B-cell responses to vaccination at the extremes of age

Mortality Associated With Influenza and Respiratory Syncytial Virus in the United States

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WHO estimates of the causes of death in children

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Prevalence of monoclonal gammopathy of undetermined significance

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Duration of Humoral Immunity to Common Viral and Vaccine Antigens

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Innate immunity of the newborn: basic mechanisms and clinical correlates

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Antibody response to influenza vaccination in the elderly: A quantitative review

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Competence and competition: the challenge of becoming a long-lived plasma cell

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Neonatal adaptive immunity comes of age

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Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments

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A New Population of Cells Lacking Expression of CD27 Represents a Notable Component of the B Cell Memory Compartment in Systemic Lupus Erythematosus

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Antibody Persistence after Serogroup C Meningococcal Conjugate Immunization of United Kingdom Primary‐School Children in 1999–2000 and Response to a Booster: A Phase 4 Clinical Trial

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Influenza Vaccines: Successes and Continuing Challenges

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Anti-Cytokine Autoantibodies Preceding Onset of Autoimmune Polyendocrine Syndrome Type I Features in Early Childhood

Wolff, A. S. B., Sarkadi, A. K., Maródi, L., Kärner, J., Orlova, E., Oftedal, B. E., Kisand, K. E., Oláh, É., Meloni, A., Myhre, A. G., et al. (2013) · Journal of Clinical Immunology · doi:10.1007/s10875-013-9938-6 · Cited by 86

Natural Antibody Repertoires: Development and Functional Role in Inhibiting Allergic Airway Disease

Kearney, J. F., Patel, P. S., Stefanov, E. K., & King, R. G. (2015) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120140 · Cited by 83

Environmental and T Cell–Intrinsic Factors Limit the Expansion of Neonatal Follicular T Helper Cells but May Be Circumvented by Specific Adjuvants

Mastelic, B., Kamath, A. T., Fontannaz, P., Tougne, C., Rochat, A., Belnoue, E., Combescure, C., Auderset, F., Lambert, P., Tacchini‐Cottier, F., et al. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1201143 · Cited by 82

Maternal vaccination: moving the science forward

Faucette, A. N., Unger, B. L., Gonik, B., & Chen, K. (2015) · Human Reproduction Update · doi:10.1093/humupd/dmu041 · Cited by 81

The Impact of Age on the Efficacy of 13-valent Pneumococcal Conjugate Vaccine in Elderly

van Werkhoven, C. H., Huijts, S. M., Bolkenbaas, M., Grobbee, D. E., & Bonten, M. J. M. (2015) · Clinical Infectious Diseases · doi:10.1093/cid/civ686 · Cited by 80

Neonatal immunization: where do we stand?

Wood, N. J., & Siegrist, C. (2011) · Current Opinion in Infectious Diseases · doi:10.1097/qco.0b013e328345d563 · Cited by 80

Antibodies to SARS-CoV-2 and their potential for therapeutic passive immunization

Klasse, P. J., & Moore, J. P. (2020) · eLife · doi:10.7554/elife.57877 · Cited by 79

Immune Vulnerability of Infants to Tuberculosis

Driessche, K. V., Persson, A., Marais, B. J., Fink, P. J., & Urdahl, K. B. (2013) · Clinical and Developmental Immunology · doi:10.1155/2013/781320 · Cited by 83

Vaccination in early life: standing up to the challenges

Mohr, E., & Siegrist, C. (2016) · Current Opinion in Immunology · doi:10.1016/j.coi.2016.04.004 · Cited by 79

Immunosenescence: Implications for vaccination programmes in adults

Lang, P. O., Govind, S., Michel, J. P., Aspinall, R., & Mitchell, W. A. (2011) · Maturitas · doi:10.1016/j.maturitas.2011.01.011 · Cited by 76

