Cited by 6,753Immune cells in cancerImmunotherapy and Immune ResponsesPhagocytosis and Immune Regulation

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Myeloid-derived-suppressor cells as regulators of the immune system

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Gabrilovich, Dmitry I., Nagaraj, Srinivas·2009·Nature Reviews Immunology

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Abstract

Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells that expand during cancer, inflammation and infection, and that have a remarkable ability to suppress T-cell responses. These cells constitute a unique component of the immune system that regulates immune responses in healthy individuals and in the context of various diseases. In this Review, we discuss the origin, mechanisms of expansion and suppressive functions of MDSCs, as well as the potential to target these cells for therapeutic benefit.

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Bronte, V., & Zanovello, P. (2005) · Nature Reviews Immunology · doi:10.1038/nri1668 · Cited by 1,775 · cited 1×
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Murdoch, C., Muthana, M., Coffelt, S. B., & Lewis, C. E. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2444 · Cited by 1,642 · cited 1×
“However,as these non-immunological aspects of MDSC biology have recently been reviewed elsewher”
Reactive oxygen species: role in the development of cancer and various chronic conditions.
Waris, G., & Ahsan, H. (2006) · Journal of Carcinogenesis · doi:10.1186/1477-3163-5-14 · Cited by 1,447
Gr-1+CD115+ immature myeloid suppressor cells mediate the development of tumor-induced T regulatory cells and T-cell anergy in tumor-bearing host
Huang, B., Pan, P.-Y., Li, Q., Sato, A. I., Levy, D. E., Bromberg, J., Divino, C. M., & Chen, S.-H. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-1299 · Cited by 1,435 · cited 1×
“, CD115 (also known as macrophage colony-stimulating factor receptor (M-CSF) and CSF1”
Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct T cell-suppressive activity.
Movahedi, K., Guilliams, M., van den Bossche, J., den Bergh, R. V., Gysemans, C., Beschin, A., Baetselier, P. D., & Ginderachter, J. V. V. (2008) · Blood · doi:10.1182/blood-2007-07-099226 · Cited by 1,352
Increased Production of Immature Myeloid Cells in Cancer Patients: A Mechanism of Immunosuppression in Cancer
Almand, B., Clark, J. I., Nikitina, E., van Beynen, J., English, N. R., Knight, S. C., Carbone, D. P., & Gabrilovich, D. I. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.1.678 · Cited by 1,340
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Diaz-Montero, C. M., Salem, M. L., Nishimura, M. I., Garrett-Mayer, E. S., Cole, D. J., & Montero, A. J. (2008) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-008-0523-4 · Cited by 1,217
Altered recognition of antigen is a mechanism of CD8+ T cell tolerance in cancer
Nagaraj, S., Gupta, K., Писарев, В. М., Kinarsky, L., Sherman, S., Kang, L., Herber, D. L., Schneck, J. P., & Gabrilovich, D. I. (2007) · Nature Medicine · doi:10.1038/nm1609 · Cited by 1,176
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Yang, L., DeBusk, L. M., Fukuda, K., Fingleton, B., Green-Jarvis, B., Shyr, Y., Matrisian, L. M., Carbone, D. P., & Lin, P. C. (2004) · Cancer Cell · doi:10.1016/j.ccr.2004.08.031 · Cited by 1,140
Subpopulations of Mouse Blood Monocytes Differ in Maturation Stage and Inflammatory Response
Sunderkötter, C., Nikolic, T., Dillon, M. J., van Rooijen, N., Stehling, M., Drevets, D. A., & Leenen, P. J. M. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.7.4410 · Cited by 1,124
Reactive Oxygen Species as Intracellular Messengers During Cell Growth and Differentiation
Sauer, H., Wartenberg, M., & Hescheler, J. (2001) · Cellular Physiology and Biochemistry · doi:10.1159/000047804 · Cited by 1,118 · cited 1×
“In addition, several known tumour-derived factors, such as TGFβ, IL-3, IL-6, IL-10, platelet-derived growth factor and GM-CSF, can induce the production of ROS by MDSCs (for a review, see Ref”
Gemcitabine selectively eliminates splenic Gr-1+/CD11b+ myeloid suppressor cells in tumor-bearing animals and enhances antitumor immune activity
Suzuki, E., Kapoor, V., Jassar, A. S., Kaiser, L. R., & Albelda, S. M. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-0883 · Cited by 1,054
Vascular Endothelial Growth Factor Inhibits the Development of Dendritic Cells and Dramatically Affects the Differentiation of Multiple Hematopoietic Lineages In Vivo
Gabrilovich, D., Ishida, T., Oyama, T., Ran, S., Kravtsov, V., Nadaf, S., & Carbone, D. P. (1998) · Blood · doi:10.1182/blood.v92.11.4150 · Cited by 1,048
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Kortylewski, M., Kujawski, M., Wang, T., Sheng, W., Zhang, S., Pilon‐Thomas, S., Niu, G., Kay, H. D., Mulé, J. J., Kerr, W. G., et al. (2005) · Nature Medicine · doi:10.1038/nm1325 · Cited by 1,026
L-arginine availability regulates T-lymphocyte cell-cycle progression.
