Regulation of immunity and inflammation by hypoxia in immunological niches

Targeting Hypoxia-Inducible Factors for the Treatment of Anemia in Chronic Kidney Disease Patients

Locatelli, F., Fishbane, S. N., Block, G. A., & Macdougall, I. C. (2017) · American Journal of Nephrology · doi:10.1159/000455166 · Cited by 4,836

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

Tannahill, G. M., Curtis, A. M., Adamik, J., Palsson-McDermott, E. M., McGettrick, A. F., Goel, G., Frezza, C., Bernard, N. J., Kelly, B., Foley, N. H., et al. (2013) · Nature · doi:10.1038/nature11986 · Cited by 4,176

Hypoxia-inducible factors in physiology and medicine

Semenza, G. L. (2012) · Cell · doi:10.1016/j.cell.2012.01.021 · Cited by 3,645

A guide to immunometabolism for immunologists

O'Neill, L. A. J., Kishton, R. J., & Rathmell, J. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2016.70 · Cited by 3,315

Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway.

Kaelin, W. G., & Ratcliffe, P. J. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.04.009 · Cited by 3,251

Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages

Mills, E. L., Kelly, B., Logan, A., Costa, A. S. H., Varma, M., Bryant, C. E., Tourlomousis, P., Däbritz, J. H. M., Gottlieb, E., Latorre, I., et al. (2016) · Cell · doi:10.1016/j.cell.2016.08.064 · Cited by 2,291

Hypoxia and inflammation

Eltzschig, H. K., & Carmeliet, P. (2011) · New England Journal of Medicine · doi:10.1056/nejmra0910283 · Cited by 2,061

Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1α during hypoxia

Chandel, N. S., McClintock, D. S., Feliciano, C. E., Wood, T. M., Melendez, J. A., Rodriguez, A. M., & Schumacker, P. T. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001914200 · Cited by 2,000

Rational design of ICD-inducing nanoparticles for cancer immunotherapy

Zhang, Z., Pan, Z., Li, Q., Huang, Q., Shi, L., & Liu, Y. (2024) · Science Advances · doi:10.1126/sciadv.adk0716 · Cited by 61

Vitamin D/VDR signaling inhibits LPS-induced IFNγ and IL-1β in Oral epithelia by regulating hypoxia-inducible factor-1α signaling pathway

Ge, X., Wang, L., Li, M., Xu, N., Yu, F., Yang, F., Li, R., Zhang, F., Zhao, B., & Du, J. (2019) · Cell Communication and Signaling · doi:10.1186/s12964-019-0331-9 · Cited by 60

Adenosine at the Interphase of Hypoxia and Inflammation in Lung Injury

Li, X., Berg, N. K., Mills, T., Zhang, K., Eltzschig, H. K., & Yuan, X. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.604944 · Cited by 59

Interplay of hypoxia-inducible factors and oxygen therapy in cardiovascular medicine

Liang, Y., Ruan, W., Jiang, Y., Smalling, R. W., Yuan, X., & Eltzschig, H. K. (2023) · Nature Reviews Cardiology · doi:10.1038/s41569-023-00886-y · Cited by 64

The immune landscape in apical periodontitis: From mechanism to therapy

Wen, Y., Lin, Y., Zhou, L., Chen, L., & Zhang, L. (2024) · International Endodontic Journal · doi:10.1111/iej.14125 · Cited by 59

Reprogramming Tumor Associated Macrophages toward M1 Phenotypes with Nanomedicine for Anticancer Immunotherapy

Xu, X., Gong, X., Wang, Y., Li, J., Wang, H., Wang, J., Sha, X., Li, Y., & Zhang, Z. (2020) · Advanced Therapeutics · doi:10.1002/adtp.201900181 · Cited by 59

Defective Mitochondrial Cardiolipin Remodeling Dampens HIF-1α Expression in Hypoxia

