Defensins: antimicrobial peptides of innate immunity

Mechanism of the binding, insertion and destabilization of phospholipid bilayer membranes by α-helical antimicrobial and cell non-selective membrane-lytic peptides

Shai, Y. (1999) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(99)00200-x · Cited by 1,904

β-Defensins: Linking Innate and Adaptive Immunity Through Dendritic and T Cell CCR6

Yang, D., Chertov, O., Bykovskaia, S. N., Chen, Q., Buffo, M. J., Shogan, J., Anderson, M., Schröder, J. M., Wang, J. M., Howard, O. M. Z., et al. (1999) · Science · doi:10.1126/science.286.5439.525 · Cited by 1,809

Defensins. Natural peptide antibiotics of human neutrophils.

Ganz, T., Selsted, M. E., Szklarek, D., Harwig, S. S. L., Daher, K. A., Bainton, D. F., & Lehrer, R. I. (1985) · Journal of Clinical Investigation · doi:10.1172/jci112120 · Cited by 1,416

A peptide antibiotic from human skin

Harder, J., Bartels, J., Christophers, E., & Schröder, J. ‐. (1997) · Nature · doi:10.1038/43088 · Cited by 1,365

Isolation and Characterization of Human μ-Defensin-3, a Novel Human Inducible Peptide Antibiotic

Harder, J., Bartels, J., Christophers, E., & Schröder, J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008557200 · Cited by 1,309

Innate antimicrobial peptide protects the skin from invasive bacterial infection

Nizet, V., Ohtake, T., Lauth, X., Trowbridge, J., Rudisill, J., Dorschner, R. A., Pestonjamasp, V., Piraino, J., Huttner, K., & Gallo, R. L. (2001) · Nature · doi:10.1038/35106587 · Cited by 1,198

Evidence for Periciliary Liquid Layer Depletion, Not Abnormal Ion Composition, in the Pathogenesis of Cystic Fibrosis Airways Disease

Matsui, H., Grubb, B. R., Tarran, R., Randell, S. H., Gatzy, J. T., Davis, C. W., & Boucher, R. C. (1998) · Cell · doi:10.1016/s0092-8674(00)81724-9 · Cited by 1,168

Regulation of Intestinal α-Defensin Activation by the Metalloproteinase Matrilysin in Innate Host Defense

Wilson, C. L., Ouellette, A. J., Satchell, D. P., Ayabe, T., López-Boado, Y. S., Stratman, J. L., Hultgren, S. J., Matrisian, L. M., & Parks, W. C. (1999) · Science · doi:10.1126/science.286.5437.113 · Cited by 1,076

Secretion of microbicidal α-defensins by intestinal Paneth cells in response to bacteria

Ayabe, T., Satchell, D. P., Wilson, C. L., Parks, W. C., Selsted, M. E., & Ouellette, A. J. (2000) · Nature Immunology · doi:10.1038/77783 · Cited by 1,060

Cystic Fibrosis Airway Epithelia Fail to Kill Bacteria Because of Abnormal Airway Surface Fluid

Smith, J. J., Travis, S. M., Greenberg, E. P., & Welsh, M. J. (1996) · Cell · doi:10.1016/s0092-8674(00)81099-5 · Cited by 1,039

Inactivation of the dlt Operon inStaphylococcus aureus Confers Sensitivity to Defensins, Protegrins, and Other Antimicrobial Peptides

Peschel, A., Otto, M. J., Jack, R. W., Kalbacher, H., Jung, G., & Götz, F. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.13.8405 · Cited by 999

Toll-Like Receptor 4-Dependent Activation of Dendritic Cells by β-Defensin 2

Biragyn, A., Ruffini, P. A., Leifer, C. A., Klyushnenkova, E., Shakhov, A., Chertov, O., Shirakawa, A., Farber, J. M., Segal, D. M., Oppenheim, J. J., et al. (2002) · Science · doi:10.1126/science.1075565 · Cited by 904

Staphylococcus aureus Resistance to Human Defensins and Evasion of Neutrophil Killing via the Novel Virulence Factor Mprf Is Based on Modification of Membrane Lipids with l -Lysine

Peschel, A., Jack, R. W., Otto, M. J., Collins, L. V., Staubitz, P., NICHOLSON, G. J., Kalbacher, H., Nieuwenhuizen, W. F., Jung, G., Tarkowski, A., et al. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.193.9.1067 · Cited by 785

Protection against enteric salmonellosis in transgenic mice expressing a human intestinal defensin

Salzman, N. H., Ghosh, D., Huttner, K. M., Paterson, Y. Y. W., & Bevins, C. L. (2003) · Nature · doi:10.1038/nature01520 · Cited by 765

The human antimicrobial and chemotactic peptides LL-37 and α-defensins are expressed by specific lymphocyte and monocyte populations

Agerberth, B., Charo, J., Werr, J., Olsson, B., Idali, F., Lindbom, L., Kiessling, R., Jörnvall, H., Wigzell, H., & Gudmundsson, G. H. (2000) · Blood · doi:10.1182/blood.v96.9.3086 · Cited by 758

Action of Antimicrobial Peptides: Two-State Model

Huang, H. W. (2000) · Biochemistry · doi:10.1021/bi000946l · Cited by 752

Dermcidin: A novel human antibiotic peptide secreted by sweat glands

Schittek, B., Hipfel, R., Sauer, B., Bauer, J., Kalbacher, H., Stevanovic, S., Schirle, M., Schroeder, K., Blin, N., Meier, F., et al. (2001) · Nature Immunology · doi:10.1038/ni732 · Cited by 730

Interaction of human defensins with Escherichia coli. Mechanism of bactericidal activity.

Lehrer, R. I., Barton, A. P., Daher, K. A., Harwig, S. S. L., Ganz, T., & Selsted, M. E. (1989) · Journal of Clinical Investigation · doi:10.1172/jci114198 · Cited by 727

Human beta-defensin-1: an antimicrobial peptide of urogenital tissues.

