T-bet: a bridge between innate and adaptive immunity

Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes

Whyte, W. A., Orlando, D. A., Hnisz, D., Abraham, B. J., Lin, C. Y., Kagey, M. H., Rahl, P. B., Lee, T. I., & Young, R. A. (2013) · Cell · doi:10.1016/j.cell.2013.03.035 · Cited by 4,143

A Novel Transcription Factor, T-bet, Directs Th1 Lineage Commitment

Szabo, S. J., Kim, S. T., Costa, G. L., Zhang, X., Fathman, C. G., & Glimcher, L. H. (2000) · Cell · doi:10.1016/s0092-8674(00)80702-3 · Cited by 3,589

The Transcription Factor GATA-3 Is Necessary and Sufficient for Th2 Cytokine Gene Expression in CD4 T Cells

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Innate lymphoid cells — a proposal for uniform nomenclature

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Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection

Blackburn, S. D., Shin, H., Haining, W. N., Zou, T., Workman, C. J., Polley, A., Betts, M. R., Freeman, G. J., Vignali, D. A. A., & Wherry, E. J. (2009) · Nature Immunology · doi:10.1038/ni.1679 · Cited by 2,062

Inflammation Directs Memory Precursor and Short-Lived Effector CD8+ T Cell Fates via the Graded Expression of T-bet Transcription Factor

Joshi, N. S., Cui, W., Chandele, A., Lee, H. K., Urso, D. R., Hagman, J., Gapin, L., & Kaech, S. M. (2007) · Immunity · doi:10.1016/j.immuni.2007.07.010 · Cited by 1,861

Generation of pathogenic TH17 cells in the absence of TGF-β signalling

Ghoreschi, K., Laurence, A., Yang, X.-P., Tato, C. M., McGeachy, M. J., Konkel, J. E., Ramos, H. L., Wei, L., Davidson, T. S., Bouladoux, N., et al. (2010) · Nature · doi:10.1038/nature09447 · Cited by 1,388

Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin

Intlekofer, A. M., Takemoto, N., Wherry, E. J., Longworth, S. A., Northrup, J. T., Palanivel, V., Mullen, A. C., Gasink, C. R., Kaech, S. M., Miller, J. D., et al. (2005) · Nature Immunology · doi:10.1038/ni1268 · Cited by 1,293

The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation

Koch, M. A., Tucker-Heard, G., Perdue, N. R., Killebrew, J. R., Urdahl, K. B., & Campbell, D. J. (2009) · Nature Immunology · doi:10.1038/ni.1731 · Cited by 1,258

Fate mapping of IL-17-producing T cells in inflammatory responses

Hirota, K., Duarte, J. H., Veldhoen, M., Hornsby, E., Li, Y., Cua, D. J., Ahlfors, H., Wilhelm, C., Tolaini, M., Menzel, U., et al. (2011) · Nature Immunology · doi:10.1038/ni.1993 · Cited by 1,176

Induction and molecular signature of pathogenic TH17 cells

Lee, Y., Awasthi, A., Yosef, N., Quintana, F. J., Xiao, S., Peters, A., Wu, C., Kleinewietfeld, M., Kunder, S., Hafler, D. A., et al. (2012) · Nature Immunology · doi:10.1038/ni.2416 · Cited by 1,174

Distinct Effects of T-bet in T H 1 Lineage Commitment and IFN-γ Production in CD4 and CD8 T Cells

Szabo, S. J., Sullivan, B. M., Stemmann, C., Satoskar, A. R., Sleckman, B. P., & Glimcher, L. H. (2002) · Science · doi:10.1126/science.1065543 · Cited by 1,172

A Validated Regulatory Network for Th17 Cell Specification

Ciofani, M., Madar, A., Galan, C., Sellars, M., Mace, K., Pauli, F., Agarwal, A., Huang, W., Parkurst, C. N., Muratet, M., et al. (2012) · Cell · doi:10.1016/j.cell.2012.09.016 · Cited by 1,160

Global Mapping of H3K4me3 and H3K27me3 Reveals Specificity and Plasticity in Lineage Fate Determination of Differentiating CD4+ T Cells

Wei, G., Wei, L., Zhu, J., Zang, C., Hu-Li, J., Yao, Z., Cui, K., Kanno, Y., Roh, T.-Y., Watford, W. T., et al. (2009) · Immunity · doi:10.1016/j.immuni.2008.12.009 · Cited by 1,152