Preterm Birth Affects the Risk of Developing Immune-Mediated Diseases

Goedicke‐Fritz, S., Härtel, C., Krasteva‐Christ, G., Kopp, M., Meyer, S., & Zemlin, M. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01266 · Cited by 77

The Protective Role of Maternal Immunization in Early Life

Cinicola, B. L., Conti, M. G., Terrin, G., Sgrulletti, M., Elfeky, R., Carsetti, R., Salinas, A. F., Mortari, E. P., Brindisi, G., Curtis, M. D., et al. (2021) · Frontiers in Pediatrics · doi:10.3389/fped.2021.638871 · Cited by 79

The effect of ageing on macrophage Toll-like receptor-mediated responses in the fight against pathogens

Dunston, C. R., & Griffiths, H. R. (2010) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2010.04213.x · Cited by 78

Quantification of HTLV-1 Clonality and TCR Diversity

Laydon, D. J., Melamed, A., Sim, A., Gillet, N. A., Sim, K., Darko, S. W., Kroll, J. S., Douek, D. C., Price, D. A., Bangham, C. R. M., et al. (2014) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1003646 · Cited by 79

Vaccine Immunology

Siegrist, C. (2017) · Elsevier eBooks · doi:10.1016/b978-0-323-35761-6.00002-x · Cited by 81

Interventions to improve oral vaccine performance: a systematic review and meta-analysis

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Efficacy of 13-Valent Pneumococcal Conjugate Vaccine (PCV13) Versus That of 7-Valent PCV (PCV7) Against Nasopharyngeal Colonization of Antibiotic-NonsusceptibleStreptococcus pneumoniae

Dagan, R., Juergens, C., Trammel, J., Patterson, S., Greenberg, D., Givon‐Lavi, N., Porat, N., Gurtman, A., Gruber, W. C., & Scott, D. A. (2014) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiu576 · Cited by 74

The Association between Influenza and Pneumococcal Vaccinations and SARS-Cov-2 Infection: Data from the EPICOVID19 Web-Based Survey

Noale, M., Trevisan, C., Maggi, S., Incalzi, R. A., Pedone, C., Bari, M. D., Adorni, F., Jesuthasan, N., Šojić, A., Galli, M., et al. (2020) · Vaccines · doi:10.3390/vaccines8030471 · Cited by 73

Viral infection engenders bona fide and bystander subsets of lung-resident memory B cells through a permissive mechanism

Grégoire, C., Spinelli, L., Villazala‐Merino, S., Gil, L., Holgado, M. P., Moussa, M., Dong, C., Zarubica, A., Fallet, M., Navarro, J., et al. (2022) · Immunity · doi:10.1016/j.immuni.2022.06.002 · Cited by 74

Immunization in the adult immunocompromised host

Löbermann, M., Boršo, D., Hilgendorf, I., Fritzsche, C., Zettl, U. K., & Reisinger, E. C. (2011) · Autoimmunity Reviews · doi:10.1016/j.autrev.2011.05.015 · Cited by 71

Research priorities for the development and implementation of serological tools for malaria surveillance

Elliott, S. R., Fowkes, F. J. I., Richards, J. S., Reiling, L., Drew, D. R., & Beeson, J. G. (2014) · F1000Prime Reports · doi:10.12703/p6-100 · Cited by 70

Long-term protection after immunization with protein–polysaccharide conjugate vaccines in infancy

Rohner, G. B., & Pollard, A. J. (2011) · Expert Review of Vaccines · doi:10.1586/erv.11.14 · Cited by 69

Neonatal Follicular Th Cell Responses Are Impaired and Modulated by IL-4

Debock, I., Jaworski, K., Chadlaoui, H., Delbauve, S., Passon, N., Twyffels, L., Léo, O., & Flamand, V. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1203288 · Cited by 69

Age of recipient and number of doses differentially impact human B and T cell immune memory responses to HPV vaccination

