Apoptotic cell clearance: basic biology and therapeutic potential

Inflammation and cancer

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Neutrophil Extracellular Traps Kill Bacteria

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Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages

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Immunogenic Cell Death in Cancer Therapy

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Immunogenic cell death and DAMPs in cancer therapy

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Calreticulin exposure dictates the immunogenicity of cancer cell death

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DAMPs, PAMPs and alarmins: all we need to know about danger

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TLR2 Promotes Monocyte/Macrophage Recruitment Into the Liver and Microabscess Formation to Limit the Spread of Listeria Monocytogenes

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3D Chiral Self‐Assembling Matrixes for Regulating Polarization of Macrophages and Enhance Repair of Myocardial Infarction

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Efferocytosis: the art of cellular clearance and novel perspectives in disease therapy

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Stoking the Fire: How Dying Cells Propagate Inflammatory Signalling through Extracellular Vesicle Trafficking

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Apoptotic Cells for Therapeutic Use in Cytokine Storm Associated With Sepsis– A Phase Ib Clinical Trial

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Increased Intestinal Permeability: An Avenue for the Development of Autoimmune Disease?

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Generation of a 3D Outer Blood–Retinal Barrier with Advanced Choriocapillaris and Its Application in Diabetic Retinopathy in a Microphysiological System

Nam, U., Lee, S., & Jeon, J. S. (2023) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.3c00326 · Cited by 22

The intestinal epithelial-macrophage-crypt stem cell axis plays a crucial role in regulating and maintaining intestinal homeostasis

Hu, X., Yuan, X., Zhang, G., Song, H., Ji, P., Guo, Y., Liu, Z., Tian, Y., Shen, R., & Wang, D. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.122452 · Cited by 24

Association between Prediagnostic Allergy-Related Serum Cytokines and Glioma

Schwartzbaum, J., Seweryn, M. T., Holloman, C. H., Harris, R. E., Handelman, S. K., Rempała, G. A., Huang, R.-P., Burkholder, B., Brandemihl, A., Källberg, H., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0137503 · Cited by 22

Apoptotic membrane dynamics in health and disease

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The role of inflammation in adipocytolytic nonsurgical esthetic procedures for body contouring

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Substantial changes in hemocyte parameters of Manila clam Ruditapes philippinarum two years after the Hebei Spirit oil spill off the west coast of Korea

Hong, H.-K., Donaghy, L., Kang, C., Kang, H., Lee, H.-J., Park, H., & Choi, K. (2016) · Marine Pollution Bulletin · doi:10.1016/j.marpolbul.2016.04.033 · Cited by 22

Tailoring of apoptotic bodies for diagnostic and therapeutic applications:advances, challenges, and prospects

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Targeting CXCR2 signaling in inflammatory lung diseases: neutrophil-driven inflammation and emerging therapies

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Phagocytosis at a glance

Depierre, M., Pompili, C., & Niedergang, F. (2025) · Journal of Cell Science · doi:10.1242/jcs.263833 · Cited by 22

Inactivation of Apoptosis Antagonizing Transcription Factor in tubular epithelial cells induces accumulation of DNA damage and nephronophthisis

Jain, M., Kaiser, R. W. J., Bohl, K., Hoehne, M., Göbel, H., Bartram, M. P., Habbig, S., Müller, R., Fogo, A. B., Benzing, T. R., et al. (2019) · Kidney International · doi:10.1016/j.kint.2018.10.034 · Cited by 24

Autonomous regulation of IgE-mediated mast cell degranulation and immediate hypersensitivity reaction by an inhibitory receptor CD300a

Wang, Y., Nakahashi-Oda, C., Okayama, Y., & Shibuya, A. (2019) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2019.03.005 · Cited by 21

The Role of Sphingolipids in Cancer Immunotherapy

Giussani, P., Prinetti, A., & Tringali, C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22126492 · Cited by 21

At the Crossroads: Mechanisms of Apoptosis and Autophagy in Cell Life and Death

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Role of ELMO1 in inflammation and cancer—clinical implications

Tocci, S., Ibeawuchi, S., Das, S., & Sayed, I. M. (2022) · Cellular Oncology · doi:10.1007/s13402-022-00680-x · Cited by 20

Crosstalk between dendritic cells and T lymphocytes during atherogenesis: Focus on antigen presentation and break of tolerance

Bellini, R., Bonacina, F., & Norata, G. D. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.934314 · Cited by 21

Artificial Homeostasis Systems Based on Feedback Reaction Networks: Design Principles and Future Promises

Ranganath, V. A., & Maity, I. (2024) · Angewandte Chemie International Edition · doi:10.1002/anie.202318134 · Cited by 23

Blood-Borne RNA Correlates with Disease Activity and IFN-Stimulated Gene Expression in Systemic Lupus Erythematosus

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Contributions of transferrin to acute inflammation in the goldfish, C. auratus

Trites, M. J., & Barreda, D. R. (2016) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2016.09.004 · Cited by 21

Cytoprotective effect of autophagy on phagocytosis of apoptotic cells by macrophages

