Regulation of immunity and inflammation by hypoxia in immunological niches

Targeting Hypoxia-Inducible Factors for the Treatment of Anemia in Chronic Kidney Disease Patients

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Succinate is an inflammatory signal that induces IL-1β through HIF-1α

Tannahill, G. M., Curtis, A. M., Adamik, J., Palsson-McDermott, E. M., McGettrick, A. F., Goel, G., Frezza, C., Bernard, N. J., Kelly, B., Foley, N. H., et al. (2013) · Nature · doi:10.1038/nature11986 · Cited by 4,176

Hypoxia-inducible factors in physiology and medicine

Semenza, G. L. (2012) · Cell · doi:10.1016/j.cell.2012.01.021 · Cited by 3,645

A guide to immunometabolism for immunologists

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Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway.

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Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages

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Hypoxia and inflammation

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Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1α during hypoxia

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Immunoregulatory mechanisms of mesenchymal stem and stromal cells in inflammatory diseases

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Regulation of glycolysis by the hypoxia-inducible factor (HIF): Implications for cellular physiology

Kierans, S. J., & Taylor, C. T. (2021) · The Journal of Physiology · doi:10.1113/jp280572 · Cited by 1,015

Pathway paradigms revealed from the genetics of inflammatory bowel disease

Graham, D. B., & Xavier, R. J. (2020) · Nature · doi:10.1038/s41586-020-2025-2 · Cited by 801

The application of nanoparticles in cancer immunotherapy: Targeting tumor microenvironment

Yang, M., Li, J., Gu, P., & Fan, X. (2020) · Bioactive Materials · doi:10.1016/j.bioactmat.2020.12.010 · Cited by 688

Improving immune–vascular crosstalk for cancer immunotherapy

Huang, Y., Kim, B. Y. S., Chan, C. K., Hahn, S. M., Weissman, I. L., & Jiang, W. (2018) · Nature Reviews Immunology · doi:10.1038/nri.2017.145 · Cited by 563

The effect of HIF on metabolism and immunity

Taylor, C. T., & Scholz, C. C. (2022) · Nature Reviews Nephrology · doi:10.1038/s41581-022-00587-8 · Cited by 517

Hypoxia signaling in human health and diseases: implications and prospects for therapeutics

Luo, Z., Tian, M., Yang, G., Tan, Q., Chen, Y., Li, G., Zhang, Q., Li, Y., Wan, P., & Wu, J. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01080-1 · Cited by 499

Spatial architecture of the immune microenvironment orchestrates tumor immunity and therapeutic response

Fu, T., Dai, L.-J., Wu, S.-Y., Xiao, Y., Ma, D., Jiang, Y.-Z., & Shao, Z.-M. (2021) · Journal of Hematology & Oncology · doi:10.1186/s13045-021-01103-4 · Cited by 480

Tumor‐Microenvironment‐Responsive Nanomedicine for Enhanced Cancer Immunotherapy

Peng, S., Xiao, F., Chen, M., & Gao, H. (2021) · Advanced Science · doi:10.1002/advs.202103836 · Cited by 451

Aging, obesity, and inflammatory age-related diseases

Frasca, D., Blomberg, B. B., & Paganelli, R. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01745 · Cited by 371

Nanoparticles in tumor microenvironment remodeling and cancer immunotherapy

Lu, Q., Kou, D., Lou, S., Ashrafizadeh, M., Aref, A. R., Canadas, I., Tian, Y., Niu, X., Wang, Y., Torabian, P., et al. (2024) · Journal of Hematology & Oncology · doi:10.1186/s13045-024-01535-8 · Cited by 373

Butyrate Protects Mice from Clostridium difficile-Induced Colitis through an HIF-1-Dependent Mechanism

Fachi, J. L., Felipe, J. D. S., Pral, L. P., da Silva, B. K., Corrêa, R. O., de Andrade, M. C. P., da Fonseca, D. M., Basso, P. J., Câmara, N. O. S., de Sales e Souza, É. L., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.03.054 · Cited by 364

