Understanding the role of SOCS signaling in neurodegenerative diseases: Current and emerging concepts

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IL-10 plays a pivotal role in anti-inflammatory effects of resveratrol in activated microglia cells

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Folic Acid Is Able to Polarize the Inflammatory Response in LPS Activated Microglia by Regulating Multiple Signaling Pathways

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Deletion of the SOCS box of suppressor of cytokine signaling 3 (SOCS3) in embryonic stem cells reveals SOCS box-dependent regulation of JAK but not STAT phosphorylation

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Ischemic brain injury: A consortium analysis of key factors involved in mesenchymal stem cell-mediated inflammatory reduction

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Current Opinions and Perspectives on the Role of Immune System in the Pathogenesis of Parkinson's Disease

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Suppressor of Cytokine Signaling-3 Antagonizes cAMP Effects on Proliferation and Apoptosis and Is Expressed in Human Prostate Cancer

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Reviewing the Role of Resveratrol as a Natural Modulator of Microglial Activities

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p38 MAPK, but not p42/p44 MAPK mediated inducible nitric oxide synthase expression in C6 glioma cells

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Resveratrol counteracts lipopolysaccharide-mediated microglial inflammation by modulating a SOCS-1 dependent signaling pathway

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Adipokine pathways are altered in hippocampus of an experimental mouse model of Alzheimer's disease

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TCR‐engineered T cells: A model of inducible TCR expression to dissect the interrelationship between two TCRs

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Evolving cognition of the JAK-STAT signaling pathway: autoimmune disorders and cancer

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Curcumin as Prospective Anti-Aging Natural Compound: Focus on Brain

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Targeting connexin 43 provides anti-inflammatory effects after intracerebral hemorrhage injury by regulating YAP signaling

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Beneficial Effects of Spirulina Consumption on Brain Health

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The Emerging Role of Curcumin in the Modulation of TLR-4 Signaling Pathway: Focus on Neuroprotective and Anti-Rheumatic Properties

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The Potential Neuroprotective Role of Free and Encapsulated Quercetin Mediated by miRNA against Neurological Diseases

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MiR‐409‐3p and MiR‐1896 co‐operatively participate in IL‐17‐induced inflammatory cytokine production in astrocytes and pathogenesis of EAE mice via targeting SOCS3/STAT3 signaling

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Insights into the Evolution of the Suppressors of Cytokine Signaling (SOCS) Gene Family in Vertebrates

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Inflammaging and Brain: Curcumin and Its Beneficial Potential as Regulator of Microglia Activation

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LncRNA-AC006129.1 reactivates a SOCS3-mediated anti-inflammatory response through DNA methylation-mediated CIC downregulation in schizophrenia

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Extracellular Vesicles miRNA Cargo for Microglia Polarization in Traumatic Brain Injury

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Neurodegenerative Diseases: Can Caffeine Be a Powerful Ally to Weaken Neuroinflammation?

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Hypothalamic Neuropeptide Brain Protection: Focus on Oxytocin

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Suppressor of Cytokine Signaling 3: Emerging Role Linking Central Insulin Resistance and Alzheimer’s Disease

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SOCS modulates JAK-STAT pathway as a novel target to mediate the occurrence of neuroinflammation: Molecular details and treatment options

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Glial polarization in neurological diseases: Molecular mechanisms and therapeutic opportunities

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Whole‐transcriptome sequencing uncovers core regulatory modules and gene signatures of human fetal growth restriction

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Ischemia and reperfusion-injured liver-derived exosomes elicit acute lung injury through miR-122-5p regulated alveolar macrophage polarization

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RNA sequencing screening of differentially expressed genes after spinal cord injury

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The Role of Hypothalamic Microglia in the Onset of Insulin Resistance and Type 2 Diabetes: A Neuro-Immune Perspective

Darwish, R., Alcibahy, Y., Bucheeri, S., Albishtawi, A., Tama, M., Shetty, J. K., & Butler, A. E. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252313169 · Cited by 24 · see citing works

The Immuno-Glial Connectome in Alzheimer’s Disease: Integrating Central and Peripheral Inflammatory Networks

