Regulation of innate immune responses in the brain

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Untitled work

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The inflammatory response in stroke

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Cytokines and acute neurodegeneration

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Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis

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Neuroinflammation in Alzheimer's disease

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From stress to inflammation and major depressive disorder: A social signal transduction theory of depression.

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An environment-dependent transcriptional network specifies human microglia identity

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Visceral influences on brain and behavior

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Emerging targets in neuroinflammation-driven chronic pain

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Role of neuroinflammation in neurodegenerative diseases (Review)

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A systemic view of Alzheimer disease — insights from amyloid-β metabolism beyond the brain

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Does neuroinflammation fan the flame in neurodegenerative diseases?

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Diverse Brain Myeloid Expression Profiles Reveal Distinct Microglial Activation States and Aspects of Alzheimer’s Disease Not Evident in Mouse Models

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Alternatively activated microglia and macrophages in the central nervous system

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Inflammation in intracerebral hemorrhage: From mechanisms to clinical translation

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Determining the Presence of Periodontopathic Virulence Factors in Short-Term Postmortem Alzheimer's Disease Brain Tissue

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Sequential activation of microglia and astrocyte cytokine expression precedes increased iba‐1 or GFAP immunoreactivity following systemic immune challenge

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Microglial cell dysregulation in brain aging and neurodegeneration

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Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: a microarray study

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Astrocyte TLR4 activation induces a proinflammatory environment through the interplay between MyD88‐dependent NFκB signaling, MAPK, and Jak1/Stat1 pathways

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An Inflammation-Centric View of Neurological Disease: Beyond the Neuron

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Peroxiredoxin family proteins are key initiators of post-ischemic inflammation in the brain

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Inflammation, microglia, and alzheimer's disease

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The neurobiology of interoception in health and disease

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Balancing the immune response in the brain: IL-10 and its regulation

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The HPA – Immune Axis and the Immunomodulatory Actions of Glucocorticoids in the Brain

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Suppression of neuroinflammation by astrocytic dopamine D2 receptors via αB-crystallin

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Exploring the Neuroimmunopharmacology of Opioids: An Integrative Review of Mechanisms of Central Immune Signaling and Their Implications for Opioid Analgesia

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NLR members NLRC4 and NLRP3 mediate sterile inflammasome activation in microglia and astrocytes

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Innate and adaptive immune responses regulated by glycogen synthase kinase-3 (GSK3)

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Curcumin attenuates acute inflammatory injury by inhibiting the TLR4/MyD88/NF-κB signaling pathway in experimental traumatic brain injury

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IRF8 Is a Critical Transcription Factor for Transforming Microglia into a Reactive Phenotype

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Choroid plexus and the blood–cerebrospinal fluid barrier in disease

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P2X4R+ microglia drive neuropathic pain

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Identification of a microglia phenotype supportive of remyelination

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Review: Systemic inflammation andAlzheimer's disease

Holmes, C. (2013) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2012.01307.x · Cited by 356

The fractalkine receptor but not CCR2 is present on microglia from embryonic development throughout adulthood

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Microglia Function in Alzheimer’s Disease

Solito, E., & Sastre, M. (2012) · Frontiers in Pharmacology · doi:10.3389/fphar.2012.00014 · Cited by 361

Heme activates TLR4-mediated inflammatory injury via MyD88/TRIF signaling pathway in intracerebral hemorrhage

Lin, S., Yin, Q., Zhong, Q., Lv, F., Zhou, Y., Li, J.-Q., Wang, J., Su, B., & Yang, Q. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-46 · Cited by 332

Features of Microglia and Neuroinflammation Relevant to Environmental Exposure and Neurotoxicity

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The Impact of Systemic Inflammation on Alzheimer’s Disease Pathology

Xie, J., Van Hoecke, L., & Vandenbroucke, R. E. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2021.796867 · Cited by 324

The Innate Immune Receptors TLR2/4 Mediate Repeated Social Defeat Stress-Induced Social Avoidance through Prefrontal Microglial Activation

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Neuroimmunology and neuroepigenetics in the establishment of sex differences in the brain

McCarthy, M. M., Nugent, B. M., & Lenz, K. M. (2017) · Nature reviews. Neuroscience · doi:10.1038/nrn.2017.61 · Cited by 322

Function of microglia and macrophages in secondary damage after spinal cord injury

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Myocardial Inflammation Predicts Remodeling and Neuroinflammation After Myocardial Infarction

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Cellular infiltration in traumatic brain injury

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Is Glycogen Synthase Kinase-3 a Central Modulator in Mood Regulation?

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Innate Immunity in the CNS: Redefining the Relationship between the CNS and Its Environment

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Role of astroglial toll-like receptors (TLRs) in central nervous system infections, injury and neurodegenerative diseases

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TLR4 mutation reduces microglial activation, increases Aβ deposits and exacerbates cognitive deficits in a mouse model of Alzheimer’s disease

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Glial and Neuroimmune Mechanisms as Critical Modulators of Drug Use and Abuse

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Brain Infiltration of Leukocytes Contributes to the Pathophysiology of Temporal Lobe Epilepsy

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Angiotensin II AT1 Receptor Blockade Ameliorates Brain Inflammation

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Real-Time In Vivo Imaging Reveals the Ability of Monocytes to Clear Vascular Amyloid Beta

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Toll-like receptor 4 stimulation with the detoxified ligand monophosphoryl lipid A improves Alzheimer’s disease-related pathology

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Toll-like receptors in chronic pain

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Early Brain Injury After Subarachnoid Hemorrhage: Incidence and Mechanisms

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Rodent models of neuroinflammation for Alzheimer’s disease