T-bet is a STAT1-induced regulator of IL-12R expression in naïve CD4+ T cells

Afkarian, M., Šedý, J. R., Yang, J., Jacobson, N. G., Cereb, N., Yang, S. Y., Murphy, T. L., & MURPHY, K. M. M. (2002) · Nature Immunology · doi:10.1038/ni794 · Cited by 1,074

Late Developmental Plasticity in the T Helper 17 Lineage

Lee, Y. K., Turner, H., Maynard, C. L., Oliver, J. R., Chen, D., Elson, C. O., & Weaver, C. T. (2009) · Immunity · doi:10.1016/j.immuni.2008.11.005 · Cited by 1,053

Redefining Chronic Viral Infection

Virgin, H. W., Wherry, E. J., & Ahmed, R. (2009) · Cell · doi:10.1016/j.cell.2009.06.036 · Cited by 1,031

Control of Effector CD8 + T Cell Function by the Transcription Factor Eomesodermin

Pearce, E. L., Mullen, A. C., Martins, G. A., Krawczyk, C. M., Hutchins, A. S., Zediak, V. P., Banica, M., DiCioccio, C. B., Gross, D. A., Mao, C.-A., et al. (2003) · Science · doi:10.1126/science.1090148 · Cited by 1,014

Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues

Bernink, J. H., Peters, C. P., Munneke, M., Velde, A. A. T., Meijer, S. L., Weijer, K. C., Hreggvidsdottir, H. S., Heinsbroek, S. E. M., Legrand, N., Buskens, C. J., et al. (2013) · Nature Immunology · doi:10.1038/ni.2534 · Cited by 1,009

Origin and evolution of the adaptive immune system: genetic events and selective pressures

Flajnik, M. F., & Kasahara, M. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2703 · Cited by 972

Communicable Ulcerative Colitis Induced by T-bet Deficiency in the Innate Immune System

Garrett, W. S., Lord, G. M., Punit, S., Lugo‐Villarino, G., Mazmanian, S. K., Ito, S., Glickman, J. N., & Glimcher, L. H. (2007) · Cell · doi:10.1016/j.cell.2007.08.017 · Cited by 915

Intraepithelial Type 1 Innate Lymphoid Cells Are a Unique Subset of IL-12- and IL-15-Responsive IFN-γ-Producing Cells

Fuchs, A. G., Vermi, W., Lee, J. S., Lonardi, S., Gilfillan, S., Newberry, R. D., Cella, M., & Colonna, M. (2013) · Immunity · doi:10.1016/j.immuni.2013.02.010 · Cited by 904

Progenitor and Terminal Subsets of CD8 + T Cells Cooperate to Contain Chronic Viral Infection

Paley, M., Kroy, D. C., Odorizzi, P. M., Johnnidis, J. B., Dolfi, D. V., Barnett, B. E., Bikoff, E. K., Robertson, E. J., Lauer, G. M., Reiner, S. L., et al. (2012) · Science · doi:10.1126/science.1229620 · Cited by 903

Role of T-bet in Commitment of T H 1 Cells Before IL-12-Dependent Selection

Mullen, A. C., High, F. A., Hutchins, A. S., Lee, H. W., Villarino, A. V., Livingston, D. M., Kung, A. L., Cereb, N., Yao, T., Yang, S. Y., et al. (2001) · Science · doi:10.1126/science.1059835 · Cited by 840

Interleukin-2 and Inflammation Induce Distinct Transcriptional Programs that Promote the Differentiation of Effector Cytolytic T Cells

Pipkin, M. E., Sacks, J. A., Cruz‐Guilloty, F., Lichtenheld, M. G., Bevan, M. J., & Rao, A. (2010) · Immunity · doi:10.1016/j.immuni.2009.11.012 · Cited by 817

Enterobacteriaceae Act in Concert with the Gut Microbiota to Induce Spontaneous and Maternally Transmitted Colitis

Garrett, W. S., Gallini, C. A., Yatsunenko, T., Michaud, M., DuBois, A., Delaney, M. L., Punit, S., Karlsson, M., Bry, L., Glickman, J. N., et al. (2010) · Cell Host & Microbe · doi:10.1016/j.chom.2010.08.004 · Cited by 788

T-bet is rapidly induced by interferon-γ in lymphoid and myeloid cells

Lighvani, A. A., Frucht, D. M., Jankovic, D., Yamane, H., Aliberti, J., Hissong, B. D., Nguyen, B. V., Gadina, M., Sher, A., Paul, W. E., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.261570598 · Cited by 783

