Cited by 843Neuroinflammation and Neurodegeneration MechanismsInflammasome and immune disordersTraumatic Brain Injury and Neurovascular Disturbances

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Regulation of innate immune responses in the brain

Rivest, Serge·2009·Nature Reviews Immunology

DOI 10.1038/nri2565

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Abstract

Microglial cells are the main innate immune cells of the complex cellular structure of the brain. These cells respond quickly to pathogens and injury, accumulate in regions of degeneration and produce a wide variety of pro-inflammatory molecules. These observations have resulted in active debate regarding the exact role of microglial cells in the brain and whether they have beneficial or detrimental functions. Careful targeting of these cells could have therapeutic benefits for several types of trauma and disease specific to the central nervous system. This Review discusses the molecular details underlying the innate immune response in the brain during infection, injury and disease.

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RETRACTED ARTICLE: A specific amyloid-β protein assembly in the brain impairs memory
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Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
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Authors: Rivest, S.
Affiliations: Centre hospitalier universitaire de Québec (CA)
Corresponding author: Rivest, Serge
ORCID: Rivest, Serge
Venue: Nature Reviews Immunology
Publisher: Springer Science and Business Media LLC
Published: 2009-06
Volume: 9
Issue: 6
Pages: 429-439
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/nri2565
OpenAlex: W2145938600
Cited by: 843
References: 115
Citations by year: 2026: 17 · 2025: 24 · 2024: 25 · 2023: 33 · 2022: 47 · 2021: 42 · 2020: 40 · 2019: 43 · 2018: 48 · 2017: 52 · 2016: 54 · 2015: 79 · 2014: 86 · 2013: 69 · 2012: 69
FWCI: 4.71
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
Funders: Canada Research Chairs
Canadian Institutes of Health Research
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
Keywords: microglia, innate immunity, neuroinflammation, microglial activation, neuroprotection, neurodegeneration, Alzheimer's disease, infection, brain injury, proinflammatory molecules
MeSH terms: Alzheimer Disease, Amyloid, Animals, Brain, Encephalitis, Glucocorticoids, Humans, Immunity, Innate, Lipopolysaccharides, Oligodendroglia, Wounds and Injuries, Microglia, Toll-Like Receptors

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