Smolen, K. K., Gelinas, L., Franzén, L., Dobson, S., Dawar, M., Ogilvie, G. S., Krajden, M., Fortuno, E. S., & Kollmann, T. R. (2012) · Vaccine · doi:10.1016/j.vaccine.2012.03.051 · Cited by 68

Antibody and Th1-type cell-mediated immune responses in elderly and young adults immunized with the standard or a high dose influenza vaccine

Chen, W. H., Cross, A. S., Edelman, R., Sztein, M. B., Blackwelder, W. C., & Pasetti, M. F. (2011) · Vaccine · doi:10.1016/j.vaccine.2011.02.017 · Cited by 67

Mode of action of adjuvants: Implications for vaccine safety and design

Mastelic, B., Ahmed, S., Egan, W. M., Giudice, G. D., Golding, H., Gust, I. D., Neels, P., Reed, S. G., Sheets, R., Siegrist, C., et al. (2010) · Biologicals · doi:10.1016/j.biologicals.2010.06.002 · Cited by 66

T Cell Responses to the RTS,S/AS01E and RTS,S/AS02D Malaria Candidate Vaccines Administered According to Different Schedules to Ghanaian Children

Ansong, D., Asante, K. P., Vekemans, J., Owusu, S. K., Owusu, R., Brobby, N. W., Dosoo, D., Osei‐Akoto, A., Osei-Kwakye, K., Asafo‐Adjei, E., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018891 · Cited by 66

Measuring changes in transmission of neglected tropical diseases, malaria, and enteric pathogens from quantitative antibody levels

Arnold, B. F., van der Laan, M. J., Hubbard, A., Steel, C., Kubofcik, J., Hamlin, K. L., Moss, D. M., Nutman, T. B., Priest, J. W., & Lammie, P. J. (2017) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0005616 · Cited by 66

Does Regular Exercise Counter T Cell Immunosenescence Reducing the Risk of Developing Cancer and Promoting Successful Treatment of Malignancies?

Turner, J. E., & Brum, P. C. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/4234765 · Cited by 66

Vaccine effectiveness in older individuals: What has been learned from the influenza-vaccine experience

Lang, P. O., Govind, S., Mitchell, W. A., Siegrist, C., & Aspinall, R. (2010) · Ageing Research Reviews · doi:10.1016/j.arr.2010.09.005 · Cited by 63

Differential immunogenicity of BNT162b2 or ChAdOx1 vaccines after extended-interval homologous dual vaccination in older people

Parry, H., Bruton, R. K., Stephens, C., Brown, K. E., Amirthalingam, G., Otter, A. D., Hallis, B., Zuo, J., & Moss, P. A. H. (2021) · Immunity & Ageing · doi:10.1186/s12979-021-00246-9 · Cited by 65

The ageing human B cell repertoire: a failure of selection?

Dunn‐Walters, D. K. (2015) · Clinical & Experimental Immunology · doi:10.1111/cei.12700 · Cited by 63

Age-dependent changes in innate immune phenotype and function in rhesus macaques ( Macaca mulatta )

Asquith, M. J., Haberthur, K., Brown, M. A., Engelmann, F., Murphy, A., Al-Mahdi, Z. K. A., & Messaoudi, I. (2012) · Pathobiology of Aging & Age-related Diseases · doi:10.3402/pba.v2i0.18052 · Cited by 63

Homeostatic impact of indigenous microbiota and secretory immunity

Brandtzaeg, P. (2010) · Beneficial Microbes · doi:10.3920/bm2010.0009 · Cited by 63

The Suckling Rat as a Model for Immunonutrition Studies in Early Life

Pérez-Cano, F. J., Franch, À., Castellote, C., & Castell, M. (2012) · Clinical and Developmental Immunology · doi:10.1155/2012/537310 · Cited by 63

SARS-CoV-2 DNA Vaccine INO-4800 Induces Durable Immune Responses Capable of Being Boosted in a Phase 1 Open-Label Trial

