Colony-stimulating factors in inflammation and autoimmunity

Obesity is associated with macrophage accumulation in adipose tissue

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Inflammation and metabolic disorders

Hotamisligil, G. S. (2006) · Nature · doi:10.1038/nature05485 · Cited by 9,199

Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes

MANTOVANI, A., SOZZANI, S., LOCATI, M., ALLAVENA, P., & SICA, A. (2002) · Trends in Immunology · doi:10.1016/s1471-4906(02)02302-5 · Cited by 5,528

Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor.

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Blood Monocytes Consist of Two Principal Subsets with Distinct Migratory Properties

Geissmann, F., Jung, S., & Littman, D. R. (2003) · Immunity · doi:10.1016/s1074-7613(03)00174-2 · Cited by 3,504

Tumour-educated macrophages promote tumour progression and metastasis

Pollard, J. W. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1256 · Cited by 3,413

Macrophages: Obligate Partners for Tumor Cell Migration, Invasion, and Metastasis

Condeelis, J. S., & Pollard, J. W. (2006) · Cell · doi:10.1016/j.cell.2006.01.007 · Cited by 2,677

Cytokines in the pathogenesis of rheumatoid arthritis

McInnes, I. B., & Schett, G. A. (2007) · Nature reviews. Immunology · doi:10.1038/nri2094 · Cited by 2,575

Ischemia- and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization

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The c-fms proto-oncogene product is related to the receptor for the mononuclear phagocyte growth factor, CSF 1

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IRF5 Is a Specific Marker of Inflammatory MacrophagesIn Vivo

Weiss, M., Blazek, K. D., Byrne, A. J., Perocheau, D. P. B., & Udalova, I. A. (2013) · Mediators of Inflammation · doi:10.1155/2013/245804 · Cited by 132

GM-CSF Promotes Macrophage Alternative Activation after Renal Ischemia/Reperfusion Injury

Huen, S. C., Huynh, L. K., Marlier, A., Lee, Y., Moeckel, G. W., & Cantley, L. G. (2014) · Journal of the American Society of Nephrology · doi:10.1681/asn.2014060612 · Cited by 130

Cytokines and effector T cell subsets causing autoimmune CNS disease

Petermann, F., & Korn, T. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.03.064 · Cited by 134

A randomised phase IIb study of mavrilimumab, a novel GM–CSF receptor alpha monoclonal antibody, in the treatment of rheumatoid arthritis

Burmester, G. R., McInnes, I. B., Kremer, J. M., Miranda, P., Korkosz, M., Vencovský, J., Rubbert‐Roth, A., Mysler, E., Sleeman, M. A., Godwood, A., et al. (2017) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2016-210624 · Cited by 127

GM-CSF Regulates Fusion of Mononuclear Osteoclasts into Bone-Resorbing Osteoclasts by Activating the Ras/ERK Pathway

Lee, M. S., Kim, H. S., Yeon, J., Choi, S., Chun, C. H., Kwak, H. B., & Oh, J. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0804314 · Cited by 126

ATF3 Is a Key Regulator of Macrophage IFN Responses

Labzin, L. I., Schmidt, S. V., Masters, S. L., Beyer, M., Krebs, W., Klee, K., Stahl, R., Lütjohann, D., Schultze, J. L., Latz, E., et al. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1500204 · Cited by 124

Adenosine as an endogenous immunoregulator in cancer pathogenesis: where to go?

Kumar, V. (2012) · Purinergic Signalling · doi:10.1007/s11302-012-9349-9 · Cited by 131

Amplification of the response to Toll‐like receptor ligands by prolonged exposure to interleukin‐6 in mice: Implication for the pathogenesis of macrophage activation syndrome

Strippoli, R., Carvello, F., Scianaro, R., Pasquale, L. D., Vivarelli, M., Petrini, S., Bracci‐Laudiero, L., & Benedetti, F. D. (2011) · Arthritis & Rheumatism · doi:10.1002/art.33496 · Cited by 123

TLR2 stimulation impairs anti-inflammatory activity of M2-like macrophages, generating a chimeric M1/M2 phenotype

Quero, L., Hanser, E., Manigold, T., Tiaden, A. N., & Kyburz, D. (2017) · Arthritis Research & Therapy · doi:10.1186/s13075-017-1447-1 · Cited by 123