The Transcription Factors T-bet and Eomes Control Key Checkpoints of Natural Killer Cell Maturation

Gordon, S. M., Chaix, J., Rupp, L. J., Wu, J., Madera, S., Sun, J. C.-Y., Lindsten, T., & Reiner, S. L. (2012) · Immunity · doi:10.1016/j.immuni.2011.11.016 · Cited by 765

A T-bet gradient controls the fate and function of CCR6−RORγt+ innate lymphoid cells

Klose, C. S. N., Kiss, E. A., Schwierzeck, V., Ebert, K., Hoyler, T., d’Hargues, Y., Göppert, N., Croxford, A. L., Waisman, A., Tanriver, Y., et al. (2013) · Nature · doi:10.1038/nature11813 · Cited by 734

T-bet Regulates the Terminal Maturation and Homeostasis of NK and Vα14i NKT Cells

Townsend, M. J., Weinmann, A. S., Matsuda, J. L., Salomon, R., Farnham, P., Biron, C. A., Gapin, L., & Glimcher, L. H. (2004) · Immunity · doi:10.1016/s1074-7613(04)00076-7 · Cited by 722

Innate Lymphoid Cells: Emerging Insights in Development, Lineage Relationships, and Function

Spits, H., & Cupedo, T. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-075053 · Cited by 722

Progressive loss of RORγt expression confers distinct functional fates to natural killer cell receptor-expressing RORγt+ innate lymphocytes

Vonarbourg, C., Mortha, A., Bui, V. L., Hernández, P. P., Kiss, E. A., Hoyler, T., Flach, M., Bengsch, B., Thimme, R., Hölscher, C., et al. (2010) · Immunity · doi:10.1016/j.immuni.2010.10.017 · Cited by 669

The mTOR Kinase Determines Effector versus Memory CD8+ T Cell Fate by Regulating the Expression of Transcription Factors T-bet and Eomesodermin

Rao, R. R., Li, Q., Odunsi, K., & Shrikant, P. A. (2010) · Immunity · doi:10.1016/j.immuni.2009.10.010 · Cited by 656

Transcription factors T-bet and Runx3 cooperate to activate Ifng and silence Il4 in T helper type 1 cells

Djuretic, I. M., Levanon, D., Negreanu, V., Groner, Y., Rao, A., & Ansel, K. M. (2006) · Nature Immunology · doi:10.1038/ni1424 · Cited by 532

TH cell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genes

Avni, O., Lee, D. H., Macián, F., Szabo, S. J., Glimcher, L. H., & Rao, A. (2002) · Nature Immunology · doi:10.1038/ni808 · Cited by 524

T Helper Cell Fate Specified by Kinase-Mediated Interaction of T-bet with GATA-3

Hwang, E. S., Szabo, S. J., Schwartzberg, P. L., & Glimcher, L. H. (2005) · Science · doi:10.1126/science.1103336 · Cited by 519

Runx3 and T-box proteins cooperate to establish the transcriptional program of effector CTLs

Cruz‐Guilloty, F., Pipkin, M. E., Djuretic, I. M., Levanon, D., Lotem, J., Lichtenheld, M. G., Groner, Y., & Rao, A. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20081242 · Cited by 518

Transcription factor T-bet represses expression of the inhibitory receptor PD-1 and sustains virus-specific CD8+ T cell responses during chronic infection

Kao, C., Oestreich, K. J., Paley, M., Crawford, A., Angelosanto, J., Ali, M.-A. A., Intlekofer, A. M., Boss, J. M., Reiner, S. L., Weinmann, A. S., et al. (2011) · Nature Immunology · doi:10.1038/ni.2046 · Cited by 508

T-bet regulates IgG class switching and pathogenic autoantibody production

Peng, S. L., Szabo, S. J., & Glimcher, L. H. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.082114899 · Cited by 498

Modulation of cytokine receptors by IL-2 broadly regulates differentiation into helper T cell lineages

Liao, W., Lin, J.-X., Wang, L., Li, P., & Leonard, W. J. (2011) · Nature Immunology · doi:10.1038/ni.2030 · Cited by 474

Antigen-driven effector CD8 T cell function regulated by T-bet

Sullivan, B. M., Juedes, A. E., Szabo, S. J., von Herrath, M., & Glimcher, L. H. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2636938100 · Cited by 439

Cutting Edge: The Transcription Factor Eomesodermin Enables CD8+ T Cells To Compete for the Memory Cell Niche