Kraynyak, K. A., Blackwood, E., Agnes, J. T., Tebas, P., Giffear, M., Amante, D. H., Reuschel, E. L., Purwar, M., Christensen-Quick, A., Liu, N., et al. (2022) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiac016 · Cited by 62

Enhanced inflammation in aged mice following infection withStreptococcus pneumoniaeis associated with decreased IL-10 and augmented chemokine production

Williams, A. E., José, R. J. P., Brown, J., & Chambers, R. C. (2015) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00141.2014 · Cited by 62

Impact of host genetic polymorphisms on vaccine induced antibody response

Linnik, J., & Egli, A. (2016) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2015.1119345 · Cited by 65

Granulocytic myeloid‐derived suppressor cells from human cord blood modulate T‐helper cell response towards an anti‐inflammatory phenotype

Köstlin, N., Vogelmann, M., Spring, B., Schwarz, J., Feucht, J., Härtel, C., Orlikowsky, T. W., Poets, C. F., & Gille, C. (2017) · Immunology · doi:10.1111/imm.12751 · Cited by 62

“IDEAL” vaccines for resource poor settings

Levine, M. M. (2011) · Vaccine · doi:10.1016/j.vaccine.2011.11.090 · Cited by 64

Immunosenescence and herd immunity: with an ever-increasing aging population do we need to rethink vaccine schedules?

Lang, P. O., & Aspinall, R. (2012) · Expert Review of Vaccines · doi:10.1586/erv.11.187 · Cited by 61

Bone Density Loss Is Associated With Blood Cell Counts

Valderrábano, R. J., Lui, L., Lee, J. S., Cummings, S. R., ORWOLL, E. S., Hoffman, A. R., & Wu, J. Y. (2016) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3000 · Cited by 61

Sex Steroid Ablation Enhances Hematopoietic Recovery following Cytotoxic Antineoplastic Therapy in Aged Mice

Dudakov, J. A., Goldberg, G. L., Reiseger, J. J., Vlahos, K., Chidgey, A. P., & Boyd, R. L. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0900196 · Cited by 60

Innate Immunity to Respiratory Infection in Early Life

Lambert, L., & Culley, F. J. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01570 · Cited by 65

B Cell Response and Hemagglutinin Stalk-Reactive Antibody Production in Different Age Cohorts following 2009 H1N1 Influenza Virus Vaccination

Sangster, M. Y., Baer, J., Santiago, F. W., Fitzgerald, T. F., Ilyushina, N. A., Sundararajan, A., Henn, A. D., Krammer, F., Yang, H., Luke, C. J., et al. (2013) · Clinical and Vaccine Immunology · doi:10.1128/cvi.00735-12 · Cited by 59

Circulating Myeloperoxidase (MPO)-DNA complexes as marker for Neutrophil Extracellular Traps (NETs) levels and the association with cardiovascular risk factors in the general population

Donkel, S. J., Wolters, F. J., Ikram, M. A., & de Maat, M. P. M. (2021) · PLoS ONE · doi:10.1371/journal.pone.0253698 · Cited by 59

Characteristics associated with serological COVID-19 vaccine response and durability in an older population with significant comorbidity: the Danish Nationwide ENFORCE Study

Søgaard, O. S., Reekie, J., Johansen, I. S., Nielsen, H., Benfield, T., Wiese, L., Stærke, N. B., Iversen, K. K., Fogh, K., Bodilsen, J., et al. (2022) · Clinical Microbiology and Infection · doi:10.1016/j.cmi.2022.03.003 · Cited by 59

Differential effects of Cytomegalovirus carriage on the immune phenotype of middle-aged males and females

van der Heiden, M., van Zelm, M. C., Bartol, S. J. W., de Rond, L., Berbers, G. A. M., Boots, A. M. H., & Buisman, A. (2016) · Scientific Reports · doi:10.1038/srep26892 · Cited by 59

The human thymus perivascular space is a functional niche for viral-specific plasma cells