Vancomycin relieves mycophenolate mofetil–induced gastrointestinal toxicity by eliminating gut bacterial β-glucuronidase activity

Taylor, M. R., Flannigan, K. L., Rahim, H., Mohamud, A., Lewis, I. A., Hirota, S. A., & Greenway, S. C. (2019) · Science Advances · doi:10.1126/sciadv.aax2358 · Cited by 123

Gene regulatory network modeling of macrophage differentiation corroborates the continuum hypothesis of polarization states

Palma, A., Jarrah, A. S., Tieri, P., Cesareni, G., & Castiglione, F. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.01659 · Cited by 122

The five “Ws” for bone pain due to the administration of granulocyte-colony stimulating factors (G-CSFs)

Lambertini, M., Mastro, L. D., Bellodi, A., & Pronzato, P. (2013) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2013.08.006 · Cited by 122

Mavrilimumab, a human monoclonal antibody targeting GM-CSF receptor-α, in subjects with rheumatoid arthritis: a randomised, double-blind, placebo-controlled, phase I, first-in-human study

Burmester, G. R., Feist, E., Sleeman, M., Wang, B., White, B., & Magrini, F. (2011) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2010.146225 · Cited by 122

IL-4 orchestrates STAT6-mediated DNA demethylation leading to dendritic cell differentiation

Vento‐Tormo, R., Rodríguez‐Ubreva, J., de la Rica, L., Urquiza, J., Javierre, B. M., Sabarinathan, R., Luque, A., Esteller, M., Aran, J. M., Álvarez‐Errico, D., et al. (2016) · Genome biology · doi:10.1186/s13059-015-0863-2 · Cited by 126

Future therapeutic targets in rheumatoid arthritis?

Cheung, T. T., & McInnes, I. B. (2017) · Seminars in Immunopathology · doi:10.1007/s00281-017-0623-3 · Cited by 121

Deficiency of the macrophage growth factor CSF-1 disrupts pancreatic neuroendocrine tumor development

Pyonteck, S. M., Gadea, B. B., Wang, H.-W., Gocheva, V., Hunter, K. E., Tang, L. H., & Joyce, J. A. (2011) · Oncogene · doi:10.1038/onc.2011.337 · Cited by 125

A role for miR-155 in enabling tumor-infiltrating innate immune cells to mount effective antitumor responses in mice

Zonari, E., Pucci, F., Saini, M., Mazzieri, R., Politi, L. S., Gentner, B., & Naldini, L. (2013) · Blood · doi:10.1182/blood-2012-08-449306 · Cited by 120

Batf3-Dependent CD11blow/− Peripheral Dendritic Cells Are GM-CSF-Independent and Are Not Required for Th Cell Priming after Subcutaneous Immunization

Edelson, B. T., Bradstreet, T. R., Wumesh, K. C., Hildner, K., Herzog, J., Sim, J. E., Russell, J. H., Murphy, T. L., Unanue, E. R., & MURPHY, K. M. M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025660 · Cited by 127

A Review of GM-CSF Therapy in Sepsis

Mathias, B. J., Szpila, B. E., Moore, F. A., Efron, P. A., & Moldawer, L. L. (2015) · Medicine · doi:10.1097/md.0000000000002044 · Cited by 123

Genetic targeting of microglia

Wieghofer, P., Knobeloch, K., & Prinz, M. (2014) · Glia · doi:10.1002/glia.22727 · Cited by 118

MicroRNA-24 Regulates Macrophage Behavior and Retards Atherosclerosis

Gregoli, K. D., Jenkins, N., Salter, R., White, S., Newby, A., & Johnson, J. L. (2014) · Arteriosclerosis, Thrombosis and Vascular Biology · doi:10.1161/atvbaha.114.304088 · Cited by 112

G-CSF in tumors: Aggressiveness, tumor microenvironment and immune cell regulation

Karagiannidis, I., Salataj, E., Egal, É. S. A., & Beswick, E. J. (2021) · Cytokine · doi:10.1016/j.cyto.2021.155479 · Cited by 118

CSF1R Inhibition Reduces Microglia Proliferation, Promotes Tissue Preservation and Improves Motor Recovery After Spinal Cord Injury