Banerjee, A., Gordon, S. M., Intlekofer, A. M., Paley, M., Mooney, E. C., Lindsten, T., Wherry, E. J., & Reiner, S. L. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1002042 · Cited by 429

Opposing Signals from the Bcl6 Transcription Factor and the Interleukin-2 Receptor Generate T Helper 1 Central and Effector Memory Cells

Pepper, M., Pagán, A. J., Igyártó, B. Z., Taylor, J. J., & Jenkins, M. K. (2011) · Immunity · doi:10.1016/j.immuni.2011.09.009 · Cited by 425

Early Th1 Cell Differentiation Is Marked by a Tfh Cell-like Transition

Nakayamada, S., Kanno, Y., Takahashi, H., Jankovic, D. L., Lu, K. T., Johnson, T. A., Sun, H., Vahedi, G., Hakim, O., Handon, R., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.11.012 · Cited by 417

Anomalous Type 17 Response to Viral Infection by CD8 + T Cells Lacking T-bet and Eomesodermin

Intlekofer, A. M., Banerjee, A., Takemoto, N., Gordon, S. M., DeJong, C. S., Shin, H., Hunter, C. A., Wherry, E. J., Lindsten, T., & Reiner, S. L. (2008) · Science · doi:10.1126/science.1159806 · Cited by 410

T-bet represses TH17 differentiation by preventing Runx1-mediated activation of the gene encoding RORγt

Lazarevic, V., Chen, X., Shim, J., Hwang, E. S., Jang, E., Bolm, A. N., Oukka, M., Kuchroo, V. K., & Glimcher, L. H. (2010) · Nature Immunology · doi:10.1038/ni.1969 · Cited by 410

STATs Shape the Active Enhancer Landscape of T Cell Populations

Vahedi, G., Takahashi, H., Nakayamada, S., Sun, H., Sartorelli, V., Kanno, Y., & O’Shea, J. J. (2012) · Cell · doi:10.1016/j.cell.2012.09.044 · Cited by 380

Jmjd3 and UTX Play a Demethylase-Independent Role in Chromatin Remodeling to Regulate T-Box Family Member-Dependent Gene Expression

Miller, S. A., Mohn, S. E., & Weinmann, A. S. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.10.028 · Cited by 373

MicroRNA-29 Regulates T-Box Transcription Factors and Interferon-γ Production in Helper T Cells

Steiner, D. F., Thomas, M. F., Hu, J. K., Yang, Z., Babiarz, J., Allen, C. D. C., Matloubian, M., Blelloch, R. H., & Ansel, K. M. (2011) · Immunity · doi:10.1016/j.immuni.2011.07.009 · Cited by 365

The Cytokines Interleukin 27 and Interferon-γ Promote Distinct Treg Cell Populations Required to Limit Infection-Induced Pathology

Hall, A. O., Beiting, D. P., Tato, C. M., John, B., Oldenhove, G., Lombana, C., Pritchard, G. H., Silver, J. S., Bouladoux, N. J., Stumhofer, J. S., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.06.014 · Cited by 354

T-bet and GATA3 orchestrate Th1 and Th2 differentiation through lineage-specific targeting of distal regulatory elements

Kanhere, A., Hertweck, A., Bhatia, U., Gökmen, M. R., Perucha, E., Jackson, I., Lord, G. M., & Jenner, R. G. (2012) · Nature Communications · doi:10.1038/ncomms2260 · Cited by 345

Interferons Direct Th2 Cell Reprogramming to Generate a Stable GATA-3+T-bet+ Cell Subset with Combined Th2 and Th1 Cell Functions

Hegazy, A. N., Peine, C., Helmstetter, C., Panse, I., Fröhlich, A., Bergthaler, A., Flatz, L., Pinschewer, D. D., Radbruch, A., & Löhning, M. (2010) · Immunity · doi:10.1016/j.immuni.2009.12.004 · Cited by 341

Cutting Edge: IL-12 Inversely Regulates T-bet and Eomesodermin Expression during Pathogen-Induced CD8+ T Cell Differentiation

Takemoto, N., Intlekofer, A. M., Northrup, J. T., Wherry, E. J., & Reiner, S. L. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.11.7515 · Cited by 339

Genome-wide Analyses of Transcription Factor GATA3-Mediated Gene Regulation in Distinct T Cell Types

Wei, G., Abraham, B. J., Yagi, R., Jothi, R., Cui, K., Sharma, S., Narlikar, L., Northrup, D. L., Tang, Q., Paul, W. E., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.08.007 · Cited by 337