Núñez, S., Moore, C., Gao, B., Rogers, K., Hidalgo, Y., del Nido, P. J., Restaino, S. W., Naka, Y., Bhagat, G., Madsen, J. C., et al. (2016) · Science Immunology · doi:10.1126/sciimmunol.aah4447 · Cited by 58

Seasonal immune modulation in humans: Observed patterns and potential environmental drivers

Paynter, S., Ware, R. S., Sly, P. D., Williams, G. M., & Weinstein, P. (2014) · Journal of Infection · doi:10.1016/j.jinf.2014.09.006 · Cited by 57

Maturation of the Human Immunoglobulin Heavy Chain Repertoire With Age

Ghraichy, M., Galson, J. D., Kovaltsuk, A., von Niederhäusern, V., Schmid, J. P., Recher, M., Jauch, A., Miho, E., Kelly, D. F., Deane, C. M., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01734 · Cited by 57

Immunosenescence and Altered Vaccine Efficiency in Older Subjects: A Myth Difficult to Change

Fülöp, T., Larbi, A., Pawelec, G., Cohen, A. A., Provost, G., Khalil, A., Lacombe, G., Rodrigues, S., Desroches, M., Hirokawa, K., et al. (2022) · Vaccines · doi:10.3390/vaccines10040607 · Cited by 58

IgA Response in Preterm Neonates Shows Little Evidence of Antigen-Driven Selection

Rogosch, T., Kerzel, S., Hoß, K., Hörsch, G., Zemlin, C., Heckmann, M., Berek, C., Schroeder, H. W., Maier, R. F., & Zemlin, M. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1103347 · Cited by 56

Differences in Antibody Responses of Individuals with Natural Infection and Those Vaccinated against Pandemic H1N1 2009 Influenza

Chan, K., To, K. K., Hung, I. F., Zhang, J., Chan, J. F., Cheng, V. C., Tse, H., Che, X.-Y., Chen, H., & Yuen, K. (2011) · Clinical and Vaccine Immunology · doi:10.1128/cvi.00555-10 · Cited by 56

Immune Defects in the Risk of Infection and Response to Vaccination in Monoclonal Gammopathy of Undetermined Significance and Multiple Myeloma

Tete, S. M., Bijl, M., Sahota, S., & Bos, N. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00257 · Cited by 56

Remote immune processes revealed by immune-derived circulating cell-free DNA

Fox-Fisher, I., Piyanzin, S., Ochana, B.-L., Klochendler, A., Magenheim, J., Peretz, A., Loyfer, N., Moss, J., Cohen, D., Drori, Y., et al. (2021) · eLife · doi:10.7554/elife.70520 · Cited by 58

Challenges in vaccination of neonates, infants and young children

Pichichero, M. E. (2014) · Vaccine · doi:10.1016/j.vaccine.2014.05.008 · Cited by 54

Variation between Populations in the Innate Immune Response to Vaccine Adjuvants

Kollmann, T. R. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00081 · Cited by 56

Serotype-Specific Hyporesponsiveness to Pneumococcal Conjugate Vaccine in Infants Carrying Pneumococcus at the Time of Vaccination

Väkeväinen, M., Soininen, A., Lucero, M., Nohynek, H., Auranen, K. J., Mäkelä, P. H., Williams, G. M., & Käyhty, H. M. (2010) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2010.04.071 · Cited by 54

Immune Senescence and Vaccination in the Elderly

Lang, P., Govind, S., ten Bokum, A. M. C., Kenny, N., Matas, E., Pitts, D., & Aspinall, R. (2013) · Current Topics in Medicinal Chemistry · doi:10.2174/15680266113136660181 · Cited by 33

Timing and surgical management of neonatal testicular torsions

Djahangirian, O., Ouimet, A., & St‐Vil, D. (2010) · Journal of Pediatric Surgery · doi:10.1016/j.jpedsurg.2010.02.032 · Cited by 54

Env Exceptionalism: Why Are HIV-1 Env Glycoproteins Atypical Immunogens?

