The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Early local immune defences in the respiratory tract
Open accessAbstract
The respiratory immune response consists of multiple tiers of cellular responses that are engaged in a sequential manner in order to control infections. The stepwise engagement of effector functions with progressively increasing host fitness costs limits tissue damage. In addition, specific mechanisms are in place to promote disease tolerance in response to respiratory infections. Environmental factors, obesity and the ageing process can alter the efficiency and regulation of this tiered response, increasing pathology and mortality as a result. In this Review, we describe the cell types that coordinate pathogen clearance and tissue repair through the serial secretion of cytokines, and discuss how the environment and comorbidity influence this response.
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Citations
Cites
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Cited by
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“In particular, transcription of a broad range of interferon-stimulated genes (ISGs), known to be typically activated by type I and III interferons (Iwasaki et al., 2017), was remarkably increased.”
Aging impairs both primary and secondary RIG-I signaling for interferon induction in human monocytes
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Self-citation
Metadata
- Authors
- Iwasaki, A., Foxman, E. F., & Molony, R. D.
- Venue
- Nature Reviews Immunology
- Published
- 2016-11-28
- Volume
- 17
- Issue
- 1
- Pages
- 7-20
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W2557403528
- Cited by
- 328
- References
- 19
- FWCI
- 1.22
- Type
- journal article
- Language
- en
- Open access
- green
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