B-cell responses to vaccination at the extremes of age

Mortality Associated With Influenza and Respiratory Syncytial Virus in the United States

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WHO estimates of the causes of death in children

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Prevalence of monoclonal gammopathy of undetermined significance

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Duration of Humoral Immunity to Common Viral and Vaccine Antigens

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Innate immunity of the newborn: basic mechanisms and clinical correlates

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Antibody response to influenza vaccination in the elderly: A quantitative review

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Competence and competition: the challenge of becoming a long-lived plasma cell

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Neonatal adaptive immunity comes of age

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Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments

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A New Population of Cells Lacking Expression of CD27 Represents a Notable Component of the B Cell Memory Compartment in Systemic Lupus Erythematosus

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Distinct TLR-mediated cytokine production and immunoglobulin secretion in human newborn naïve B cells

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Adjuvant Effect of Bacille Calmette–Guérin on Hepatitis B Vaccine Immunogenicity in the Preterm and Term Newborn

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Negative Effect of Age, but Not of Latent Cytomegalovirus Infection on the Antibody Response to a Novel Influenza Vaccine Strain in Healthy Adults

van den Berg, S. P. H., Wong, A., Hendriks, M., Jacobi, R. H. J., van Baarle, D., & van Beek, J. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00082 · Cited by 40

Immunogenicity of single vaccination with BNT162b2 or ChAdOx1 nCoV-19 at 5–6 weeks post vaccine in participants aged 80 years or older: an exploratory analysis

Parry, H., Bruton, R. K., Tut, G., Ali, M., Stephens, C., Greenwood, D., Faustini, S. E., Hughes, S. A., Huissoon, A. P., Meade, R., et al. (2021) · The Lancet Healthy Longevity · doi:10.1016/s2666-7568(21)00169-0 · Cited by 39

Antibodies to Polymorphic Invasion-Inhibitory and Non-Inhibitory Epitopes of Plasmodium falciparum Apical Membrane Antigen 1 in Human Malaria

Mugyenyi, C. K., Elliott, S. R., McCallum, F. J., Anders, R. F., Marsh, K., & Beeson, J. G. (2013) · PLoS ONE · doi:10.1371/journal.pone.0068304 · Cited by 39

Pharmacokinetics and Pharmacokinetic–Pharmacodynamic Relationships of Monoclonal Antibodies in Children

Edlund, H., Melin, J., Parra-Guillen, Z. P., & Kloft, C. (2014) · Clinical Pharmacokinetics · doi:10.1007/s40262-014-0208-4 · Cited by 39

Interventions to restore appropriate immune function in the elderly

Aspinall, R., & Lang, P. O. (2018) · Immunity & Ageing · doi:10.1186/s12979-017-0111-6 · Cited by 39

Impact of pregravid obesity on maternal and fetal immunity: Fertile grounds for reprogramming

Sureshchandra, S., Marshall, N., & Messaoudi, I. (2019) · Journal of Leukocyte Biology · doi:10.1002/jlb.3ri0619-181r · Cited by 38

Human Cord Blood B Cells Differ from the Adult Counterpart by Conserved Ig Repertoires and Accelerated Response Dynamics

Budeus, B., Kibler, A., Brauser, M., Homp, E., Bronischewski, K., Ross, J. A., Görgens, A., Weniger, M. A., Dunst, J., Kreslavsky, T., et al. (2021) · The Journal of Immunology · doi:10.4049/jimmunol.2100113 · Cited by 38

Effects of Aging on the Adaptive Immune Response to Respiratory Virus Infections

Fulton, R. B., & Varga, S. M. (2009) · Aging Health · doi:10.2217/ahe.09.69 · Cited by 39

Nanocarrier vaccine therapeutics for global infectious and chronic diseases

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Federal Clinical Guidelines on Vaccination of pneumococcal infection in children and adults

Avdeev, S. N., Alyeva, M. K., Aa, B., Bikmieva, A. V., Briko, N. I., Булгакова, В. А., Vishneva, Е. A., Gorelov, A. V., Демко, И. В., Андреевна, Д. Е., et al. (2023) · Russian Journal of Preventive Medicine · doi:10.17116/profmed2023260923 · Cited by 37