Rodriguez, P. C., Quiceno, D. G., & Ochoa, A. C. (2007) · Blood · doi:10.1182/blood-2006-06-031856 · Cited by 926
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Yang, L., Huang, J., Ren, X., Gorska, A. E., Chytil, A., Aakre, M., Carbone, D. P., Matrisian, L. M., Richmond, A., Lin, P. C., et al. (2008) · Cancer Cell · doi:10.1016/j.ccr.2007.12.004 · Cited by 918
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Cheng, P., Corzo, C. A., Luetteke, N., Yu, B., Nagaraj, S., Bui, M. M., Ortiz, M. L., Nacken, W. K. F., Sorg, C., Vogl, T., et al. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20080132 · Cited by 904
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Schmielau, J., & Finn, O. J. (2001) · PubMed · Cited by 867
Stat proteins and oncogenesis
Bromberg, J. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15617 · Cited by 863 · cited 1×
“2 ), which are signalling molecules that are involved in cell survival, proliferation, differentiation and apoptosi”
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Zea, A. H., Rodrı́guez, P. C., Atkins, M. B., Hernandez, C., Signoretti, S., Zabaleta, J., McDermott, D. F., Quiceno, D. G., Youmans, A. J., O’Neill, A., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-4505 · Cited by 852 · cited 1×
“Accordingly, cyclooxygenase 2 inhibitors were found to downregulate the expression of arginase 1 by MDSCs, which improved antitumour T-cell responses and enhanced the therapeutic efficacy of immunotherap”
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“The shortage of L -arginine inhibits T-cell proliferation through several different mechanisms, including decreasing their expression of CD3 ζ-chai”
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Bronte, V., Apolloni, E., Cabrelle, A., Ronca, R., Serafini, P., Zamboni, P., Restifo, N. P., & Zanovello, P. (2000) · Blood · doi:10.1182/blood.v96.12.3838 · Cited by 527 · cited 1×
“Early studies showed that 1–5% of MDSCs can form myeloid-cell colonie”
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Bronte, V., Serafini, P., Santo, C. D., Marigo, I., Tosello, V., Mazzoni, A., Segal, D. M., Staib, C., Löwel, M., Sutter, G., et al. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.1.270 · Cited by 526
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“The theory that MDSCs suppress T-cell responses in an antigen-specific manner helps to explain the finding that T cells in the peripheral lymphoid organs of tumour-bearing mice and in the peripheral blood of patients with cancer can still respond to stimuli other than tumour-associated antigens, including viruses, lec…”
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“The main mechanism of ATRA-mediated differentiation involves an upregulation of glutathione synthesis and a reduction in ROS levels in MDSC”
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Bronte, V., Kasic, T., Gri, G., Gallana, K., Borsellino, G., Marigo, I., Battistini, L., Iafrate, M., Prayer‐Galetti, T., Pagano, F. C., et al. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20042028 · Cited by 408
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Huang, B., Lei, Z., Zhao, J., Gong, W., Liu, J., Chen, Z., Liu, Y., Li, D., Yuan, Y., Zhang, G.-M., et al. (2007) · Cancer Letters · doi:10.1016/j.canlet.2006.12.012 · Cited by 349
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Self-citation
Apoptotic Death of CD8+ T Lymphocytes After Immunization: Induction of a Suppressive Population of Mac-1+/Gr-1+ Cells
Bronte, V., Wang, M. L., Overwijk, W. W., Surman, D. R., Pericle, F., Rosenberg, S. A., & Restifo, N. P. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.10.5313 · Cited by 312
