The DOI matches its Crossref record; 101 of the 101 references it cites were found in a registry or an index.
Molecular programming of B cell memory
Open accessAbstract
The development of high-affinity B cell memory is regulated through three separable phases, each involving antigen recognition by specific B cells and cognate T helper cells. Initially, antigen-primed B cells require cognate T cell help to gain entry into the germinal centre pathway to memory. Once in the germinal centre, B cells with variant B cell receptors must access antigens and present them to germinal centre T helper cells to enter long-lived memory B cell compartments. Following antigen recall, memory B cells require T cell help to proliferate and differentiate into plasma cells. A recent surge of information - resulting from dynamic B cell imaging in vivo and the elucidation of T follicular helper cell programmes - has reshaped the conceptual landscape surrounding the generation of memory B cells. In this Review, we integrate this new information about each phase of antigen-specific B cell development to describe the newly unravelled molecular dynamics of memory B cell programming.
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“underscoring the immunological connection between memory B cells and antibody recall responses (35).”
From Distinct antibody and memory B cell responses in SARS-CoV-2 naïve and recovered individuals after mRNA vaccination (2021) · cites this paper as [35]
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Vinuesa, C. G., Linterman, M. A., Yu, D., & MacLennan, I. C. M. (2016) · Annual Review of Immunology · doi:10.1146/annurev-immunol-041015-055605 · Cited by 1,141
Dynamics of B cells in germinal centres
De Silva, N. S., & Klein, U. (2015) · Nature Reviews Immunology · doi:10.1038/nri3804 · Cited by 1,084
CD4+ follicular helper T cell infiltration predicts breast cancer survival
Gu‐Trantien, C., Loi, S., Garaud, S., Equeter, C., Libin, M., de Wind, A., Ravoet, M., Buanec, H. L., Sibille, C., Manfouo-Foutsop, G., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci67428 · Cited by 1,098
MicroRNAs as regulatory elements in immune system logic
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Metadata
- Authors
- McHeyzer-Williams, M., Okitsu, S., Wang, N., & McHeyzer-Williams, L.
- Affiliations
- Scripps Research Institute (US)
- ORCID
- Wang, Nathaniel
- Venue
- Nature Reviews Immunology
- Published
- 2011-12-09
- Volume
- 12
- Issue
- 1
- Pages
- 24-34
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- PMC
- PMC3947622
- OpenAlex
- W1991780615
- Cited by
- 449
- References
- 100
- Citations by year
- 2026: 7 · 2025: 13 · 2024: 21 · 2023: 24 · 2022: 26 · 2021: 41 · 2020: 28 · 2019: 34 · 2018: 24 · 2017: 28 · 2016: 43 · 2015: 49 · 2014: 44 · 2013: 42 · 2012: 24
- FWCI
- 3.18
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (R01AI047231)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Keywords
- memory B cells, T follicular helper cells, T cell help, B cell development, vaccination strategies
- MeSH terms
- Animals, Antigens, B-Lymphocytes, T-Lymphocytes, Helper-Inducer, Humans, Immunologic Memory, Germinal Center
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