Common Genetic Variations Associated with the Persistence of Immunity following Childhood Immunization

O’Connor, D., Png, E., Khor, C. C., Snape, M. D., Hill, A. V. S., van der Klis, F. R. M., Hoggart, C. J., Levin, M., Hibberd, M. L., & Pollard, A. J. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.05.053 · Cited by 37

CD71+ erythroid cells from neonates born to women with preterm labor regulate cytokine and cellular responses

Miller, D., Romero, R. J., Unkel, R., Xu, Y., Vadillo‐Ortega, F., Hassan, S. S., & Gomez‐Lopez, N. (2018) · Journal of Leukocyte Biology · doi:10.1002/jlb.5a0717-291rrr · Cited by 37

Immunization of preterm infants: current evidence and future strategies to individualized approaches

Fortmann, M. I., Dirks, J., Goedicke‐Fritz, S., Liese, J. G., Zemlin, M., Morbach, H., & Härtel, C. (2022) · Seminars in Immunopathology · doi:10.1007/s00281-022-00957-1 · Cited by 37

Personalized Transcriptomics Reveals Heterogeneous Immunophenotypes in Children with Viral Bronchiolitis

Jones, A. C., Anderson, D. R., Galbraith, S., Fantino, E., Cardenas, D. G., Read, J. F., Serralha, M., Holt, B. J., Strickland, D. H., Sly, P. D., et al. (2018) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201804-0715oc · Cited by 38

Host response to respiratory syncytial virus infection

Arruvito, L., Raiden, S., & Geffner, J. R. (2015) · Current Opinion in Infectious Diseases · doi:10.1097/qco.0000000000000159 · Cited by 35

Models and methods for analysis of lymphocyte repertoire generation, development, selection and evolution

Mehr, R., Sternberg‐Simon, M., Michaeli, M., & Pickman, Y. (2012) · Immunology Letters · doi:10.1016/j.imlet.2012.08.002 · Cited by 35

mRNA vaccination in people over 80 years of age induces strong humoral immune responses against SARS-CoV-2 with cross neutralization of P.1 Brazilian variant

Parry, H., Tut, G., Bruton, R. K., Faustini, S. E., Stephens, C., Saunders, P., Bentley, C., Hilyard, K., Brown, K. E., Amirthalingam, G., et al. (2021) · eLife · doi:10.7554/elife.69375 · Cited by 35

Rebalancing the unbalanced aged immune system – A special focus on zinc

Baarz, B. R., & Rink, L. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101541 · Cited by 37

Autoantibodies Associated with Prenatal and Childhood Exposure to Environmental Chemicals in Faroese Children

Osuna, C. E., Grandjean, P., Weihe, P., & El‐Fawal, H. A. N. (2014) · Toxicological Sciences · doi:10.1093/toxsci/kfu163 · Cited by 35

Novel Protein-Based Pneumococcal Vaccines Administered with the Th1-Promoting Adjuvant IC31 Induce Protective Immunity against Pneumococcal Disease in Neonatal Mice

Olafsdottir, T. A., Lingnau, K., Nagy, E., & Jónsdóttir, I. (2011) · Infection and Immunity · doi:10.1128/iai.05801-11 · Cited by 35

Focusing on the implementation of 21st century vaccines for adults

Bonanni, P., Bonaccorsi, G., Lorini, C., Santomauro, F., Tiscione, E., Boccalini, S., & Bechini, A. (2017) · Vaccine · doi:10.1016/j.vaccine.2017.07.100 · Cited by 36

Human IgM–expressing memory B cells

Budeus, B., Kibler, A., & Küppers, R. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1308378 · Cited by 36

Neonatal immunology: responses to pathogenic microorganisms and epigenetics reveal an “immunodiverse” developmental state

Adkins, B. (2013) · Immunologic Research · doi:10.1007/s12026-013-8439-2 · Cited by 37

Broadly neutralizing antibodies: What is needed to move from a rare event in HIV-1 infection to vaccine efficacy?

