Cited by 85Neuroinflammation and Neurodegeneration MechanismsTraumatic Brain Injury and Neurovascular DisturbancesInflammasome and immune disorders

Molecular and cellular immune mediators of neuroprotection

Turrin, Nicolas P., Rivest, Serge·2006·Molecular Neurobiology

Abstract

Our view of the immune privileged status of the brain has dramatically changed during the past two decades. Even though systemic immune stimuli have the ability to activate different populations of neurons, cells of monocytic lineage also have access to the neuronal tissue and populate it as microglia. Although such a phenomenon is limited in intact brains, it is greatly increased during neurodegenerative processes associated with innate immunity and the release of pro-inflammatory molecules by either resident microglia or those derived from the bone marrow stem cells. The role of these events is currently a matter of great debate and controversy, especially as it relates to brain protection, repair, or further injury. In recent years, accumulating data have supported the notion that when immune molecules are timely released by microglia, they limit neuronal injury in the presence of pathogens and toxic agents, help clear debris from degenerated cells, and restore the cerebral environment for repair. It has been shown that alteration of the natural innate immune response by microglia has direct consequences in exacerbating the damages following acute injury to neurons. This article presents and discusses these data, supporting a powerful neuroprotective role for microglia and their innate immune reactions in response to pathogens and central nervous system insults.

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Crossref · 10.1385/mn:34:3:221

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Authors
Turrin, N. P., & Rivest, S.
Affiliations
Centre hospitalier de l'Université Laval (CA)
Corresponding author
Turrin, Nicolas P.
Venue
Molecular Neurobiology
Published
2006
Volume
34
Issue
3
Pages
221-242
ISSN
0893-7648 (ISSN-L)
OpenAlex
W1966525994
Cited by
85
References
103
Citations by year
2025: 3 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 7 · 2020: 5 · 2019: 4 · 2018: 5 · 2017: 4 · 2016: 3 · 2015: 2 · 2014: 5 · 2013: 6 · 2012: 8
FWCI
2.60
Type
journal article
Language
en
Open access
closed
Locations
  • Molecular Neurobiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
Keywords
neuroprotection, microglia, innate immunity, neurodegeneration, proinflammatory molecules, neuroinflammation, neuronal injury, central nervous system injury
MeSH terms
Animals, Blood-Brain Barrier, Brain, Humans, Immunity, Innate, Inflammation, Neurons, Spinal Cord, Motor Neuron Disease, Cell Death

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