Valore, E. V., Park, C. H., Quayle, A. J., Wiles, K., McCray, P. B., & Ganz, T. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1861 · Cited by 724

Cathelicidins: a novel protein family with a common proregion and a variable C‐terminal antimicrobial domain

Zanetti, M., Gennaro, R., & Romeo, D. (1995) · FEBS Letters · doi:10.1016/0014-5793(95)01050-o · Cited by 708

A Cyclic Antimicrobial Peptide Produced in Primate Leukocytes by the Ligation of Two Truncated α-Defensins

Tang, Y., Yuan, J. J., Ösapay, G., Ősapay, K., Tran, D., Miller, C. J., Ouellette, A. J., & Selsted, M. E. (1999) · Science · doi:10.1126/science.286.5439.498 · Cited by 698

Lipid A Acylation and Bacterial Resistance against Vertebrate Antimicrobial Peptides

Guo, L., Lim, K. B., Poduje, C. M., Daniel, M., Gunn, J. S., Hackett, M., & Miller, S. I. (1998) · Cell · doi:10.1016/s0092-8674(00)81750-x · Cited by 645

Identification of Defensin-1, Defensin-2, and CAP37/Azurocidin as T-cell Chemoattractant Proteins Released from Interleukin-8-stimulated Neutrophils

Chertov, O., Michiel, D. F., Xu, L., Wang, J., Tani, K., Murphy, W. J., Longo, D. L., Taub, D. D., & Oppenheim, J. J. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.6.2935 · Cited by 548

hBD‐1: a novel β‐defensin from human plasma

Bensch, K. W., Raida, M., Mägert, H., Schulz‐Knappe, P., & Forssmann, W. (1995) · FEBS Letters · doi:10.1016/0014-5793(95)00687-5 · Cited by 544

Paneth cells of the human small intestine express an antimicrobial peptide gene

Jones, D. E., & Bevins, C. L. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)50079-x · Cited by 539

Direct inactivation of viruses by human granulocyte defensins

Daher, K. A., Selsted, M. E., & Lehrer, R. I. (1986) · Journal of Virology · doi:10.1128/jvi.60.3.1068-1074.1986 · Cited by 535

Primary structures of three human neutrophil defensins.

Selsted, M. E., Harwig, S. S. L., Ganz, T., Schilling, J., & Lehrer, R. I. (1985) · Journal of Clinical Investigation · doi:10.1172/jci112121 · Cited by 534

Antimicrobial defensin peptides form voltage-dependent ion-permeable channels in planar lipid bilayer membranes.

Kagan, B. L., Selsted, M. E., Ganz, T., & Lehrer, R. I. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.1.210 · Cited by 532

Protegrins: leukocyte antimicrobial peptides that combine features of corticostatic defensins and tachyplesins

Kokryakov, V. N., Harwig, S. S. L., Panyutich, E. A., Shevchenko, A. A., Gm, A., Валерьевна, Ш. О., Korneva, E. A., & Lehrer, R. I. (1993) · FEBS Letters · doi:10.1016/0014-5793(93)80175-t · Cited by 517

Crystal Structure of Defensin HNP-3, an Amphiphilic Dimer: Mechanisms of Membrane Permeabilization

Hill, C. P., Yee, J., Selsted, M. E., & Eisenberg, D. S. (1991) · Science · doi:10.1126/science.2006422 · Cited by 507

Tracheal antimicrobial peptide, a cysteine-rich peptide from mammalian tracheal mucosa: peptide isolation and cloning of a cDNA.

Diamond, G., ZASLOFF, M. A., Eck, H. S., Brasseur, M., Maloy, W. L., & Bevins, C. L. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.9.3952 · Cited by 506

Human neutrophil defensins selectively chemoattract naive T and immature dendritic cells

Yang, D., Chen, Q., Chertov, O., & Oppenheim, J. J. (2000) · Journal of Leukocyte Biology · doi:10.1189/jlb.68.1.9 · Cited by 501

Discovery of five conserved β-defensin gene clusters using a computational search strategy

Schutte, B. C., Mitros, J., Bartlett, J. A., Walters, J. D., Jia, H. P., Welsh, M. J., Casavant, T. L., & McCray, P. B. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.042692699 · Cited by 491

Monocyte-chemotactic activity of defensins from human neutrophils.

Territo, M., Ganz, T., Selsted, M. E., & Lehrer, R. I. (1989) · Journal of Clinical Investigation · doi:10.1172/jci114394 · Cited by 489

Human β‐defensin 4: a novel inducible peptide with a specific salt‐sensitive spectrum of antimicrobial activity

Conejo-Garcia, J. R., Krause, A., Schulz, S., Rodríguez-Jiménez, F. J., Klüver, E., Adermann, K., Forssmann, U., Frimpong‐Boateng, A., Bals, R., & Forssmann, W. (2001) · The FASEB Journal · doi:10.1096/fj.00-0865fje · Cited by 469

Purification, primary structures, and antibacterial activities of beta-defensins, a new family of antimicrobial peptides from bovine neutrophils.

Selsted, M. E., Tang, Y., Morris, W. L., McGuire, P. A., Novotny, M., Smith, W. W., Henschen, A., & Cullor, J. S. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53298-1 · Cited by 443

Paneth cell trypsin is the processing enzyme for human defensin-5

Ghosh, D., Porter, E. M., Shen, B., Lee, S. K., Wilk, D. J., Drazba, J. A., Yadav, S. P., Crabb, J. W., Ganz, T., & Bevins, C. L. (2002) · Nature Immunology · doi:10.1038/ni797 · Cited by 428

Epithelial Antibiotics Induced at Sites of Inflammation

Schonwetter, B. S., Stolzenberg, E. D., & ZASLOFF, M. A. (1995) · Science · doi:10.1126/science.7886453 · Cited by 402

Modulation of Neisseria gonorrhoeae susceptibility to vertebrate antibacterial peptides due to a member of the resistance/nodulation/division efflux pump family

Shafer, W. M., Qu, X. D., Waring, A. J., & Lehrer, R. I. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.4.1829 · Cited by 391

Wound Healing and Expression of Antimicrobial Peptides/Polypeptides in Human Keratinocytes, a Consequence of Common Growth Factors

Sørensen, O. E., Cowland, J. B., Theilgaard‐Mönch, K., Liu, L., Ganz, T., & Borregaard, N. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.11.5583 · Cited by 370

Interactions between human defensins and lipid bilayers: Evidence for formation of multimeric pores

Wimley, W. C., Selsted, M. E., & White, S. H. (1994) · Protein Science · doi:10.1002/pro.5560030902 · Cited by 350

Defensin‐6 mRNA in human Paneth cells: implications for antimicrobia peptides in host defense of the human bowel

Jones, D. E., & Bevins, C. L. (1993) · FEBS Letters · doi:10.1016/0014-5793(93)81160-2 · Cited by 345

Salmonella typhimurium phoP virulence gene is a transcriptional regulator.