Tumor-Associated CD8+ T Cell Tolerance Induced by Bone Marrow-Derived Immature Myeloid Cells
Kusmartsev, S. A., Nagaraj, S., & Gabrilovich, D. I. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.7.4583 · Cited by 310
Self-citation
Myeloid-Derived Suppressor Cells in Inflammatory Bowel Disease: A New Immunoregulatory Pathway
Haile, L. A., von Wasielewski, R., Gamrekelashvili, J., Krüger, C., Bachmann, O. P., Westendorf, A. M., Buer, J., Liblau, R., Manns, M. P., Korangy, F., et al. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.06.032 · Cited by 308
RAGE, carboxylated glycans and S100A8/A9 play essential roles in colitis-associated carcinogenesis
Turovskaya, O., Foell, D., Sinha, P., Vogl, T., Newlin, R., Nayak, J., Nguyen, M. T. X., Olsson, A., Nawroth, P. P., Bierhaus, A., et al. (2008) · Carcinogenesis · doi:10.1093/carcin/bgn188 · Cited by 300
Immunity to cancer: attack and escape in T lymphocyte–tumor cell interaction
Rivoltini, L., Carrabba, M. G., Huber, V., Castelli, C., Novellino, L., Dalerba, P. D., Mortarini, R., Arancia, G., Anichini, A., Fais, S., et al. (2002) · Immunological Reviews · doi:10.1034/j.1600-065x.2002.18809.x · Cited by 296
Inhibition of myeloid cell differentiation in cancer: the role of reactive oxygen species
Kusmartsev, S. A., & Gabrilovich, D. I. (2003) · Journal of Leukocyte Biology · doi:10.1189/jlb.0103010 · Cited by 292 · cited 1×
“Early studies showed that 1–5% of MDSCs can form myeloid-cell colonie”
Self-citation
CD11b+/Gr-1+ Immature Myeloid Cells Mediate Suppression of T Cells in Mice Bearing Tumors of IL-1β-Secreting Cells
Song, X., Krelin, Y., Dvorkin, T., Björkdahl, O., Segal, S., Dinarello, C. A., Voronov, E., & Apte, R. N. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.12.8200 · Cited by 290
Nitroaspirin corrects immune dysfunction in tumor-bearing hosts and promotes tumor eradication by cancer vaccination
Santo, C. D., Serafini, P., Marigo, I., Dolcetti, L., Bolla, M., Soldato, P. D., Melani, C. C., Guiducci, C., Colombo, M. P., Iezzi, M., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0409783102 · Cited by 284
Myeloid-Derived Suppressor Cells Accumulate in Kidney Allograft Tolerance and Specifically Suppress Effector T Cell Expansion
Dugast, A., Haudebourg, T., Coulon, F., Heslan, M., Haspot, F., Poirier, N., de Silly, R. V., Usal, C., Smit, H., Martinet, B., et al. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.12.7898 · Cited by 283
Oxidative Stress Regulates Expression of VEGFR1 in Myeloid Cells: Link to Tumor-Induced Immune Suppression in Renal Cell Carcinoma
Kusmartsev, S. A., Eruslanov, E. B., Kübler, H. R., Tseng, T. Y., Sakai, Y., Su, Z. Z., Kaliberov, S. A., Heiser, A., Rosser, C. J., Dahm, P., et al. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.1.346 · Cited by 280
Neuroblastoma-derived gangliosides inhibit dendritic cell generation and function.
Shurin, G. V., Shurin, M. R., Быковская, С. Н., Shogan, J., Lotze, M. T., & Barksdale, E. M. (2001) · PubMed · Cited by 250
Role of tumor-associated gangliosides in cancer progression
Birklé, S., Zeng, G., Gao, L., Yu, R. K., & Aubry, J. (2003) · Biochimie · doi:10.1016/s0300-9084(03)00006-3 · Cited by 239
Hematopoiesis and suppressor bone marrow cells in mice bearing large metastatic Lewis lung carcinoma tumors.
Young, M. R., Newby, M., & Wepsic, H. T. (1987) · PubMed · Cited by 231
A Combination of Chemoimmunotherapies Can Efficiently Break Self-Tolerance and Induce Antitumor Immunity in a Tolerogenic Murine Tumor Model
Ko, H., Kim, Y., Kim, Y.-S., Chang, W., Ko, S., Chang, S., Sakaguchi, S., & Kang, C. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-4639 · Cited by 205
Inducible nitric oxide synthase and nitrotyrosine in human metastatic melanoma tumors correlate with poor survival.
