Cited by 1,223Phagocytosis and Immune RegulationCell death mechanisms and regulationAutophagy in Disease and Therapy

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Apoptotic cell clearance: basic biology and therapeutic potential

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Poon, Ivan K. H., Lucas, Christopher D., Rossi, Adriano G., Ravichandran, Kodi S.·2014·Nature Reviews Immunology

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Abstract

The prompt removal of apoptotic cells by phagocytes is important for maintaining tissue homeostasis. The molecular and cellular events that underpin apoptotic cell recognition and uptake, and the subsequent biological responses, are increasingly better defined. The detection and disposal of apoptotic cells generally promote an anti-inflammatory response at the tissue level, as well as immunological tolerance. Consequently, defects in apoptotic cell clearance have been linked with various inflammatory diseases and autoimmunity. Conversely, under certain conditions, such as the killing of tumour cells by specific cell-death inducers, the recognition of apoptotic tumour cells can promote an immunogenic response and antitumour immunity. Here, we review the current understanding of the complex process of apoptotic cell clearance in physiology and pathology, and discuss how this knowledge could be harnessed for new therapeutic strategies.

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Authors: Poon, I. K. H., Lucas, C. D., Rossi, A. G., & Ravichandran, K. S.
Affiliations: La Trobe University (AU)
Centre for Inflammation Research (GB)
University of Virginia (US)
Corresponding author: Rossi, Adriano G.
Ravichandran, Kodi S.
ORCID: Poon, Ivan K. H.
Lucas, Christopher D.
Rossi, Adriano G.
Ravichandran, Kodi S.
Venue: Nature Reviews Immunology
Publisher: Springer Science and Business Media LLC
Published: 2014-01-31
Volume: 14
Issue: 3
Pages: 166-180
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/nri3607
PMC: PMC4040260
OpenAlex: W2150334056
Cited by: 1,223
References: 197
Citations by year: 2026: 69 · 2025: 87 · 2024: 100 · 2023: 97 · 2022: 112 · 2021: 120 · 2020: 115 · 2019: 97 · 2018: 106 · 2017: 106 · 2016: 101 · 2015: 87 · 2014: 23
FWCI: 10.31
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, other-oa)
Funders: Wellcome Trust (WT094415)
Medical Research Council (MR/K013386/1)
National Institute of Mental Health (R01MH096484, MH096484)
National Institute of General Medical Sciences (GM-64709, R01GM107848, R01GM064709, GM107848)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD074981, R01HD074981)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Keywords: efferocytosis, phagocytes, apoptotic cell recognition, tissue homeostasis, immune tolerance, inflammation, autoimmunity, immunogenic cell death, antitumor immunity
MeSH terms: Animals, Humans, Immune Tolerance, Inflammation, Lupus Erythematosus, Systemic, Macrophages, Neoplasms, Phagocytes, Phagocytosis, Autoimmunity, Apoptosis, Atherosclerosis, Mice

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