The DOI matches its Crossref record; 178 of the 178 references it cites were found in a registry or an index.
Protective and pathogenic functions of macrophage subsets
Open accessAbstract
Macrophages are strategically located throughout the body tissues, where they ingest and process foreign materials, dead cells and debris and recruit additional macrophages in response to inflammatory signals. They are highly heterogeneous cells that can rapidly change their function in response to local microenvironmental signals. In this Review, we discuss the four stages of orderly inflammation mediated by macrophages: recruitment to tissues; differentiation and activation in situ; conversion to suppressive cells; and restoration of tissue homeostasis. We also discuss the protective and pathogenic functions of the various macrophage subsets in antimicrobial defence, antitumour immune responses, metabolism and obesity, allergy and asthma, tumorigenesis, autoimmunity, atherosclerosis, fibrosis and wound healing. Finally, we briefly discuss the characterization of macrophage heterogeneity in humans.
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“CD68 and reelin, markers for MΦs and HSCs, respectively (12,13), were expressed in our system at the end of the experiment, reflecting the maintenance of the cell types in a differentiated state.”
From Development of an in vitro human liver system for interrogating nonalcoholic steatohepatitis (2016) · cites this paper as [13]
In the citing paper
“Macrophage polarization and plasticity have been shown to play important roles in a diverse spectrum of disease processes [32,33].”
From Macrophage polarization: an opportunity for improved outcomes in biomaterials and regenerative medicine (2012) · cites this paper as [32]
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“In some cases, as will be discussed in further detail, prolonged inflammation and remodeling leading to fibrosis or hypertrophic scar formation may occur due to dysregulation of the default healing process [32,86,101,102].”
From Macrophage polarization: an opportunity for improved outcomes in biomaterials and regenerative medicine (2012) · cites this paper as [32]
In the citing paper
“One of the major events at this time is a change in the phenotype of macrophages from an inflammatory and microbicidal phenotype, grouped as M1 macrophages, secreting IL-1, TNFα, IL-6, IL-12, MMPs, and other cytokines, to an anti-inflammatory, regulatory, and reparative phenotype, classed and grouped as M2, producing arginase, TGFβ, CCL18, PGE2, and IL-10 (Fig. 4).”
From The Innate Immune System in Acute and Chronic Wounds (2016) · cites this paper as [93]
In the citing paper
“However, chronic inflammation and persistent Mp accumulation are often associated with tissue destruction and fibrosis [6 -8].”
From Macrophage phenotypes during tissue repair (2013) · cites this paper as [8]
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1 retracted
RETRACTED: Foxp3-positive macrophages display immunosuppressive properties and promote tumor growth
Manrique, S. Z., Correa, M. A. D., Hoelzinger, D. B., Dominguez, A. L., Mirza, N. N., Lin, H., Stein‐Streilein, J., Gordon, S., & Lustgarten, J. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20100730 · Cited by 72
RetractedHallmarks of Cancer: The Next Generation
Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590
Exploring the full spectrum of macrophage activation
Mosser, D. M., & Edwards, J. P. (2008) · Nature Reviews Immunology · doi:10.1038/nri2448 · Cited by 9,144
Alternative activation of macrophages
Gordon, S. (2003) · Nature Reviews Immunology · doi:10.1038/nri978 · Cited by 6,189
Monocyte and macrophage heterogeneity
Gordon, S., & Taylor, P. R. (2005) · Nature Reviews Immunology · doi:10.1038/nri1733 · Cited by 5,190
Curiel, T. J., Coukos, G., Zou, L., Alvarez, X., Cheng, P., Mottram, P., Evdemon-Hogan, M., Conejo-Garcia, J. R., Zhang, L., Burow, M., et al. (2004) · Nature Medicine · doi:10.1038/nm1093 · Cited by 5,151
Cytokine-mediated regulation of CXCR4 expression in human neutrophils
Nagase, H., Miyamasu, M., Yamaguchi, M., Imanishi, M., Tsuno, N. H., Matsushima, K., Yamamoto, K., Morita, Y., & Hirai, K. (2002) · Journal of Leukocyte Biology · doi:10.1189/jlb.71.4.711 · Cited by 4,713
Obesity induces a phenotypic switch in adipose tissue macrophage polarization
Lumeng, C. N., Bodzin, J. L., & Saltiel, A. R. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29881 · Cited by 4,664
Cellular and molecular mechanisms of fibrosis
Wynn, T. (2008) · The Journal of Pathology · doi:10.1002/path.2277 · Cited by 4,495
Self-citationMacrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm
Biswas, S. K., & Mantovani, A. (2010) · Nature Immunology · doi:10.1038/ni.1937 · Cited by 3,840
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Macrophage activation and polarization: nomenclature and experimental guidelines
Murray, P. J., Allen, J. E., Biswas, S. K., Fisher, E. A., Gilroy, D. W., Goerdt, S., Gordon, S., Hamilton, J. A., Ivashkiv, L. B., Lawrence, T., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.06.008 · Cited by 6,337
Self-citationMacrophage plasticity, polarization, and function in health and disease
Shapouri‐Moghaddam, A., Mohammadian, S., Vazini, H., Taghadosi, M., Esmaeili, S., Mardani, F., Seifi, B., Mohammadi, A., Afshari, J. T., & Sahebkar, A. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.26429 · Cited by 4,930
The M1 and M2 paradigm of macrophage activation: Time for reassessment
Martinez, F. O., & Gordon, S. (2014) · F1000Prime Reports · doi:10.12703/p6-13 · Cited by 4,689
Macrophage biology in development, homeostasis and disease
Wynn, T. A., Chawla, A., & Pollard, J. W. (2013) · Nature · doi:10.1038/nature12034 · Cited by 4,684
Self-citationMacrophages in Tissue Repair, Regeneration, and Fibrosis
Wynn, T. A., & Vannella, K. M. (2016) · Immunity · doi:10.1016/j.immuni.2016.02.015 · Cited by 4,481
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Metadata
- Authors
- Murray, P. J., & Wynn, T. A.
- Affiliations
- St. Jude Children's Research Hospital (US)
- National Institutes of Health (US)
- Corresponding author
- Murray, Peter J.
- Wynn, Thomas A.
- Venue
- Nature Reviews Immunology
- Published
- 2011-10-14
- Volume
- 11
- Issue
- 11
- Pages
- 723-737
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- PMC
- PMC3422549
- OpenAlex
- W1985859986
- Cited by
- 5,269
- References
- 178
- Citations by year
- 2026: 300 · 2025: 355 · 2024: 374 · 2023: 403 · 2022: 423 · 2021: 421 · 2020: 379 · 2019: 353 · 2018: 336 · 2017: 363 · 2016: 381 · 2015: 395 · 2014: 362 · 2013: 265 · 2012: 147
- FWCI
- 22.32
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Cancer Institute (P 30CA 21765, P30CA021765)
- National Institute of Allergy and Infectious Diseases (Z01AI001019, ZIAAI001019, ZIAAI000829, Z01AI000829)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Keywords
- macrophage heterogeneity, macrophage plasticity, macrophage polarization, tissue homeostasis, inflammation, macrophage recruitment, antimicrobial defense, antitumor immunity, obesity, allergy, asthma, carcinogenesis, autoimmunity, atherosclerosis, fibrosis, wound healing
- MeSH terms
- Bacterial Infections, Humans, Inflammation, Macrophage Activation, Macrophages, Neoplasms, Phagocytosis, Signal Transduction, Models, Immunological, Cell Proliferation
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