Gopalakrishna, P. K., Nassir, C. M. N. C. M., Anandan, S., Hussan, F., Dandala, K. C. R., Sura, S., Jagadeesan, S., Moklas, M. A. M., Vishnumukkala, T., & Hein, Z. M. (2026) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-026-01671-4 · Cited by 22 · see citing works

Chronic changes in oligodendrocyte sub‐populations after middle cerebral artery occlusion in neonatal mice

Frazier, A. P., Mitchell, D. N., Given, K. S., Hunn, G., Burch, A. M., Childs, C. R., Moreno‐Garcia, M., Corigilano, M. R., Quillinan, N., Macklin, W. B., et al. (2023) · Glia · doi:10.1002/glia.24349 · Cited by 20 · see citing works

Neuroinflammation in Parkinson’s disease: focus on the relationship between miRNAs and microglia

Xu, K., Li, Y., Zhou, Y., Zhang, Y., Shi, Y. X., Zhang, C., Bai, Y., & Wang, S. (2024) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2024.1429977 · Cited by 19 · see citing works

IRAK-M Ablation Promotes Status Epilepticus-Induced Neuroinflammation via Activating M1 Microglia and Impairing Excitatory Synaptic Function

Liang, X.-S., Qian, T., Xiong, Y., Liang, X., Ding, Y., Zhu, X., Li, Y.-L., Zhou, J.-L., Tan, L., Li, W., et al. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03407-7 · Cited by 17 · see citing works

Identification and characterization of Prokineticin receptor 2 splicing variant and its modulation in an animal model of Alzheimer's disease

Lattanzi, R., Maftei, D., Fullone, M. R., & Miele, R. (2018) · Neuropeptides · doi:10.1016/j.npep.2018.11.006 · Cited by 16 · see citing works

Aspirin up‐regulates suppressor of cytokine signaling 3 in glial cells via PPARα

Chakrabarti, S., Roy, A., Prorok, T., Patel, D. R., Dasarathi, S., & Pahan, K. (2019) · Journal of Neurochemistry · doi:10.1111/jnc.14813 · Cited by 16 · see citing works

SOCS1 is associated with clinical progression and acts as an oncogenic role in triple‐negative breast cancer

Qian, Q., Lv, Y., & Li, P. (2018) · IUBMB Life · doi:10.1002/iub.1728 · Cited by 15 · see citing works

BC-Box Motif in SOCS6 Induces Differentiation of Epidermal Stem Cells into GABAnergic Neurons

Yoshizumi, T., Kubo, A., Murata, H., Shinonaga, M., & Kanno, H. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21144947 · Cited by 13 · see citing works

Function and Mechanism of Abscisic Acid on Microglia-Induced Neuroinflammation in Parkinson’s Disease

Han, T., Xu, Y., Liu, H., Sun, L., Cheng, X., Shen, Y., & Wei, J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25094920 · Cited by 13 · see citing works

Investigating the Potential Therapeutic Targeting of the JAK-STAT Pathway in Cerebrovascular Diseases: Opportunities and Challenges

Wu, J., Wang, B., Shen, L.-P., Chen, Y.-L., Du, Z., Du, S., Lu, X.-J., & Zhao, X. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-04834-4 · Cited by 12 · see citing works

Lithium Chloride Promotes Milk Protein and Fat Synthesis in Bovine Mammary Epithelial Cells via HIF-1α and β-Catenin Signaling Pathways

Zong, J., Shen, J., Liu, X., Liu, J., Zhang, J., Zhou, C., Fan, Y., & Jin, Y. (2022) · Biological Trace Element Research · doi:10.1007/s12011-022-03131-8 · Cited by 12 · see citing works

The role of non-coding RNAs in neuroinflammatory process in multiple sclerosis

Nowak, A., Wicik, Z., Wolska, M., Shahzadi, A., Szwed, P., Jarosz-Popek, J., Palatini, J., Postula, M. A., Członkowska, A., Mirowska-Guzel, D. M., et al. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-02854-y · Cited by 12 · see citing works

Molecular characterization and immunoregulatory analysis of suppressors of cytokine signaling 1 (SOCS1) in black rockfish, Sebastes schlegeli

