Triggering of NOD2 Receptor Converts Inflammatory Ly6Chigh into Ly6Clow Monocytes with Patrolling Properties
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The signals that regulate the fate of circulating monocytes remain unknown. In the present study, we demonstrate that triggering of the NOD2 receptor by muramyl dipeptide (MDP) converts inflammatory Ly6C high monocytes into patrolling Ly6C low monocytes. Administration of MDP to Nr4a1 −/− mice, which lack Ly6C low monocytes, or to Ly6C low -depleted mice led to the emergence of blood-patrolling monocytes with a profile similar to that of Ly6C low monocytes, including high expression of CX3CR1 and LFA1. Using intravital microscopy in animal models of inflammatory diseases, we also found that converted Ly6C high monocytes patrol the endothelium of blood vessels and that their presence contributes to a reduction in the inflammatory response following MDP injection. Our results demonstrate that NOD2 contributes to the regulation of blood monocytes and suggest that it could be therapeutically targeted to treat inflammatory diseases.
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Prior work has linked NOD2 activation to an increase in circulating Cx3cr1+ monocytes with patrolling-like activity.
“NOD2 activation has previously been linked to a similar increase of Cx3cr1+ monocytes with patrolling-like activities in circulation (32)”
From <i>Enterococcus</i> peptidoglycan remodeling promotes checkpoint inhibitor cancer immunotherapy (2021) · cites this paper as [32]
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- Authors
- Lessard, A.-J., LeBel, M., Egarnes, B., Préfontaine, P., Thériault, P., Droit, A., Brunet, A., Rivest, S., & Gosselin, J.
- Affiliations
- Centre de recherche du CHU de Québec-Université Laval (CA)
- Université Laval (CA)
- Corresponding author
- Gosselin, Jean
- Venue
- Cell Reports
- Publisher
- Elsevier BV
- Published
- 2017-08
- Volume
- 20
- Issue
- 8
- Pages
- 1830-1843
- ISSN
- 2211-1247 (ISSN-L)
- OpenAlex
- W2749762170
- Cited by
- 70
- References
- 48
- Citations by year
- 2026: 8 · 2025: 4 · 2024: 9 · 2023: 10 · 2022: 9 · 2021: 15 · 2020: 7 · 2019: 4 · 2018: 4
- FWCI
- 1.86
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Cell Reports (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- Canadian Institutes of Health Research (MOP-123440, MOP-142304)
- Canadian Research Chair in Neuroimmunology (950-231099)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Keywords
- muramyl dipeptide, Ly6Chi monocytes, non-classical monocytes, Nur77, CX3CR1, LFA-1, inflammation, intravital microscopy, endothelium, inflammatory diseases, therapeutic targeting
- MeSH terms
- Animals, Antigens, Ly, Humans, Mice, Inbred C57BL, Mice, Transgenic, Monocytes, Mice, Nod2 Signaling Adaptor Protein
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