Subbaraman, H., Schanz, M. M., & Trkola, A. (2018) · Retrovirology · doi:10.1186/s12977-018-0433-2 · Cited by 34

Identification and Validation of a Prognostic Risk-Scoring Model Based on Ferroptosis-Associated Cluster in Acute Myeloid Leukemia

Wang, J., Zhuo, Z., Wang, Y., Yang, S., Chen, J., Wang, Y., Geng, S., Li, M., Du, X., Lai, P., et al. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.800267 · Cited by 34

Long-Lasting Protective Antiviral Immunity Induced by Passive Immunotherapies Requires both Neutralizing and Effector Functions of the Administered Monoclonal Antibody

Nasser, R., Pelegrín, M., Michaud, H., Plays, M., Piechaczyk, M., & Gros, L. (2010) · Journal of Virology · doi:10.1128/jvi.00568-10 · Cited by 34

An R848 adjuvanted influenza vaccine promotes early activation of B cells in the draining lymph nodes of non‐human primate neonates

Holbrook, B. C., Aycock, S. T., Machiele, E., Clemens, E. A., Gries, D., Jorgensen, M. J., Hadimani, M. B., King, S. B., & Alexander‐Miller, M. A. (2017) · Immunology · doi:10.1111/imm.12845 · Cited by 33

Sex bias in mouse humoral immune response to influenza vaccine depends on the vaccine type

Zivkovic, I. P., Petrović, R., Arsenović-Ranin, N., Petrušić, V., Minić, R., Bufan, B., Popović, O., & Leposavić, G. (2018) · Biologicals · doi:10.1016/j.biologicals.2018.01.007 · Cited by 33

Strategies for active and passive pediatric RSV immunization

Eichinger, K. M., Kosanovich, J. L., Lipp, M. A., Empey, K. M., & Petrovsky, N. (2021) · Therapeutic Advances in Vaccines and Immunotherapy · doi:10.1177/2515135520981516 · Cited by 34

T-independent antigen induces humoral memory through germinal centers

Liu, X., Zhao, Y., & Qi, H. (2022) · The Journal of Experimental Medicine · doi:10.1084/jem.20210527 · Cited by 33

Vaccines against human respiratory syncytial virus in clinical trials, where are we now?

Rossey, I., & Saelens, X. (2019) · Expert Review of Vaccines · doi:10.1080/14760584.2019.1675520 · Cited by 32

Interaction of Iron Oxide Nanoparticles with Macrophages Is Influenced Distinctly by “Self” and “Non-Self” Biological Identities

Portilla, Y., Mulens‐Arias, V., Daviu, N., Paradela, A., Pérez-Yagüe, S., & Barber, D. F. (2023) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.3c05555 · Cited by 32

Risk Factors for Long COVID in Older Adults

Hu, Y., Liu, Y., Zheng, H., & Liu, L. (2023) · Biomedicines · doi:10.3390/biomedicines11113002 · Cited by 32

B cells drive CD4 T cell immunosenescence and age-associated health decline

Khan, S., Chakraborty, M., Wu, F., Chen, N., Wang, T., Chan, Y. T., Sayad, A., Vásquez, J. D. S., Kotlyar, M., Nguyen, K., et al. (2026) · Science Immunology · doi:10.1126/sciimmunol.adv7615 · Cited by 37

The Adjuvant LT-K63 Can Restore Delayed Maturation of Follicular Dendritic Cells and Poor Persistence of Both Protein- and Polysaccharide-Specific Antibody-Secreting Cells in Neonatal Mice

Bjarnarson, S. P., Adarna, B. C., Benonisson, H., Giudice, G. D., & Jónsdóttir, I. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1200761 · Cited by 32

Inflammatory responses to influenza vaccination at the extremes of age

McDonald, J. U., Zhong, Z., Groves, H., & Tregoning, J. S. (2017) · Immunology · doi:10.1111/imm.12742 · Cited by 32

Influence of maternal vaccination against diphtheria, tetanus, and pertussis on the avidity of infant antibody responses to a pertussis containing vaccine in Belgium