Groisman, E. A., Chiao, E. T., Lipps, C. J., & Heffron, F. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.18.7077 · Cited by 337

Cathelicidins: a family of endogenous antimicrobial peptides

Lehrer, R. I., & Ganz, T. (2002) · Current Opinion in Hematology · doi:10.1097/00062752-200201000-00004 · Cited by 324

A PhoP-Regulated Outer Membrane Protease of Salmonella enterica Serovar Typhimurium Promotes Resistance to Alpha-Helical Antimicrobial Peptides

Guina, T., Yi, E. C., Wang, H., Hackett, M., & Miller, S. I. (2000) · Journal of Bacteriology · doi:10.1128/jb.182.14.4077-4086.2000 · Cited by 322

Refined three-dimensional solution structure of insect defensin A

Cornet, B., Bonmatin, J., Hétru, C., Hoffmann, J. A., Ptak, M., & Vovelle, F. (1995) · Structure · doi:10.1016/s0969-2126(01)00177-0 · Cited by 321

The Structure of Human β-Defensin-2 Shows Evidence of Higher Order Oligomerization

Hoover, D. M., Rajashankar, K. R., Blumenthal, R., Puri, A., Oppenheim, J. J., Chertov, O., & Lubkowski, J. T. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m006098200 · Cited by 318

Gene expression, immunolocalization, and secretion of human defensin-5 in human female reproductive tract.

Quayle, A. J., Porter, E. M., Nussbaum, A. A., Wang, Y. M., Brabec, C., Yip, K., & Mok, S. C. (1998) · Europe PMC (PubMed Central) · Cited by 315

Purification and antibacterial activity of antimicrobial peptides of rabbit granulocytes

Selsted, M. E., Szklarek, D., & Lehrer, R. I. (1984) · Infection and Immunity · doi:10.1128/iai.45.1.150-154.1984 · Cited by 306

Retrocyclin: A primate peptide that protects cells from infection by T- and M-tropic strains of HIV-1

Cole, A. M., Hong, T., Boo, L. M., Nguyen, T. X., Zhao, C., Bristol, G., Zack, J. A., Waring, A. J., Yang, O. O., & Lehrer, R. I. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.052706399 · Cited by 298

Human Enteric Defensins

Mallow, E. B., Harris, A., Salzman, N. H., Russell, J. P., DeBerardinis, R. J., Ruchelli, E. D., & Bevins, C. L. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.8.4038 · Cited by 296

The genesis of cystic fibrosis lung disease

Wine, J. J. (1999) · Journal of Clinical Investigation · doi:10.1172/jci6222 · Cited by 275

Techniques in Protein Chemistry V

Walker, J. (1993) · Cited by 269

Inducible expression of an antibiotic peptide gene in lipopolysaccharide-challenged tracheal epithelial cells.

Diamond, G., Russell, J. P., & Bevins, C. L. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.10.5156 · Cited by 263

Structure and mapping of the human β-defensin HBD-2 gene and its expression at sites of inflammation

Liu, L., Wang, L., Jia, H. P., Zhao, C., Heng, H. H., Schutte, B. C., McCray, P. B., & Ganz, T. (1998) · Gene · doi:10.1016/s0378-1119(98)00480-6 · Cited by 258

In vitro tumor cell cytolysis mediated by peptide defensins of human and rabbit granulocytes

Lichtenstein, A., Ganz, T., Selsted, M., & Lehrer, R. (1986) · Blood · doi:10.1182/blood.v68.6.1407.1407 · Cited by 257

Developmental regulation of cryptdin, a corticostatin/defensin precursor mRNA in mouse small intestinal crypt epithelium.

Ouellette, A. J., Greco, R. M., James, M. F., Frederick, D., Naftilan, J., & Fallon, J. T. (1989) · The Journal of Cell Biology · doi:10.1083/jcb.108.5.1687 · Cited by 249

The individual regulation of granule protein mRNA levels during neutrophil maturation explains the heterogeneity of neutrophil granules

Cowland, J. B., & Borregaard, N. (1999) · Journal of Leukocyte Biology · doi:10.1002/jlb.66.6.989 · Cited by 243

Extracellular release of antimicrobial defensins by human polymorphonuclear leukocytes

Ganz, T. (1987) · Infection and Immunity · doi:10.1128/iai.55.3.568-571.1987 · Cited by 241

Role of airway surface liquid and submucosal glands in cystic fibrosis lung disease

Verkman, A. S., Song, Y., & Thiagarajah, J. R. (2003) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00417.2002 · Cited by 235

Modulation of the in vitro candidacidal activity of human neutrophil defensins by target cell metabolism and divalent cations.