Ekmekçioglu, S., Ellerhorst, J. A., Smid, C. M., Prieto, V. G., Munsell, M. F., Buzaid, A. C., & Grimm, E. A. (2000) · PubMed · Cited by 190
Phenotypic and Functional Analysis of Dendritic Cells and Clinical Outcome in Patients With High-Risk Melanoma Treated With Adjuvant Granulocyte Macrophage Colony-Stimulating Factor
DAUD, A. I., Mirza, N. N., Lenox, B. C., Andrews, S., Urbas, P., Gao, G. X., Lee, J., Sondak, V. K., Riker, A. I., DeConti, R. C., et al. (2008) · Journal of Clinical Oncology · doi:10.1200/jco.2007.13.9048 · Cited by 184
Self-citation
Vascular Endothelial Growth Factor-Trap Overcomes Defects in Dendritic Cell Differentiation but Does Not Improve Antigen-Specific Immune Responses
Fricke, I., Mirza, N. N., Dupont, J., Lockhart, C., Jackson, A. L., Lee, J., Sosman, J. A., & Gabrilovich, D. I. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-0409 · Cited by 181 · cited 1×
“The theory that MDSCs suppress T-cell responses in an antigen-specific manner helps to explain the finding that T cells in the peripheral lymphoid organs of tumour-bearing mice and in the peripheral blood of patients with cancer can still respond to stimuli other than tumour-associated antigens, including viruses, lec…”
Self-citation
Immunosuppression during acute Trypanosoma cruzi infection: involvement of Ly6G (Gr1+)CD11b+ immature myeloid suppressor cells
Goni, O., Alcaide, P., & Fresno, M. (2002) · International Immunology · doi:10.1093/intimm/dxf076 · Cited by 179
Synergy between T-cell immunity and inhibition of paracrine stimulation causes tumor rejection.
Seung, L. P., Rowley, D. A., Dubey, P., & Schreiber, H. W. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.14.6254 · Cited by 176 · cited 1×
“jpg" NDATA ITEM> ]> Suppressive myeloid cells were described more than 20 years ago in patients with cance”
TCR ζ Down-Regulation under Chronic Inflammation Is Mediated by Myeloid Suppressor Cells Differentially Distributed between Various Lymphatic Organs
Ezernitchi, A. V., Vaknin, I., Cohen‐Daniel, L., Levy, O., Manaster, E., Halabi, A., Pikarsky, E., Shapira, L., & Baniyash, M. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.7.4763 · Cited by 173
Refractoriness to Antivascular Endothelial Growth Factor Treatment: Role of Myeloid Cells
Shojaei, F., & Ferrara, N. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-0925 · Cited by 172
The Schistosome Oligosaccharide Lacto- N -neotetraose Expands Gr1+ Cells That Secrete Anti-inflammatory Cytokines and Inhibit Proliferation of Naive CD4+ Cells: A Potential Mechanism for Immune Polarization in Helminth Infections
Terrazas, L. I., Walsh, K. L., Piskorska, D., McGuire, E., & Harn, D. A. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.9.5294 · Cited by 169
Analysis of retinal cellular infiltrate in experimental autoimmune uveoretinitis reveals multiple regulatory cell populations
Kerr, E. C., Raveney, B. J. E., Copland, D. A., Dick, A. D., & Nicholson, L. B. (2008) · Journal of Autoimmunity · doi:10.1016/j.jaut.2008.08.006 · Cited by 162 · cited 1×
“A great increase in the number of MDSCs was also detected in experimental autoimmune uveoretinitis, an animal model of human intraocular inflammatory diseas”
The Ly-6Chigh Monocyte Subpopulation Transports Listeria monocytogenes into the Brain during Systemic Infection of Mice
Drevets, D. A., Dillon, M. J., Schawang, J. S., van Rooijen, N., Ehrchen, J. M., Sunderkötter, C. H., & Leenen, P. J. M. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.7.4418 · Cited by 160
Inhibition of MHC II Gene Transcription by Nitric Oxide and Antioxidants
Harari, O., & Liao, J. K. (2004) · Current Pharmaceutical Design · doi:10.2174/1381612043452893 · Cited by 157
Defective Function of Langerhans Cells in Tumor-Bearing Animals Is the Result of Defective Maturation from Hemopoietic Progenitors
Ishida, T., Oyama, T., Carbone, D. P., & Gabrilovich, D. I. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.9.4842 · Cited by 150
Self-citation
Phase 1B study to improve immune responses in head and neck cancer patients using escalating doses of 25-hydroxyvitamin D 3
Lathers, D. M. R., Clark, J. I., Achille, N. J., & Young, M. R. (2004) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-003-0459-7 · Cited by 149 · cited 1×
“So far, evidence suggests that vitamin D3 may be another compound that has the potential to decrease MDSC numbers in patients with cancer, as it is also known to promote myeloid-cell differentiatio”
Indoleamine 2,3-Dioxygenase in Immune Suppression and Cancer
Muller, A. J., & Prendergast, G. C. (2007) · Current Cancer Drug Targets · doi:10.2174/156800907780006896 · Cited by 147
Inactivation of wild-type p53 protein function by reactive oxygen and nitrogen species in malignant glioma cells.
