The DOI matches its Crossref record; 107 of the 107 references it cites were found in a registry or an index.
T-bet: a bridge between innate and adaptive immunity
Open accessAbstract
Originally described over a decade ago as a T cell transcription factor regulating T helper 1 cell lineage commitment, T-bet is now recognized as having an important role in many cells of the adaptive and innate immune system. T-bet has a fundamental role in coordinating type 1 immune responses by controlling a network of genetic programmes that regulate the development of certain immune cells and the effector functions of others. Many of these transcriptional networks are conserved across innate and adaptive immune cells and these shared mechanisms highlight the biological functions that are regulated by T-bet.
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Citations
Cites
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“The resulting T-betEomes cells are thought to represent a ‘‘short-termmemory’’ population that produces cytokines and can self-renew or further differentiate into effector CTLs (Lazarevic et al., 2013).”
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Metadata
- Authors
- Lazarevic, V., Glimcher, L. H., & Lord, G. M.
- Affiliations
- National Institutes of Health (US)
- Weill Cornell Medicine (US)
- King's College London (GB)
- Corresponding author
- Glimcher, Laurie H.
- Venue
- Nature Reviews Immunology
- Published
- 2013-10-11
- Volume
- 13
- Issue
- 11
- Pages
- 777-789
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- PMC
- PMC6290922
- OpenAlex
- W2055897422
- Cited by
- 486
- References
- 107
- Citations by year
- 2026: 19 · 2025: 38 · 2024: 26 · 2023: 34 · 2022: 40 · 2021: 41 · 2020: 42 · 2019: 36 · 2018: 50 · 2017: 47 · 2016: 48 · 2015: 32 · 2014: 30 · 2013: 2
- FWCI
- 3.16
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- Research Explorer (The University of Manchester) (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Research Portal (King's College London) (submittedVersion)
- Funders
- Wellcome Trust (WT088747MA)
- British Heart Foundation (PG/12/36/29444)
- National Institutes of Health
- U.S. Public Health Service (P01NSO38037)
- Medical Research Council (MR/J006742/1)
- National Cancer Institute (R01CA112663, CA112663, ZIABC011431)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Keywords
- T-bet, transcription factors, innate immunity, adaptive immunity, memory CD8+ T cells, B cells, innate lymphoid cells, dendritic cells, natural killer cells, type 1 immune response, transcriptional regulatory networks, immune cell development
- MeSH terms
- T-bet Transcription Factor, Animals, B-Lymphocytes, Humans, Immunity, Innate, Immunologic Memory, T-Lymphocyte Subsets, T-Box Domain Proteins, Adaptive Immunity
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