Lehrer, R. I., Ganz, T., Szklarek, D., & Selsted, M. E. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113527 · Cited by 229

Defensin-rich dense granules of human neutrophils

Rice, W. G., Ganz, T., Kinkade, J. J., Selsted, M., Lehrer, R., & Parmley, R. (1987) · Blood · doi:10.1182/blood.v70.3.757.bloodjournal703757 · Cited by 227

Mouse neutrophils lack defensins

Eisenhauer, P. B., & Lehrer, R. (1992) · Infection and Immunity · doi:10.1128/iai.60.8.3446-3447.1992 · Cited by 227

Differences in the Interaction of Heparin with Arginine and Lysine and the Importance of these Basic Amino Acids in the Binding of Heparin to Acidic Fibroblast Growth Factor

Fromm, J. R., Hileman, R. E., Caldwell, E. E. O., Weiler, J. M., & Linhardt, R. J. (1995) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1995.9963 · Cited by 226

Purification and Characterization of Human Neutrophil Peptide 4, a Novel Member of the Defensin Family

WILDE, C. G., Griffith, J. E., Marra, M. N., Snable, J. L., & Scott, R. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)60449-1 · Cited by 224

Epithelial antibiotic induced in states of disease

Stolzenberg, E. D., Anderson, G. M., Ackermann, M. R., Whitlock, R. H., & ZASLOFF, M. A. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.16.8686 · Cited by 219

Expression of Antimicrobial Defensins in the Male Reproductive Tract of Rats, Mice, and Humans1

Com, E., Bourgeon, F., Evrard, B., Ganz, T., Colleu, D., Jégou, B., & Pineau, C. (2003) · Biology of Reproduction · doi:10.1095/biolreprod.102.005389 · Cited by 219

Gallinacins: cysteine‐rich antimicrobial peptides of chicken leukocytes

Harwig, S. S. L., Swiderek, K. M., Kokryakov, V. N., Tan, L., Lee, T. D., Panyutich, E. A., Gm, A., Валерьевна, Ш. О., & Lehrer, R. I. (1994) · FEBS Letters · doi:10.1016/0014-5793(94)80517-2 · Cited by 217

Transcriptional Regulation of β-Defensin Gene Expression in Tracheal Epithelial Cells

Diamond, G., Kaiser, V. L., Rhodes, J., Russell, J. P., & Bevins, C. L. (2000) · Infection and Immunity · doi:10.1128/iai.68.1.113-119.2000 · Cited by 215

β-Defensin 1 Contributes to Pulmonary Innate Immunity in Mice

Moser, C., Weiner, D. J., Lysenko, E., Bals, R., Weiser, J. N., & Wilson, J. M. (2002) · Infection and Immunity · doi:10.1128/iai.70.6.3068-3072.2002 · Cited by 213

The Human β-Defensin-1 and α-Defensins Are Encoded by Adjacent Genes: Two Peptide Families with Differing Disulfide Topology Share a Common Ancestry

Liu, L., Zhao, C., Heng, H. H., & Ganz, T. (1997) · Genomics · doi:10.1006/geno.1997.4801 · Cited by 212

Antibacterial and Enzymic Basic Proteins from Leukocyte Lysosomes: Separation and Identification

Zeya, H. I., & Spitznagel, J. K. (1963) · Science · doi:10.1126/science.142.3595.1085 · Cited by 210

Characterization of the Mouse Beta Defensin 1, Defb1 , Mutant Mouse Model

Morrison, G. M., Kilanowski, F. M., Davidson, D. J., & Dorin, J. R. (2002) · Infection and Immunity · doi:10.1128/iai.70.6.3053-3060.2002 · Cited by 209

Primary structures of MCP-1 and MCP-2, natural peptide antibiotics of rabbit lung macrophages.

Selsted, M. E., Brown, D. M., DeLange, R. J., & Lehrer, R. I. (1983) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)43888-9 · Cited by 205

Effect of defensins on interleukin-8 synthesis in airway epithelial cells

van Wetering, S., Mannesse-Lazeroms, S. P. G., van Sterkenburg, M. A. J. A., Daha, M. R., Dijkman, J. H., & Hiemstra, P. S. (1997) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1997.272.5.l888 · Cited by 202

Retrocyclin, an Antiretroviral θ-Defensin, Is a Lectin

Wang, W., Cole, A. M., Hong, T., Waring, A. J., & Lehrer, R. I. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.9.4708 · Cited by 190

Posttranslational processing of defensins in immature human myeloid cells

Valore, E. V., & Ganz, T. (1992) · Blood · doi:10.1182/blood.v79.6.1538.bloodjournal7961538 · Cited by 190

Mouse β-Defensin 3 Is an Inducible Antimicrobial Peptide Expressed in the Epithelia of Multiple Organs

Bals, R., Wang, X., Meegalla, R. L., Wattler, S., Weiner, D. J., Nehls, M. C., & Wilson, J. M. (1999) · Infection and Immunity · doi:10.1128/iai.67.7.3542-3547.1999 · Cited by 186

By IL-1 Signaling, Monocyte-Derived Cells Dramatically Enhance the Epidermal Antimicrobial Response to Lipopolysaccharide

Liu, L., Roberts, A. A., & Ganz, T. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.1.575 · Cited by 184

Direct inactivation of viruses by MCP-1 and MCP-2, natural peptide antibiotics from rabbit leukocytes

Lehrer, R. I., Daher, K. A., Ganz, T., & Selsted, M. E. (1985) · Journal of Virology · doi:10.1128/jvi.54.2.467-472.1985 · Cited by 181

Mouse β-Defensin 1 Is a Salt-Sensitive Antimicrobial Peptide Present in Epithelia of the Lung and Urogenital Tract

Bals, R., Goldman, M. J., & Wilson, J. M. (1998) · Infection and Immunity · doi:10.1128/iai.66.3.1225-1232.1998 · Cited by 179

Enteric β-Defensin: Molecular Cloning and Characterization of a Gene with Inducible Intestinal Epithelial Cell Expression Associated with Cryptosporidium parvum Infection

Tarver, A. P., Clark, D. P., Diamond, G., Russell, J. P., Erdjument‐Bromage, H., Tempst, P., Cohen, K. S., Jones, D. E., Sweeney, R. W., Wines, M. E., et al. (1998) · Infection and Immunity · doi:10.1128/iai.66.3.1045-1056.1998 · Cited by 178

Modulation of Human β-Defensin-2 Transcription in Pulmonary Epithelial Cells by Lipopolysaccharide-Stimulated Mononuclear Phagocytes Via Proinflammatory Cytokine Production