Cobbs, C., Whisenhunt, T. R., Wesemann, D. R., Harkins, L. E., Meir, E. G. V., & Samanta, M. (2003) · PubMed · Cited by 144
Suppression of T cell proliferation by tumor-induced granulocyte-macrophage progenitor cells producing transforming growth factor-β and nitric oxide
Young, M. R., Wright, M. A., Matthews, J. P., Malik, I., & Prechel, M. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.156.5.1916 · Cited by 142
Vitamin A deficiency in mice causes a systemic expansion of myeloid cells
Kuwata, T., Wang, I., Tamura, T., Ponnamperuma, R. M., Levine, R., Holmes, K. L., Morse, H. C., Luca, L. M. D., & Ozato, K. (2000) · Blood · doi:10.1182/blood.v95.11.3349 · Cited by 141
Reactive Oxygen Species and 12/15-Lipoxygenase Contribute to the Antiproliferative Capacity of Alternatively Activated Myeloid Cells Elicited during Helminth Infection
Brys, L., Beschin, A., Raes, G., Ghassabeh, G. H., Noël, W., Brandt, J., Brombacher, F., & BAETSELIER, P. D. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.10.6095 · Cited by 138
CD80+Gr-1+ Myeloid Cells Inhibit Development of Antifungal Th1 Immunity in Mice with Candidiasis
Mencacci, A., Montagnoli, C., Bacci, A., Cenci, E., Pitzurra, L., Spreca, A., Köpf, M., Sharpe, A. H., & Romani, L. R. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.6.3180 · Cited by 136
Role of Immature Myeloid Gr-1+ Cells in the Development of Antitumor Immunity
Li, Q., Pan, P., Gu, P., Xu, D., & Chen, S. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-1715 · Cited by 135
Chemoprevention by cyclooxygenase-2 inhibition reduces immature myeloid suppressor cell expansion
Talmadge, J. E., Hood, K. C., Zobel, L., Shafer, L. R., Coles, M., & Tóth, B. (2006) · International Immunopharmacology · doi:10.1016/j.intimp.2006.09.021 · Cited by 134
Nitric oxide in breast cancer: induction of vascular endothelial growth factor-C and correlation with metastasis and poor prognosis.
Nakamura, Y., Yasuoka, H., Tsujimoto, M., Yoshidome, K., Nakahara, M., Nakao, K., Nakamura, M., & Kakudo, K. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-1269 · Cited by 133
Tumor-Induced CD11b+Gr-1+ Myeloid Cells Suppress T Cell Sensitization in Tumor-Draining Lymph Nodes
Watanabe, S., Deguchi, K., Zheng, R., Tamai, H., Wang, L.-X., Cohen, P. A., & Shu, S. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.5.3291 · Cited by 131
Expansion of immunoregulatory macrophages by granulocyte-macrophage colony-stimulating factor derived from a murine mammary tumor.