Distinct Memory CD4+ T Cells with Commitment to T Follicular Helper- and T Helper 1-Cell Lineages Are Generated after Acute Viral Infection

Hale, J. S., Youngblood, B., Latner, D. R., Mohammed, A. U. R., Ye, L., Akondy, R. S., Wu, T., Iyer, S. S., & Ahmed, R. (2013) · Immunity · doi:10.1016/j.immuni.2013.02.020 · Cited by 336

Dual nature of the adaptive immune system in lampreys

Guo, P., Hirano, M., Herrin, B. R., Li, J., Yu, C., Sadlonova, A., & Cooper, M. D. (2009) · Nature · doi:10.1038/nature08068 · Cited by 336

The Transcription Factor T-bet Is Induced by Multiple Pathways and Prevents an Endogenous Th2 Cell Program during Th1 Cell Responses

Zhu, J., Jankovic, D., Oler, A. J., Wei, G., Sharma, S., Hu, G., Guo, L., Yagi, R., Yamane, H., Punkosdy, G., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.09.007 · Cited by 335

The Transcription Factor T-bet Regulates Intestinal Inflammation Mediated by Interleukin-7 Receptor+ Innate Lymphoid Cells

Powell, N., Walker, A. W., Stolarczyk, É., Canavan, J. B., Gökmen, R., Marks, E., Jackson, I., Hashim, A., Curtis, M. A., Jenner, R. G., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.09.008 · Cited by 322

Molecular mechanisms that control the expression and activity of Bcl-6 in TH1 cells to regulate flexibility with a TFH-like gene profile

Oestreich, K. J., Mohn, S. E., & Weinmann, A. S. (2012) · Nature Immunology · doi:10.1038/ni.2242 · Cited by 321

Hlx is induced by and genetically interacts with T-bet to promote heritable TH1 gene induction

Mullen, A. C., Hutchins, A. S., High, F. A., Lee, H. W., Sykes, K. J., Chodosh, L. A., & Reiner, S. L. (2002) · Nature Immunology · doi:10.1038/ni807 · Cited by 308

Transcription Factor Foxo1 Represses T-bet-Mediated Effector Functions and Promotes Memory CD8+ T Cell Differentiation

Rao, R. R., Li, Q., Bupp, M. G., & Shrikant, P. A. (2012) · Immunity · doi:10.1016/j.immuni.2012.01.015 · Cited by 305

Differential Expression of Ly6C and T-bet Distinguish Effector and Memory Th1 CD4+ Cell Properties during Viral Infection

Marshall, H. D., Chandele, A., Jung, Y. W., Meng, H., Poholek, A. C., Parish, I. A., Rutishauser, R. L., Cui, W., Kleinstein, S. H., Craft, J. E., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.08.016 · Cited by 299

Requirement for T-bet in the aberrant differentiation of unhelped memory CD8+ T cells

Intlekofer, A. M., Takemoto, N., Kao, C., Banerjee, A., Schambach, F., Northrop, J. K., Shen, H., Wherry, E. J., & Reiner, S. L. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070841 · Cited by 288

T-bet is essential for encephalitogenicity of both Th1 and Th17 cells

Yang, Y., Weiner, J., Liu, Y., Smith, A. J., Huss, D. J., Winger, R. C., Peng, H., Cravens, P. D., Racke, M. K., & Lovett‐Racke, A. E. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20082584 · Cited by 286

Epigenetic Instability of Cytokine and Transcription Factor Gene Loci Underlies Plasticity of the T Helper 17 Cell Lineage

Mukasa, R., Balasubramani, A., Lee, Y. K., Whitley, S. K., Weaver, B. T., Shibata, Y., Crawford, G. E., Hatton, R. D., & Weaver, C. T. (2010) · Immunity · doi:10.1016/j.immuni.2010.04.016 · Cited by 284

Sequential Polarization and Imprinting of Type 1 T Helper Lymphocytes by Interferon-γ and Interleukin-12

Schulz, E. G., Mariani, L., Radbruch, A., & Höfer, T. (2009) · Immunity · doi:10.1016/j.immuni.2009.03.013 · Cited by 280

T-bet is required for optimal proinflammatory CD4+ T-cell trafficking

Lord, G. M. (2005) · Blood · doi:10.1182/blood-2005-04-1393 · Cited by 270

Functional and Epigenetic Studies Reveal Multistep Differentiation and Plasticity of In Vitro-Generated and In Vivo-Derived Follicular T Helper Cells

