Cited by 3,066Antimicrobial Peptides and ActivitiesInvertebrate Immune Response MechanismsImmune Response and Inflammation

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Defensins: antimicrobial peptides of innate immunity

Ganz, Tomas·2003·Nature Reviews Immunology

DOI 10.1038/nri1180

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Abstract

The production of natural antibiotic peptides has emerged as an important mechanism of innate immunity in plants and animals. Defensins are diverse members of a large family of antimicrobial peptides, contributing to the antimicrobial action of granulocytes, mucosal host defence in the small intestine and epithelial host defence in the skin and elsewhere. This review, inspired by a spate of recent studies of defensins in human diseases and animal models, focuses on the biological function of defensins.

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Authors: Ganz, T.
Affiliations: University of California, Los Angeles (US)
Corresponding author: Ganz, Tomas
ORCID: Ganz, Tomas
Venue: Nature Reviews Immunology
Publisher: Springer Science and Business Media LLC
Published: 2003-09
Volume: 3
Issue: 9
Pages: 710-720
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/nri1180
OpenAlex: W2057198053
Cited by: 3,066
References: 163
Citations by year: 2026: 79 · 2025: 97 · 2024: 112 · 2023: 111 · 2022: 138 · 2021: 126 · 2020: 145 · 2019: 147 · 2018: 157 · 2017: 133 · 2016: 139 · 2015: 150 · 2014: 161 · 2013: 170 · 2012: 165
FWCI: 12.60
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
Topics: Life Sciences › Immunology and Microbiology › Microbiology › Antimicrobial Peptides and Activities
Life Sciences › Immunology and Microbiology › Immunology › Invertebrate Immune Response Mechanisms
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: defensins, antimicrobial peptides, innate immunity, granulocytes, mucosal immunity, small intestine, natural antibiotics, human disease
MeSH terms: Amino Acid Sequence, Animals, Humans, Immunity, Innate, Models, Molecular, Molecular Sequence Data, Salmonella, Salmonella Infections, Sequence Alignment, Defensins

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