Klasse, P. J., Ozorowski, G., Sanders, R. W., & Moore, J. P. (2020) · Cell Host & Microbe · doi:10.1016/j.chom.2020.03.018 · Cited by 54

Reversing the immune ageing clock: lifestyle modifications and pharmacological interventions

Duggal, N. A. (2018) · Biogerontology · doi:10.1007/s10522-018-9771-7 · Cited by 56

Applications of Nanovaccines for Disease Prevention in Cattle

Maina, T., Grego, E., Boggiatto, P. M., Sacco, R. E., Narasimhan, B., & McGill, J. L. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.608050 · Cited by 52

Consequences of Immature and Senescent Immune Responses for Infection with Respiratory Syncytial Virus

Malloy, A. M. W., Falsey, A. R., & Ruckwardt, T. J. (2013) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-38919-1_11 · Cited by 51

Peripheral B cells repress B-cell regeneration in aging through a TNF-α/IGFBP-1/IGF-1 immune-endocrine axis

Dowery, R., Benhamou, D., Ben‐Chetrit, E., Harel, O., Nevelsky, A., Zisman‐Rozen, S., Braun‐Moscovici, Y., Balbir‐Gurman, A., Avivi, I. M., Shechter, A., et al. (2021) · Blood · doi:10.1182/blood.2021012428 · Cited by 50

Identifying long-term memory B-cells in vaccinated children despite waning antibody levels specific for Bordetella pertussis proteins

Hendrikx, L. H., Öztürk, K., de Rond, L., Veenhoven, R. H., Sanders, E. A. M., Berbers, G. A. M., & Buisman, A. (2010) · Vaccine · doi:10.1016/j.vaccine.2010.12.033 · Cited by 50

Can We Translate Vitamin D Immunomodulating Effect on Innate and Adaptive Immunity to Vaccine Response?

Lang, P. O., & Aspinall, R. (2015) · Nutrients · doi:10.3390/nu7032044 · Cited by 50

COVID-19 Vaccination and the Rate of Immune and Autoimmune Adverse Events Following Immunization: Insights From a Narrative Literature Review

Mahroum, N., Lavine, N., Ohayon, A., Seida, R., Alwani, A., Alrais, M., Zoubi, M., & Bragazzi, N. L. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.872683 · Cited by 50

The Immunosuppressed Traveler

Visser, L. G. (2012) · Infectious Disease Clinics of North America · doi:10.1016/j.idc.2012.06.003 · Cited by 51

Searching for the human genetic factors standing in the way of universally effective vaccines

Mentzer, A. J., O’Connor, D., Pollard, A. J., & Hill, A. V. S. (2015) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2014.0341 · Cited by 52

Immunogenicity of the 13-Valent Pneumococcal Conjugate Vaccine in Older Adults With and Without Comorbidities in the Community-Acquired Pneumonia Immunization Trial in Adults (CAPiTA)

van Deursen, A. M. M., van Houten, M. A., Webber, C., Patton, M., Scott, D. A., Patterson, S., Sidhu, M. S., Drews, W., Gruber, W. C., Emini, E. A., et al. (2017) · Clinical Infectious Diseases · doi:10.1093/cid/cix419 · Cited by 53

Federal Clinical Guidelines on Preventive Vaccination Against Pneumococcal infections in Adults

Chuchalin, A. G., Briko, N. I., Avdeev, S. N., Belevskiy, А. S., Биличенко, Т. Н., Демко, И. В., Drapkina, O. M., Zhestkov, A. V., Zaytsev, A., Ignatova, G. L., et al. (2019) · PULMONOLOGIYA · doi:10.18093/0869-0189-2019-29-1-19-34 · Cited by 49

T-independent responses to polysaccharides in humans mobilize marginal zone B cells prediversified against gut bacterial antigens

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Vaccination and heterologous immunity: educating the immune system

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