Caboré, R. N., Maertens, K., Dobly, A., Leuridan, E. E., Damme, P. V., & Huygen, K. (2017) · Virulence · doi:10.1080/21505594.2017.1296998 · Cited by 31

Development and maturation of norovirus antibodies in childhood

Blazevic, V., Malm, M., Honkanen, H., Knip, M., Hyöty, H., & Vesikari, T. (2015) · Microbes and Infection · doi:10.1016/j.micinf.2015.12.004 · Cited by 31

Neonatal immune function and inflammatory illnesses in later life: lessons to be learnt from the developing world?

Lisciandro, J. G., & van den Biggelaar, A. H. J. (2010) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2010.03629.x · Cited by 31

Organoid Polymer Functionality and Mode of Klebsiella pneumoniae Membrane Antigen Presentation Regulates Ex Vivo Germinal Center Epigenetics in Young and Aged B Cells

Graney, P. L., Lai, K., Post, S. E., Brito, I., Cyster, J. G., & Singh, A. K. (2020) · Advanced Functional Materials · doi:10.1002/adfm.202001232 · Cited by 30

Limited effect of duration of CMV infection on adaptive immunity and frailty: insights from a 27‐year‐long longitudinal study

Samson, L. D., van den Berg, S. P. H., Engelfriet, P. M., Boots, A. M. H., Hendriks, M., de Rond, L., de Zeeuw‐Brouwer, M., Verschuren, W. M. M., Borghans, J. A. M., Buisman, A., et al. (2020) · Clinical & Translational Immunology · doi:10.1002/cti2.1193 · Cited by 30

Evaluation of Anti-PT Antibody Response after Pertussis Vaccination and Infection: The Importance of Both Quantity and Quality

Barkoff, A., Knuutila, A., Mertsola, J., & He, Q. (2021) · Toxins · doi:10.3390/toxins13080508 · Cited by 30

Nanovaccines for cancer immunotherapy: Current knowledge and future perspectives

Wu, Y., Zhang, Z., Wei, Y., Qian, Z., & Wei, X. (2022) · Chinese Chemical Letters · doi:10.1016/j.cclet.2022.108098 · Cited by 30

Current challenges: from the path of “original antigenic sin” towards the development of universal flu vaccines

Biswas, A., Chakrabarti, A. K., & Dutta, S. (2019) · International Reviews of Immunology · doi:10.1080/08830185.2019.1685990 · Cited by 32

Peeling back the layers of immunogenicity in Cas9-based genomic medicine

Stigzelius, V., Cavallo, A. L., Chandode, R. K., & Nitsch, R. (2025) · Molecular Therapy · doi:10.1016/j.ymthe.2025.06.045 · Cited by 30

The Combination of 2′-Fucosyllactose with Short-Chain Galacto-Oligosaccharides and Long-Chain Fructo-Oligosaccharides that Enhance Influenza Vaccine Responses Is Associated with Mucosal Immune Regulation in Mice

Xiao, L., Engen, P. A., Leusink-Muis, T., van Ark, I., Stahl, B., Overbeek, S. A., Garssen, J., Naqib, A. D., Green, S. J., Keshavarzian, A., et al. (2019) · Journal of Nutrition · doi:10.1093/jn/nxz006 · Cited by 31

Neonatal vaccine effectiveness and the role of adjuvants

Sakala, I. G., Eichinger, K. M., & Petrovsky, N. (2019) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2019.1642748 · Cited by 29

Age-associated changes in the circulating human antibody repertoire are upregulated in autoimmunity

Arvey, A. J., Rowe, M., Legutki, J. B., An, G., Gollapudi, A., Lei, A., Colston, B. W., Putterman, C., Smith, D. S., Stiles, J., et al. (2020) · Immunity & Ageing · doi:10.1186/s12979-020-00193-x · Cited by 30

Age Related Differences in Dynamics of Specific Memory B Cell Populations after Clinical Pertussis Infection

van Twillert, I., den Brink, J. A. M. V. G.-V., Poelen, M. C. M., Helm, K., Kuipers, B., Schipper, M., Boog, C. J. P., Verheij, T. J., Versteegh, F. G. A., & van Els, C. A. C. M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0085227 · Cited by 29

