Cited by 284Gastrointestinal motility and disordersGut microbiota and healthNeuropeptides and Animal Physiology

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Non-conventional features of peripheral serotonin signalling — the gut and beyond

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Spohn, Stephanie N., Mawe, Gary M.·2017·Nature Reviews Gastroenterology & Hepatology

DOI 10.1038/nrgastro.2017.51PMC PMC5672796

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Abstract

Serotonin was first discovered in the gut, and its conventional actions as an intercellular signalling molecule in the intrinsic and extrinsic enteric reflexes are well recognized, as are a number of serotonin signalling pharmacotherapeutic targets for treatment of nausea, diarrhoea or constipation. The latest discoveries have greatly broadened our understanding of non-conventional actions of peripheral serotonin within the gastrointestinal tract and in a number of other tissues. For example, it is now clear that bacteria within the lumen of the bowel influence serotonin synthesis and release by enterochromaffin cells. Also, serotonin can act both as a pro-inflammatory and anti-inflammatory signalling molecule in the intestinal mucosa via activation of serotonin receptors (5-HT 7 or 5-HT 4 receptors, respectively). For decades, serotonin receptors have been known to exist in a variety of tissues other than the gut, but studies have now provided strong evidence for physiological roles of serotonin in several important processes, including haematopoiesis, metabolic homeostasis and bone metabolism. Furthermore, evidence for serotonin synthesis in peripheral tissues outside of the gut is emerging. In this Review, we expand the discussion beyond gastrointestinal functions to highlight the roles of peripheral serotonin in colitis, haematopoiesis, energy and bone metabolism, and how serotonin is influenced by the gut microbiota.

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Gong, Y., Slee, R. B., Fukai, N., Rawadi, G., Roman-Roman, S., Reginato, A. M., Wang, H., Cundy, T., Glorieux, F. H., Lev, D., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00571-2 · Cited by 2,235
The expanded biology of serotonin
Berger, M., Gray, J. A., & Roth, B. L. (2009) · Annual Review of Medicine · doi:10.1146/annurev.med.60.042307.110802 · Cited by 2,100
High Bone Density Due to a Mutation in LDL-Receptor–Related Protein 5
Boyden, L. M., Mao, J., Belsky, J., Mitzner, L., Farhi, A., Mitnick, M. A., Wu, D., Insogna, K., & Lifton, R. P. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa013444 · Cited by 1,591
Gut microbes promote colonic serotonin production through an effect of short-chain fatty acids on enterochromaffin cells
Reigstad, C. S., Salmonson, C. E., III, J. F. R., Szurszewski, J. H., Linden, D. R., Sonnenburg, J. L., Farrugia, G., & Kashyap, P. C. (2015) · The FASEB Journal · doi:10.1096/fj.14-259598 · Cited by 1,335
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Self-citation
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Yadav, V. K., Ryu, J.-H., Suda, N., Tanaka, K. F., Gingrich, J. A., Schütz, G., Glorieux, F. H., Chiang, C. Y., Zajac, J. D., Insogna, K. L., et al. (2008) · Cell · doi:10.1016/j.cell.2008.09.059 · Cited by 839
A unique central tryptophan hydroxylase isoform
Walther, D. J., & Bäder, M. (2003) · Biochemical Pharmacology · doi:10.1016/s0006-2952(03)00556-2 · Cited by 752
Evidence for Possible Involvement of 5-HT 2B Receptors in the Cardiac Valvulopathy Associated With Fenfluramine and Other Serotonergic Medications
Rothman, R. B., Baumann, M. H., Savage, J. E., Rauser, L., McBride, A., Hufeisen, S. J., & Roth, B. L. (2000) · Circulation · doi:10.1161/01.cir.102.23.2836 · Cited by 722
Identification of Enteramine, the Specific Hormone of the Enterochromaffin Cell System, as 5-Hydroxytryptamine
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Show all 90 references

Research works printed but not linked: 2

Erspamer, V. Experimental research on the biological significance of enterochromaffin cells [Italian]. Arch. Fisiol. 37, 156–159 (1937). This report represents the discovery of serotonin.
Page, I. H., Rapport, M. M. & Green, A. A. The crystallization of serotonin. J. Lab. Clin. Med. 33, 1606 (1948). This paper demonstrates that the structure of serotonin is 5-hydroxytryptamine.

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Authors: Spohn, S. N., & Mawe, G. M.
Affiliations: University of Vermont (US)
Corresponding author: Mawe, Gary M.
ORCID: Spohn, Stephanie N.
Mawe, Gary M.
Venue: Nature Reviews Gastroenterology & Hepatology
Publisher: Springer Science and Business Media LLC
Published: 2017-05-10
Volume: 14
Issue: 7
Pages: 412-420
ISSN: 1759-5045 (ISSN-L)
1759-5053
DOI: 10.1038/nrgastro.2017.51
PMC: PMC5672796
OpenAlex: W2612522158
Cited by: 282
References: 90
Citations by year: 2026: 19 · 2025: 26 · 2024: 57 · 2023: 28 · 2022: 32 · 2021: 37 · 2020: 28 · 2019: 25 · 2018: 24 · 2017: 5
FWCI: 3.77
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Gastroenterology & Hepatology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK062267)
Topics: Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords: serotonin, gut microbiota, enterochromaffin cells, serotonin receptors, 5-HT7 receptor, 5-HT4 receptor, gastrointestinal inflammation, colitis, hematopoiesis, metabolic homeostasis, bone remodeling, enteric reflexes, gut-brain axis
MeSH terms: Gastrointestinal Microbiome, Colitis, Hematopoiesis, Homeostasis, Humans, Serotonin, Signal Transduction, Bone Remodeling, Enteric Nervous System, Inflammation Mediators, Gastrointestinal Tract

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