Gerber, Y. N., Saint-Martin, G., Bringuier, C. M., Bartolami, S., Goze‐Bac, C., Noristani, H. N., & Perrin, F. E. (2018) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2018.00368 · Cited by 119

Role of Inflammatory Mediators, Macrophages, and Neutrophils in Glioma Maintenance and Progression: Mechanistic Understanding and Potential Therapeutic Applications

Basheer, A. S., Abas, F., Othman, I., & Naidu, R. (2021) · Cancers · doi:10.3390/cancers13164226 · Cited by 120

A role for G‐CSF and GM‐CSF in nonmyeloid cancers

Aliper, A. M., Korovkina, V. P., Buzdin, A. A., Roumiantsev, S. A., & Zhavoronkov, A. A. (2014) · Cancer Medicine · doi:10.1002/cam4.239 · Cited by 116

Oncogenic RAS pathway activation promotes resistance to anti-VEGF therapy through G-CSF–induced neutrophil recruitment

Phan, V. T., Wu, X., Cheng, J. H., Sheng, R. X., Chung, A. S., Zhuang, G., Tran, C., Song, Q., Kowanetz, M., Sambrone, A., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1303302110 · Cited by 116

The impact of surface chemistry modification on macrophage polarisation

Rostam, H. M., Singh, S., Salazar, F., Magennis, E. P., Hook, A. L., Singh, T., Vrana, N. E., Alexander, M. R., & Ghaemmaghami, A. M. (2016) · Immunobiology · doi:10.1016/j.imbio.2016.06.010 · Cited by 117

Myeloid-derived suppressor cells—a new therapeutic target to overcome resistance to cancer immunotherapy

Chesney, J. A., Mitchell, R. A., & Yaddanapudi, K. (2017) · Journal of Leukocyte Biology · doi:10.1189/jlb.5vmr1116-458rrr · Cited by 120

The multifaceted role of plasminogen in inflammation

Heissig, B., Salama, Y., Takahashi, S., Osada, T., & Hattori, K. (2020) · Cellular Signalling · doi:10.1016/j.cellsig.2020.109761 · Cited by 118

Autoimmune Pulmonary Alveolar Proteinosis

McCarthy, C., Carey, B. C., & Trapnell, B. C. (2022) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202112-2742so · Cited by 116

GM-CSF: a role in immune and inflammatory reactions in the intestine

Egea, L., Hirata, Y., & Kagnoff, M. F. (2010) · Expert Review of Gastroenterology & Hepatology · doi:10.1586/egh.10.73 · Cited by 116

Granulocyte-macrophage colony-stimulating factor is a key mediator in experimental osteoarthritis pain and disease development

Cook, A. D., Pobjoy, J., Steidl, S., Dürr, M. C., Braine, E. L., Turner, A. L., Lacey, D. C., & Hamilton, J. A. (2012) · Arthritis Research & Therapy · doi:10.1186/ar4037 · Cited by 115

GM-CSF–Responsive Monocyte-Derived Dendritic Cells Are Pivotal in Th17 Pathogenesis

Ko, H., Brady, J. L., Ryg-Cornejo, V., Hansen, D. S., Vremec, D., Shortman, K., Zhan, Y., & Lew, A. M. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1302040 · Cited by 115

Histone deacetylases in monocyte/macrophage development, activation and metabolism: refining HDAC targets for inflammatory and infectious diseases

Gupta, K. D., Shakespear, M. R., Iyer, A., Fairlie, D. P., & Sweet, M. J. (2016) · Clinical & Translational Immunology · doi:10.1038/cti.2015.46 · Cited by 116

Neurophysiological mechanisms of cancer-induced bone pain

Zheng, X.-Q., Wu, Y., Huang, J.-F., & Wu, A. (2021) · Journal of Advanced Research · doi:10.1016/j.jare.2021.06.006 · Cited by 124

Orally Administrated Inflamed Colon-Targeted Nanotherapeutics for Inflammatory Bowel Disease Treatment by Oxidative Stress Level Modulation in Colitis

Min, D. K., Kim, Y. E., Kim, M. K., Choi, S. W., Park, N., & Kim, J. (2023) · ACS Nano · doi:10.1021/acsnano.3c11089 · Cited by 120

Small intestinal eosinophils regulate Th17 cells by producing IL-1 receptor antagonist