Delivery of Cytokines by Recombinant Virus in Early Life Alters the Immune Response to Adult Lung Infection

Harker, J. A., Lee, D. C. P., Yamaguchi, Y., Wang, B. L., Bukreyev, A. A., Collins, P. L., Tregoning, J. S., & Openshaw, P. (2010) · Journal of Virology · doi:10.1128/jvi.02503-09 · Cited by 30

Schedules for Pneumococcal Vaccination of Preterm Infants: An RCT

Kent, A., Ladhani, S. N., Andrews, N. J., Scorrer, T., Pollard, A. J., Clarke, P., Hughes, S. M., Heal, C., Menson, E. N., Chang, J. K., et al. (2016) · PEDIATRICS · doi:10.1542/peds.2015-3945 · Cited by 29

Is background methotrexate advantageous in extending TNF inhibitor drug survival in elderly patients with rheumatoid arthritis? An analysis of the British Society for Rheumatology Biologics Register

Bechman, K., Oke, A., Yates, M., Norton, S., Dennison, E. M., Cope, A. P., & Galloway, J. B. (2019) · Rheumatology · doi:10.1093/rheumatology/kez671 · Cited by 29

Inter-Pathogen Peptide Sharing and the Original Antigenic Sin: Solving a Paradox

Kanduc, D., & Shoenfeld, Y. (2018) · The Open Immunology Journal · doi:10.2174/1874226201808010016 · Cited by 28

Multiple Levels of Immunological Memory and Their Association with Vaccination

Bugya, Z., Prechl, J., Szénási, T., Nemes, É., Bácsi, A., & Koncz, G. (2021) · Vaccines · doi:10.3390/vaccines9020174 · Cited by 30

Immunological Biomarkers of Fatal COVID-19: A Study of 868 Patients

Martín‐Sánchez, E., Garcés, J., Maia, C., Inogés, S., de Cerio, A. L.-D., Carmona-Torre, F., Marín‐Oto, M., Alegre, F., Molano, E., Fernández-Alonso, M., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.659018 · Cited by 29

Immunotherapy in Alzheimer's Disease: Where Do We Stand? Where Should We Go?

Rommy von Bernhardi, M. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-1248 · Cited by 28

Neonatal Immunization with a Single IL-4/Antigen Dose Induces Increased Antibody Responses after Challenge Infection with Equine Herpesvirus Type 1 (EHV-1) at Weanling Age

Wagner, B., Perkins, G. A., Babasyan, S., Freer, H., Keggan, A., Goodman, L. B., Glaser, A. L., Torsteinsdóttir, S., Svansson, V., & Björnsdóttir, S. (2017) · PLoS ONE · doi:10.1371/journal.pone.0169072 · Cited by 28

Comparative Analysis of B-Cell Receptor Repertoires Induced by Live Yellow Fever Vaccine in Young and Middle-Age Donors

Davydov, A. N., Obraztsova, A., Lebedin, M. Y., Turchaninova, M. A., Staroverov, D. B., Merzlyak, E. M., Sharonov, G. V., Кладова, О. В., Shugay, M., Britanova, O. V., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02309 · Cited by 29

Neonatal Rhesus Macaques Have Distinct Immune Cell Transcriptional Profiles following HIV Envelope Immunization

Han, Q., Bradley, T., Williams, W. B., Cain, D. W., Montefiori, D. C., Saunders, K. O., Parks, R., Edwards, R. W., Ferrari, G., Mueller, O., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2019.12.091 · Cited by 28

Decreased production of class-switched antibodies in neonatal B cells is associated with increased expression of miR-181b

Glaesener, S., Jaenke, C., Habener, A., Geffers, R., Hagendorff, P., Witzlau, K., Imelmann, E., Krueger, A., & Meyer‐Bahlburg, A. (2018) · PLoS ONE · doi:10.1371/journal.pone.0192230 · Cited by 26

