The DOI matches its Crossref record; 197 of the 197 references it cites were found in a registry or an index.
Apoptotic cell clearance: basic biology and therapeutic potential
Open accessAbstract
The prompt removal of apoptotic cells by phagocytes is important for maintaining tissue homeostasis. The molecular and cellular events that underpin apoptotic cell recognition and uptake, and the subsequent biological responses, are increasingly better defined. The detection and disposal of apoptotic cells generally promote an anti-inflammatory response at the tissue level, as well as immunological tolerance. Consequently, defects in apoptotic cell clearance have been linked with various inflammatory diseases and autoimmunity. Conversely, under certain conditions, such as the killing of tumour cells by specific cell-death inducers, the recognition of apoptotic tumour cells can promote an immunogenic response and antitumour immunity. Here, we review the current understanding of the complex process of apoptotic cell clearance in physiology and pathology, and discuss how this knowledge could be harnessed for new therapeutic strategies.
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“Both pathways finally converge in the activation of Rho GTPases such as Rac1 to promote actin polymerization, membrane ruffling, and phagocytosis (131, 132).”
From Macrophage defense mechanisms against intracellular bacteria (2015) · cites this paper as [132]
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“Apoptotic cells release ‘find me’ and expose ‘eat me’ signals such as PS, lysoPS, cardiolipin, calreticulin, and CD31, as well as the chemokine fractalkine (CX3CL1 as recognized by CX3CR1) and small amounts of nucleotides (ATP, UTP). These ligands are recognized by phagocytes promoting efferocytosis (131, 132).”
From Macrophage defense mechanisms against intracellular bacteria (2015) · cites this paper as [132]
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Immunogenic cell death in cancer and infectious disease
Galluzzi, L., Buqué, A., Kepp, O., Zitvogel, L., & Kroemer, G. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2016.107 · Cited by 3,119
Pyroptosis: Mechanisms and Diseases
Yu, P., Zhang, X., Liu, N., Tang, L., Peng, C., & Chen, X. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00507-5 · Cited by 2,353
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Necroptosis and its role in inflammation
Pasparakis, M., & Vandenabeele, P. (2015) · Nature · doi:10.1038/nature14191 · Cited by 2,148
Mesenchymal Stromal Cells: Clinical Challenges and Therapeutic Opportunities
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Metadata
- Authors
- Poon, I. K. H., Lucas, C. D., Rossi, A. G., & Ravichandran, K. S.
- Affiliations
- La Trobe University (AU)
- Centre for Inflammation Research (GB)
- University of Virginia (US)
- Corresponding author
- Rossi, Adriano G.
- Ravichandran, Kodi S.
- Venue
- Nature Reviews Immunology
- Published
- 2014-01-31
- Volume
- 14
- Issue
- 3
- Pages
- 166-180
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- PMC
- PMC4040260
- OpenAlex
- W2150334056
- Cited by
- 1,223
- References
- 197
- Citations by year
- 2026: 69 · 2025: 87 · 2024: 100 · 2023: 97 · 2022: 112 · 2021: 120 · 2020: 115 · 2019: 97 · 2018: 106 · 2017: 106 · 2016: 101 · 2015: 87 · 2014: 23
- FWCI
- 10.31
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, other-oa)
- Funders
- Wellcome Trust (WT094415)
- Medical Research Council (MR/K013386/1)
- National Institute of Mental Health (R01MH096484, MH096484)
- National Institute of General Medical Sciences (GM-64709, R01GM107848, R01GM064709, GM107848)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD074981, R01HD074981)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Keywords
- efferocytosis, phagocytes, apoptotic cell recognition, tissue homeostasis, immune tolerance, inflammation, autoimmunity, immunogenic cell death, antitumor immunity
- MeSH terms
- Animals, Humans, Immune Tolerance, Inflammation, Lupus Erythematosus, Systemic, Macrophages, Neoplasms, Phagocytes, Phagocytosis, Autoimmunity, Apoptosis, Atherosclerosis, Mice
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