Lu, K. T., Kanno, Y., Cannons, J. L., Handon, R., Bible, P. W., Elkahloun, A. G., Anderson, S. M., Wei, L., Sun, H., O’Shea, J. J., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.07.015 · Cited by 269

T-bet is required for optimal production of IFN-γ and antigen-specific T cell activation by dendritic cells

Lugo‐Villarino, G., Maldonado-López, R., Possemato, R., Peñaranda, C., & Glimcher, L. H. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1332767100 · Cited by 269

T-bet+ Treg Cells Undergo Abortive Th1 Cell Differentiation due to Impaired Expression of IL-12 Receptor β2

Koch, M. A., Thomas, K. R., Perdue, N., Smigiel, K. S., Srivastava, S., & Campbell, D. (2012) · Immunity · doi:10.1016/j.immuni.2012.05.031 · Cited by 260

The transcription factors T-bet and GATA-3 control alternative pathways of T-cell differentiation through a shared set of target genes

Jenner, R. G., Townsend, M. J., Jackson, I., Sun, K., Bouwman, R. D., Young, R. A., Glimcher, L. H., & Lord, G. M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909357106 · Cited by 252

Signal Transducer and Activator of Transcription 4 Is Required for the Transcription Factor T-bet to Promote T Helper 1 Cell-Fate Determination

Thieu, V. T., Yu, Q., Chang, H., Yeh, N., Nguyen, E., Sehra, S., & Kaplan, M. H. (2008) · Immunity · doi:10.1016/j.immuni.2008.08.017 · Cited by 244

A Distal Conserved Sequence Element Controls Ifng Gene Expression by T Cells and NK Cells

Hatton, R. D., Harrington, L. E., Luther, R. J., Wakefield, T., Janowski, K. M., Oliver, J. R., Lallone, R. L., MURPHY, K. M. M., & Weaver, C. T. (2006) · Immunity · doi:10.1016/j.immuni.2006.09.007 · Cited by 191

Asymmetric Proteasome Segregation as a Mechanism for Unequal Partitioning of the Transcription Factor T-bet during T Lymphocyte Division

Chang, J. T., Ciocca, M. L., Kinjyo, I., Palanivel, V., McClurkin, C. E., DeJong, C. S., Mooney, E. C., Kim, J. S., Steinel, N. C., Oliaro, J., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.03.017 · Cited by 189

miR-29ab1 Deficiency Identifies a Negative Feedback Loop Controlling Th1 Bias That Is Dysregulated in Multiple Sclerosis

Smith, K. M., Guerau‐de‐Arellano, M., Costinean, S., Williams, J. L., Bottoni, A., Cox, G. M., Satoskar, A. R., Croce, C. M., Racke, M. K., Lovett‐Racke, A. E., et al. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1103171 · Cited by 183

The Transcription Factor GATA3 Actively Represses RUNX3 Protein-Regulated Production of Interferon-γ

Yagi, R., Junttila, I., Wei, G., Urban, J. F., Zhao, K., Paul, W. E., & Zhu, J. (2010) · Immunity · doi:10.1016/j.immuni.2010.04.004 · Cited by 179

Distinct requirements for T-bet in gut innate lymphoid cells

Sciumè, G., Hirahara, K., Takahashi, H., Laurence, A. D. J., Villarino, A. V., Singleton, K. L., Spencer, S. P., Wilhelm, C., Poholek, A. C., Vahedi, G., et al. (2012) · The Journal of Experimental Medicine · doi:10.1084/jem.20122097 · Cited by 177

Divergent transcriptional programming of class-specific B cell memory by T-bet and RORα

Wang, N. S., McHeyzer‐Williams, L. J., Okitsu, S. L., Burris, T. P., Reiner, S. L., & McHeyzer‐Williams, M. G. (2012) · Nature Immunology · doi:10.1038/ni.2294 · Cited by 170

IL-2 production in developing Th1 cells is regulated by heterodimerization of RelA and T-bet and requires T-bet serine residue 508

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The lineage-defining factors T-bet and Bcl-6 collaborate to regulate Th1 gene expression patterns

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Colitis-Associated Colorectal Cancer Driven by T-bet Deficiency in Dendritic Cells

Garrett, W. S., Punit, S., Gallini, C. A., Michaud, M., Zhang, D., Sigrist, K. S., Lord, G. M., Glickman, J. N., & Glimcher, L. H. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.07.015 · Cited by 155