Sugawara, R., Lee, E., Jang, M. S., Jeun, E.-J., Hong, C., Kim, J.-H., Park, A., Yun, C. H., Hong, S., Kim, Y., et al. (2016) · The Journal of Experimental Medicine · doi:10.1084/jem.20141388 · Cited by 116

Colony-stimulating factor (CSF) 1 receptor blockade reduces inflammation in human and murine models of rheumatoid arthritis

García, S., Hartkamp, L. M., Fernandez, B. M., van Es, I. E., Lin, H., Wong, J., Long, L., Zanghi, J. A., Rankin, A. L., Masteller, E. L., et al. (2016) · Arthritis Research & Therapy · doi:10.1186/s13075-016-0973-6 · Cited by 114

The multifaceted effects of granulocyte colony‐stimulating factor in immunomodulation and potential roles in intestinal immune homeostasis

Martins, A. J., Han, J., & Kim, S. O. (2010) · IUBMB Life · doi:10.1002/iub.361 · Cited by 120

Identification of CCR9− murine plasmacytoid DC precursors with plasticity to differentiate into conventional DCs

Schlitzer, A., Loschko, J., Mair, K., Vogelmann, R., Henkel, L., Einwächter, H., Schiemann, M., Niess, J. H., Reindl, W., & Krug, A. (2011) · Blood · doi:10.1182/blood-2010-12-326678 · Cited by 113

M2 macrophage polarisation is associated with alveolar formation during postnatal lung development

Jones, C. V., Williams, T. M., Walker, K. A., Dickinson, H., Sakkal, S., Rumballe, B. A., Little, M. H., Jenkin, G., & Ricardo, S. D. (2013) · Respiratory Research · doi:10.1186/1465-9921-14-41 · Cited by 111

Immunomodulators as adjuvants for vaccines and antimicrobial therapy

Nicholls, E. F., Madera, L., & Hancock, R. E. W. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05787.x · Cited by 111

Myeloid cells, BAFF, and IFN-γ establish an inflammatory loop that exacerbates autoimmunity in Lyn-deficient mice

Scapini, P., Hu, Y., Chu, C., Migone, T., DeFranco, A. L., Cassatella, M. A., & Lowell, C. A. (2010) · The Journal of Experimental Medicine · doi:10.1084/jem.20100086 · Cited by 111

Alveolar epithelial cells orchestrate DC function in murine viral pneumonia

Unkel, B., Högner, K., Clausen, B. E., Lewe-Schlosser, P., Bodner, J., Gattenloehner, S., Janßen, H., Seeger, W., Lohmeyer, J., & Herold, S. (2012) · Journal of Clinical Investigation · doi:10.1172/jci62139 · Cited by 111

Chimeric Antigen Receptor T Cells Shape Myeloid Cell Function within the Tumor Microenvironment through IFN-γ and GM-CSF

Spear, P., Barber, A., Rynda‐Apple, A., & Sentman, C. L. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1103019 · Cited by 114

Transcriptional Profile of Tuberculosis Antigen–Specific T Cells Reveals Novel Multifunctional Features

Arlehamn, C. S. L., Seumois, G., Gerasimova, A. V., Huang, C. C., Fu, Z., Yue, X., Sette, A., Vijayanand, P., & Peters, B. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1401151 · Cited by 104

Synovial cellular and molecular markers in rheumatoid arthritis

Amin, M. A., Fox, D. A., & Ruth, J. H. (2017) · Seminars in Immunopathology · doi:10.1007/s00281-017-0631-3 · Cited by 110

Monocyte homeostasis and the plasticity of inflammatory monocytes

Mitchell, A. J., Roediger, B., & Weninger, W. (2014) · Cellular Immunology · doi:10.1016/j.cellimm.2014.05.010 · Cited by 117

Antibacterial and immunomodulatory activities of insect defensins-DLP2 and DLP4 against multidrug-resistant Staphylococcus aureus

Li, Z., Mao, R., Teng, D., Hao, Y., Chen, H., Wang, X., Yang, N., Yang, N., & Wang, J. (2017) · Scientific Reports · doi:10.1038/s41598-017-10839-4 · Cited by 109

Monocyte alterations in rheumatoid arthritis are dominated by preterm release from bone marrow and prominent triggering in the joint