Fu, Y., Watson, G. A., Jimenez, J. J., Wang, Y., & Lopez, D. M. (1990) · PubMed · Cited by 127
Antioxidant agents are effective in inducing lymphocyte progression through cell cycle in advanced cancer patients: assessment of the most important laboratory indexes of cachexia and oxidative stress
Mantovani, G., Macci�, A., Madeddu, C., Mura, L., Gramignano, G., Lusso, M. R., Massa, E., Mocci, M., & Serpe, R. (2003) · Journal of Molecular Medicine · doi:10.1007/s00109-003-0476-1 · Cited by 126
Immunogenicity of premalignant lesions is the primary cause of general cytotoxic T lymphocyte unresponsiveness
Willimsky, G., Czéh, M., Loddenkemper, C., Gellermann, J., Schmidt, K., Wust, P., Stein, H., & Blankenstein, T. J. F. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20072016 · Cited by 118 · cited 1×
“This is consistent with the recent observation that large numbers of tumour-induced MDSCs did not inhibit CD8 + T-cell responses specific for unrelated antigens in a model of sporadic cance”
Association of Increased Immunostaining for Inducible Nitric Oxide Synthase and Nitrotyrosine With Fibroblast Growth Factor Transformation in Pancreatic Cancer
Vickers, S. M. (1999) · Archives of Surgery · doi:10.1001/archsurg.134.3.245 · Cited by 111 · cited 1×
“It induces the nitration and nitrosylation of the amino acids cysteine, methionine, tryptophan and tyrosin”
Mycobacteria-induced Gr-1+ subsets from distinct myeloid lineages have opposite effects on T cell expansion
Dietlin, T. A., Hofman, F. M., Lund, B. T., Gilmore, W., Stohlman, S. A., & van der Veen, R. C. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.1006640 · Cited by 105
Myeloid progenitor cells mediate immune suppression in patients with head and neck cancers
Young, M. R., & Lathers, D. M. R. (1999) · International Journal of Immunopharmacology · doi:10.1016/s0192-0561(99)00008-9 · Cited by 96
Superantigen-Induced CD4 T Cell Tolerance Mediated by Myeloid Cells and IFN-γ
Cauley, L. S., Miller, E., Yen, M., & Swain, S. L. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.11.6056 · Cited by 87
The Importance of Myeloid-Derived Suppressor Cells in the Regulation of Autoimmune Effector Cells by a Chronic Contact Eczema
Marhaba, R., Vitacolonna, M., Hildebrand, D., Baniyash, M., Freyschmidt‐Paul, P., & Zöller, M. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.8.5071 · Cited by 85
Physiological Concentrations of Retinoic Acid Favor Myeloid Dendritic Cell Development over Granulocyte Development in Cultures of Bone Marrow Cells from Mice
Hengesbach, L. M., & Hoag, K. A. (2004) · Journal of Nutrition · doi:10.1093/jn/134.10.2653 · Cited by 83
Non-irradiation-derived reactive oxygen species (ROS) and cancer: therapeutic implications
Agostinelli, E., & Seiler, N. (2006) · Amino Acids · doi:10.1007/s00726-005-0271-8 · Cited by 79
Dendritic cells transduced with wild-type p53 gene elicit potent anti-tumour immune responses
Ishida, T., Chada, S., Stipanov, M. A., Nadaf, S., Ciernik, F. I., Gabrilovich, D. I., & Carbone, D. P. (1999) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.1999.00913.x · Cited by 79
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Both Expansion of Regulatory GR1+CD11b+Myeloid Cells and Anergy of T Lymphocytes Participate in Hyporesponsiveness of the Lung-Associated Immune System during Acute Toxoplasmosis
Voisin, M.-B., Buzoni–Gatel, D., Bout, D. T., & Velge-Roussel, F. (2004) · Infection and Immunity · doi:10.1128/iai.72.9.5487-5492.2004 · Cited by 78
Reactive oxygen species production by blood neutrophils of patients with laryngeal carcinoma and antioxidative enzyme activity in their blood
Szuster‐Ciesielska, A., Hryciuk-Umer, E., Stepulak, A., Kupisz, K., & Kandefer‐Szerszeń, M. (2004) · Acta Oncologica · doi:10.1080/02841860410029708 · Cited by 68
Suppression of Proximal T Cell Receptor Signaling and Lytic Function in CD8+ Tumor-Infiltrating T Cells
Monu, N. R., & Frey, A. B. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-1441 · Cited by 66
Retinoic acid receptor antagonism in vivo expands the numbers of precursor cells during granulopoiesis
Walkley, C. R., Yuan, Y.-D., Chandraratna, R., & McArthur, G. A. (2002) · Leukemia · doi:10.1038/sj.leu.2402625 · Cited by 60
Influence of mammary tumor progression on phenotype and function of spleen and in situ lymphocytes in mice.
