Human genetic variation and the gut microbiome in disease

Structure, function and diversity of the healthy human microbiome

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Diet rapidly and reproducibly alters the human gut microbiome

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A core gut microbiome in obese and lean twins

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Changes of Intestinal Functions in Liver Cirrhosis

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Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

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Revised Estimates for the Number of Human and Bacteria Cells in the Body

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A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

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Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases

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Cross-talk between <i>Akkermansia muciniphila</i> and intestinal epithelium controls diet-induced obesity

Everard, A., Belzer, C., Geurts, L., Ouwerkerk, J. P., Druart, C., Bindels, L. B., Guiot, Y., Derrien, M., Muccioli, G. G., Delzenne, N. M., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1219451110 · Cited by 4,511 · see citing works

Unravelling the pathogenesis of inflammatory bowel disease

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Gut Microbiota from Twins Discordant for Obesity Modulate Metabolism in Mice

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Evolution of mammals and their gut microbes

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The Treatment-Naive Microbiome in New-Onset Crohn’s Disease

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Human Genetics Shape the Gut Microbiome

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Genetics and pathogenesis of inflammatory bowel disease

Khor, B., Gardet, A., & Xavier, R. J. (2011) · Nature · doi:10.1038/nature10209 · Cited by 2,629 · see citing works

Gut biogeography of the bacterial microbiota

Donaldson, G. P., Lee, S. M., & Mazmanian, S. K. (2016) · Nature Reviews Microbiology · doi:10.1038/nrmicro3552 · Cited by 2,535 · see citing works

Nod2 Is a General Sensor of Peptidoglycan through Muramyl Dipeptide (MDP) Detection

Girardin, S. E., Boneca, I. G., Viala, J., Chamaillard, M., Labigne-Roussel, A., Thomas, G. D., Philpott, D. J., & Sansonetti, P. J. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.c200651200 · Cited by 2,397 · see citing works

Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist

Sayin, S. I., Wahlström, A., Felin, J., Jäntti, S., Marschall, H.-U., Bamberg, K., Angelin, B., Hyötyläinen, T., Orešič, M., & Bäckhed, F. (2013) · Cell Metabolism · doi:10.1016/j.cmet.2013.01.003 · Cited by 2,331 · see citing works

The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria

Johansson, M. E. V., Phillipson, M., Petersson, J., Velcich, A., Holm, L., & Hansson, G. C. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803124105 · Cited by 2,200 · see citing works

Akkermansia muciniphila gen. nov., sp. nov., a human intestinal mucin-degrading bacterium

Derrien, M., Vaughan, E. E., Plugge, C. M., & de Vos, W. M. (2004) · International Journal of Systematic and Evolutionary Microbiology · doi:10.1099/ijs.0.02873-0 · Cited by 2,094 · see citing works

The Long-Term Stability of the Human Gut Microbiota

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Nod2-Dependent Regulation of Innate and Adaptive Immunity in the Intestinal Tract

Kobayashi, K. S., Chamaillard, M., Ogura, Y., Henegariu, O., Inohara, N., Núñez, G., & Flavell, R. A. (2005) · Science · doi:10.1126/science.1104911 · Cited by 1,776 · see citing works

Metagenomic microbial community profiling using unique clade-specific marker genes

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Host Recognition of Bacterial Muramyl Dipeptide Mediated through NOD2

Inohara, N., Ogura, Y., Fontalba, A., Gutierrez, O., Pons, F., Crespo, J., Fukase, K., Inamura, S., Kusumoto, S., Hashimoto, M., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.c200673200 · Cited by 1,694 · see citing works

The Framingham Heart Study and the epidemiology of cardiovascular disease: a historical perspective

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Convergent adaptation of human lactase persistence in Africa and Europe

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New genetic loci link adipose and insulin biology to body fat distribution

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Unravelling the effects of the environment and host genotype on the gut microbiome

Spor, A., Koren, O., & Ley, R. (2011) · Nature Reviews Microbiology · doi:10.1038/nrmicro2540 · Cited by 1,509 · see citing works

CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands

Lamas, B., Richard, M. L., Leducq, V., Pham, H.-P., Michel, M.-L., Da Costa, G., Bridonneau, C., Jegou, S., Hoffmann, T. W., Natividad, J. M., et al. (2016) · Nature Medicine · doi:10.1038/nm.4102 · Cited by 1,482 · see citing works

Transkingdom Control of Microbiota Diurnal Oscillations Promotes Metabolic Homeostasis

Thaiss, C. A., Zeevi, D., Levy, M., Zilberman-Schapira, G., Suez, J., Tengeler, A. C., Abramson, L., Katz, M. N., Korem, T., Zmora, N., et al. (2014) · Cell · doi:10.1016/j.cell.2014.09.048 · Cited by 1,449 · see citing works

Mucolytic Bacteria With Increased Prevalence in IBD Mucosa Augment In Vitro Utilization of Mucin by Other Bacteria

Png, C. W., Lindén, S. K., Gilshenan, K. S., Zoetendal, E. G., McSweeney, C. S., Sly, L. I., McGuckin, M. A., & Florin, T. H. J. (2010) · American Journal of Gastroenterology · doi:10.1038/ajg.2010.281 · Cited by 1,364 · see citing works

The composition of the gut microbiota throughout life, with an emphasis on early life