Smiljanovic, B., Radzikowska, A., Kuca‐Warnawin, E., Kurowska, W., Grün, J. R., Stuhlmüller, B., Bonin, M., Schulte‐Wrede, U., Sörensen, T., Kyogoku, C., et al. (2017) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2017-211649 · Cited by 109

The Role of Macrophages in Promoting and Maintaining Homeostasis at the Fetal–Maternal Interface

Svensson‐Arvelund, J., & Ernerudh, J. (2015) · American Journal of Reproductive Immunology · doi:10.1111/aji.12357 · Cited by 109

Control of macrophage lineage populations by CSF‐1 receptor and GM‐CSF in homeostasis and inflammation

Lenzo, J. C., Turner, A. L., Cook, A. D., Vlahos, R., Anderson, G. P., Reynolds, E. C., & Hamilton, J. A. (2011) · Immunology and Cell Biology · doi:10.1038/icb.2011.58 · Cited by 105

Myeloid-derived suppressor cells and their role in pancreatic cancer

Pergamo, M., & Miller, G. (2016) · Cancer Gene Therapy · doi:10.1038/cgt.2016.65 · Cited by 106

Nano‐curcumin safely prevents streptozotocin‐induced inflammation and apoptosis in pancreatic beta cells for effective management of Type 1 diabetes mellitus

Ganugula, R., Arora, M., Jaisamut, P., Wiwattanapatapee, R., Jørgensen, H. G., Venkatpurwar, V. P., Zhou, B., Hoffmann, A. R., Basu, R., Guo, S., et al. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13816 · Cited by 106

Randomized phase 1b trial of MOR103, a human antibody to GM-CSF, in multiple sclerosis

Constantinescu, C. S., Asher, A., Fryze, W., Kozubski, W. P., Wagner, F. D., Aram, J., Tănăsescu, R., Korolkiewicz, R. P., Dirnberger‐Hertweck, M., Steidl, S., et al. (2015) · Neurology Neuroimmunology & Neuroinflammation · doi:10.1212/nxi.0000000000000117 · Cited by 105

Evidence for CD16a-Mediated NK Cell Stimulation in Antibody-Mediated Kidney Transplant Rejection

Parkes, M., Halloran, P. F., & Hidalgo, L. G. (2016) · Transplantation · doi:10.1097/tp.0000000000001586 · Cited by 105

Macrophage uptake and accumulation of folates are polarization-dependent in vitro and in vivo and are regulated by activin A

Samaniego, R., Palacios, B. S., Domínguez‐Soto, Á., Vidal, C., Salas, A., Matsuyama, T., Sánchez‐Torres, C., de la Torre, I., Miranda‐Carús, M., Sánchez‐Mateos, P., et al. (2014) · Journal of Leukocyte Biology · doi:10.1189/jlb.0613345 · Cited by 106

Growth factor release from dentine matrix by pulp‐capping agents promotes pulp tissue repair‐associated events

Tomson, P. L. M., Lumley, P. J., Smith, A. J., & Cooper, P. R. (2016) · International Endodontic Journal · doi:10.1111/iej.12624 · Cited by 106

CSF-1R Inhibitor Development: Current Clinical Status

Peyraud, F., Cousin, S., & Italiano, A. (2017) · Current Oncology Reports · doi:10.1007/s11912-017-0634-1 · Cited by 108

Patient-derived Granulocyte/Macrophage Colony–Stimulating Factor Autoantibodies Reproduce Pulmonary Alveolar Proteinosis in Nonhuman Primates

Sakagami, T., Beck, D. C., Uchida, K., Suzuki, T., Carey, B. C., Nakata, K., Keller, G. L., Wood, R. E., Wert, S. E., Ikegami, M., et al. (2010) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201001-0008oc · Cited by 103

Antibody blockade of c-fms suppresses the progression of inflammation and injury in early diabetic nephropathy in obese db/db mice

Lim, A. K. H., Ma, F. Y., Nikolic‐Paterson, D. J., Thomas, M. C., Hurst, L., & Tesch, G. H. (2009) · Diabetologia · doi:10.1007/s00125-009-1399-3 · Cited by 102

Estrogen receptor signaling promotes dendritic cell differentiation by increasing expression of the transcription factor IRF4

Carreras, E., Turner, S., Frank, M. B., Knowlton, N. S., Osban, J., Centola, M. B., Park, C. G., Simmons, A., Alberola‐Ila, J., & Kovats, S. (2009) · Blood · doi:10.1182/blood-2009-08-236935 · Cited by 103

