Cited by 1,846Stress Responses and CortisolEstrogen and related hormone effectsAdrenal Hormones and Disorders

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Immune regulation by glucocorticoids

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Cain, Derek W., Cidlowski, John A.·2017·Nature Reviews Immunology

DOI 10.1038/nri.2017.1PMC PMC9761406

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Abstract

Endogenous glucocorticoids are crucial to various physiological processes, including metabolism, development and inflammation. Since 1948, synthetic glucocorticoids have been used to treat various immune-related disorders. The mechanisms that underlie the immunosuppressive properties of these hormones have been intensely scrutinized, and it is widely appreciated that glucocorticoids have pleiotropic effects on the immune system. However, a clear picture of the cellular and molecular basis of glucocorticoid action has remained elusive. In this Review, we distil several decades of intense (and often conflicting) research that defines the interface between the endocrine stress response and the immune system.

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Authors: Cain, D. W., & Cidlowski, J. A.
Affiliations: National Institutes of Health (US)
Corresponding author: Cidlowski, John A.
ORCID: Cain, Derek W.
Cidlowski, John A.
Venue: Nature Reviews Immunology
Publisher: Springer Science and Business Media LLC
Published: 2017-02-13
Volume: 17
Issue: 4
Pages: 233-247
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/nri.2017.1
PMC: PMC9761406
OpenAlex: W2587941297
Cited by: 1,846
References: 140
Citations by year: 2026: 252 · 2025: 242 · 2024: 225 · 2023: 228 · 2022: 206 · 2021: 239 · 2020: 202 · 2019: 122 · 2018: 93 · 2017: 29
FWCI: 10.70
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: CYTED Ciencia y Tecnología para el Desarrollo
National Institutes of Health
National Institute of Environmental Health Sciences (Z01ES090057, ZIAES090079, Z01ES090079, ZICES102486, ZIAES090057)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords: glucocorticoids, immunosuppression, innate immunity, adaptive immunity, endocrine stress response, synthetic glucocorticoids, inflammation, immune-related diseases
MeSH terms: Animals, Glucocorticoids, Humans, Immune System, Immunosuppressive Agents, Inflammation

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