Living in the liver: hepatic infections

Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3

Alexopoulou, L., Holt, A. C., Medzhitov, R., & Flavell, R. A. (2001) · Nature · doi:10.1038/35099560 · Cited by 6,129

T cell exhaustion

Wherry, E. J. (2011) · Nature Immunology · doi:10.1038/ni.2035 · Cited by 4,062

Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus

Meylan, E., Curran, J., Hofmann, K., Moradpour, D., Binder, M., Bartenschlager, R., & Tschopp, J. (2005) · Nature · doi:10.1038/nature04193 · Cited by 2,401

Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors

Ghiringhelli, F., Apetoh, L., Tesniere, A., Aymeric, L., Ma, Y., Ortiz, C., Vermaelen, K., Panaretakis, T., Mignot, G., Ullrich, E., et al. (2009) · Nature Medicine · doi:10.1038/nm.2028 · Cited by 1,898

Efficient presentation of exogenous antigen by liver endothelial cells to CD8+ T cells results in antigen-specific T-cell tolerance

Limmer, A., Ohl, J., Kurts, C., Ljunggren, H.-G., Reiss, Y., Groettrup, M., Momburg, F., Arnold, B., & Knolle, P. A. (2000) · Nature Medicine · doi:10.1038/82161 · Cited by 758

Identification of a dendritic cell receptor that couples sensing of necrosis to immunity

Sancho, D., Joffre, O. P., Keller, A. M., Rogers, N. C., Martínez, D., Hernanz-Falcón, P., Rosewell, I., & Sousa, C. R. E. (2009) · Nature · doi:10.1038/nature07750 · Cited by 750

PD-L1 is induced in hepatocytes by viral infection and by interferon-α and -γ and mediates T cell apoptosis

Mühlbauer, M., Fleck, M., Schütz, C., Weiss, T., Froh, M., Blank, C., Schölmerich, J., & Hellerbrand, C. (2006) · Journal of Hepatology · doi:10.1016/j.jhep.2006.05.007 · Cited by 378

Coexpression of PD-1, 2B4, CD160 and KLRG1 on exhausted HCV-specific CD8+ T cells is linked to antigen recognition and T cell differentiation

Bengsch, B., Seigel, B., Ruhl, M., Timm, J., Kuntz, M., Blum, H. E., Pircher, H., & Thimme, R. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1000947 · Cited by 373

The Human Liver Contains Multiple Populations of NK Cells, T Cells, and CD3+CD56+ Natural T Cells with Distinct Cytotoxic Activities and Th1, Th2, and Th0 Cytokine Secretion Patterns

Doherty, D. G., Norris, S., Madrigal-Estebas, L., McEntee, G., Traynor, O., Hegarty, J. E., & O’Farrelly, C. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.4.2314 · Cited by 350

The site of primary T cell activation is a determinant of the balance between intrahepatic tolerance and immunity

Bowen, D. G., Zen, M., Holz, L., Davis, T., McCaughan, G. W., & Bertolino, P. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21593 · Cited by 316

Liver immunology and its role in inflammation and homeostasis

Robinson, M. W., Harmon, C., & O’Farrelly, C. (2016) · Cellular & Molecular Immunology · doi:10.1038/cmi.2016.3 · Cited by 1,151

The immunology of hepatocellular carcinoma

Ringelhan, M., Pfister, D., O’Connor, T., Pikarsky, E., & Heikenwalder, M. (2018) · Nature Immunology · doi:10.1038/s41590-018-0044-z · Cited by 1,076

Immune Responses in the Liver

Kubes, P., & Jenne, C. (2018) · Annual Review of Immunology · doi:10.1146/annurev-immunol-051116-052415 · Cited by 923

Liver — guardian, modifier and target of sepsis

Strnad, P., Tacke, F., Koch, A., & Trautwein, C. (2017) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.168 · Cited by 692

Liver sinusoidal endothelial cells — gatekeepers of hepatic immunity

Shetty, S., Lalor, P. F., & Adams, D. H. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0020-y · Cited by 523