Proinflammatory cytokines, IL-1β and TNF-α, induce expression of interleukin-34 mRNA via JNK- and p44/42 MAPK-NF-κB pathway but not p38 pathway in osteoblasts

Eda, H., Shimada, H., Beidler, D. R., & Monahan, J. B. (2010) · Rheumatology International · doi:10.1007/s00296-010-1688-7 · Cited by 103

Unique Proteomic Signatures Distinguish Macrophages and Dendritic Cells

Becker, L., Liu, N.-C., Averill, M. M., Yuan, W., Pamir, N., Peng, Y., Irwin, A. D., Fu, X., Bornfeldt, K., & Heinecke, J. W. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033297 · Cited by 105

Tumor necrosis factor alpha secreted from oral squamous cell carcinoma contributes to cancer pain and associated inflammation

Scheff, N. N., Ye, Y., Bhattacharya, A., MacRae, J., Hickman, D. N., Sharma, A. K., Dolan, J. C., & Schmidt, B. L. (2017) · Pain · doi:10.1097/j.pain.0000000000001044 · Cited by 102

The Newly Discovered Cytokine IL-34 Is Expressed in Gingival Fibroblasts, Shows Enhanced Expression by Pro-Inflammatory Cytokines, and Stimulates Osteoclast Differentiation

Boström, E. A., & Lundberg, P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0081665 · Cited by 105

A guide to picking the most selective kinase inhibitor tool compounds for pharmacological validation of drug targets

Uitdehaag, J. C. M., Verkaar, F., Alwan, H. A. J., de Man, J., Buijsman, R. C., & Zaman, G. J. R. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2012.01859.x · Cited by 103

3D biomaterial matrix to support long term, full thickness, immuno-competent human skin equivalents with nervous system components

Yucha, S. E. V., Tamamoto, K. A., Nguyen, H., Abbott, R. D., Cairns, D. M., & Kaplan, D. L. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.04.044 · Cited by 101

Tumor-Associated Macrophages as Incessant Builders and Destroyers of the Cancer Stroma

Liguori, M., Solinas, G., Germano, G., Mantovani, A., & Allavena, P. (2011) · Cancers · doi:10.3390/cancers3043740 · Cited by 104

Global mRNA sequencing of human skeletal muscle: Search for novel exercise-regulated myokines

Pourteymour, S., Eckardt, K., Holen, T., Langleite, T. M., Lee-Ødegård, S., Jensen, J., Birkeland, K. I., Drevon, C. A., & Hjorth, M. (2017) · Molecular Metabolism · doi:10.1016/j.molmet.2017.01.007 · Cited by 98

Cytokine-Defined B Cell Responses as Therapeutic Targets in Multiple Sclerosis

Li, R., Rezk, A., Healy, L. M., Muirhead, G., Prat, A., Gommerman, J. L., & Bar‐Or, A. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00626 · Cited by 107

Cytokines and inflammation in adipogenesis: an updated review

Jiang, N., Yao, L., Shu, T., & Wang, J. (2018) · Frontiers of Medicine · doi:10.1007/s11684-018-0625-0 · Cited by 104

Extracellular assembly and activation principles of oncogenic class III receptor tyrosine kinases

Verstraete, K., & Savvides, S. N. (2012) · Nature reviews. Cancer · doi:10.1038/nrc3371 · Cited by 102

Comparative Analysis of Monocyte Subsets in the Pig

Fairbairn, L., Kapétanovic, R., Beraldi, D., Sester, D. P., Tuggle, C. K., Archibald, A. L., & Hume, D. A. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1300365 · Cited by 99

Macrophages in the microenvironment of head and neck cancer: potential targets for cancer therapy

Evrard, D., Szturz, P., Tijeras‐Raballand, A., Astorgues‐Xerri, L., Abitbol, C., Paradis, V., Raymond, É., Albert, S., Barry, B., & Faivre, S. J. (2018) · Oral Oncology · doi:10.1016/j.oraloncology.2018.10.040 · Cited by 98

Signalling by the βc family of cytokines

Hercus, T. R., Dhagat, U., Kan, W. L., Broughton, S. E., Nero, T. L., Perugini, M., Sandow, J. J., D’Andrea, R. J., Ekert, P. G., Hughes, T. P., et al. (2013) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2013.03.002 · Cited by 97