Chowdhury, A., Aich, A., Jain, G., Wozny, K., Lüchtenborg, C., Hartmann, M., Bernhard, O., Balleiniger, M., Alfar, E. A., Zieseniß, A., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.09.057 · Cited by 57

Immunobiology and application of toll-like receptor 4 agonists to augment host resistance to infection

Hernandez, A., Patil, N. K., Stothers, C. L., Luan, L., McBride, M. A., Owen, A. M., Burelbach, K. R., Williams, D. L., Sherwood, E. R., & Bohannon, J. K. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104502 · Cited by 58

Now a Nobel gas: oxygen

Fandrey, J., Schödel, J., Eckardt, K., Katschinski, D. M., & Wenger, R. H. (2019) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-019-02334-8 · Cited by 54

Cell-free DNA as diagnostic and prognostic biomarkers for adult sepsis: a systematic review and meta-analysis

Charoensappakit, A., Sae‐khow, K., Rattanaliam, P., Vutthikraivit, N., Pecheenbuvan, M., Udomkarnjananun, S., & Leelahavanichkul, A. (2023) · Scientific Reports · doi:10.1038/s41598-023-46663-2 · Cited by 61

Hippocampal neurons respond to brain activity with functional hypoxia

Butt, U. J., Steixner-Kumar, A. A., Depp, C., Sun, T., Hassouna, I. A., Wüstefeld, L., Arinrad, S., Zillmann, M. R., Schopf, N., Garcia‐Agudo, L. F., et al. (2021) · Molecular Psychiatry · doi:10.1038/s41380-020-00988-w · Cited by 53

Integration of Epigenetic Mechanisms into Non-Genotoxic Carcinogenicity Hazard Assessment: Focus on DNA Methylation and Histone Modifications

Desaulniers, D. M., Vasseur, P., Jacobs, A. C., Aguila, M. C., Ertych, N., & Jacobs, M. N. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222010969 · Cited by 55

HIF-1α hampers dendritic cell function and Th1 generation during chronic visceral leishmaniasis

Hammami, A., Abidin, B. M., Heinonen, K. M., & Stäger, S. (2018) · Scientific Reports · doi:10.1038/s41598-018-21891-z · Cited by 54

HIF-1α-induced xenobiotic transporters promote Th17 responses in Crohn's disease

Xie, A., Robles, R. J., Mukherjee, S., Zhang, H., Feldbrügge, L., Csizmadia, E., Wu, Y., Enjyoji, K., Moss, A. C., Otterbein, L. E., et al. (2018) · Journal of Autoimmunity · doi:10.1016/j.jaut.2018.07.022 · Cited by 53

Nanomaterials-Involved Tumor-Associated Macrophages’ Reprogramming for Antitumor Therapy

Li, S., Hou, H., Chu, X., Zhu, Y., Zhang, Y., Duan, M., Liu, J., & Liu, Y. (2024) · ACS Nano · doi:10.1021/acsnano.3c12387 · Cited by 53

Recapitulation of In Situ Endochondral Ossification Using an Injectable Hypoxia‐Mimetic Hydrogel

Sun, L., Ma, Y., Niu, H., Liu, Y., Yuan, Y., & Liu, C. (2020) · Advanced Functional Materials · doi:10.1002/adfm.202008515 · Cited by 52

Role of microRNAs in Pressure Ulcer Immune Response, Pathogenesis, and Treatment

Niemiec, S. M., Louiselle, A. E., Liechty, K. W., & Zgheib, C. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms22010064 · Cited by 53

Adenosine Awakens Metabolism to Enhance Growth-Independent Killing of Tolerant and Persister Bacteria across Multiple Classes of Antibiotics

Kitzenberg, D., Lee, J. S., Mills, K. B., Kim, J.-S., Liu, L., Vázquez‐Torres, A., Colgan, S. P., & Kao, D. J. (2022) · mBio · doi:10.1128/mbio.00480-22 · Cited by 52