Wang, G., Liu, W., Wang, C., Wang, J., Liu, H., Hao, D., & Zhang, M. (2022) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2022.104355 · Cited by 11 · see citing works

Cadmium-induced gut dysbiosis precedes the onset of hippocampus-dependent learning and memory deficits in mice

Wang, H., Lim, J. J., Gu, H., Xia, Z., & Cui, J. Y. (2025) · Toxicology · doi:10.1016/j.tox.2025.154265 · Cited by 11 · see citing works

Astrocytes in intracerebral hemorrhage: impact and therapeutic objectives

Dong, H., Wen, X., Zhang, B., Wu, Z., & Zou, W. (2024) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2024.1327472 · Cited by 10 · see citing works

TRIM21 Promotes Endothelial Cell Activation via Accelerating SOCS3 Ubiquitination Degradation in Atherosclerosis

Hao, Z., Wang, Y., Chen, L., Zhou, Y., Fang, D., Yao, W., Xiao, L., & Zhang, Y. (2025) · Cardiovascular Toxicology · doi:10.1007/s12012-025-09965-7 · Cited by 9 · see citing works

IFN-τ Maintains Immune Tolerance by Promoting M2 Macrophage Polarization via Modulation of Bta-miR-30b-5p in Early Uterine Pregnancy in Dairy Cows

Feng, X., Yang, C., Wang, T., Zhang, J., Zhou, H., Ma, B., Xu, M., & Deng, G. (2025) · Cells · doi:10.3390/cells14020087 · Cited by 8 · see citing works

Ulinastatin affects focal cerebral ischemia–reperfusion injury via SOCS1 ‐mediated JAK2 / STAT3 signalling pathway

Chen, X., Li, P., Huang, R., Zhang, J., Ouyang, X., & Tan, D. (2022) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.13731 · Cited by 5 · see citing works

Quantitative proteomics of the miR-301a/SOCS3/STAT3 axis reveals underlying autism and anxiety-like behavior

Li, X., Fu, Q., Zhong, M., Long, Y., Zhao, F., Huang, Y., Zhang, Z., Wen, M., Chen, K., Chen, R., et al. (2024) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2024.102136 · Cited by 4 · see citing works

Genome-wide identification of socs gene in rainbow trout (Oncorhynchus mykiss) and response to microplastic exposure

Ma, F., Wang, W., Dong, J., Zhou, X., Lin, Z., Zheng, P., Nian, X., & Dong, L. (2025) · Molecular Biology Reports · doi:10.1007/s11033-025-10601-4 · Cited by 3 · see citing works

Suppression of miR-218 promotes SOCS3 expression to alleviate cognitive impairment and white matter injury after chronic cerebral hypoperfusion

Zhu, Y., Tong, J., Jiang, J., Shi, K., Xie, J., Zhu, Y., Li, Y., & Xu, Y. (2025) · Metabolic Brain Disease · doi:10.1007/s11011-025-01572-3 · Cited by 3 · see citing works

Identification of neutrophil extracellular trap-related genes in Alzheimer’s disease based on comprehensive bioinformatics analysis

Qiao, N., & Shao, H. (2024) · Computer Methods in Biomechanics & Biomedical Engineering · doi:10.1080/10255842.2024.2399029 · Cited by 2 · see citing works

SOCS7-Derived BC-Box Motif Peptide Mediated Cholinergic Differentiation of Human Adipose-Derived Mesenchymal Stem Cells

Kanno, H., Matsumoto, S., Yoshizumi, T., Nakahara, K., Shinonaga, M., Kubo, A., Fujii, S., Ishizuka, Y., Tanaka, M., Ichihashi, M., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032786 · Cited by 2 · see citing works

The Spatiotemporal Expression of SOCS3 in the Brainstem and Spinal Cord of Amyotrophic Lateral Sclerosis Mice

Lin, C., Vanoverbeke, V. R., Trent, D., Willey, K., & Lee, Y. (2024) · Brain Sciences · doi:10.3390/brainsci14060564 · Cited by 1 · see citing works

JAK-STAT signaling: molecular mechanism and targeted treatment in dento-maxillofacial abnormalities