Interkeukin‐34, a cytokine crucial for the differentiation and maintenance of tissue resident macrophages and Langerhans cells

Wang, Y., & Colonna, M. (2014) · European Journal of Immunology · doi:10.1002/eji.201344365 · Cited by 97

Emergence, origin, and function of neutrophil–dendritic cell hybrids in experimentally induced inflammatory lesions in mice

Geng, S., Matsushima, H., Okamoto, T., Yao, Y., Lu, R., Page, K., Blumenthal, R., Ward, N. L., Miyazaki, T., & Takashima, A. (2013) · Blood · doi:10.1182/blood-2012-07-445197 · Cited by 97

GM-CSF Induces Inflammatory Macrophages by Regulating Glycolysis and Lipid Metabolism

Na, Y. R., Gu, G., Jung, D., Kim, Y. W., Na, J., Woo, J. S., Cho, J., Youn, H., & Seok, S. H. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1600745 · Cited by 95

M-CSF, IL-6, and TGF-β promote generation of a new subset of tissue repair macrophage for traumatic brain injury recovery

Li, Z., Xiao, J., Xu, X., Li, W., Zhong, R., Qi, L., Chen, J., Cui, G., Wang, S., Zheng, Y., et al. (2021) · Science Advances · doi:10.1126/sciadv.abb6260 · Cited by 98

Novel GM-CSF signals via IFN-γR/IRF-1 and AKT/mTOR license monocytes for suppressor function

Ribechini, E., Hutchinson, J. A., Hergovits, S., Heuer, M., Lucas, J., Schleicher, U., Garrote, A.-L. J., Potter, S. J., Riquelme, P., Brackmann, H., et al. (2017) · Blood Advances · doi:10.1182/bloodadvances.2017006858 · Cited by 101

Calcium/calmodulin-signaling supports TRPV4 activation in osteoclasts and regulates bone mass

Masuyama, R., Mizuno, A., Komori, H., Kajiya, H., Uekawa, A., Kitaura, H., Okabe, K., Ohyama, K., & Komori, T. (2012) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1629 · Cited by 100

GM‐CSF promotes migration of human monocytes across the blood brain barrier

Vogel, D. Y. S., Kooij, G., Heijnen, P. D. A. M., Breur, M., Peferoen, L. A. N., van der Valk, P., de Vries, H. E., Amor, S., & Dijkstra, C. D. (2015) · European Journal of Immunology · doi:10.1002/eji.201444960 · Cited by 94

Elevated Serum and Synovial Fluid Levels of Interleukin-34 in Rheumatoid Arthritis: Possible Association with Disease Progression via Interleukin-17 Production

Tian, Y., Shen, H., Xia, L., & Lu, J. (2013) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2012.0122 · Cited by 94

Group 2 Innate Lymphoid Cells Express Functional NKp30 Receptor Inducing Type 2 Cytokine Production

Salimi, M., Xue, L., Jolin, H. E., Hardman, C. S., Cousins, D. J., McKenzie, A. N. J., & Ogg, G. S. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1501102 · Cited by 96

Therapeutic Effects of Human Umbilical Cord-Derived Mesenchymal Stem Cells in Acute Lung Injury Mice

Zhu, H., Xiong, Y., Xia, Y., Zhang, R., Tian, D., Wang, T., Dai, J., Wang, L., Yao, H., Jiang, H., et al. (2017) · Scientific Reports · doi:10.1038/srep39889 · Cited by 94

GM-CSF as a target in inflammatory/autoimmune disease: current evidence and future therapeutic potential

Hamilton, J. A. (2015) · Expert Review of Clinical Immunology · doi:10.1586/1744666x.2015.1024110 · Cited by 94

CCL17 blockade as a therapy for osteoarthritis pain and disease

Lee, M.-C., Saleh, R., Achuthan, A. A., Fleetwood, A. J., Förster, I., Hamilton, J. A., & Cook, A. D. (2018) · Arthritis Research & Therapy · doi:10.1186/s13075-018-1560-9 · Cited by 93

Cytokines and Interferons: Types and Functions

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Exposure to multiple heavy metals associate with aberrant immune homeostasis and inflammatory activation in preschool children