Ulcerative colitis: Recent advances in the understanding of disease pathogenesis

Porter, R. J., Kalla, R., & Ho, G. (2020) · F1000Research · doi:10.12688/f1000research.20805.1 · Cited by 308

Germinal center B cells selectively oxidize fatty acids for energy while conducting minimal glycolysis

Weisel, F. J., Mullett, S. J., Elsner, R. A., Menk, A. V., Trivedi, N. H., Luo, W., Wikenheiser, D. J., Hawse, W. F., Chikina, M. D., Smita, S., et al. (2020) · Nature Immunology · doi:10.1038/s41590-020-0598-4 · Cited by 283

Control and dysregulation of redox signalling in the gastrointestinal tract

Campbell, E. L., & Colgan, S. P. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0079-5 · Cited by 267

Hypoxia and Inflammation: Insights From High-Altitude Physiology

Pham, K., Parikh, K. D., & Heinrich, E. C. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.676782 · Cited by 257

Injectable redox and light responsive MnO2 hybrid hydrogel for simultaneous melanoma therapy and multidrug-resistant bacteria-infected wound healing

Wang, S., Zheng, H. S., Zhou, L., Cheng, F., Liu, Z., Zhang, H., & Zhang, Q. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120314 · Cited by 233

NADPH oxidases and ROS signaling in the gastrointestinal tract

Aviello, G., & Knaus, U. G. (2018) · Mucosal Immunology · doi:10.1038/s41385-018-0021-8 · Cited by 235

Bioresponsive drug delivery systems for the treatment of inflammatory diseases

Dou, Y., Li, C., Li, L., Guo, J., & Zhang, J. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.09.008 · Cited by 226

Tumor hypoxia: From basic knowledge to therapeutic implications

Liao, C., Liu, X., Zhang, C., & Zhang, Q. (2023) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2022.12.011 · Cited by 223

Hypoxia, Metabolism and Immune Cell Function

Krzywińska, E., & Stockmann, C. (2018) · Biomedicines · doi:10.3390/biomedicines6020056 · Cited by 216

Neuroinflammation: An Integrating Overview of Reactive‐Neuroimmune Cell Interactions in Health and Disease

Kölliker-Frers, R., Udovin, L., Otero-Losada, M., Kobiec, T., Herrera, M. I., Palacios, J., Razzitte, G., & Capani, F. (2021) · Mediators of Inflammation · doi:10.1155/2021/9999146 · Cited by 258

The Tumor Vascular Endothelium as Decision Maker in Cancer Therapy

Klein, D. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00367 · Cited by 204

Regulation of the Hypoxia-Inducible Factor (HIF) by Pro-Inflammatory Cytokines

Malkov, M. I., Lee, C. T., & Taylor, C. T. (2021) · Cells · doi:10.3390/cells10092340 · Cited by 190

Hypoxia-inducible factors and innate immunity in liver cancer

Yuen, V. W., & Wong, C. C. (2020) · Journal of Clinical Investigation · doi:10.1172/jci137553 · Cited by 187

Importance of Type I and III Interferons at Respiratory and Intestinal Barrier Surfaces

Stanifer, M. L., Guo, C., Doldan, P., & Boulant, S. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.608645 · Cited by 195

Hypoxia and HIF Signaling: One Axis with Divergent Effects

Corrado, C., & Fontana, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21165611 · Cited by 184

The Impact of Hypoxia in Early Pregnancy on Placental Cells

Zhao, H. F., Wong, R. J., & Stevenson, D. K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22189675 · Cited by 190

Sporadic on/off switching of HTLV-1 Tax expression is crucial to maintain the whole population of virus-induced leukemic cells

Mahgoub, M., Yasunaga, J., Iwami, S., Nakaoka, S., Koizumi, Y., Shimura, K., & Matsuoka, M. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1715724115 · Cited by 184

Crosstalk between Hypoxia and ER Stress Response: a Key Regulator of Macrophage Polarization

Díaz-Bulnes, P., Saiz, M. L., López-Larrea, C., & Rodríguez, R. M. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02951 · Cited by 175