Hypoxia-inducible factor-1α regulation of myeloid cells

Stothers, C. L., Luan, L., Fensterheim, B. A., & Bohannon, J. K. (2018) · Journal of Molecular Medicine · doi:10.1007/s00109-018-1710-1 · Cited by 52

Relationship between Hypoxic and Immune Pathways Activation in the Progression of Neuroinflammation: Role of HIF-1α and Th17 Cells

Arias, C., Sepúlveda, P., Castillo, R. L., & Salazar, L. A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043073 · Cited by 53

The transcription factor HIF-1α mediates plasticity of NKp46+ innate lymphoid cells in the gut

Krzywińska, E., Sobecki, M., Nagarajan, S., Zacharjasz, J., Tambuwala, M. M., Pelletier, A., Cummins, E. P., Gotthardt, D., Fandrey, J., Kerdiles, Y. M., et al. (2022) · The Journal of Experimental Medicine · doi:10.1084/jem.20210909 · Cited by 51

Reinventing the Penumbra — the Emerging Clockwork of a Multi-modal Mechanistic Paradigm

Walther, J., Kirsch, E. M., Hellwig, L., Schmerbeck, S. S., Holloway, P. M., Buchan, A. M., & Mergenthaler, P. (2022) · Translational Stroke Research · doi:10.1007/s12975-022-01090-9 · Cited by 49

Enhanced radiotherapy efficacy and induced anti-tumor immunity in HCC by improving hypoxia microenvironment using oxygen microcapsules

Dai, X., Ruan, J., Guo, Y., Sun, Z., Liu, J., Bao, X., Zhang, H., Li, Q., Ye, C., Wang, X., et al. (2021) · Chemical Engineering Journal · doi:10.1016/j.cej.2021.130109 · Cited by 49

The Potential Role of Hypoxia-Inducible Factor-1 in the Progression and Therapy of Central Nervous System Diseases

Chen, H., Ma, D., Yue, F., Qi, Y., Dou, M., Cui, L., & Xing, Y. (2021) · Current Neuropharmacology · doi:10.2174/1570159x19666210729123137 · Cited by 51

Live Microscopy of Multicellular Spheroids with the Multimodal Near-Infrared Nanoparticles Reveals Differences in Oxygenation Gradients

Debruyne, A. C., Okkelman, I. A., Heymans, N., Pinheiro, C., Hendrix, A., Nobis, M., Borisov, S. M., & Dmitriev, R. I. (2024) · ACS Nano · doi:10.1021/acsnano.3c12539 · Cited by 58

Bridging angiogenesis and immune evasion in the hypoxic tumor microenvironment

Schito, L. (2018) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00209.2018 · Cited by 49

Substance P participates in periodontitis by upregulating HIF-1α and RANKL/OPG ratio

Yan, K., Lin, Q., Tang, K., Liu, S., Du, Y., Yu, X., & Li, S. (2020) · BMC Oral Health · doi:10.1186/s12903-020-1017-9 · Cited by 48

Immune metabolism regulation of the germinal center response

Choi, S., & Morel, L. M. (2020) · Experimental & Molecular Medicine · doi:10.1038/s12276-020-0392-2 · Cited by 50

Hypoxia and its possible relationship with endometrial receptivity in adenomyosis: a preliminary study

Guo, S., Zhang, D., Lu, X., Zhang, Q. Y., Gu, R., Sun, B., & Sun, Y. (2021) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-020-00692-y · Cited by 50

Hypoxia-Inducible Factor Prolyl 4-Hydroxylases and Metabolism

Koivunen, P., & Kietzmann, T. (2018) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2018.10.004 · Cited by 47

Shaping of Dendritic Cell Function by the Metabolic Micro-Environment

Brombacher, E. C., & Everts, B. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00555 · Cited by 45

Hypoxia-adaptive pathways: A pharmacological target in fibrotic disease?