Expression of T-bet by CD4 T Cells Is Essential for Resistance to Salmonella Infection

Ravindran, R., Foley, J., Stoklasek, T. A., Glimcher, L. H., & McSorley, S. J. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.7.4603 · Cited by 153

Coordinated but physically separable interaction with H3K27-demethylase and H3K4-methyltransferase activities are required for T-box protein-mediated activation of developmental gene expressionPreprint

Miller, S. A., Huang, A. C., Miazgowicz, M. M., Brassil, M. M., & Weinmann, A. S. (2008) · Genes & Development · doi:10.1101/gad.1689708 · Cited by 150

CCCTC-Binding Factor and the Transcription Factor T-bet Orchestrate T Helper 1 Cell-Specific Structure and Function at the Interferon-γ Locus

Sekimata, M., Pérez‐Melgosa, M., Miller, S. A., Weinmann, A. S., Sabo, P. J., Sandstrom, R. S., Dorschner, M. O., Stamatoyannopoulos, J. A., & Wilson, C. B. (2009) · Immunity · doi:10.1016/j.immuni.2009.08.021 · Cited by 149

T-bet concomitantly controls migration, survival, and effector functions during the development of Vα14i NKT cells

Matsuda, J. L., Zhang, Q., Ndonye, R. M., Richardson, S. K., Howell, A. R., & Gapin, L. (2005) · Blood · doi:10.1182/blood-2005-08-3103 · Cited by 145

T-bet is a critical determinant in the instability of the IL-17-secreting T-helper phenotype

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Induction of IgG2a Class Switching in B Cells by IL-27

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Increased Susceptibility of Mice Lacking T-bet to Infection with Mycobacterium tuberculosis Correlates with Increased IL-10 and Decreased IFN-γ Production

Sullivan, B. M., Jobe, O., Lazarevic, V., Vasquez, K. O., Bronson, R. T., Glimcher, L. H., & Kramnik, I. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.7.4593 · Cited by 139

Evolutionarily conserved sequence elements that positively regulate IFN-γ expression in T cells

Shnyreva, M., Weaver, W. M., Blanchette, M., Taylor, S. L., Tompa, M., Fitzpatrick, D. R., & Wilson, C. B. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400849101 · Cited by 137

STAT1-Activating Cytokines Limit Th17 Responses through Both T-bet–Dependent and –Independent Mechanisms

Villarino, A. V., Gallo, E., & Abbas, A. K. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001343 · Cited by 136

Transcription factor T-bet regulates inflammatory arthritis through its function in dendritic cells

Wang, J. H. (2006) · Journal of Clinical Investigation · doi:10.1172/jci26631 · Cited by 121

Modular Utilization of Distal cis-Regulatory Elements Controls Ifng Gene Expression in T Cells Activated by Distinct Stimuli

Balasubramani, A., Shibata, Y., Crawford, G. E., Baldwin, A. S., Hatton, R. D., & Weaver, C. T. (2010) · Immunity · doi:10.1016/j.immuni.2010.07.004 · Cited by 103

T-Bet Expression and Failure of GATA-3 Cross-Regulation Lead to Default Production of IFN-γ by γδ T Cells

Yin, Z., Chen, C.-H., Szabo, S. J., Glimcher, L. H., Ray, A., & Craft, J. E. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.4.1566 · Cited by 103

Increased numbers of pre-existing memory CD8 T cells and decreased T-bet expression can restrain terminal differentiation of secondary effector and memory CD8 T cells

Joshi, N., Cui, W., Dominguez, C. X., Chen, J. H., Hand, T., & Kaech, S. (2011) · Journal of Immunology · doi:10.4049/jimmunol.1002145 · Cited by 94

T-Bet Plays a Key Role in NK-Mediated Control of Melanoma Metastatic Disease

Werneck, M. B. F., Lugo‐Villarino, G., Hwang, E. S., Cantor, H., & Glimcher, L. H. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.12.8004 · Cited by 84

Molecular mechanisms by which T‐bet regulates T‐helper cell commitment

Miller, S. A., & Weinmann, A. S. (2010) · Immunological Reviews · doi:10.1111/j.1600-065x.2010.00952.x · Cited by 80

Stat1-Dependent Synergistic Activation of T-bet for IgG2a Production during Early Stage of B Cell Activation

Xu, W., & Zhang, J. J. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.11.7419 · Cited by 70

Epigenetic and Transcriptional Programs Lead to Default IFN-γ Production by γδ T Cells