MiRNA-210 induces microglial activation and regulates microglia-mediated neuroinflammation in neonatal hypoxic-ischemic encephalopathy

Li, B., Dasgupta, C., Huang, L., Meng, X., & Zhang, L. (2019) · Cellular and Molecular Immunology · doi:10.1038/s41423-019-0257-6 · Cited by 168

Cyclooxygenase-2 in Endometriosis

Lai, Z., Yang, H., Ha, S., Chang, K., Mei, J., Zhou, W.-J., Qiu, X., Wang, X.-Q., Zhu, R., Li, D., et al. (2019) · International Journal of Biological Sciences · doi:10.7150/ijbs.35128 · Cited by 176

Hypoxia and Innate Immunity: Keeping Up with the HIFsters

Colgan, S. P., Furuta, G. T., & Taylor, C. T. (2020) · Annual Review of Immunology · doi:10.1146/annurev-immunol-100819-121537 · Cited by 167

Hypoxia and HIF-1 as key regulators of gut microbiota and host interactions

Pral, L. P., Fachi, J. L., Corrêa, R. O., Colonna, M., & Vinolo, M. A. R. (2021) · Trends in Immunology · doi:10.1016/j.it.2021.05.004 · Cited by 174

Manipulating cell fate: dynamic control of cell behaviors on functional platforms

Li, W., Yan, Z., Ren, J., & Qu, X. (2018) · Chemical Society Reviews · doi:10.1039/c8cs00053k · Cited by 152

Hypoxia-inducible factor activity promotes antitumor effector function and tissue residency by CD8+ T cells

Liikanen, I., Lauhan, C. R., Quon, S., Omilusik, K. D., Phan, A. T., Bartrolí, L. B., Ferry, A., Goulding, J., Chen, J., Scott-Browne, J. P., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci143729 · Cited by 160

Silent hypoxia in COVID-19: pathomechanism and possible management strategy

Rahman, A., Tabassum, T., Araf, Y., Nahid, A. A., Ullah, M. A., & Hosen, M. J. (2021) · Molecular Biology Reports · doi:10.1007/s11033-021-06358-1 · Cited by 150

Persistence of Staphylococcus aureus: Multiple Metabolic Pathways Impact the Expression of Virulence Factors in Small-Colony Variants (SCVs)

Tuchscherr, L. P. N., Löffler, B., & Proctor, R. A. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.01028 · Cited by 154

Hypoxia-inducible factors in CD4 + T cells promote metabolism, switch cytokine secretion, and T cell help in humoral immunity

Cho, S. H., Raybuck, A. L., Blagih, J., Kemboi, E., Haase, V. H., Jones, R. G., & Boothby, M. R. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1811702116 · Cited by 139

Hypoxia-induced ZEB1 promotes cervical cancer progression via CCL8-dependent tumour-associated macrophage recruitment

Chen, X.-J., Deng, Y.-R., Wang, Z., Wei, W.-F., Zhou, C.-F., Zhang, Y., Yan, R.-M., Liang, L.-J., Zhong, M., Li, L., et al. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1748-1 · Cited by 139

Neutrophil Recruitment: From Model Systems to Tissue-Specific Patterns

Margraf, A., Ley, K. F., & Zarbock, A. (2019) · Trends in Immunology · doi:10.1016/j.it.2019.04.010 · Cited by 143

Dynamic responses of the haematopoietic stem cell niche to diverse stresses

Batsivari, A., Haltalli, M. L. R., Passaro, D., Pospori, C., Celso, C. L., & Bonnet, D. A. (2020) · Nature Cell Biology · doi:10.1038/s41556-019-0444-9 · Cited by 139

Single-cell genomic and transcriptomic landscapes of primary and metastatic colorectal cancer tumors

Wang, R., Li, J., Zhou, X., Mao, Y., Wang, W., Gao, S., Wang, W., Gao, Y., Chen, K., Yu, S., et al. (2022) · Genome Medicine · doi:10.1186/s13073-022-01093-z · Cited by 140