Strowitzki, M. J., Ritter, A. S., Kimmer, G., & Schneider, M. A. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104364 · Cited by 47

Macrophage Motility in Wound Healing Is Regulated by HIF-1α via S1P Signaling

Hutami, I. R., Izawa, T., Khurel‐Ochir, T., Sakamaki, T., Iwasa, A., & Tanaka, E. I. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168992 · Cited by 49

The induction of natural competence adapts staphylococcal metabolism to infection

Cordero, M., García‐Fernández, J., Acosta, I. C., Yepes, A., Ortiz, J. A., Lisowski, C., Oesterreicht, B., Ohlsen, K., López‐Collazo, E., Förstner, K. U., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-29206-7 · Cited by 45

Regulation of CD11b by HIF-1α and the STAT3 signaling pathway contributes to the immunosuppressive function of B cells in inflammatory bowel disease

Qian, T., Hong, J., Wang, L., Wang, Z., Zhou, L., Li, Y., Liu, R., & Chu, Y. (2019) · Molecular Immunology · doi:10.1016/j.molimm.2019.04.005 · Cited by 46

HIF-1α Modulates Core Metabolism and Virus Replication in Primary Airway Epithelial Cells Infected with Respiratory Syncytial Virus

Morris, D. R., Qu, Y., Agrawal, A. S., Garofalo, R. P., & Casola, A. (2020) · Viruses · doi:10.3390/v12101088 · Cited by 45

Metabolic regulation of the bone marrow microenvironment in leukemia

Xu, B., Hu, R., Zhao, L., Chen, T., Chen, J., Hu, Y., Jiang, Y., & Li, Y. (2020) · Blood Reviews · doi:10.1016/j.blre.2020.100786 · Cited by 46

Role of hypoxia in inhibiting dendritic cells by VEGF signaling in tumor microenvironments: mechanism and application.

Han, Z., Dong, Y., Lu, J., Yang, F., Zheng, Y., & Yang, H. (2021) · PubMed Central · Cited by 45

Implications of cellular metabolism for immune cell migration

Guak, H., & Krawczyk, C. M. (2020) · Immunology · doi:10.1111/imm.13260 · Cited by 47

Upregulated of ANXA3, SORL1, and Neutrophils May Be Key Factors in the Progressionof Ankylosing Spondylitis

Jiang, J., Zhan, X., Qu, H., Liang, T., Li, H., Chen, L., Huang, S., Sun, X., Jiang, W., Chen, J., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.861459 · Cited by 43

A Novel “Inside‐Out” Intraocular Nanomedicine Delivery Mode for Nanomaterials’ Biological Effect Enhanced Choroidal Neovascularization Occlusion and Microenvironment Regulation

Jin, Y., Guo, Y., Yang, J., Chu, X., Huang, X., Wang, Q., Zeng, Y., Su, L., Lu, S. T., Wang, C., et al. (2022) · Advanced Materials · doi:10.1002/adma.202209690 · Cited by 43

Anti‐angiogenic therapy enhances cancer immunotherapy: Mechanism and clinical application

Li, A., & Fang, J. (2024) · Interdisciplinary medicine · doi:10.1002/inmd.20230025 · Cited by 46

Overcoming physical stromal barriers to cancer immunotherapy

Chung, S. W., Xie, Y., & Suk, J. S. (2021) · Drug Delivery and Translational Research · doi:10.1007/s13346-021-01036-y · Cited by 46

The Asparagine Hydroxylase FIH: A Unique Oxygen Sensor

Volkova, Y. L., Pickel, C., Jucht, A. E., Wenger, R. H., & Scholz, C. C. (2022) · Antioxidants and Redox Signaling · doi:10.1089/ars.2022.0003 · Cited by 43

Cross-talk between signal transduction and metabolism in B cells

Jellusova, J. (2018) · Immunology Letters · doi:10.1016/j.imlet.2018.11.003 · Cited by 44

Compliant substratum modulates vinculin expression in focal adhesion plaques in skeletal cells

