The DOI matches its Crossref record; 132 of the 133 references it cites were found in a registry or an index.
Myeloid-derived-suppressor cells as regulators of the immune system
Open accessAbstract
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells that expand during cancer, inflammation and infection, and that have a remarkable ability to suppress T-cell responses. These cells constitute a unique component of the immune system that regulates immune responses in healthy individuals and in the context of various diseases. In this Review, we discuss the origin, mechanisms of expansion and suppressive functions of MDSCs, as well as the potential to target these cells for therapeutic benefit.
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“CD11b+Gr1+ myeloid cells are a heterogeneous group with previously identified roles in tumor angiogenesis and T cell immunosuppression (Gabrilovich and Nagaraj, 2009; Ostrand-Rosenberg and Sinha, 2009; Shojaei et al., 2007).”
From A CXCL1 Paracrine Network Links Cancer Chemoresistance and Metastasis (2012) · cites this paper as Gabrilovich and Nagaraj, 2009
In the citing paper
“MDSCs play a role in the immune system through their suppressive action on T cells (116).”
From The Role of Immune and Inflammatory Cells in Idiopathic Pulmonary Fibrosis (2018) · cites this paper as [116]
In the citing paper
“Through different mediators such as arginase 1, Inducible nitric oxide synthase (iNOS), reactive oxygen species (ROS), and peroxynitrite, MDSCs attenuate the activity of Teffs and NK cells (Gabrilovich and Nagaraj, 2009), regulate the differentiation of Tregs (Huang et al., 2006), and induce an immunosuppressive phenotype in macrophages (Sinha et al., 2007).”
From Hallmarks of response, resistance, and toxicity to immune checkpoint blockade (2021) · cites this paper as Gabrilovich and Nagaraj, 2009
In the citing paper
“On a similar note, immunosuppressive myeloid cells can be differentiated/polarized for anti‐tumor phenotypes [88, 89].”
From Tumor microenvironment signaling and therapeutics in cancer progression (2023) · cites this paper as [89]
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Citations
Cites
MANTOVANI, A., SOZZANI, S., LOCATI, M., ALLAVENA, P., & SICA, A. (2002) · Trends in Immunology · doi:10.1016/s1471-4906(02)02302-5 · Cited by 5,528 · cited 1×
“In addition, TAMs produce several cytokines (reviewed in Ref”
Regulation of immune responses by L-arginine metabolism
Bronte, V., & Zanovello, P. (2005) · Nature Reviews Immunology · doi:10.1038/nri1668 · Cited by 1,775 · cited 1×
“MDSCs express high levels of both arginase 1 and iNOS, and a direct role for both of these enzymes in the inhibition of T-cell function is well established; this has been reviewed recentl”
Subsets of Myeloid-Derived Suppressor Cells in Tumor-Bearing Mice
Youn, J., Nagaraj, S., Collazo, M. M., & Gabrilovich, D. I. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.8.5791 · Cited by 1,645
Self-citationThe role of myeloid cells in the promotion of tumour angiogenesis
Murdoch, C., Muthana, M., Coffelt, S. B., & Lewis, C. E. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2444 · Cited by 1,642 · cited 1×
“However,as these non-immunological aspects of MDSC biology have recently been reviewed elsewher”
Reactive oxygen species: role in the development of cancer and various chronic conditions.
Waris, G., & Ahsan, H. (2006) · Journal of Carcinogenesis · doi:10.1186/1477-3163-5-14 · Cited by 1,447
Huang, B., Pan, P.-Y., Li, Q., Sato, A. I., Levy, D. E., Bromberg, J., Divino, C. M., & Chen, S.-H. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-1299 · Cited by 1,435 · cited 1×
“, CD115 (also known as macrophage colony-stimulating factor receptor (M-CSF) and CSF1”
Movahedi, K., Guilliams, M., van den Bossche, J., den Bergh, R. V., Gysemans, C., Beschin, A., Baetselier, P. D., & Ginderachter, J. V. V. (2008) · Blood · doi:10.1182/blood-2007-07-099226 · Cited by 1,352
Almand, B., Clark, J. I., Nikitina, E., van Beynen, J., English, N. R., Knight, S. C., Carbone, D. P., & Gabrilovich, D. I. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.1.678 · Cited by 1,340
Self-citationDiaz-Montero, C. M., Salem, M. L., Nishimura, M. I., Garrett-Mayer, E. S., Cole, D. J., & Montero, A. J. (2008) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-008-0523-4 · Cited by 1,217
Altered recognition of antigen is a mechanism of CD8+ T cell tolerance in cancer
Nagaraj, S., Gupta, K., Писарев, В. М., Kinarsky, L., Sherman, S., Kang, L., Herber, D. L., Schneck, J. P., & Gabrilovich, D. I. (2007) · Nature Medicine · doi:10.1038/nm1609 · Cited by 1,176
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Research works printed but not linked: 1
- Fricke, I. et al. Treatment of cancer patients with VEGF-Trap overcomes defects in DC differentiation but is insufficient to improve antigen-specific immune responses. Clin. Cancer Res. 13, 4840–4848 (2007). · DOI
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Kolaczkowska, E., & Kubes, P. (2013) · Nature Reviews Immunology · doi:10.1038/nri3399 · Cited by 5,472
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Metadata
- Authors
- Gabrilovich, D. I., & Nagaraj, S.
- Affiliations
- University of South Florida (US)
- Corresponding author
- Gabrilovich, Dmitry I.
- Venue
- Nature Reviews Immunology
- Published
- 2009-03
- Volume
- 9
- Issue
- 3
- Pages
- 162-174
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- PMC
- PMC2828349
- OpenAlex
- W2004150448
- Cited by
- 6,753
- References
- 133
- Citations by year
- 2026: 267 · 2025: 335 · 2024: 384 · 2023: 418 · 2022: 488 · 2021: 537 · 2020: 498 · 2019: 384 · 2018: 433 · 2017: 409 · 2016: 405 · 2015: 422 · 2014: 403 · 2013: 430 · 2012: 378
- FWCI
- 24.43
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Repositorio Institucional E-DocUR (Universidad Del Rosario) (submittedVersion)
- Funders
- National Cancer Institute (R01CA084488, R01CA100062)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Keywords
- myeloid-derived suppressor cells, T cell suppression, tumor immunosuppression, inflammation, infection, immune regulation
- MeSH terms
- Animals, Cell Movement, Communicable Diseases, Humans, Immune System, Immune Tolerance, Inflammation, Lymphocyte Activation, Neoplasms, Stem Cells, T-Lymphocytes, Myeloid Cells, Myelopoiesis, T-Lymphocytes, Regulatory
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