IL-2high tissue-resident T cells in the human liver: Sentinels for hepatotropic infection

Pallett, L. J., Davies, J., Colbeck, E. J., Robertson, F., Hansi, N., Easom, N. J. W., Burton, A. R., Stegmann, K. A., Schurich, A., Swadling, L., et al. (2017) · Journal of Experimental Medicine · doi:10.1084/jem.20162115 · Cited by 347

Up-regulation of a death receptor renders antiviral T cells susceptible to NK cell–mediated deletion

Peppa, D., Gill, U. S., Reynolds, G., Easom, N. J. W., Pallett, L. J., Schurich, A., Micco, L., Nebbia, G., Singh, H. D., Adams, D. H., et al. (2013) · Journal of Experimental Medicine · doi:10.1084/jem.20121172 · Cited by 342

Recent Advances in Understanding of Pathogenesis of Alcohol-Associated Liver Disease

Wu, X., Fan, X., Miyata, T., Kim, A., Cajigas-Du Ross, C. K., Ray, S., Huang, E., Taiwo, M., Arya, R., Wu, J., et al. (2023) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathmechdis-031521-030435 · Cited by 289

Towards an HBV cure: state-of-the-art and unresolved questions—report of the ANRS workshop on HBV cure

Zeisel, M. B., Lucifora, J., Mason, W. S., Sureau, C., Beck, J., Levrero, M., Kann, M., Knolle, P. A., Benkirane, M., Durantel, D., et al. (2015) · Gut · doi:10.1136/gutjnl-2014-308943 · Cited by 256

Metabolic reprogramming in the tumor microenvironment of liver cancer

Lin, J., Rao, D., Zhang, M., & Gao, Q. (2024) · Journal of Hematology & Oncology · doi:10.1186/s13045-024-01527-8 · Cited by 251

Intrahepatic myeloid-cell aggregates enable local proliferation of CD8+ T cells and successful immunotherapy against chronic viral liver infection

Huang, L.-R., Wohlleber, D., Reisinger, F., Jenne, C. N., Cheng, R.-L., Abdullah, Z., Schildberg, F. A., Odenthal, M., Dienes, H.-P., van Rooijen, N., et al. (2013) · Nature Immunology · doi:10.1038/ni.2573 · Cited by 216

The gut-liver axis in sepsis: interaction mechanisms and therapeutic potential

Zhang, X., Liu, H., Hashimoto, K., Yuan, S., & Zhang, J. (2022) · Critical Care · doi:10.1186/s13054-022-04090-1 · Cited by 200

Liver-Resident NK Cells Control Antiviral Activity of Hepatic T Cells via the PD-1-PD-L1 Axis

Zhou, J., Peng, H., Li, K., Qu, K., Wang, B., Wu, Y., Ye, L., Dong, Z., Wei, H., Sun, R., et al. (2019) · Immunity · doi:10.1016/j.immuni.2018.12.024 · Cited by 157

Longevity and replenishment of human liver-resident memory T cells and mononuclear phagocytes

Pallett, L. J., Burton, A. R., Amin, O. E., Rodriguez-Tajes, S., Patel, A. A., Zakeri, N., Jeffery-Smith, A., Swadling, L., Schmidt, N. M., Baiges, A., et al. (2020) · Journal of Experimental Medicine · doi:10.1084/jem.20200050 · Cited by 134

The Role of Sinusoidal Endothelial Cells in the Axis of Inflammation and Cancer Within the Liver

Wilkinson, A. L., Qurashi, M., & Shetty, S. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00990 · Cited by 121

Extracellular matrix-penetrating nanodrill micelles for liver fibrosis therapy

Fan, Q.-Q., Zhang, C.-L., Qiao, J.-B., Cui, P.-F., Xing, L., Oh, Y.-K., & Jiang, H.-L. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2019.119616 · Cited by 111