Tsutsumi‐Ishii, Y., & Nagaoka, I. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.8.4226 · Cited by 176

In human epidermis, β-defensin 2 is packaged in lamellar bodies

Oren, A., Ganz, T., Liu, L., & Meerloo, T. (2003) · Experimental and Molecular Pathology · doi:10.1016/s0014-4800(02)00023-0 · Cited by 176

Single-Nucleotide Polymorphisms (SNPs) in Human β-Defensin 1: High-Throughput SNP Assays and Association with Candida Carriage in Type I Diabetics and Nondiabetic Controls

Jurevic, R. J., Bai, M., Chadwick, R. B., White, T. C., & Dale, B. A. (2003) · Journal of Clinical Microbiology · doi:10.1128/jcm.41.1.90-96.2003 · Cited by 172

Isolation of antimicrobial peptides from avian heterophils

Evans, E. W., Beach, G. G., Wunderlich, J. K., & Harmon, B. G. (1994) · Journal of Leukocyte Biology · doi:10.1002/jlb.56.5.661 · Cited by 172

Activity of rabbit leukocyte peptides against Candida albicans

Selsted, M. E., Szklarek, D., Ganz, T., & Lehrer, R. I. (1985) · Infection and Immunity · doi:10.1128/iai.49.1.202-206.1985 · Cited by 162

Gallinacin-3, an Inducible Epithelial β-Defensin in the Chicken

Zhao, C., Nguyen, T. X., Liu, L., Sacco, R. E., Brogden, K. A., & Lehrer, R. I. (2001) · Infection and Immunity · doi:10.1128/iai.69.4.2684-2691.2001 · Cited by 160

Human Salivary Histatins: Promising Anti-Fungal Therapeutic Agents

Tsai, H., & Bobek, L. A. (1998) · Critical Reviews in Oral Biology & Medicine · doi:10.1177/10454411980090040601 · Cited by 155

Defensins promote fusion and lysis of negatively charged membranes

Fujii, G., Eisenberg, D., & Selsted, M. E. (1993) · Protein Science · doi:10.1002/pro.5560020813 · Cited by 154

Determination of the disulfide array in the human defensin HNP-2

Selsted, M. E., & Harwig, S. S. L. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)84952-9 · Cited by 153

Isolation and characterization of human defensin cDNA clones.

Daher, K. A., Lehrer, R. I., Ganz, T., & Kronenberg, M. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.19.7327 · Cited by 145

Characterization of defensin resistance phenotypes associated with mutations in the phoP virulence regulon of Salmonella typhimurium

Miller, S. I., Pulkkinen, W. S., Selsted, M. E., & Mekalanos, J. J. (1990) · Infection and Immunity · doi:10.1128/iai.58.11.3706-3710.1990 · Cited by 144

Solution Structure of Bovine Neutrophil .beta.-Defensin-12: The Peptide Fold of the .beta.-Defensins Is Identical to That of the Classical Defensins

Zimmermann, G. R., Legault, P., Selsted, M. E., & Pardi, A. (1995) · Biochemistry · doi:10.1021/bi00041a048 · Cited by 143

Mechanism of mammalian cell lysis mediated by peptide defensins. Evidence for an initial alteration of the plasma membrane.

Lichtenstein, A. K. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115310 · Cited by 139

PhoP/PhoQ: macrophage‐specific modulators of Salmonella virulence?

Miller, S. I. (1991) · Molecular Microbiology · doi:10.1111/j.1365-2958.1991.tb02135.x · Cited by 135

Mechanism of target cytolysis by peptide defensins. Target cell metabolic activities, possibly involving endocytosis, are crucial for expression of cytotoxicity.

Lichtenstein, A. K., Ganz, T., Nguyen, T. M., Selsted, M. E., & Lehrer, R. I. (1988) · The Journal of Immunology · doi:10.4049/jimmunol.140.8.2686 · Cited by 134

Intramolecular inhibition of human defensin HNP-1 by its propiece.

Valore, E. V., Martin-Porter, E., Harwig, S. S. L., & Ganz, T. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118588 · Cited by 131

Cationic defensins arise from charge-neutralized propeptides: a mechanism for avoiding leukocyte autocytotoxicity?

Michaelson, D., Rayner, J. R., Couto, M., & Ganz, T. (1992) · Journal of Leukocyte Biology · doi:10.1002/jlb.51.6.634 · Cited by 129

Antibacterial activity of microbicidal cationic proteins 1 and 2, natural peptide antibiotics of rabbit lung macrophages

Lehrer, R. I., Selsted, M. E., Szklarek, D., & Fleischmann, J. (1983) · Infection and Immunity · doi:10.1128/iai.42.1.10-14.1983 · Cited by 126

The NMR Structure of Human β-Defensin-2 Reveals a Novel α-Helical Segment,

Sawai, M. V., Jia, H. P., Liu, L., Aseyev, V. O., Wiencek, J. M., McCray, P. B., Ganz, T., Kearney, W. R., & Tack, B. F. (2001) · Biochemistry · doi:10.1021/bi002519d · Cited by 121

The opsonizing ligand on Salmonella typhimurium influences incorporation of specific, but not azurophil, granule constituents into neutrophil phagosomes.

Joiner, K. A., Ganz, T., Albert, J. P., & Rotrosen, D. (1989) · The Journal of Cell Biology · doi:10.1083/jcb.109.6.2771 · Cited by 117

NMR studies of defensin antimicrobial peptides. 2. Three-dimensional structures of rabbit NP-2 and human HNP-1

Pardi, A., Zhang, X. L., Selsted, M. E., Skalicky, J. J., & Yip, P. F. (1992) · Biochemistry · doi:10.1021/bi00161a013 · Cited by 115

Characterization of the disulfide motif in BNBD-12, an antimicrobial beta-defensin peptide from bovine neutrophils.