Immunogenicity and Safety of the New Inactivated Quadrivalent Influenza Vaccine Vaxigrip Tetra: Preliminary Results in Children ≥6 Months and Older Adults

Montomoli, E., Torelli, A., Manini, I., & Gianchecchi, E. (2018) · Vaccines · doi:10.3390/vaccines6010014 · Cited by 26

The CTA1-DD adjuvant strongly potentiates follicular dendritic cell function and germinal center formation, which results in improved neonatal immunization

Schussek, S., Bernasconi, V., Mattsson, J., Wenzel, U. A., Strömberg, A., Gribonika, I., Schön, K., & Lycke, N. Y. (2020) · Mucosal Immunology · doi:10.1038/s41385-020-0253-2 · Cited by 26

Extensive age-dependent loss of antibody diversity in naturally short-lived turquoise killifish

Bradshaw, W. J., Poeschla, M., Placzek, A., Kean, S., & Valenzano, D. R. (2022) · eLife · doi:10.7554/elife.65117 · Cited by 25

Evaluating the antibody response to SARS-COV-2 vaccination amongst kidney transplant recipients at a single nephrology centre

Chukwu, C., Mahmood, K., Elmakki, S., Gorton, J., Kalra, P. A., Poulikakos, D. J., & Middleton, R. (2022) · PLoS ONE · doi:10.1371/journal.pone.0265130 · Cited by 25

Ion channel TRPV2 is critical in enhancing B cell activation and function

Li, C., Zhao, M., Liu, X., Li, Y., Xu, B., Zhou, L., Sun, X., Sun, W., Kang, N., Ji, Z., et al. (2024) · The Journal of Experimental Medicine · doi:10.1084/jem.20221042 · Cited by 25

Reduced dose human papillomavirus vaccination: An update of the current state-of-the-art

Toh, Z. Q., Licciardi, P. V., Fong, J., Garland, S. M., Tabrizi, S. N., Russell, F. M., & Mulholland, E. K. (2015) · Vaccine · doi:10.1016/j.vaccine.2015.07.102 · Cited by 26

Yersinia enterocoliticaPromotes Robust Mucosal Inflammatory T-Cell Immunity in Murine Neonates

Echeverry, A., Saijo, S., Schesser, K., & Adkins, B. (2010) · Infection and Immunity · doi:10.1128/iai.01272-09 · Cited by 25

Vaccination and healthy aging

Maggi, S. (2010) · Expert Review of Vaccines · doi:10.1586/erv.10.26 · Cited by 25

Adjuvants Enhance the Induction of Germinal Center and Antibody Secreting Cells in Spleen and Their Persistence in Bone Marrow of Neonatal Mice

Pind, A. A. A., Dubik, M., Thorsdottir, S., Meinke, A. L., Harandi, A. M., Holmgren, J. R., Giudice, G. D., Jónsdóttir, I., & Bjarnarson, S. P. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02214 · Cited by 25

Vaccine-Induced Cellular Immunity against Bordetella pertussis: Harnessing Lessons from Animal and Human Studies to Improve Design and Testing of Novel Pertussis Vaccines

Saso, A., Kampmann, B., & Roetynck, S. (2021) · Vaccines · doi:10.3390/vaccines9080877 · Cited by 24

Infection in the Developing Brain: The Role of Unique Systemic Immune Vulnerabilities

Singh, G., Tucker, E. W., & Rohlwink, U. K. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2021.805643 · Cited by 25

Reduced Antibody Acquisition with Increasing Age following Vaccination with BNT162b2: Results from Two Longitudinal Cohort Studies in The Netherlands

van den Hoogen, L. L., Boer, M. C., Postema, A., de Rond, L., de Zeeuw‐Brouwer, M., Pronk, I., Wijmenga‐Monsuur, A. J., Bijvank, E., Kruiper, C., Beckers, L., et al. (2022) · Vaccines · doi:10.3390/vaccines10091480 · Cited by 25

HI responses induced by seasonal influenza vaccination are associated with clinical protection and with seroprotection against non-homologous strains

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