Zhou, C., Wang, Q., Zhang, D., Cai, L., Du, W. T., & Xie, J. (2019) · International Journal of Oral Science · doi:10.1038/s41368-019-0052-3 · Cited by 42

Mucosal inflammation downregulates PHD1 expression promoting a barrier‐protective HIF‐1α response in ulcerative colitis patients

Brown, E., Rowan, C. R., Strowitzki, M. J., Fagundes, R. R., Faber, K. N., Güntsch, A., Halligan, D. N., Kugler, J., Jones, F., Lee, C. T., et al. (2020) · The FASEB Journal · doi:10.1096/fj.201902103r · Cited by 43

Acidosis-Induced TGF-β2 Production Promotes Lipid Droplet Formation in Dendritic Cells and Alters Their Potential to Support Anti-Mesothelioma T Cell Response

Trempolec, N., Degavre, C., Doix, B., Brusa, D., Corbet, C., & Féron, O. (2020) · Cancers · doi:10.3390/cancers12051284 · Cited by 42

Potential biomarkers in septic shock besides lactate

Yang, H., Du, L., & Zhang, Z. (2020) · Experimental Biology and Medicine · doi:10.1177/1535370220919076 · Cited by 44

Hypoxia‐sensitive pathways in intestinal inflammation

Brown, E., & Taylor, C. T. (2017) · The Journal of Physiology · doi:10.1113/jp274350 · Cited by 41

Metabolic Regulation of Hypoxia-Inducible Transcription Factors: The Role of Small Molecule Metabolites and Iron

Bailey, P. S. J., & Nathan, J. A. (2018) · Biomedicines · doi:10.3390/biomedicines6020060 · Cited by 41

Shigella-mediated oxygen depletion is essential for intestinal mucosa colonization

Tinévez, J.-Y., Arena, E. T., Anderson, M. C., Nigro, G., Injarabian, L., André, A. C., Ferrari, M. L., Campbell‐Valois, F., Devin, A., Shorte, S. L., et al. (2019) · Nature Microbiology · doi:10.1038/s41564-019-0525-3 · Cited by 42

Phospholipid membrane-decorated deep-penetrated nanocatalase relieve tumor hypoxia to enhance chemo-photodynamic therapy

Yin, J., Cao, H., Wang, H., Sun, K., Li, Y., & Zhang, Z. (2020) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2020.06.004 · Cited by 41

Thyroid Hormone and Deiodination in Innate Immune Cells

van der Spek, A. H., Fliers, E., & Boelen, A. (2020) · Endocrinology · doi:10.1210/endocr/bqaa200 · Cited by 41

Static and Dynamic Biomaterial Engineering for Cell Modulation

Park, H.-J., Hong, H., Thangam, R., Song, M.-G., Kim, J., Jo, E.-H., Jang, Y.-J., Choi, W.-H., Lee, M., Kang, H., et al. (2022) · Nanomaterials · doi:10.3390/nano12081377 · Cited by 42

Toll-like receptors in innate immunity and inflammation: from fundamental biology to clinic insights

Qian, C., Cao, X., & Hoffmann, J. A. (2026) · Immunity & Inflammation · doi:10.1007/s44466-026-00040-6 · Cited by 43

Synthetic CpG-ODN rapidly enriches immune compartments in neonatal chicks to induce protective immunity against bacterial infections

Gunawardana, T., Ahmed, K. A., Goonewardene, K. B., Popowich, S., Kurukulasuriya, S., Karunarathna, R., Gupta, A. V., Lockerbie, B. P., Földvári, M., Tikoo, S. K., et al. (2019) · Scientific Reports · doi:10.1038/s41598-018-36588-6 · Cited by 40

Hypoxia Inducible Factor 1α Inhibits the Expression of Immunosuppressive Tryptophan-2,3-Dioxygenase in Glioblastoma

Mohapatra, S. R., Sadik, A., Tykocinski, L., Dietze, J., Poschet, G., Heiland, I., & Opitz, C. A. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02762 · Cited by 40

Novel Functions of the Septin Cytoskeleton

Ivanov, A. I., Le, H. T., Naydenov, N. G., & Rieder, F. (2020) · American Journal Of Pathology · doi:10.1016/j.ajpath.2020.09.007 · Cited by 40

Hypoxia-Inducible Factor–Prolyl Hydroxyl Domain Inhibitors: From Theoretical Superiority to Clinical Noninferiority Compared with Current ESAs?

