Cited by 1,305Cytokine Signaling Pathways and InteractionsImmune Response and InflammationImmune cells in cancer

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Colony-stimulating factors in inflammation and autoimmunity

Hamilton, John A.·2008·Nature reviews. Immunology

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Abstract

Although they were originally defined as haematopoietic-cell growth factors, colony-stimulating factors (CSFs) have been shown to have additional functions by acting directly on mature myeloid cells. Recent data from animal models indicate that the depletion of CSFs has therapeutic benefit in many inflammatory and/or autoimmune conditions and as a result, early-phase clinical trials targeting granulocyte/macrophage colony-stimulating factor and macrophage colony-stimulating factor have now commenced. The distinct biological features of CSFs offer opportunities for specific targeting, but with some associated risks. Here, I describe these biological features, discuss the probable specific outcomes of targeting CSFs in vivo and highlight outstanding questions that need to be addressed.

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Authors: Hamilton, J. A.
Affiliations: The Royal Melbourne Hospital (AU)
Corresponding author: Hamilton, John A.
ORCID: Hamilton, John A.
Venue: Nature reviews. Immunology
Publisher: Springer Science and Business Media LLC
Published: 2008-07
Volume: 8
Issue: 7
Pages: 533-544
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/nri2356
OpenAlex: W2063680739
Cited by: 1,305
References: 141
Citations by year: 2026: 33 · 2025: 45 · 2024: 49 · 2023: 57 · 2022: 81 · 2021: 83 · 2020: 75 · 2019: 63 · 2018: 82 · 2017: 94 · 2016: 85 · 2015: 92 · 2014: 94 · 2013: 71 · 2012: 89
FWCI: 6.60
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Keywords: colony-stimulating factors, inflammation, autoimmunity, granulocyte colony-stimulating factor, macrophage colony-stimulating factor, myeloid cells, hematopoietic growth factors
MeSH terms: Animals, Arthritis, Colony-Stimulating Factors, Encephalomyelitis, Autoimmune, Experimental, Humans, Inflammation, Lung Diseases, Neoplasms, Nephritis, Autoimmunity, Receptors, Colony-Stimulating Factor, Atherosclerosis

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Colony-stimulating factors in inflammation and autoimmunity

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