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Regulation of immunity and inflammation by hypoxia in immunological niches
Open accessAbstract
Immunological niches are focal sites of immune activity that can have varying microenvironmental features. Hypoxia is a feature of physiological and pathological immunological niches. The impact of hypoxia on immunity and inflammation can vary depending on the microenvironment and immune processes occurring in a given niche. In physiological immunological niches, such as the bone marrow, lymphoid tissue, placenta and intestinal mucosa, physiological hypoxia controls innate and adaptive immunity by modulating immune cell proliferation, development and effector function, largely via transcriptional changes driven by hypoxia-inducible factor (HIF). By contrast, in pathological immunological niches, such as tumours and chronically inflamed, infected or ischaemic tissues, pathological hypoxia can drive tissue dysfunction and disease development through immune cell dysregulation. Here, we differentiate between the effects of physiological and pathological hypoxia on immune cells and the consequences for immunity and inflammation in different immunological niches. Furthermore, we discuss the possibility of targeting hypoxia-sensitive pathways in immune cells for the treatment of inflammatory disease.
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“On the other hand, NK cells remain active against tumor cells in hypoxia [51].”
From Hypoxia Signaling in Cancer: From Basics to Clinical Practice (2021) · cites this paper as [51]
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Metadata
- Authors
- Taylor, C. T., & Colgan, S. P.
- Affiliations
- University College Dublin (IE)
- University of Colorado Anschutz (US)
- Corresponding author
- Taylor, Cormac T.
- Venue
- Nature reviews. Immunology
- Published
- 2017-10-03
- Volume
- 17
- Issue
- 12
- Pages
- 774-785
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- PMC
- PMC5799081
- OpenAlex
- W2763829062
- Cited by
- 713
- References
- 167
- Citations by year
- 2026: 89 · 2025: 90 · 2024: 90 · 2023: 86 · 2022: 108 · 2021: 90 · 2020: 71 · 2019: 50 · 2018: 35 · 2017: 2
- FWCI
- 4.40
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Department of Veterans Affairs (I01BX002182)
- Crohn's and Colitis Foundation (327021)
- Science Foundation Ireland
- National Institute of Diabetes and Digestive and Kidney Diseases (R37DK050189, R01DK103712, R01DK104713, P30DK048520, R01DK095491)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- hypoxia, inflammation, hypoxia-inducible factor, immune cell proliferation, immune cell differentiation, tumor microenvironment, chronic inflammation, hypoxia-targeted therapy, bone marrow, lymphoid tissue, placenta, intestinal mucosa
- MeSH terms
- Animals, Hypoxia, Gene Expression Regulation, Humans, Immune System, Immunity, Immunity, Innate, Inflammation, Transcription, Genetic, Signal Transduction, Hypoxia-Inducible Factor 1, Immunomodulation, Cellular Microenvironment
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