Mechanisms and Consequences of Oxygen and Carbon Dioxide Sensing in Mammals

Cummins, E. P., Strowitzki, M. J., & Taylor, C. T. (2019) · Physiological Reviews · doi:10.1152/physrev.00003.2019 · Cited by 140

Nanoparticles-mediated reoxygenation strategy relieves tumor hypoxia for enhanced cancer therapy

Wang, H., Li, J., Wang, Y., Gong, X., Xu, X., Wang, J., Li, Y., Sha, X., & Zhang, Z. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.12.028 · Cited by 129

Hypoxia-inducible factor 1-dependent expression of adenosine receptor 2B promotes breast cancer stem cell enrichment

Lan, J., Lu, H., Samanta, D., Salman, S., Lü, Y., & Semenza, G. L. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1809695115 · Cited by 127

The development of phosphorescent probes for in vitro and in vivo bioimaging

Xu, Z. C., Qu, R., Chen, W., Wu, W., & Jiang, X. (2020) · Biomaterials Science · doi:10.1039/d0bm00819b · Cited by 122

Gut Microbiota in Intestinal and Liver Disease

Jones, R. M., & Neish, A. S. (2020) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-030320-095722 · Cited by 117

Collagen at the maternal-fetal interface in human pregnancy

Shi, J., Lai, Z., Yang, H., Yang, S., Wang, C., Ao, D., Ruan, L., Shen, H., Zhou, W., Mei, J., et al. (2020) · International Journal of Biological Sciences · doi:10.7150/ijbs.45586 · Cited by 116

Advancement of cancer immunotherapy using nanoparticles-based nanomedicine

Gowd, V., Ahmad, A., Tarique, M., Suhail, M., Zughaibi, T. A., Tabrez, S. S. M., & Khan, R. (2022) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2022.03.026 · Cited by 115

Hypoxia, angiogenesis, and metabolism in the hereditary kidney cancers

Chappell, J. C., Payne, L. B., & Rathmell, W. K. (2019) · Journal of Clinical Investigation · doi:10.1172/jci120855 · Cited by 117

Current Understanding of Hypoxia in Glioblastoma Multiforme and Its Response to Immunotherapy

Park, J. H., & Lee, H. K. (2022) · Cancers · doi:10.3390/cancers14051176 · Cited by 117

Hypoxia Signaling in Cancer: From Basics to Clinical Practice

Sebestyén, A., Kopper, L., Dankó, T., & Tímár, J. (2021) · Pathology and Oncology Research · doi:10.3389/pore.2021.1609802 · Cited by 110

Stimuli-Responsive Nanomedicines for the Treatment of Non-cancer Related Inflammatory Diseases

Yang, J., Rieux, A. D., & Malfanti, A. (2025) · ACS Nano · doi:10.1021/acsnano.5c00700 · Cited by 116

Biomimetic nanoparticles directly remodel immunosuppressive microenvironment for boosting glioblastoma immunotherapy

Wang, T., Zhang, H., Qiu, W., Han, Y., Liu, H., & Li, Z. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2021.12.029 · Cited by 106

Metabolic adaptation supports enhanced macrophage efferocytosis in limited-oxygen environments

Wang, Y., Trzeciak, A. J., Rojas, W. S., Saavedra, P. H. V., Chen, Y., Chirayil, R., Etchegaray, J. I., Lucas, C. D., Puleston, D. J., Keshari, K. R., et al. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2022.12.005 · Cited by 110

Biomimetic micro/nano structures for biomedical applications

Xiang, T., Hou, J., Xie, H. Q., Liu, X., Gong, T., & Zhou, S. (2020) · Nano Today · doi:10.1016/j.nantod.2020.100980 · Cited by 103

Oxygen-Delivering Polyfluorocarbon Nanovehicles Improve Tumor Oxygenation and Potentiate Photodynamic-Mediated Antitumor Immunity

Wang, Z., Gong, X., Li, J., Wang, H., Xu, X., Li, Y., Sha, X., & Zhang, Z. (2021) · ACS Nano · doi:10.1021/acsnano.1c00033 · Cited by 104

