Cited by 1,054Phagocytosis and Immune RegulationNeutrophil, Myeloperoxidase and Oxidative MechanismsImmune cells in cancer

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Phagocyte partnership during the onset and resolution of inflammation

Soehnlein, Oliver, Lindbom, Lennart·2010·Nature Reviews Immunology

DOI 10.1038/nri2779

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Abstract

Neutrophils, monocytes and macrophages are closely related phagocytic cells that cooperate during the onset, progression and resolution of inflammation. This Review highlights the mechanisms involved in the intimate partnership of phagocytes during each progressive phase of the inflammatory response. We describe how tissue-resident macrophages recognize tissue damage to promote the recruitment of neutrophils and the mechanisms by which infiltrating neutrophils can then promote monocyte recruitment. Furthermore, we discuss the phagocyte-derived signals that abrogate neutrophil recruitment and how the uptake of apoptotic neutrophils by macrophages leads to termination of the inflammatory response. Finally, we highlight the potential therapeutic relevance of these interactions.

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Authors: Soehnlein, O., & Lindbom, L.
Affiliations: Karolinska Institutet (SE)
Corresponding author: Soehnlein, Oliver
ORCID: Soehnlein, Oliver
Lindbom, Lennart
Venue: Nature Reviews Immunology
Publisher: Springer Science and Business Media LLC
Published: 2010-06
Volume: 10
Issue: 6
Pages: 427-439
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/nri2779
OpenAlex: W2074171762
Cited by: 1,054
References: 138
Citations by year: 2026: 34 · 2025: 44 · 2024: 61 · 2023: 50 · 2022: 73 · 2021: 80 · 2020: 59 · 2019: 58 · 2018: 56 · 2017: 65 · 2016: 75 · 2015: 61 · 2014: 61 · 2013: 104 · 2012: 71
FWCI: 6.95
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
RWTH Publications (RWTH Aachen) (submittedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Keywords: neutrophils, monocytes, macrophages, inflammation resolution, neutrophil recruitment, monocyte recruitment, tissue-resident macrophages, therapeutic targeting
MeSH terms: Animals, Cell Movement, Homeostasis, Humans, Inflammation, Phagocytes, Signal Transduction, Apoptosis

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