Rodríguez, J. M., Murphy, K., Stanton, C., Ross, R. P., Kober, O. I., Juge, N., Avershina, E., Rudi, K., Narbad, A., Jenmalm, M. C., et al. (2015) · Microbial Ecology in Health and Disease · doi:10.3402/mehd.v26.26050 · Cited by 1,320 · see citing works

Human susceptibility and resistance to Norwalk virus infection

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Diet dominates host genotype in shaping the murine gut microbiota

Carmody, R. N., Gerber, G. K., Luevano, J. M., Gatti, D. M., Somes, L., Svenson, K. L., & Turnbaugh, P. J. (2015) · Cell Host &amp; Microbe · doi:10.1016/j.chom.2014.11.010 · Cited by 1,103 · see citing works

Association between insertion mutation in NOD2 gene and Crohn's disease in German and British populations

Hampe, J., Cuthbert, A. P., Croucher, P. J. P., Mirza, M. M., Mascheretti, S., Fisher, S. A., Frenzel, H., King, K., Hasselmeyer, A., Macpherson, A. J., et al. (2001) · The Lancet · doi:10.1016/s0140-6736(00)05063-7 · Cited by 1,090 · see citing works

Interactions between commensal fungi and the C-type lectin receptor Dectin-1 influence colitis

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Metabolic Reconstruction for Metagenomic Data and Its Application to the Human Microbiome

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Genetic determinants of the gut microbiome in UK twins

Goodrich, J. K., Davenport, E. R., Beaumont, M., Jackson, M. A., Knight, R., Ober, C., Spector, T. D., Bell, J. T., Clark, A. G., & Ley, R. E. (2016) · Cell Host &amp; Microbe · doi:10.1016/j.chom.2016.04.017 · Cited by 1,048 · see citing works

Natural history of the infant gut microbiome and impact of antibiotic treatment on bacterial strain diversity and stability

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Ecology drives a global network of gene exchange connecting the human microbiome

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Mapping of a susceptibility locus for Crohn's disease on chromosome 16

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Mucin glycan foraging in the human gut microbiome

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NOD2 (CARD15) mutations in Crohn’s disease are associated with diminished mucosal α-defensin expression

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Inflammation, antibiotics, and diet as environmental stressors of the gut microbiome in pediatric Crohn's disease

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The effect of host genetics on the gut microbiome

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The host shapes the gut microbiota via fecal microRNA

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Host genetic variation impacts microbiome composition across human body sites

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Aberrant expansion of segmented filamentous bacteria in IgA-deficient gut

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Intestinal Integrity and <i>Akkermansia muciniphila</i> , a Mucin-Degrading Member of the Intestinal Microbiota Present in Infants, Adults, and the Elderly

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Comparison of fermentation reactions in different regions of the human colon

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NOD proteins: regulators of inflammation in health and disease

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The Mucin Degrader Akkermansia muciniphila Is an Abundant Resident of the Human Intestinal Tract

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Genome-wide association analysis identifies variation in vitamin D receptor and other host factors influencing the gut microbiota

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Campylobacter jejuni Binds Intestinal H(O) Antigen (Fucα1, 2Galβ1, 4GlcNAc), and Fucosyloligosaccharides of Human Milk Inhibit Its Binding and Infection

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NOD2-mediated dysbiosis predisposes mice to transmissible colitis and colorectal cancer

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Sequence and Expression of a Candidate for the Human Secretor Blood Group α(1,2)Fucosyltransferase Gene (FUT2)

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Cospeciation of gut microbiota with hominids

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Nod2 is required for the regulation of commensal microbiota in the intestine

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The outer mucus layer hosts a distinct intestinal microbial niche

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Fucose sensing regulates bacterial intestinal colonization

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Evolutionary Relationships of Wild Hominids Recapitulated by Gut Microbial Communities

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Advances in inflammatory bowel disease pathogenesis: linking host genetics and the microbiome

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Association of host genome with intestinal microbial composition in a large healthy cohort

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α‐Defensins in human innate immunity

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The Genome of Akkermansia muciniphila, a Dedicated Intestinal Mucin Degrader, and Its Use in Exploring Intestinal Metagenomes

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Complex host genetics influence the microbiome in inflammatory bowel disease

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Antimicrobial peptide resistance mediates resilience of prominent gut commensals during inflammation

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Genetic and environmental control of host-gut microbiota interactions

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The Environmental Determinants of Diabetes in the Young (TEDDY) study: study design

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Bacteria from Diverse Habitats Colonize and Compete in the Mouse Gut

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Synergistic stimulation of human monocytes and dendritic cells by Toll-like receptor 4 and NOD1- and NOD2-activating agonists

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Shotgun Metagenomics of 250 Adult Twins Reveals Genetic and Environmental Impacts on the Gut Microbiome

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Human Symbionts Use a Host-Like Pathway for Surface Fucosylation

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Adherent-invasive Escherichia coli in inflammatory bowel disease

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An integrative view of microbiome-host interactions in inflammatory bowel diseases

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Genetically dictated change in host mucus carbohydrate landscape exerts a diet-dependent effect on the gut microbiota

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Akkermansia muciniphila mediates negative effects of IFNγ on glucose metabolism

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Crohn disease–associated adherent-invasive E. coli bacteria target mouse and human Peyer’s patches via long polar fimbriae

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