A liver immune rheostat regulates CD8 T cell immunity in chronic HBV infection

Bosch, M., Kallin, N., Donakonda, S., Zhang, J. D., Wintersteller, H., Hegenbarth, S., Heim, K., Ramirez, C., Fürst, A., Lattouf, E. I., et al. (2024) · Nature · doi:10.1038/s41586-024-07630-7 · Cited by 97

The Balance between CD8(+) T Cell-Mediated Clearance of AAV-Encoded Antigen in the Liver and Tolerance Is Dependent on the Vector Dose

Kumar, S. R. P., Hoffman, B. E., Terhorst, C., de Jong, Y. P., & Herzog, R. W. (2017) · Molecular Therapy · doi:10.1016/j.ymthe.2017.02.014 · Cited by 83

Interleukin-6: A promising cytokine to support liver regeneration and adaptive immunity in liver pathologies

Naseem, S., Hussain, T., & Manzoor, S. (2018) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2018.01.002 · Cited by 72

Crosstalk between gut microbiota and sepsis

Niu, M., & Chen, P. (2021) · Burns & Trauma · doi:10.1093/burnst/tkab036 · Cited by 69

TLR2 Stimulation Strengthens Intrahepatic Myeloid-Derived Cell-Mediated T Cell Tolerance through Inducing Kupffer Cell Expansion and IL-10 Production

Liu, J., Yu, Q., Wu, W., Huang, X., Broering, R., Werner, M., Roggendorf, M., Yang, D., & Lu, M. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1700540 · Cited by 50

Acute hepatitis B virus infection in humanized chimeric mice has multiphasic viral kinetics

Ishida, Y., Chung, T. L., Imamura, M., Hiraga, N., Sen, S., Yokomichi, H., Tateno, C., Canini, L., Perelson, A. S., Uprichard, S. L., et al. (2018) · Hepatology · doi:10.1002/hep.29891 · Cited by 47

Staying local-antigen presentation in the liver

Knolle, P. A. (2016) · Current Opinion in Immunology · doi:10.1016/j.coi.2016.02.009 · Cited by 42

Transfer of MHC-class-I molecules among liver sinusoidal cells facilitates hepatic immune surveillance

Schölzel, K., Schildberg, F. A., Welz, M., Börner, C., Geiger, S., Kurts, C., Heikenwälder, M., Knolle, P. A., & Wohlleber, D. (2014) · Journal of Hepatology · doi:10.1016/j.jhep.2014.04.028 · Cited by 31

TLR9-independent CD8+ T cell responses in hepatic AAV gene transfer through IL-1R1-MyD88 signaling

Kumar, S. R. P., Biswas, M., Cao, D., Arisa, S., Muñoz-Melero, M., Lam, A. K., Piñeros, A. R., Kapur, R., Kaisho, T., Kaufman, R. J., et al. (2024) · Molecular Therapy · doi:10.1016/j.ymthe.2023.11.029 · Cited by 31

Neutrophils in MASLD and MASH

Shrestha, S., Jeon, J.-H., & Hong, C.-W. (2025) · BMB Reports · doi:10.5483/bmbrep.2024-0058 · Cited by 30

A decade of liver organoids: Advances in disease modeling

Liu, Y., Sheng, J.-Y., Yang, C.-F., Ding, J., & Chan, Y.-S. (2023) · Clinical and Molecular Hepatology · doi:10.3350/cmh.2022.0428 · Cited by 30

Liver-resident memory T cells: life in lockdown

Pallett, L. J., & Maini, M. K. (2022) · Seminars in Immunopathology · doi:10.1007/s00281-022-00932-w · Cited by 28

Single MHC‐I Expression Promotes Virus‐Induced Liver Immunopathology

Xu, H. C., Huang, J., Pandyra, A. A., Pandey, P., Wang, R., Zhang, Z., Zhuang, Y., Gertzen, C. G. W., Münk, C., Herebian, D., et al. (2022) · Hepatology Communications · doi:10.1002/hep4.1913 · Cited by 9