Mechanisms underlying the health benefits of intermittent hypoxia conditioning

Burtscher, J., Citherlet, T., Camacho-Cardeñosa, A., Camacho-Cardeñosa, M., Raberin, A., Krumm, B., Hohenauer, E., Egg, M., Lichtblau, M., Müller, J., et al. (2023) · The Journal of Physiology · doi:10.1113/jp285230 · Cited by 132

Hypoxia in Breast Cancer—Scientific Translation to Therapeutic and Diagnostic Clinical Applications

Zhang, Y., Zhang, H., Wang, M., Schmid, T., Xin, Z., Kozhuharova, L., Yu, W.-K., Huang, Y., Cai, F., & Biskup, E. M. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.652266 · Cited by 103

NF-κB: Governing Macrophages in Cancer

Cornice, J., Verzella, D., Arboretto, P., Vecchiotti, D., Capece, D., Zazzeroni, F., & Franzoso, G. (2024) · Genes · doi:10.3390/genes15020197 · Cited by 108

Hypoxia/HIF Modulates Immune Responses

Chen, Y., & Gaber, T. (2021) · Biomedicines · doi:10.3390/biomedicines9030260 · Cited by 100

Nanoparticles mediated tumor microenvironment modulation: current advances and applications

Raju, G. S. R., Pavitra, E., Varaprasad, G. L., Bandaru, S. S., Nagaraju, G. P., Farran, B., Huh, Y. S., & Han, Y. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01476-9 · Cited by 101

Histone citrullination by PADI4 is required for HIF-dependent transcriptional responses to hypoxia and tumor vascularization

Wang, Y., Lyu, Y., Tu, K., Xu, Q., Yang, Y., Salman, S., Le, N., Lu, H., Chen, C. O., Zhu, Y., et al. (2021) · Science Advances · doi:10.1126/sciadv.abe3771 · Cited by 95

Nanoparticle-Based Drug Delivery Systems Targeting Tumor Microenvironment for Cancer Immunotherapy Resistance: Current Advances and Applications

Wu, P., Han, J., Gong, Y., Liu, C., Yu, H., & Xie, N. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14101990 · Cited by 99

The influence of hypoxia and IFN-γ on the proteome and metabolome of therapeutic mesenchymal stem cells

Wobma, H., Tamargo, M. A., Goeta, S., Brown, L. M., Duran‐Struuck, R., & Vunjak‐Novakovic, G. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.03.027 · Cited by 93

Personalized redox medicine in inflammatory bowel diseases: an emerging role for HIF-1α and NRF2 as therapeutic targets

Bourgonje, A. R., Klóska, D., Grochot‐Przeczek, A., Feelisch, M., Cuadrado, A., & van Goor, H. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102603 · Cited by 101

Emerging Microbes & Infections

Yuen, K. (2016) · Cited by 92

Necrotizing Enterocolitis: The Role of Hypoxia, Gut Microbiome, and Microbial Metabolites

Kaplina, A., Kononova, S., Zaikova, E. K., Pervunina, T. M., Petrova, N. A., & Sitkin, S. I. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032471 · Cited by 95

Evasion of Immune Surveillance in Low Oxygen Environments Enhances Candida albicans Virulence

Lopes, J. P., Stylianou, M., Backman, E., Holmberg, S., Jass, J., Claesson, R., & Urban, C. F. (2018) · mBio · doi:10.1128/mbio.02120-18 · Cited by 88

Myeloid-Derived Suppressor Cells and Radiotherapy

Jiménez‐Cortegana, C., Galassi, C., Klapp, V., Gabrilovich, D. I., & Galluzzi, L. (2022) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-21-1105 · Cited by 88

Immune system modulation in aging: Molecular mechanisms and therapeutic targets

Cisneros, B., García‐Aguirre, I., Unzueta, J., Arrieta‐Cruz, I., González-Morales, O., Domínguez-Larrieta, J. M., Tamez-González, A., Leyva‐Gómez, G., & Magaña, J. J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1059173 · Cited by 97