Buessow, S. C., Paul, R. D., & Lopez, D. M. (1984) · PubMed · Cited by 58
Antibodies to colony-stimulating factors block Lewis lung carcinoma cell stimulation of immune-suppressive bone marrow cells
Young, M. R., Wright, M. A., & Young, M. E. (1991) · Cancer Immunology Immunotherapy · doi:10.1007/bf01756134 · Cited by 57
Intact glycans from cestode antigens are involved in innate activation of myeloid suppressor cells
Gómez-García, L., Lopez-Marin, L. M., Saavedra, R., Reyes, J. L., Rodríguez‐Sosa, M., & Terrazas, L. I. (2005) · Parasite Immunology · doi:10.1111/j.1365-3024.2005.00790.x · Cited by 57
The yin and yang of nitric oxide: Reflections on the physiology and pathophysiology of NO�
Bentz, B. G., Simmons, R. L., Haines, G. K., & Radosevich, J. A. (2000) · Head & Neck · doi:10.1002/(sici)1097-0347(200001)22:1 · Cited by 56
Disruption of the C5a receptor gene fails to protect against experimental allergic encephalomyelitis
Reiman, R. M., Gerard, C. J., Campbell, I. L., & Barnum, S. R. (2002) · European Journal of Immunology · doi:10.1002/1521-4141(200204)32:4 · Cited by 53
Defective Differentiation of Myeloid and Plasmacytoid Dendritic Cells in Advanced Cancer Patients is not Normalized by Tyrosine Kinase Inhibition of the Vascular Endothelial Growth Factor Receptor
van Cruijsen, H., Hoekman, K., Stam, A. G. M., van den Eertwegh, A. J. M., Kuenen, B. C., Scheper, R. J., Giaccone, G., & de Gruijl, T. D. (2007) · Clinical and Developmental Immunology · doi:10.1155/2007/17315 · Cited by 28
Ultrastructural and Chromosomal Studies on Manganese Superoxide Dismutase in Malignant Mesothelioma
Kinnula, V. L., Torkkeli, T. K., Kristo, P., Sormunen, R. T., Soini, Y., Pääkkö, P. K., Ollikainen, T., Kahlos, K., Hirvonen, A., & Knuutila, S. (2004) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2003-0409oc · Cited by 26
c‐kit+ FcR+ myelocytes are increased in cancer and prevent the proliferation of fully cytolytic T cells in the presence of immune serum
Beck, C., Schreiber, K., Schreiber, H. W., & Rowley, D. A. (2002) · European Journal of Immunology · doi:10.1002/immu.200390003 · Cited by 24
Impairment of the activity of the xenobiotic‐metabolizing enzymes arylamine N‐acetyltransferases 1 and 2 (NAT1/NAT2) by peroxynitrite in mouse skeletal muscle cells
Dairou, J., Dupret, J., & Rodrigues‐Lima, F. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.07.043 · Cited by 22

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Fricke, I. et al. Treatment of cancer patients with VEGF-Trap overcomes defects in DC differentiation but is insufficient to improve antigen-specific immune responses. Clin. Cancer Res. 13, 4840–4848 (2007). · DOI

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Authors: Gabrilovich, D. I., & Nagaraj, S.
Affiliations: University of South Florida (US)
Corresponding author: Gabrilovich, Dmitry I.
ORCID: Gabrilovich, Dmitry I.
Venue: Nature Reviews Immunology
Publisher: Springer Science and Business Media LLC
Published: 2009-03
Volume: 9
Issue: 3
Pages: 162-174
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/nri2506
PMC: PMC2828349
OpenAlex: W2004150448
Cited by: 6,753
References: 133
Citations by year: 2026: 267 · 2025: 335 · 2024: 384 · 2023: 418 · 2022: 488 · 2021: 537 · 2020: 498 · 2019: 384 · 2018: 433 · 2017: 409 · 2016: 405 · 2015: 422 · 2014: 403 · 2013: 430 · 2012: 378
FWCI: 24.43
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Repositorio Institucional E-DocUR (Universidad Del Rosario) (submittedVersion)
Funders: National Cancer Institute (R01CA084488, R01CA100062)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
Keywords: myeloid-derived suppressor cells, T cell suppression, tumor immunosuppression, inflammation, infection, immune regulation
MeSH terms: Animals, Cell Movement, Communicable Diseases, Humans, Immune System, Immune Tolerance, Inflammation, Lymphocyte Activation, Neoplasms, Stem Cells, T-Lymphocytes, Myeloid Cells, Myelopoiesis, T-Lymphocytes, Regulatory

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Myeloid-derived-suppressor cells as regulators of the immune system

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