Locatelli, F., & Vecchio, L. D. (2022) · Journal of the American Society of Nephrology · doi:10.1681/asn.2022040413 · Cited by 40

Two-photon fluorescent probe for detection of nitroreductase and hypoxia-specific microenvironment of cancer stem cell

Liu, Y., Liu, W., Li, H., Yan, W., Yang, X., Liu, D., Wang, S., & Zhang, J. (2018) · Analytica Chimica Acta · doi:10.1016/j.aca.2018.03.030 · Cited by 39

Bone marrow infiltrated Lnc-INSR induced suppressive immune microenvironment in pediatric acute lymphoblastic leukemia

Wang, Y., Yang, X., Sun, X., Rong, L., Kang, M., Wu, P., Ji, X., Lin, R., Huang, J., Xue, Y., et al. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-1078-8 · Cited by 38

The transcription factor HIF-1α mediates plasticity of NKp46+ innate lymphoid cells in the gut

Krzywińska, E., Sobecki, M., Nagarajan, S., Zacharjasz, J., Tambuwala, M. M., Pelletier, A., Cummins, E. P., Gotthardt, D., Fandrey, J., Kerdiles, Y. M., et al. (2022) · Zurich Open Repository and Archive (University of Zurich) · doi:10.5167/uzh-215811 · Cited by 39

Intermittent hypoxia conditioning as a potential prevention and treatment strategy for ischemic stroke: Current evidence and future directions

Yuan, H., Liu, J., Gu, Y., Ji, X., & Nan, G. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.1067411 · Cited by 37

The role of hypoxia-inducible factor 1α in hepatic lipid metabolism

Luo, M., Li, T., & Sang, H. (2023) · Journal of Molecular Medicine · doi:10.1007/s00109-023-02308-5 · Cited by 42

Investigational hypoxia-inducible factor prolyl hydroxylase inhibitors (HIF-PHI) for the treatment of anemia associated with chronic kidney disease

Vecchio, L. D., & Locatelli, F. (2018) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2018.1493455 · Cited by 39

Inflammation research sails through the sea of immunology to reach immunometabolism

Kumar, V. (2019) · International Immunopharmacology · doi:10.1016/j.intimp.2019.05.002 · Cited by 41

Sustained maternal inflammation during the early third-trimester yields intrauterine growth restriction, impaired skeletal muscle glucose metabolism, and diminished β-cell function in fetal sheep1,2

Cadaret, C. N., Merrick, E. M., Barnes, T. L., Beede, K. A., Posont, R. J., Petersen, J. L., & Yates, D. T. (2019) · Journal of Animal Science · doi:10.1093/jas/skz321 · Cited by 38

Hypoxia and viral infectious diseases

Huang, R., Huestis, M., Gan, E. S., Ooi, E. E., & Ohh, M. (2021) · JCI Insight · doi:10.1172/jci.insight.147190 · Cited by 37

A novel human enteroid-anaerobe co-culture system to study microbial-host interaction under physiological hypoxiaPreprint

Fofanova, T. Y., Stewart, C. J., Auchtung, J. M., Wilson, R. L., Britton, R. A., Grande-Allen, K. J., Estes, M., & Petrosino, J. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/555755 · Cited by 37

Hypoxia and renal fibrosis

Naas, S., Schiffer, M., & Schödel, J. (2023) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00201.2023 · Cited by 46