Tang, Y. Q., & Selsted, M. E. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53299-3 · Cited by 111

Defensin-rich granules of human neutrophils: characterization of secretory properties

Faurschou, M., Sørensen, O. E., Johnsen, A. H., Askaa, J., & Borregaard, N. (2002) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/s0167-4889(02)00243-4 · Cited by 110

Mapping of the Gene Encoding Human β-Defensin-2 (DEFB2) to Chromosome Region 8p22–p23.1

Harder, J., Siebert, R., Zhang, Y., Matthiesen, P., Christophers, E., Schlegelberger, B., & Schröder, J. (1997) · Genomics · doi:10.1006/geno.1997.5074 · Cited by 108

Induction of epithelial chloride secretion by channel-forming cryptdins 2 and 3

Lencer, W. I., Cheung, G., Strohmeier, G. R., Currie, M. G., Ouellette, A. J., Selsted, M. E., & Madara, J. L. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.16.8585 · Cited by 108

Porcine Epithelial β-Defensin 1 Is Expressed in the Dorsal Tongue at Antimicrobial Concentrations

Shi, J. N., Zhang, G., Wu, H. J., Ross, C. R., Blecha, F., & Ganz, T. (1999) · Infection and Immunity · doi:10.1128/iai.67.6.3121-3127.1999 · Cited by 108

Purification and antimicrobial properties of three defensins from rat neutrophils

Eisenhauer, P. B., Harwig, S. S. L., Szklarek, D., Ganz, T., Selsted, M. E., & Lehrer, R. I. (1989) · Infection and Immunity · doi:10.1128/iai.57.7.2021-2027.1989 · Cited by 107

レトロサイクリン HIV‐1のT‐及びM‐親和性株による感染から細胞を保護する霊長類ペプチド

Cole, A., Hong, T., M, B. L., Nguyen, T. T. V., Zhao, C., Bristol, G., Zack, J. A., Yang, O. O., & Lehrer, R. I. (2002) · Cited by 106

Secretion of type II phospholipase A2 and cryptdin by rat small intestinal Paneth cells

Qu, X. D., Lloyd, K. C. K., Walsh, J. H., & Lehrer, R. I. (1996) · Infection and Immunity · doi:10.1128/iai.64.12.5161-5165.1996 · Cited by 105

Solution structures of the rabbit neutrophil defensin NP-5

Pardi, A., Hare, D. R., Selsted, M. E., Morrison, R. D., Bassolino, D. A., & Bach, A. (1988) · Journal of Molecular Biology · doi:10.1016/0022-2836(88)90643-2 · Cited by 103

Genetic Variants of Human β-Defensin-1 and Chronic Obstructive Pulmonary Disease

Matsushita, I., Hasegawa, K., Nakata, K., Yasuda, K., Tokunaga, K., & Keicho, N. (2002) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2002.6395 · Cited by 101

Neutrophil defensins mediate acute inflammatory response and lung dysfunction in dose-related fashion

Zhang, H., Porro, G. A., Orzech, N., Mullen, B. M., Liu, M., & Slutsky, A. S. (2001) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.2001.280.5.l947 · Cited by 99

The mouse genome encodes a single homolog of the antimicrobial peptide human β‐defensin 1

Huttner, K. M., Kozak, C. A., & Bevins, C. L. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)00875-2 · Cited by 98

A 450-kb contig of defensin genes on human chromosome 8p23

Linzmeier, R. M., Ho, C.-M., Hoang, B., & Ganz, T. (1999) · Gene · doi:10.1016/s0378-1119(99)00136-5 · Cited by 96

Differential Scanning Microcalorimetry Indicates That Human Defensin, HNP-2, Interacts Specifically with Biomembrane Mimetic Systems,

Lohner, K., Latal, A., Lehrer, R. I., & Ganz, T. (1997) · Biochemistry · doi:10.1021/bi961300p · Cited by 93

The structure of the rabbit macrophage defensin genes and their organ-specific expression.

Ganz, T., Rayner, J. R., Valore, E. V., Tumolo, A., Talmadge, K., & Fuller, F. (1989) · The Journal of Immunology · doi:10.4049/jimmunol.143.4.1358 · Cited by 92

Molecular cloning and tissue expression of porcine β‐defensin‐1

Zhang, G., Wu, H. J., Shi, J. N., Ganz, T., Ross, C. R., & Blecha, F. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)00134-3 · Cited by 88

Mouse beta defensin-1 is a functional homolog of human beta defensin-1

Morrison, G. M., Davidson, D. J., Kilanowski, F. M., Borthwick, D. W., Crook, K., Maxwell, A., Govan, J. R. W., & Dorin, J. R. (1998) · Mammalian Genome · doi:10.1007/s003359900795 · Cited by 88

The pro region of human neutrophil defensin contains a motif that is essential for normal subcellular sorting

Liu, L., & Ganz, T. (1995) · Blood · doi:10.1182/blood.v85.4.1095.bloodjournal8541095 · Cited by 85

Small, anionic, and charge-neutralizing propeptide fragments of zymogens are antimicrobial

Brogden, K. A., Ackermann, M. R., & Huttner, K. M. (1997) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.41.7.1615 · Cited by 85

Molecular genetic analysis of the Escherichia coli phoP locus

Groisman, E. A., Heffron, F., & Solomon, F. (1992) · Journal of Bacteriology · doi:10.1128/jb.174.2.486-491.1992 · Cited by 84

Characterization of defensin precursors in mature human neutrophils

Harwig, S. S. L., Park, A., & Lehrer, R. (1992) · Blood · doi:10.1182/blood.v79.6.1532.1532 · Cited by 83

A novel mouse beta defensin, Defb2, which is upregulated in the airways by lipopolysaccharide

Morrison, G. M., Davidson, D. J., & Dorin, J. R. (1999) · FEBS Letters · doi:10.1016/s0014-5793(98)01630-5 · Cited by 82

Assignment of defensin gene(s) to human chromosome 8p23

Sparkes, R. S. (1989) · Genomics · doi:10.1016/0888-7543(89)90052-9 · Cited by 79

A Novel Murine β-Defensin Expressed in Tongue, Esophagus, and Trachea

Jia, H. P., Wowk, S. A., Schutte, B. C., Lee, S. K., Vivado, A., Tack, B. F., Bevins, C. L., & McCray, P. B. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m006603200 · Cited by 76

ACID MUCOSUBSTANCE AND BASIC PROTEIN IN MOUSE PANETH CELLS

Spicer, S. S., Staley, M. W., Wetzel, M. G., & Wetzel, B. (1967) · Journal of Histochemistry & Cytochemistry · doi:10.1177/15.4.225 · Cited by 76

Isolation of human intestinal defensins from ileal neobladder urine

Porter, E. M., Poles, M. A., Lee, J. S., Naitoh, J., Bevins, C. L., & Ganz, T. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)00994-6 · Cited by 75

Why and how are peptide-lipid interactions utilized for self defence?

