Cited by 5,269Immune cells in cancerPhagocytosis and Immune RegulationCardiac Fibrosis and Remodeling

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Protective and pathogenic functions of macrophage subsets

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Murray, Peter J., Wynn, Thomas A.·2011·Nature Reviews Immunology

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Abstract

Macrophages are strategically located throughout the body tissues, where they ingest and process foreign materials, dead cells and debris and recruit additional macrophages in response to inflammatory signals. They are highly heterogeneous cells that can rapidly change their function in response to local microenvironmental signals. In this Review, we discuss the four stages of orderly inflammation mediated by macrophages: recruitment to tissues; differentiation and activation in situ; conversion to suppressive cells; and restoration of tissue homeostasis. We also discuss the protective and pathogenic functions of the various macrophage subsets in antimicrobial defence, antitumour immune responses, metabolism and obesity, allergy and asthma, tumorigenesis, autoimmunity, atherosclerosis, fibrosis and wound healing. Finally, we briefly discuss the characterization of macrophage heterogeneity in humans.

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Macrophage activation and polarization: nomenclature and experimental guidelines
Murray, P. J., Allen, J. E., Biswas, S. K., Fisher, E. A., Gilroy, D. W., Goerdt, S., Gordon, S., Hamilton, J. A., Ivashkiv, L. B., Lawrence, T., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.06.008 · Cited by 6,337
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Macrophage plasticity, polarization, and function in health and disease
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Macrophages in Tissue Repair, Regeneration, and Fibrosis
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Authors: Murray, P. J., & Wynn, T. A.
Affiliations: St. Jude Children's Research Hospital (US)
National Institutes of Health (US)
Corresponding author: Murray, Peter J.
Wynn, Thomas A.
ORCID: Murray, Peter J.
Wynn, Thomas A.
Venue: Nature Reviews Immunology
Publisher: Springer Science and Business Media LLC
Published: 2011-10-14
Volume: 11
Issue: 11
Pages: 723-737
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/nri3073
PMC: PMC3422549
OpenAlex: W1985859986
Cited by: 5,269
References: 178
Citations by year: 2026: 300 · 2025: 355 · 2024: 374 · 2023: 403 · 2022: 423 · 2021: 421 · 2020: 379 · 2019: 353 · 2018: 336 · 2017: 363 · 2016: 381 · 2015: 395 · 2014: 362 · 2013: 265 · 2012: 147
FWCI: 22.32
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Cancer Institute (P 30CA 21765, P30CA021765)
National Institute of Allergy and Infectious Diseases (Z01AI001019, ZIAAI001019, ZIAAI000829, Z01AI000829)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
Keywords: macrophage heterogeneity, macrophage plasticity, macrophage polarization, tissue homeostasis, inflammation, macrophage recruitment, antimicrobial defense, antitumor immunity, obesity, allergy, asthma, carcinogenesis, autoimmunity, atherosclerosis, fibrosis, wound healing
MeSH terms: Bacterial Infections, Humans, Inflammation, Macrophage Activation, Macrophages, Neoplasms, Phagocytosis, Signal Transduction, Models, Immunological, Cell Proliferation

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