The DOI matches its Crossref record; 114 of the 115 references it cites were found in a registry or an index.
Regulation of innate immune responses in the brain
Abstract
Microglial cells are the main innate immune cells of the complex cellular structure of the brain. These cells respond quickly to pathogens and injury, accumulate in regions of degeneration and produce a wide variety of pro-inflammatory molecules. These observations have resulted in active debate regarding the exact role of microglial cells in the brain and whether they have beneficial or detrimental functions. Careful targeting of these cells could have therapeutic benefits for several types of trauma and disease specific to the central nervous system. This Review discusses the molecular details underlying the innate immune response in the brain during infection, injury and disease.
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“Microglia are the resident macrophage population of the central nervous system (CNS) that perform functions required for typical development, as well as homeostasis, plasticity, immunity and repair (1–5).”
From An environment-dependent transcriptional network specifies human microglia identity (2017) · cites this paper as [1]
In the citing paper
“TLRs and associated signaling pathways contribute to both injurious and regenerative processes in CNS diseases (33–35).”
From UNC93B1 Is Widely Expressed in the Murine CNS and Is Required for Neuroinflammation and Neuronal Injury Induced by MicroRNA let-7b (2021) · cites this paper as [35]
In the citing paper
“Microglia represent a heterogeneous cell population accounting for approximately 5–12% of total brain cells. They are distributed unevenly throughout the CNS, as grey matter and specific structures such as the hippocampus, basal ganglia, and substantia nigra typically all exhibit greater densities than the white matter (58–60).”
From The HPA – Immune Axis and the Immunomodulatory Actions of Glucocorticoids in the Brain (2014) · cites this paper as [60]
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1 retracted
RETRACTED ARTICLE: A specific amyloid-β protein assembly in the brain impairs memory
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RetractedResting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
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Metadata
- Authors
- Rivest, S.
- Affiliations
- Centre hospitalier universitaire de Québec (CA)
- Corresponding author
- Rivest, Serge
- ORCID
- Rivest, Serge
- Venue
- Nature Reviews Immunology
- Published
- 2009-06
- Volume
- 9
- Issue
- 6
- Pages
- 429-439
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W2145938600
- Cited by
- 843
- References
- 115
- Citations by year
- 2026: 17 · 2025: 24 · 2024: 25 · 2023: 33 · 2022: 47 · 2021: 42 · 2020: 40 · 2019: 43 · 2018: 48 · 2017: 52 · 2016: 54 · 2015: 79 · 2014: 86 · 2013: 69 · 2012: 69
- FWCI
- 4.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canada Research Chairs
- Canadian Institutes of Health Research
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Keywords
- microglia, innate immunity, neuroinflammation, microglial activation, neuroprotection, neurodegeneration, Alzheimer's disease, infection, brain injury, proinflammatory molecules
- MeSH terms
- Alzheimer Disease, Amyloid, Animals, Brain, Encephalitis, Glucocorticoids, Humans, Immunity, Innate, Lipopolysaccharides, Oligodendroglia, Wounds and Injuries, Microglia, Toll-Like Receptors
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