Hypoxia reduces cell attachment of SARS-CoV-2 spike protein by modulating the expression of ACE2, neuropilin-1, syndecan-1 and cellular heparan sulfate

Prieto‐Fernández, E., Egia‐Mendikute, L., Vila-Vecilla, L., Bosch, A., Barreira-Manrique, A., Lee, S. Y., Río, A. G.-D., Antoñana-Vildosola, A., Jiménez-Lasheras, B., Moreno‐Cugnon, L., et al. (2021) · Emerging Microbes & Infections · doi:10.1080/22221751.2021.1932607 · Cited by 38

Mechanism and Basis of Traditional Chinese Medicine Against Obesity: Prevention and Treatment Strategies

Zhang, C., Sheng, J., Xie, W., Luo, X., Xue, Y., Xu, G., & Chen, C. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.615895 · Cited by 42

The Hypoxia-Adenosine Link during Myocardial Ischemia—Reperfusion Injury

Ruan, W., Ma, X., Bang, I. H., Liang, Y., Muehlschlegel, J. D., Tsai, K., Mills, T., Yuan, X., & Eltzschig, H. K. (2022) · Biomedicines · doi:10.3390/biomedicines10081939 · Cited by 37

Limitation of TCA Cycle Intermediates Represents an Oxygen-Independent Nutritional Antibacterial Effector Mechanism of Macrophages

Hayek, I., Fischer, F., Schulze‐Luehrmann, J., Dettmer, K., Sobotta, K., Schatz, V., Kohl, L., Boden, K., Lang, R., Oefner, P. J., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.02.103 · Cited by 35

Leishmania Infection Induces Macrophage Vascular Endothelial Growth Factor A Production in an ARNT/HIF-Dependent Manner

Weinkopff, T., Roys, H., Bowlin, A. K., & Scott, P. (2019) · Infection and Immunity · doi:10.1128/iai.00088-19 · Cited by 36

The role of hypoxia in the pathophysiology of chronic rhinosinusitis

Zhong, B., Seah, J. J., Liu, F., Ba, L., Du, J., & Wang, D. Y. (2022) · Allergy · doi:10.1111/all.15384 · Cited by 35

The role of PD-L1 in the immune dysfunction that mediates hypoxia-induced multiple organ injury

Sun, Y., Tan, J., Miao, Y., & Zhang, Q. (2021) · Cell Communication and Signaling · doi:10.1186/s12964-021-00742-x · Cited by 36

Attenuation of inflammatory bowel disease by oral administration of mucoadhesive polydopamine-coated yeast β-glucan via ROS scavenging and gut microbiota regulation

Yang, F., Su, Y.-T., Yan, C., Chen, T., & Cheung, P. C. K. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02434-3 · Cited by 35

Metabolic Modulation-Mediated Antibiotic and Immune Activation for Treatment of Chronic Lung Infections

Xiu, W., Dong, H., Chen, X., Wan, L., Lu, L., Yang, K., Yuwen, L., Li, Q., Ding, M., Zhang, Y., et al. (2024) · ACS Nano · doi:10.1021/acsnano.4c03527 · Cited by 36

A novel system to culture human intestinal organoids under physiological oxygen content to study microbial-host interaction

Fofanova, T. Y., Karandikar, U. C., Auchtung, J. M., Wilson, R. L., Valentin, A. J., Britton, R. A., Grande-Allen, K. J., Estes, M. K., Hoffman, K. L., Ramani, S., et al. (2024) · PLoS ONE · doi:10.1371/journal.pone.0300666 · Cited by 35

Microbiome-active drug delivery systems (MADDS): Leveraging microbial stimuli for controlled drug release

Kamath, S., Ariaee, A., Abdelhafez, A., Asif, Z., Chan, N. S. L., Collins, K., Hunter, A., & Joyce, P. (2025) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2025.115720 · Cited by 36

Hypoxic microenvironment shapes HIV-1 replication and latency

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