Cited by 449T-cell and B-cell ImmunologyImmunotherapy and Immune ResponsesImmune responses and vaccinations

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Molecular programming of B cell memory

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McHeyzer-Williams, Michael, Okitsu, Shinji, Wang, Nathaniel, McHeyzer-Williams, Louise·2012·Nature Reviews Immunology

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Abstract

The development of high-affinity B cell memory is regulated through three separable phases, each involving antigen recognition by specific B cells and cognate T helper cells. Initially, antigen-primed B cells require cognate T cell help to gain entry into the germinal centre pathway to memory. Once in the germinal centre, B cells with variant B cell receptors must access antigens and present them to germinal centre T helper cells to enter long-lived memory B cell compartments. Following antigen recall, memory B cells require T cell help to proliferate and differentiate into plasma cells. A recent surge of information - resulting from dynamic B cell imaging in vivo and the elucidation of T follicular helper cell programmes - has reshaped the conceptual landscape surrounding the generation of memory B cells. In this Review, we integrate this new information about each phase of antigen-specific B cell development to describe the newly unravelled molecular dynamics of memory B cell programming.

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Authors: McHeyzer-Williams, M., Okitsu, S., Wang, N., & McHeyzer-Williams, L.
Affiliations: Scripps Research Institute (US)
ORCID: Wang, Nathaniel
Venue: Nature Reviews Immunology
Publisher: Springer Science and Business Media LLC
Published: 2011-12-09
Volume: 12
Issue: 1
Pages: 24-34
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/nri3128
PMC: PMC3947622
OpenAlex: W1991780615
Cited by: 449
References: 100
Citations by year: 2026: 7 · 2025: 13 · 2024: 21 · 2023: 24 · 2022: 26 · 2021: 41 · 2020: 28 · 2019: 34 · 2018: 24 · 2017: 28 · 2016: 43 · 2015: 49 · 2014: 44 · 2013: 42 · 2012: 24
FWCI: 3.18
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Allergy and Infectious Diseases (R01AI047231)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
Keywords: memory B cells, T follicular helper cells, T cell help, B cell development, vaccination strategies
MeSH terms: Animals, Antigens, B-Lymphocytes, T-Lymphocytes, Helper-Inducer, Humans, Immunologic Memory, Germinal Center

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