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TNFα in synaptic function: switching gears

Santello, M., & Volterra, A. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2012.06.001 · Cited by 253

Noninvasive Molecular Imaging of Neuroinflammation

Jacobs, A. H., Tavitian, B., & the INMiND consortium (2012) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2012.53 · Cited by 245

Microglia: A new frontier for synaptic plasticity, learning and memory, and neurodegenerative disease research

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Markers of inflammation and stress distinguish subsets of individuals with schizophrenia and bipolar disorder

Fillman, S. G., Sinclair, D., Fung, S. J., Webster, M. J., & Shannon Weickert, C. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.8 · Cited by 226

Age related macular degeneration and drusen: Neuroinflammation in the retina

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Prenatal stress causes alterations in the morphology of microglia and the inflammatory response of the hippocampus of adult female mice

Diz-Chaves, Y., Pernía, O., Carrero, P., & García‐Segura, L. M. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-71 · Cited by 243

Harnessing monocyte‐derived macrophages to control central nervous system pathologies: no longer ‘if’ but ‘how’

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Fibrin-targeting immunotherapy protects against neuroinflammation and neurodegeneration

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Post-Ischemic Inflammation in the Brain

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Neuroimmune crosstalk in the central nervous system and its significance for neurological diseases

Tian, L., Ma, L., Kaarela, T., & Li, Z. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-155 · Cited by 224

WNT signaling in activated microglia is proinflammatory

Halleskog, C., Mulder, J., Dahlström, J., Mackie, K., Hortobágyi, T., Tanila, H., Puli, L., Färber, K., Harkany, T., & Schulte, G. (2010) · Glia · doi:10.1002/glia.21081 · Cited by 219

TLR4-activated microglia require IFN-γ to induce severe neuronal dysfunction and death in situ

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Danger Signals and Inflammasomes: Stress-Evoked Sterile Inflammation in Mood Disorders

Fleshner, M., Frank, M., & Maier, S. F. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.125 · Cited by 216

Transcription factor IRF5 drives P2X4R+-reactive microglia gating neuropathic pain

Masuda, T., Iwamoto, S., Yoshinaga, R., Tozaki‐Saitoh, H., Nishiyama, A., Mak, T. W., Tamura, T., Tsuda, M., & Inoue, K. (2014) · Nature Communications · doi:10.1038/ncomms4771 · Cited by 222

Impact of Cytokines and Chemokines on Alzheimer’s Disease Neuropathological Hallmarks

Domingues, C., da Cruz e Silva, O. A. B., & Henriques, A. G. (2017) · Current Alzheimer Research · doi:10.2174/1567205014666170317113606 · Cited by 203

The Role of Copper Homeostasis in Brain Disease

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Temporal Changes in Cell Marker Expression and Cellular Infiltration in a Controlled Cortical Impact Model in Adult Male C57BL/6 Mice

Jin, X., Ishii, H., Bai, Z., Itokazu, T., & Yamashita, T. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041892 · Cited by 211

Dicer ablation in oligodendrocytes provokes neuronal impairment in mice

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Annexin A1: A Central Player in the Anti-Inflammatory and Neuroprotective Role of Microglia

McArthur, S., Cristante, E., Paterno, M., Christian, H., Roncaroli, F., Gillies, G. E., & Solito, E. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001095 · Cited by 213

Biological role of Toll-like receptor-4 in the brain

Trotta, T., Porro, C., Calvello, R., & Panaro, M. A. (2014) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2014.01.014 · Cited by 209

Inflammatory mechanisms and oxidative stress as key factors responsible for progression of neurodegeneration: role of brain innate immune system

Leszek, J., E. Barreto, G., G|siorowski, K., Koutsouraki, E., Ávila-Rodrigues, M., & Aliev, G. (2016) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527315666160202125914 · Cited by 206

Oncomodulin links inflammation to optic nerve regeneration

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Functional diversity of microglia – how heterogeneous are they to begin with?

Hanisch, U.-K. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00065 · Cited by 195

Innate Immunity and Neuroinflammation

Shastri, A., Bonifati, D. M., & Kishore, U. (2013) · Mediators of Inflammation · doi:10.1155/2013/342931 · Cited by 207

Can an Infection Hypothesis Explain the Beta Amyloid Hypothesis of Alzheimer’s Disease?

Fülöp, T., Witkowski, J. M., Bourgade, K., Khalil, A., Zerif, E., Larbi, A., Hirokawa, K., Pawelec, G., Bocti, C., Lacombe, G., et al. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00224 · Cited by 208

Brain-derived neurotrophic factor from microglia: a molecular substrate for neuropathic pain

Trang, T., Beggs, S., & Salter, M. W. (2011) · Neuron Glia Biology · doi:10.1017/s1740925x12000087 · Cited by 197

Inflammation in Parkinson's Disease

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Anti-NMDA receptor encephalitis. The disorder, the diagnosis and the immunobiology

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Alzheimer's Disease: Redox Dysregulation As a Common Denominator for Diverse Pathogenic Mechanisms

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Increased Mitochondrial Calcium Sensitivity and Abnormal Expression of Innate Immunity Genes Precede Dopaminergic Defects in Pink1-Deficient Mice

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Successful therapies for Alzheimer’s disease: why so many in animal models and none in humans?

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Implications of central immune signaling caused by drugs of abuse: Mechanisms, mediators and new therapeutic approaches for prediction and treatment of drug dependence

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The link between chronic pain and Alzheimer’s disease

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Therapeutic promise of carotenoids as antioxidants and anti-inflammatory agents in neurodegenerative disorders

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Ethanol induces TLR 4/ TLR 2 association, triggering an inflammatory response in microglial cells

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