The DOI matches its Crossref record; 185 of the 185 references it cites were found in a registry or an index.
Altered B cell signalling in autoimmunity
Open accessAbstract
Recent work has provided new insights into how altered B cell-intrinsic signals — through the B cell receptor (BCR) and key co-receptors — function together to promote the pathogenesis of autoimmunity. These combined signals affect B cells at two distinct stages: first, in the selection of the naive repertoire; and second, during extrafollicular or germinal centre activation responses. Thus, dysregulated signalling can lead to both an altered naive BCR repertoire and the generation of autoantibody-producing B cells. Strikingly, high-affinity autoantibodies predate and predict disease in several autoimmune disorders, including type 1 diabetes and systemic lupus erythematosus. This Review summarizes how, rather than being a downstream consequence of autoreactive T cell activation, dysregulated B cell signalling can function as a primary driver of many human autoimmune diseases.
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Metadata
- Authors
- Rawlings, D. J., Metzler, G., Wray-Dutra, M., & Jackson, S. W.
- Venue
- Nature Reviews Immunology
- Published
- 2017-04-10
- Volume
- 17
- Issue
- 7
- Pages
- 421-436
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W2605871488
- Cited by
- 308
- References
- 185
- FWCI
- 2.03
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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