Matsuzaki, K. (2001) · Biochemical Society Transactions · doi:10.1042/bst0290598 · Cited by 73

Expression of β-Defensin Genes in Bovine Alveolar Macrophages

Ryan, L. K., Rhodes, J., Bhat, M., & Diamond, G. (1998) · Infection and Immunity · doi:10.1128/iai.66.2.878-881.1998 · Cited by 72

NMR studies of defensin antimicrobial peptides. 1. Resonance assignment and secondary structure determination of rabbit NP-2 and human HNP-1

Zhang, X. L., Selsted, M. E., & Pardi, A. (1992) · Biochemistry · doi:10.1021/bi00161a012 · Cited by 70

Cloning and Expression of Bovine Neutrophil β-Defensins

Yount, N. Y., Yuan, J. J., Tarver, A. P., Castro, T. A., Diamond, G., Tran, P. A., Levy, J. N., McCullough, C. E., Cullor, J. S., Bevins, C. L., et al. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.37.26249 · Cited by 69

Inheritance of Unequal Numbers of the Genes Encoding the Human Neutrophil Defensins HP-1 and HP-3

Mars, W. M., Patmasiriwat, P., Maity, T., Huff, V., Weil, M. M., & Saunders, G. F. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.51.30371 · Cited by 68

Rat neutrophil defensins. Precursor structures and expression during neutrophilic myelopoiesis

Yount, N. Y., Wang, M. S., Yuan, J. J., Banaei, N., Ouellette, A. J., & Selsted, M. E. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.155.9.4476 · Cited by 66

The Isolation and Characterization of a Novel Corticostatin/Defensin-like Peptide from the Kidney

Bateman, A., Macleod, J., Lembessis, P., Hu, J., Esch, F. S., & Solomon, S. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.18.10654 · Cited by 66

Bethanechol and a G-protein activator, NaF/AlCl3, induce secretory response in Paneth cells of mouse intestine

Satoh, Y., Ishikawa, K., Oomori, Y., Takeda, S., & Ono, K. (1992) · Cell and Tissue Research · doi:10.1007/bf00319611 · Cited by 66

Characterization of β‐defensin prepropeptide mRNA from chicken and turkey bone marrow

Brockus, C. W., Jackwood, M. W., & Harmon, B. G. (1998) · Animal Genetics · doi:10.1046/j.1365-2052.1998.00338.x · Cited by 63

Molecular Cloning and Characterization of Rat Genes Encoding Homologues of Human β-Defensins

Jia, H. P., Mills, J. N., Barahmand-Pour, F., Nishimura, D. Y., Mallampali, R. K., Wang, G., Wiles, K., Tack, B. F., Bevins, C. L., & McCray, P. B. (1999) · Infection and Immunity · doi:10.1128/iai.67.9.4827-4833.1999 · Cited by 62

Inhibition of hBD-3, but Not hBD-1 and hBD-2, mRNA Expression by Corticosteroids

Duits, L. A., Rademaker, M., Ravensbergen, B., van Sterkenburg, M. A. J. A., van Strijen, E., Hiemstra, P. S., & Nibbering, P. H. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.4157 · Cited by 61

Effects of corticostatin-I on rat adrenal cells in vitro

Tominaga, T., Fukata, J., Naito, Y., Nakai, Y., Funakoshi, S., Fujii, N., & Imura, H. (1990) · Journal of Endocrinology · doi:10.1677/joe.0.1250287 · Cited by 58

Corticostatic peptides cause nifedipine-sensitive volume reduction in jejunal villus enterocytes.

Macleod, J., Hamilton, J. R., Bateman, A., Belcourt, D., Hu, J., Bennett, H. P. J., & Solomon, S. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.2.552 · Cited by 58

Isolation, Characterization, cDNA Cloning, and Antimicrobial Properties of Two Distinct Subfamilies of α-Defensins from Rhesus Macaque Leukocytes

Tang, Y., Yuan, J. J., Miller, C. J., & Selsted, M. E. (1999) · Infection and Immunity · doi:10.1128/iai.67.11.6139-6144.1999 · Cited by 58

Timing, targeting and sorting of azurophil granule proteins in human myeloid cells

Arnljots, K., Sørensen, O. E., Lollike, K., & Borregaard, N. (1998) · Leukemia · doi:10.1038/sj.leu.2401202 · Cited by 57

The corticostatic (anti-ACTH) and cytotoxic activity of peptides isolated from fetal, adult and tumor-bearing lung

Qlnzhang, Z., Singh, A. V., Bateman, A., Esch, F. S., & Solomon, S. (1987) · Journal of Steroid Biochemistry · doi:10.1016/0022-4731(87)90184-1 · Cited by 55

Rhesus Monkey ( Macaca mulatta ) Mucosal Antimicrobial Peptides Are Close Homologues of Human Molecules

Bals, R., Lang, C., Weiner, D. J., Vogelmeier, C. F., WELSCH, U. N., & Wilson, J. M. (2001) · Clinical and Diagnostic Laboratory Immunology · doi:10.1128/cdli.8.2.370-375.2001 · Cited by 54

Expression of human α-defensin 5 (HD5) mRNA in nasal and bronchial epithelial cells