Oxygen-enhanced MRI Is Feasible, Repeatable, and Detects Radiotherapy-induced Change in Hypoxia in Xenograft Models and in Patients with Non–small Cell Lung Cancer

Salem, A., Little, R. A., Latif, A., Featherstone, A. K., Babur, M., Peset, I., Cheung, S., Watson, Y., Tessyman, V., Mistry, H. B., et al. (2019) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-18-3932 · Cited by 87

Synthetic Lignin-Derived Therapeutic Nano Reagent as Intestinal pH-Sensitive Drug Carriers Capable of Bypassing the Gastric Acid Environment for Colitis Treatment

Zhao, C., Yang, J., Chen, M., Chen, W., Yang, X., Ye, H., Wang, L., Wang, Y., Shi, J., Yue, F., et al. (2022) · ACS Nano · doi:10.1021/acsnano.2c11188 · Cited by 88

Resolution metabolomes activated by hypoxic environment

Norris, P. C., Libreros, S., & Serhan, C. N. (2019) · Science Advances · doi:10.1126/sciadv.aax4895 · Cited by 87

Epithelial-Derived Reactive Oxygen Species Enable AppBCX-Mediated Aerobic Respiration of Escherichia coli during Intestinal Inflammation

Chanin, R. B., Winter, M. G., Spiga, L., Hughes, E. R., Zhu, W., Taylor, S., Arenales, A., Gillis, C. C., Büttner, L., Jimenez, A. G., et al. (2020) · Cell Host & Microbe · doi:10.1016/j.chom.2020.09.005 · Cited by 87

Changes in physiology and immune system during pregnancy and coronavirus infection: A review

Chen, M., Zeng, J., Liu, X., Sun, G., Gao, Y., Liao, J., Yu, J., Luo, X., & Qi, H. (2020) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2020.10.035 · Cited by 88

Multimodule characterization of immune subgroups in intrahepatic cholangiocarcinoma reveals distinct therapeutic vulnerabilities

Lin, J., Dai, Y., Sang, C., Song, G., Xiang, B., Zhang, M., Dong, L., Xia, X., Ma, J., Shen, X., et al. (2022) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2022-004892 · Cited by 86

Microbiota-Sourced Purines Support Wound Healing and Mucous Barrier Function

Lee, J. S., Wang, R. X., Goldberg, M. S., Clifford, G. P., Kao, D. J., & Colgan, S. P. (2020) · iScience · doi:10.1016/j.isci.2020.101226 · Cited by 86

The reciprocal regulation between host tissue and immune cells in pancreatic ductal adenocarcinoma: new insights and therapeutic implications

Liu, X., Xu, J., Zhang, B., Liu, J., Liang, C., Meng, Q., Hua, J., Yu, X., & Shi, S. (2019) · Molecular Cancer · doi:10.1186/s12943-019-1117-9 · Cited by 87

Resolution of Inflammation and Gut Repair in IBD: Translational Steps Towards Complete Mucosal Healing

Ho, G., Cartwright, J. A., Thompson, E. J., Bain, C. C., & Rossi, A. G. (2020) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izaa045 · Cited by 84

MicroRNA in extracellular vesicles regulates inflammation through macrophages under hypoxia

Li, Y., Tan, J., Miao, Y., & Zhang, Q. (2021) · Cell Death Discovery · doi:10.1038/s41420-021-00670-2 · Cited by 85

Potential long-term effects of SARS-CoV-2 infection on the pulmonary vasculature: a global perspective

Halawa, S., Pullamsetti, S. S., Bangham, C. R. M., Stenmark, K. R., Dorfmüller, P., Frid, M. G., BUTROUS, G. S., Morrell, N. W., Pérez, V. D. J., Stuart, D. I., et al. (2021) · Nature Reviews Cardiology · doi:10.1038/s41569-021-00640-2 · Cited by 84

Chronic airway epithelial hypoxia exacerbates injury in muco-obstructive lung disease through mucus hyperconcentration

Mikami, Y., Grubb, B. R., Rogers, T. D., Dang, H., Asakura, T., Kota, P. B., Gilmore, R. C., Okuda, K., Morton, L. C., Sun, L., et al. (2023) · Science Translational Medicine · doi:10.1126/scitranslmed.abo7728 · Cited by 84