Huang, Z., Cui, Y., Zhang, W., Shen, J., Dai, Q., Sun, S., & Jiang, L. (2026) · International Journal of Oral Science · doi:10.1038/s41368-025-00399-z · Cited by 1 · see citing works

Loop of N2-polarized neutrophils and exhausted CD8 + T cells induces immunotherapy resistance in NSCLC

Zou, Z., Guo, Z., Wei, Y., Cai, S., & Yu, C. (2026) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-025-05457-y · Cited by 1 · see citing works

Utilização da porcentagem e escore Z para avaliar resposta broncodilatadora em crianças asmáticas de idade pré-escolar

Lisboa, S., Salviano, L. D. D. S., da Costa, A. C. C., Malafaia, A. L., Monteiro, S. L., & Cohen, R. W. F. (2020) · Arquivos de Asmas Alergia e Imunologia · doi:10.5935/2526-5393.20200028

Utilização da porcentagem e escore Z para avaliar resposta broncodilatadora em crianças asmáticas de idade pré-escolar

Lisboa, S., Salviano, L. D. D. S., da Costa, A. C. C., Malafaia, A. L., Monteiro, S. L., & Cohen, R. W. F. (2020) · Brazilian Journal of Allergy and Immunology (BJAI) · doi:10.5935/2318-5015.20200028

Identification of SOCS5 Gene in the Chinese Giant Salamander (Andrias davidianus) and Expression Profiles in Response to Citrobacter freundii Challenge

Gao, X., Huang, Y., Ren, H., & Gao, S. Y. (2022) · Russian Journal of Bioorganic Chemistry · doi:10.1134/s1068162022040100

JAK/STAT Signalling Overdrive in Immune Regulation: A Trigger for Autoimmunity

Cyriac, K. S., & N, H. (2024) · International journal of pharmaceutical sciences review and research · doi:10.47583/ijpsrr.2024.v84i06.005

Molecular Mechanisms Behind Organ-Related Aging and Regulatory Effects of Natural Therapeutics

Abaidullah, R., Ali, S., Summer, M., & Tahir, H. (2025) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-025-01792-5

Additional file 1 of Targeting connexin 43 provides anti-inflammatory effects after intracerebral hemorrhage injury by regulating YAP signaling

Yu, H., Cao, X., Li, W., Liu, P., Zhao, Y., Song, L., Chen, J., Chen, B., Yu, W., & Xu, Y. (2020) · Figshare · doi:10.6084/m9.figshare.13161527

Single-cell RNA sequencing uncovers neutrophil clusters associated with autoimmune neuroinflammation

Wang, Y. L., Turbitt, W. J., Zhou, L., Yan, Z., Patel, S. B., Yang, W., Li, Z., Buckley, J. A., Mulia, G. E., Welner, R. S., et al. (2026) · Journal of Neuroinflammation · doi:10.1186/s12974-026-03772-9

Reduced expression of SOCS1-5 and STAT5a genes in Parkinson’s disease patients: evidence for dysregulated immune signaling

Salmani, M., Rastegari‐Pouyani, M., Afshar, S., Ghane, E. T., & Eftekharian, M. M. (2026) · Molecular Biology Reports · doi:10.1007/s11033-026-11709-x

SOCS modulates JAK-STAT pathway as a novel target to mediate the occurrence of neuroinflammation: Molecular details and treatment options

Yan, M., Sun, Z., Zhang, S., Yang, G., Jiang, X. Y., Wang, G., Li, R., Wang, Q., & Tian, X. (2024) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2024.110988 · Cited by 35 · see citing works

Complications of laparoscopic Roux en-Y gastric bypass

Champion, J. K. (2003) · Current Surgery · doi:10.1016/s0149-7944(03)00038-2 · Cited by 2 · see citing works

SOCS1 and SOCS3 in the control of CNS immunity

Baker, B. J., Akhtar, L. N., & Benveniste, E. N. (2009) · Trends in Immunology · doi:10.1016/j.it.2009.07.001 · Cited by 276 · see citing works

Cytokine signaling in the brain: Putting a SOCS in it?

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Expression of suppressor of cytokine signaling genes in human elderly and Alzheimer’s disease brains and human microglia

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