The DOI matches its Crossref record; 22 of the 22 references it cites were found in a registry or an index.
The known unknowns of antigen processing and presentation
Open accessAbstract
The principal components of both MHC class I and class II antigen processing and presentation pathways are well known. In dendritic cells, these pathways are tightly regulated by Toll-like-receptor signalling and include features, such as cross-presentation, that are not seen in other cell types. However, the exact mechanisms involved in the subcellular trafficking of antigens remain poorly understood and in some cases are controversial. Recent data suggest that diverse cellular machineries, including autophagy, participate in antigen processing and presentation, although their relative contributions remain to be fully elucidated. Here, we highlight some emerging themes of antigen processing and presentation that we think merit further attention.
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Cites
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Cited by
Towards a systems understanding of MHC class I and MHC class II antigen presentation
Neefjes, J., Jongsma, M. L. M., Paul, P., & Bakke, O. (2011) · Nature Reviews Immunology · doi:10.1038/nri3084 · Cited by 2,044
Immunoregulatory functions of mTOR inhibition
Thomson, A. W., Turnquist, H. R., & Raimondi, G. (2009) · Nature Reviews Immunology · doi:10.1038/nri2546 · Cited by 847
A guide to antigen processing and presentation
Pishesha, N., Harmand, T. J., & Ploegh, H. L. (2022) · Nature Reviews Immunology · doi:10.1038/s41577-022-00707-2 · Cited by 805
Self-citationGlycosylation as a strategy to improve antibody-based therapeutics
Jefferis, R. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2804 · Cited by 829
“This is of particular interest, or concern, for the potentiation of immunogenicity, as dendritic cells are 'professional' antigen-presenting cell”
BackgroundPI3K signalling in inflammation
Hawkins, P. T., & Stephens, L. R. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.12.006 · Cited by 541
Metadata
- Authors
- Vyas, J. M., Van der Veen, A. G., & Ploegh, H. L.
- Venue
- Nature Reviews Immunology
- Published
- 2008-08
- Volume
- 8
- Issue
- 8
- Pages
- 607-618
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W2064882706
- Cited by
- 653
- References
- 22
- FWCI
- 2.35
- Type
- journal article
- Language
- en
- Open access
- green
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