The DOI matches its Crossref record; 141 of the 141 references it cites were found in a registry or an index.
Immune regulation by glucocorticoids
Open accessAbstract
Endogenous glucocorticoids are crucial to various physiological processes, including metabolism, development and inflammation. Since 1948, synthetic glucocorticoids have been used to treat various immune-related disorders. The mechanisms that underlie the immunosuppressive properties of these hormones have been intensely scrutinized, and it is widely appreciated that glucocorticoids have pleiotropic effects on the immune system. However, a clear picture of the cellular and molecular basis of glucocorticoid action has remained elusive. In this Review, we distil several decades of intense (and often conflicting) research that defines the interface between the endocrine stress response and the immune system.
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“Pro-inflammatory cytokines, however, unfold systemic effects far beyond the canonical immune response and also stimulate the secretion of CGs, while CGs, in turn, among their numerous pleiotropic effects, help terminate the inflammatory response (153, 154, 156, 157).”
From Developmental Trajectories of Early Life Stress and Trauma: A Narrative Review on Neurobiological Aspects Beyond Stress System Dysregulation (2019) · cites this paper as [156]
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“This is part of a very complex, two-way neuroimmunoendocrine interaction between the central and peripheral limbs of the stress system and the immune axis (156, 158, 159).”
From Developmental Trajectories of Early Life Stress and Trauma: A Narrative Review on Neurobiological Aspects Beyond Stress System Dysregulation (2019) · cites this paper as [156]
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Cites
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Molecular Mechanisms of Stress-Responsive Changes in Collagen and Elastin Networks in Skin
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Neutrophil recruitment and function in health and inflammation
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The Therapeutic Potential of Farm Dust Extracts in a Mouse Model of Eosinophilic Inflammation
Korkmaz, R. Ü., Omony, J., Tan, X., Klotz, M., Dragunas, G., Chen, S., Shankhwar, S., Ertüz, Z., Müller, C., Ragab, M., et al. (2026) · Allergy · doi:10.1111/all.70121 · Cited by 4
Metadata
- Authors
- Cain, D. W., & Cidlowski, J. A.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Cidlowski, John A.
- Venue
- Nature Reviews Immunology
- Published
- 2017-02-13
- Volume
- 17
- Issue
- 4
- Pages
- 233-247
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- PMC
- PMC9761406
- OpenAlex
- W2587941297
- Cited by
- 1,846
- References
- 140
- Citations by year
- 2026: 252 · 2025: 242 · 2024: 225 · 2023: 228 · 2022: 206 · 2021: 239 · 2020: 202 · 2019: 122 · 2018: 93 · 2017: 29
- FWCI
- 10.70
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- CYTED Ciencia y Tecnología para el Desarrollo
- National Institutes of Health
- National Institute of Environmental Health Sciences (Z01ES090057, ZIAES090079, Z01ES090079, ZICES102486, ZIAES090057)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- glucocorticoids, immunosuppression, innate immunity, adaptive immunity, endocrine stress response, synthetic glucocorticoids, inflammation, immune-related diseases
- MeSH terms
- Animals, Glucocorticoids, Humans, Immune System, Immunosuppressive Agents, Inflammation
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