Frye, M., Bargon, J., Dauletbaev, N., Weber, A., Wagner, T. O. F., & Gropp, R. (2000) · Journal of Clinical Pathology · doi:10.1136/jcp.53.10.770 · Cited by 52

Structure and dynamics of the neutrophil defensins NP‐2, NP‐5, and HNP‐1: NMR studies of amide hydrogen exchange kinetics

Skalicky, J. J., Selsted, M. E., & Pardi, A. (1994) · Proteins Structure Function and Bioinformatics · doi:10.1002/prot.340200107 · Cited by 52

Murine ??-Defensin-3 Is an Inducible Peptide with Limited Tissue Expression and Broad-Spectrum Antimicrobial Activity

Burd, R. S., Furrer, J. L., Sullivan, J., & Smith, A. L. (2002) · Shock · doi:10.1097/00024382-200211000-00013 · Cited by 49

Isolation and Biological Activity of Corticostatic Peptides (Anti-Acth)

Zhu, Q., Bateman, A., Singh, A., & Solomon, S. (1989) · Endocrine Research · doi:10.1080/07435808909039093 · Cited by 42

Newborn rabbit alveolar macrophages are deficient in two microbicidal cationic peptides, MCP-1 and MCP-2.

Ganz, T., Sherman, M. P., Selsted, M. E., & Lehrer, R. I. (1985) · PubMed · doi:10.1164/arrd.1985.132.4.901 · Cited by 41

Differentiation-stimulated Activity Binds an ETS-like, Essential Regulatory Element in the Human Promyelocytic defensin-1Promoter

Ma, Y., Su, Q., & Tempst, P. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.15.8727 · Cited by 34

Cryptdin-3 induces novel apical conductance(s) in Cl− secretory, including cystic fibrosis, epithelia

Merlin, D., Yue, G., Lencer, W. I., Selsted, M. E., & Madara, J. (2001) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2001.280.2.c296 · Cited by 31

Purification, primary structures, and antibacterial activities of β-defensins, a new family of antimicrobial peptides from bovine neutrophils.

Selsted, M. E., Tang, Y., Morris, W., McGuire, P. A., Novotny, M. J., Smith, W., Henschen, A., & Cullor, J. S. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.27.16430 · Cited by 27

Testis-specific expression of a novel mouse defensin-like gene, Tdl

Yamamoto, M., & Matsui, Y. (2002) · Mechanisms of Development · doi:10.1016/s0925-4773(02)00144-2 · Cited by 20

Corticostatic peptides

Solomon, S., Hu, J., Zhu, Q., Belcourt, D., Bennett, H. P. J., Bateman, A., & Antakly, T. (1991) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(91)90206-k · Cited by 20

Electrostatic Interactions between Human Leukocyte Elastase and Sulfated Glycosaminoglycans: Physiological Implications

Kostoulas, G., Hörler, D., Naggi, A., Casu, B., & Baici, A. (1997) · Biological Chemistry · doi:10.1515/bchm.1997.378.12.1481 · Cited by 18

Unmasking and redistribution of lysosomal sulfated glycoconjugates in phagocytic polymorphonuclear leukocytes.

Parmley, R. T., Doran, T., Boyd, R. L., & Gilbert, C. S. (1986) · Journal of Histochemistry & Cytochemistry · doi:10.1177/34.12.3782778 · Cited by 13

Detection of Cryptdin in Mouse Skin

Shirafuji, Y., Oono, T., Kanzaki, H., Hirakawa, S., & Arata, J. (1999) · Clinical and Diagnostic Laboratory Immunology · doi:10.1128/cdli.6.3.336-340.1999 · Cited by 10

β-Defensin 2 in the Rhesus Monkey ( Macaca mulatta ) and the Long-Tailed Macaque ( M. fascicularis )

Boniotto, M., Tossi, A., & Crovella, S. (2002) · Clinical and Vaccine Immunology · doi:10.1128/cdli.9.2.503-504.2002 · Cited by 4

Shaping animal body plans in development and evolution by modulation of Hox expression patterns

(1998) · doi:10.1002/(sici)1521-1878(199802)20:2

Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria?

Brogden, K. A. (2005) · Nature Reviews Microbiology · doi:10.1038/nrmicro1098 · Cited by 5,829

Of Mice and Not Men: Differences between Mouse and Human Immunology

Mestas, J., & Hughes, C. C. W. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.5.2731 · Cited by 3,822

Neutrophil extracellular traps in immunity and disease

Papayannopoulos, V. (2017) · Nature reviews. Immunology · doi:10.1038/nri.2017.105 · Cited by 3,542

Peptide Antimicrobial Agents

Jenssen, H., Hamill, P., & Hancock, R. E. W. (2006) · Clinical Microbiology Reviews · doi:10.1128/cmr.00056-05 · Cited by 2,605

Myeloperoxidase: friend and foe

Klebanoff, S. J. (2005) · Journal of Leukocyte Biology · doi:10.1189/jlb.1204697 · Cited by 2,282

Mammalian defensins in the antimicrobial immune response

Selsted, M. E., & Ouellette, A. J. (2005) · Nature Immunology · doi:10.1038/ni1206 · Cited by 1,231

Defensins: Natural component of human innate immunity

Jarczak, J., Kościuczuk, E. M., Lisowski, P., Strzałkowska, N., Jóźwik, A., Horbańczuk, J. O., Krzyżewski, J., Zwierzchowski, L., & Bagnicka, E. (2013) · Human Immunology · doi:10.1016/j.humimm.2013.05.008 · Cited by 200

Defensins: More than Nature�s Anti-bug Spray?

de Leeuw, E. (2013) · Journal of Bioanalysis & Biomedicine · doi:10.4172/1948-593x.s8-001 · Cited by 1

Peptides and proteins with antimicrobial activity

Coutinho, H. D. M., Lobo, K., Bezerra, D. A. C., & Lobo, I. (2008) · Indian Journal of Pharmacology · doi:10.4103/0253-7613.40481 · Cited by 42

Defensins and Host Defense

Ganz, T. (1999) · Science · doi:10.1126/science.286.5439.420 · Cited by 321