene function in females with irritable bowel syndrome

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HTR3A and HTR3E gene polymorphisms and diarrhea predominant irritable bowel syndrome risk: evidence from a meta-analysis

Guan, T., Li, T., Cai, W., Huang, D., Ouyang, P., Wang, Y., Chen, H., Wu, K., & Ma, X. (2017) · Oncotarget · doi:10.18632/oncotarget.19682 · Cited by 11 · see citing works

Gut–Brain Axis, Microbiota and Probiotics—Current Knowledge on Their Role in Irritable Bowel Syndrome: A Review

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Evaluating the Potential of Casein Glycomacropeptide in Adult Irritable Bowel Syndrome Management: A Pilot Study

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Mucosal RNA and protein expression as the next frontier in IBS: abnormal function despite morphologically intact small intestinal mucosa

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The role of fermentable carbohydrates and beverages in the symptomatology of functional gastrointestinal disease

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IBS common features among Northern Saudi population according to Rome IV criteria

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Relevance of Sex and Subtype in Patients With IBS: An Exploratory Study of Gene Expression

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Fundamentals of Neurogastroenterology: Basic Science

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Temporal Relationships Between Abdominal Pain, Psychological Distress and Coping in Patients With IBS – A Time Series Approach

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Comparative expression profiling in the intestine of patients with Giardia ‐induced postinfectious functional gastrointestinal disorders

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Acute Stress Regulates Sex-Related Molecular Responses in the Human Jejunal Mucosa: Implications for Irritable Bowel Syndrome

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G protein beta 3(GNβ3) C825T polymorphism and irritable bowel syndrome susceptibility: an updated meta-analysis based on eleven case-control studies

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Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome: A multicenter retrospective study

Berens, S., Dong, Y., Fritz, N., Walstab, J., D’Amato, M., Zheng, T., Wahl, V., Boekstegers, F., Bermejo, J. L., Martínez, C., et al. (2022) · World Journal of Gastroenterology · doi:10.3748/wjg.v28.i21.2334 · Cited by 6 · see citing works

Mucosal Microbiome Profiles Polygenic Irritable Bowel Syndrome in Mestizo Individuals

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Involvement of enteric glial cells in colonic motility in a rat model of irritable bowel syndrome with predominant diarrhea

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Bifidobacteria Was Decreased in Adult Patients With Irritable Bowel Syndrome Based on PCR and Bacterial Culture: A Systematic Review and Meta-Analysis

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Sensitivity and specificity of mean platelet volume as a laboratory marker for irritable bowel syndrome: Can it be added to Rome criteria?

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Parasitosis y síndrome de intestino irritable

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A bibliometric analysis of global research status and trends in irritable bowel syndrome and gut microbiota metabolites

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Evaluation of the Impact of Some Single-Nucleotide Gene Polymorphisms on the Development of Adenomatous Polyps of the Colon in Patients with Irritable Bowel Syndrome

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Stress, microbiota, and the gut–brain axis in mental and digestive health

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High frequency of the 472AA COMT (Val158) homozygous genotype of the catechol-O-methyltransferase (COMT) gene in children with irritable bowel syndrome

Semen, M. O., Lychkovska, O. L., Shymanska, I., Semen, V. D., & Makukh, H. (2022) · Modern pediatrics Ukraine · doi:10.15574/sp.2022.126.23 · Cited by 2 · see citing works

Current Status of Translational Research on Irritable Bowel Syndrome

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Genetic studies in irritable bowel syndrome-status quo

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Impact of Electroacupuncture on the Expression Profile of the Anterior Cingulate Cortex in a Rat Model of Irritable Bowel Syndrome Based on Transcriptome Sequencing and Bioinformatics Analysis

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Irritable bowel syndrome – diagnostic and therapeutic recommendations considering the place of antispasmodics

Cybulska, A. M. (2019) · Pediatria i Medycyna Rodzinna · doi:10.15557/pimr.2019.0043

Exploring the Interconnections of Functional Gut Disorders and Inflammatory Bowel Disease: A Narrative Review Article

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Risk factors for irritable bowel syndrome: A review

Gaus, O. V., Livzan, M. A., & Александровна, Г. Д. (2024) · Terapevticheskii arkhiv · doi:10.26442/00403660.2024.02.202597 · Cited by 1 · see citing works

Veränderungen der Darm-Gehirn-Achse beim Reizdarmsyndrom – Ein Update

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Functional polymorphism of the serotonin reuptake transporter SLC6A4 gene in various clinical variants of irritable bowel syndrome

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Current Theories for Development of Irritable Bowel Syndrome

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Publications of BH authors in journals indexed in Current Contents

Tanović, N. (2016) · Acta Medica Academica · doi:10.5644/ama2006-124.179

RNA and inflammatory autoimmune diseases

Gupta, B., Tripathy, A., & Jaiswal, K. S. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-817193-6.00012-1

Volatile organic compounds analysis in the context of gastrointestinal health and disease

Baranska, A. L. (2021) · doi:10.26481/dis.20211129ab

Associations between IBS, IBD and the risk of Insomnia: An Observational Analysis and Genome-wide Interaction StudyPreprint

Cai, Q., Zhang, H., Qin, X., He, D., Zhao, Y., Wei, W., Chu, X., Shi, S., Zhang, N., Li, C., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-1695595/v1

Hypnotherapy and IBS: Implicit and Simple Stress Memory in ENS?Preprint

Császár, N., & Bókkon, I. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4148409

The role of cellular kinetics in patients with irritable bowel syndrome in Diyala Governorate

Wahib, A. M. (2023) · Journal of Arabian Peninsula Centre for Medical and Applied Researches · doi:10.56793/pcra23112

The Brain-Like Enteric Nervous System

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Genetic Factors

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Gastrointestinal-specific Anxiety in IBD: Associations With Disease Activity, Psychological Symptoms, and Serotonergic Polymorphisms

Atanasova, K., Mellein, S., Knoedler, L.-L., Niehaus, V. D., Mirkhan, H., Thomann, P. A., Lis, S., Ebert, M. P. A., Reindl, W., & Thomann, A. (2026) · Psychosomatic Medicine · doi:10.1097/psy.0000000000001493

The genetics of irritable bowel syndrome.

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Genetic Factors

Katsumata, R., & Shiotani, A. (2024) · Springer eBooks · doi:10.1007/978-981-97-8410-3_7

Genetics of irritable bowel syndrome: shifting gear via biobank-scale studies

Camilleri, M., Zhernakova, A., Bozzarelli, I., & D’Amato, M. (2022) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-022-00662-2 · Cited by 44 · see citing works

Genetics of irritable bowel syndrome

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