Zhang, Y., Huo, X., Lu, X., Zeng, Z., Faas, M. M., & Xu, X. (2020) · Chemosphere · doi:10.1016/j.chemosphere.2020.127257 · Cited by 95

M‐CSF induces the expression of a membrane‐bound form of IL ‐18 in a subset of human monocytes differentiating in vitro toward macrophages

Bellora, F., Castriconi, R., Doni, A., Cantoni, C., Moretta, L., Mantovani, A., Moretta, A., & Bottino, C. (2012) · European Journal of Immunology · doi:10.1002/eji.201142173 · Cited by 92

Th17 cells in central nervous system autoimmunity

Sie, C., Korn, T., & Mitsdoerffer, M. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2014.03.009 · Cited by 95

Integrated multi-cohort transcriptional meta-analysis of neurodegenerative diseases

Li, M., Burns, T. C., Morgan, A. A., & Khatri, P. (2014) · Acta Neuropathologica Communications · doi:10.1186/s40478-014-0093-y · Cited by 92

Efficacy and safety of namilumab, a human monoclonal antibody against granulocyte-macrophage colony-stimulating factor (GM-CSF) ligand in patients with rheumatoid arthritis (RA) with either an inadequate response to background methotrexate therapy or an inadequate response or intolerance to an anti-TNF (tumour necrosis factor) biologic therapy: a randomized, controlled trial

for the NEXUS Study Group, Taylor, P. C., Saurigny, D., Vencovský, J., Takeuchi, T., Nakamura, T., Matsievskaia, G., Hunt, B., Wagner, T., & Souberbielle, B. E. (2019) · Arthritis Research & Therapy · doi:10.1186/s13075-019-1879-x · Cited by 90

Proteomic analysis of the secretome of human bone marrow-derived mesenchymal stem cells primed by pro-inflammatory cytokines

Maffioli, E., Nonnis, S., Angioni, R., Santagata, F., Calì, B., Zanotti, L., Negri, A. L., Viola, A., & Tedeschi, G. (2017) · Journal of Proteomics · doi:10.1016/j.jprot.2017.07.012 · Cited by 91

Pyrin Critical to Macrophage IL-1β Response to Francisella Challenge

Gavrilin, M. A., Mitra, S., Seshadri, S., Nateri, J., Berhe, F., Hall, M. W., & Wewers, M. D. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803073 · Cited by 88

GM-CSF as a therapeutic target in inflammatory diseases

van Nieuwenhuijze, A. E. M., Koenders, M. I., Roeleveld, D. M., Sleeman, M. A., van den Berg, W., & Wicks, I. P. (2013) · Molecular Immunology · doi:10.1016/j.molimm.2013.05.002 · Cited by 87

The Pleiotropic Effects of the GM-CSF Rheostat on Myeloid Cell Differentiation and Function: More Than a Numbers Game

Zhan, Y., Lew, A. M., & Chopin, M. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02679 · Cited by 89

Dendritic Cells Induce Regulatory T Cell Proliferation through Antigen-Dependent and -Independent Interactions

Zou, T., Caton, A. J., Koretzky, G. A., & Kambayashi, T. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903740 · Cited by 87

Microglia-neuron interactions in the models of neuropathic pain

Tozaki‐Saitoh, H., & Tsuda, M. (2019) · Biochemical Pharmacology · doi:10.1016/j.bcp.2019.08.016 · Cited by 84

Anti-colony-stimulating factor therapies for inflammatory and autoimmune diseases

Hamilton, J. A., Cook, A. D., & Tak, P. P. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.231 · Cited by 164

Colony Stimulating Factors (CSFs)

Fleetwood, A. J., Achuthan, A. A., & Hamilton, J. A. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-374279-7.10015-3 · Cited by 5

Colony stimulating factors and myeloid cell biology in health and disease

Hamilton, J. A., & Achuthan, A. (2013) · Trends in Immunology · doi:10.1016/j.it.2012.08.006 · Cited by 285

Targeting GM-CSF in inflammatory and autoimmune disorders

Achuthan, A. A., Lee, M.-C., & Hamilton, J. A. (2021) · Seminars in Immunology · doi:10.1016/j.smim.2021.101523 · Cited by 66

GM-CSF: A Promising Target in Inflammation and Autoimmunity

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