Post-intubation subglottic stenosis: aetiology at the cellular and molecular level

Dorris, E., Russell, J., & Murphy, M. (2021) · European Respiratory Review · doi:10.1183/16000617.0218-2020 · Cited by 91

Hypoxia: The “Invisible Pusher” of Gut Microbiota

Han, N., Pan, Z., Liu, G., Yang, R., & Bi, Y. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.690600 · Cited by 80

The Serum Metabolome of Moderate and Severe COVID-19 Patients Reflects Possible Liver Alterations Involving Carbon and Nitrogen Metabolism

Caterino, M., Costanzo, M., Fedele, R., Cevenini, A., Gelzo, M., Minno, A. D., Andolfo, I., Capasso, M., Russo, R., Annunziata, A., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22179548 · Cited by 77

Adipocyte-derived Lysophosphatidylcholine Activates Adipocyte and Adipose Tissue Macrophage Nod-Like Receptor Protein 3 Inflammasomes Mediating Homocysteine-Induced Insulin Resistance

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A Bifunctional Lysosome‐Targeting Chimera Nanoplatform for Tumor‐Selective Protein Degradation and Enhanced Cancer Immunotherapy

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Electrospun Shape Memory Polymer Micro-/Nanofibers and Tailoring Their Roles for Biomedical Applications

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Inflammatory consequences of inherited disorders affecting neutrophil function

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Investigating the possible mechanisms of autonomic dysfunction post-COVID-19

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HIF-Overexpression and Pro-Inflammatory Priming in Human Mesenchymal Stromal Cells Improves the Healing Properties of Extracellular Vesicles in Experimental Crohn’s Disease

Gómez-Ferrer, M., Amaro-Prellezo, E., Dorronsoro, A., Sánchez-Sánchez, R., Vicente, Á., Cosín‐Roger, J., Barrachina, M. D., Baquero, M. C., Valencia, J., & Sepúlveda, P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222011269 · Cited by 70

How oxygenation shapes immune responses: emerging roles for physioxia and pathological hypoxia

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Bone Immune Response to Materials, Part I: Titanium, PEEK and Copper in Comparison to Sham at 10 Days in Rabbit Tibia

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Postmortem Cortical Transcriptomics of Lewy Body Dementia Reveal Mitochondrial Dysfunction and Lack of Neuroinflammation

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Dual IFN-γ/hypoxia priming enhances immunosuppression of mesenchymal stromal cells through regulatory proteins and metabolic mechanisms

Wobma, H., Kanai, M., Ma, S. P., Shih, Y., Li, H. W., Duran‐Struuck, R., WINCHESTER, R. J., Goeta, S., Brown, L. M., & Vunjak‐Novakovic, G. (2018) · Journal of Immunology and Regenerative Medicine · doi:10.1016/j.regen.2018.01.001 · Cited by 66

Immunometabolism: Another Road to Sepsis and Its Therapeutic Targeting

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Iron–sulfur clusters as inhibitors and catalysts of viral replication

Ebrahimi, K. H., Ciofi‐Baffoni, S., Hagedoorn, P., Nicolet, Y., Brun, N. E. L., Hagen, W. R., & Armstrong, F. A. (2022) · Nature Chemistry · doi:10.1038/s41557-021-00882-0 · Cited by 63

Hypoxia and Matrix Metalloproteinase 13‐Responsive Hydrogel Microspheres Alleviate Osteoarthritis Progression In Vivo

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Hypoxia/HIF Modulates Immune Responses

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Hypoxia-dependent regulation of inflammatory pathways in immune cells

Taylor, C. T., Doherty, G. A., Fallon, P. G., & Cummins, E. P. (2016) · Journal of Clinical Investigation · doi:10.1172/jci84433 · Cited by 225

Modulation of Innate Immunity by Hypoxia

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Hypoxia: a double-edged sword of immunity

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HIF transcription factors, inflammation, and immunity

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