Chen, L., He, W., Kim, S. T., Tao, J., Gao, Y., Chi, H., Intlekofer, A. M., Harvey, B. P., Reiner, S. L., Yin, Z., et al. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.5.2730 · Cited by 69

The adjuvant activity of CpG DNA requires T-bet expression in dendritic cells

Lugo‐Villarino, G., Ito, S.-I., Klinman, D. M., & Glimcher, L. H. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506638102 · Cited by 60

Dendritic cell expression of the transcription factor T-bet regulates mast cell progenitor homing to mucosal tissue

Alcaide, P., Jones, T. G., Lord, G. M., Glimcher, L. H., Hallgren, J., Arinobu, Y., Akashi, K., Paterson, A. M., Gurish, M. A., & Luscinskas, F. W. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20060626 · Cited by 47

The Ets-1 transcription factor is required for Stat1-mediated T-bet expression and IgG2a class switching in mouse B cells

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CD8 T cells induce T-bet–dependent migration toward CXCR3 ligands by differentiated B cells produced during responses to alum-protein vaccines

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Lysine 313 of T-box Is Crucial for Modulation of Protein Stability, DNA Binding, and Threonine Phosphorylation of T-bet

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The Development of Airway Hyperreactivity in T-bet-Deficient Mice Requires CD1d-Restricted NKT Cells

Kim, H. Y., Pichavant, M., Matangkasombut, P., Koh, Y., Savage, P. B., DeKruyff, R. H., & Umetsu, D. T. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803339 · Cited by 34

Evolution of developmental functions by the Eomesodermin, T‐brain‐1, Tbx21 subfamily of T‐box genes: insights from amphioxus

Horton, A. C., & Gibson‐Brown, J. J. (2002) · Journal of Experimental Zoology · doi:10.1002/jez.10151 · Cited by 32

Inflammatory Bowel Disease — Live Transmission

Hecht, G. A. (2008) · New England Journal of Medicine · doi:10.1056/nejmcibr0707718 · Cited by 27

Transcriptional regulation of the mucosal immune system mediated by T-bet

Powell, N., Canavan, J. B., MacDonald, T. T., & Lord, G. M. (2010) · Mucosal Immunology · doi:10.1038/mi.2010.53 · Cited by 22

Cytokines in inflammatory bowel disease

Neurath, M. F. (2014) · Nature Reviews Immunology · doi:10.1038/nri3661 · Cited by 2,706

Interleukins in cancer: from biology to therapy

Briukhovetska, D., Dörr, J., Endres, S., Libby, P., Dinarello, C. A., & Kobold, S. (2021) · Nature reviews. Cancer · doi:10.1038/s41568-021-00363-z · Cited by 822

Attacking the PI3K/Akt/mTOR signaling pathway for targeted therapeutic treatment in human cancer

Yu, L., Wei, J., & Liu, P. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.06.019 · Cited by 818

MAP Kinase Inhibition Promotes T Cell and Anti-tumor Activity in Combination with PD-L1 Checkpoint Blockade.

Ebert, P. J. R., Cheung, J., Yang, Y., McNamara, E., Hong, R., Moskalenko, M., Gould, S. E., Maecker, H., Irving, B. A., Kim, J. M., et al. (2016) · Immunity · doi:10.1016/j.immuni.2016.01.024 · Cited by 713

The foundations of immune checkpoint blockade and the ipilimumab approval decennial

Korman, A. J., Garrett-Thomson, S. C., & Lönberg, N. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-021-00345-8 · Cited by 572

Transcription Factor T-bet Orchestrates Lineage Development and Function in the Immune System

Kallies, A., & Good‐Jacobson, K. L. (2017) · Trends in Immunology · doi:10.1016/j.it.2017.02.003 · Cited by 159

T-bet in the spot light: roles in distinct T-cell fate determination

Jayaraman, S. (2013) · Cellular and Molecular Immunology · doi:10.1038/cmi.2013.18 · Cited by 7

Transcription factor T-bet in immunocyte and autoimmune diseases

Ren, M. (2009) · Anhui Medical and Pharmaceutical Journal

Morphologische und funktionelle Untersuchungen zur Rolle des Transkriptionsfaktors T-bet in erregerbedingten Lymphknotenerkrankungen, Autoimmunerkrankungen und malignen Lymphomen

Jöhrens, K. (2012) · Universitätsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver · doi:10.17169/refubium-11367

The T-box transcription factor T-bet in immunity and autoimmunity.

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