Cited by 662T-cell and B-cell ImmunologyImmune responses and vaccinationsImmunotherapy and Immune Responses

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B-cell responses to vaccination at the extremes of age

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Siegrist, Claire-Anne, Aspinall, Richard·2009·Nature Reviews Immunology

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Abstract

Infants and the elderly share a high vulnerability to infections and therefore have specific immunization requirements. Inducing potent and sustained B-cell responses is as challenging in infants as it is in older subjects. Several mechanisms to explain the decreased B-cell responses at the extremes of age apply to both infants and the elderly. These include intrinsic B-cell limitations as well as numerous microenvironmental factors in lymphoid organs and the bone marrow. This Review describes the mechanisms that shape B-cell responses at the extremes of age and how they could be taken into account to design more effective immunization strategies for these high-risk age groups.

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Additional file 5 of Age-associated changes in the circulating human antibody repertoire are upregulated in autoimmunity
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Additional file 15 of Age-associated changes in the circulating human antibody repertoire are upregulated in autoimmunity
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Additional file 2 of Age-associated changes in the circulating human antibody repertoire are upregulated in autoimmunity
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Additional file 4 of Age-associated changes in the circulating human antibody repertoire are upregulated in autoimmunity
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Additional file 5 of Characterization of the primary antibody response to Plasmodium falciparum antigens in infants living in a malaria-endemic area
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Additional file 7 of Characterization of the primary antibody response to Plasmodium falciparum antigens in infants living in a malaria-endemic area
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Additional file 3 of Age-associated changes in the circulating human antibody repertoire are upregulated in autoimmunity
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Additional file 4 of Characterization of the primary antibody response to Plasmodium falciparum antigens in infants living in a malaria-endemic area
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Additional file 8 of Age-associated changes in the circulating human antibody repertoire are upregulated in autoimmunity
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Additional file 7 of Age-associated changes in the circulating human antibody repertoire are upregulated in autoimmunity
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Additional file 6 of Characterization of the primary antibody response to Plasmodium falciparum antigens in infants living in a malaria-endemic area
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Additional file 1 of Age-associated changes in the circulating human antibody repertoire are upregulated in autoimmunity
Arvey, A. J., Rowe, M., Legutki, J. B., An, G., Gollapudi, A., Lei, A., Colston, B. W., Putterman, C., Smith, D., Stiles, J., et al. (2020) · Figshare · doi:10.6084/m9.figshare.13059548
Additional file 14 of Age-associated changes in the circulating human antibody repertoire are upregulated in autoimmunity
Arvey, A. J., Rowe, M., Legutki, J. B., An, G., Gollapudi, A., Lei, A., Colston, B. W., Putterman, C., Smith, D., Stiles, J., et al. (2020) · Figshare · doi:10.6084/m9.figshare.13059542
Additional file 2 of Characterization of the primary antibody response to Plasmodium falciparum antigens in infants living in a malaria-endemic area
Yunga, S. T., Siriwardhana, C., Fouda, G. G., Bobbili, N., Sama, G., Chen, J. J., Leke, R. F. G., & Taylor, D. W. (2022) · Figshare · doi:10.6084/m9.figshare.21591038
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Additional file 1 of Characterization of the primary antibody response to Plasmodium falciparum antigens in infants living in a malaria-endemic area
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Authors: Siegrist, C.-A., & Aspinall, R.
Affiliations: University of Geneva (CH)
Cranfield University (GB)
Corresponding author: Siegrist, Claire-Anne
ORCID: Siegrist, Claire-Anne
Aspinall, Richard
Venue: Nature Reviews Immunology
Publisher: Springer Science and Business Media LLC
Published: 2009-03
Volume: 9
Issue: 3
Pages: 185-194
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/nri2508
OpenAlex: W2019896390
Cited by: 659
References: 114
Citations by year: 2026: 31 · 2025: 29 · 2024: 37 · 2023: 34 · 2022: 46 · 2021: 59 · 2020: 50 · 2019: 31 · 2018: 32 · 2017: 45 · 2016: 35 · 2015: 33 · 2014: 35 · 2013: 39 · 2012: 32
FWCI: 3.18
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springernature.com/gp/researchers/text-and-data-mining (tdm)
www.springernature.com/gp/researchers/text-and-data-mining (vor)
www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
Archive ouverte UNIGE (University of Geneva) (submittedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Keywords: B cell response, vaccination, infants, older adults, immunosenescence, immunodeficiency, antibody response, lymphoid microenvironment, bone marrow, vaccination strategies
MeSH terms: Aged, Aged, 80 and over, Aging, Animals, B-Lymphocytes, Communicable Diseases, Humans, Immunologic Memory, Infant, Infant, Newborn, Vaccination, Vaccines, Mice

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B-cell responses to vaccination at the extremes of age

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