Zhou, P., Tan, Y., Wang, H., Li, T., He, T., Yu, Y., Zhang, J., & Zhang, D. (2016) · Experimental Cell Research · doi:10.1016/j.yexcr.2016.09.011 · Cited by 21

Programmed cell clearance: From nematodes to humans

Klöditz, K., Chen, Y.-Z., Xue, D., & Fadeel, B. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.12.005 · Cited by 21

Phagocytosis: How Macrophages Tune Their Non-professional Counterparts

Freeman, S. A., & Grinstein, S. (2016) · Current Biology · doi:10.1016/j.cub.2016.10.059 · Cited by 21

Inhibition of the sphingosine‐1‐phosphate pathway promotes the resolution of neutrophilic inflammation

Perez, D., Galvão, I., Athayde, R. M., Rezende, B. M., Vago, J. P., Silva, J. D., Reis, A. C., Ribeiro, L. S., Gomes, J. H. D. S., de Pádua, R. M., et al. (2019) · European Journal of Immunology · doi:10.1002/eji.201848049 · Cited by 21

Design and Optimization of PLGA Particles to Deliver Immunomodulatory Drugs for the Prevention of Skin Allograft Rejection

Shahzad, K. A., Naeem, M., Zhang, L., Wan, X., Song, S., Pei, W., Zhao, C., Jin, X., & Shen, C. (2019) · Immunological Investigations · doi:10.1080/08820139.2019.1695134 · Cited by 21

Optimal combination of anti-inflammatory components from Chinese medicinal formula Liang-Ge-San

Lu, Z., Cao, H., Liu, D., Zheng, Y., Tian, C., Liu, S., Quan, J., Shi, L., Liu, J., & Yu, L. (2020) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2020.113747 · Cited by 21

The inflammatory response induced by Pseudomonas aeruginosa in macrophages enhances apoptotic cell removal

Jäger, A. V., Paula, A., Tribulatti, M. V., Brocco, M. A., Pepe, M. V., & Kierbel, A. (2021) · Scientific Reports · doi:10.1038/s41598-021-81557-1 · Cited by 21

Simvastatin treatment boosts benefits of apoptotic cell infusion in murine lung fibrosis

Lee, Y.-J., Kim, M.-J., Yoon, Y.-S., Choi, Y., Kim, H.-S., & Kang, J. L. (2017) · Cell Death and Disease · doi:10.1038/cddis.2017.260 · Cited by 21

Unveiling efferocytosis-related signatures through the integration of single-cell analysis and machine learning: a predictive framework for prognosis and immunotherapy response in hepatocellular carcinoma

Liu, T., Li, C. R., Zhang, J., Hu, H., & Li, C. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1237350 · Cited by 20

Augmentation of Human Monocyte Responses to Lipopolysaccharide by the Protein S and Mer/Tyro3 Receptor Tyrosine Kinase Axis

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Updates on NET formation in health and disease

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Systematic Review of the Therapeutic Role of Apoptotic Inhibitors in Neurodegeneration and Their Potential Use in Schizophrenia

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Myeloid-restricted CD68 deficiency attenuates atherosclerosis via inhibition of ROS-MAPK-apoptosis axis

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Overview of pyroptosis mechanism and in-depth analysis of cardiomyocyte pyroptosis mediated by NF-κB pathway in heart failure

Zhang, Z., Yang, Z., Wang, S., Wang, X., & Mao, J. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117367 · Cited by 22

Discovering Molecules That Regulate Efferocytosis Using Primary Human Macrophages and High Content Imaging

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Proteomic characterization of EL4 lymphoma‐derived tumors upon chemotherapy treatment reveals potential roles for lysosomes and caspase‐6 during tumor cell death in vivo

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Unique Pro-Inflammatory Response of Macrophages during Apoptotic Cancer Cell Clearance

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Extracellular Vesicles as Potential Prognostic Markers of Lymphatic Dysfunction

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Regulation of splenic monocyte homeostasis and function by gut microbial products

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Effect of diabetes on efferocytosis process

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Tulathromycin Exerts Proresolving Effects in Bovine Neutrophils by Inhibiting Phospholipases and Altering Leukotriene B4, Prostaglandin E2, and Lipoxin A4Production

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Injury derived autoimmunity: Anti-perlecan/LG3 antibodies in transplantation.

Dieudé, M., Cardinal, H., & Hébert, M. (2019) · Human Immunology · doi:10.1016/j.humimm.2019.04.009 · Cited by 19

Cleavage Region Thyrotropin Receptor Antibodies Influence Thyroid Cell Survival In Vivo

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Extracellular Vesicles Function as Bioactive Molecular Transmitters in the Mammalian Oviduct: An Inspiration for Optimizing in Vitro Culture Systems and Improving Delivery of Exogenous Nucleic Acids during Preimplantation Embryonic Development

Fu, B., Ma, H., & Liu, D. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21062189 · Cited by 20

The crosstalk between cell death and pregnancy related diseases: A narrative review

Xie, X., Liu, J., Gao, J., Shang, C., Jiang, Y., Chen, L., Qian, Z., Liu, L., Wu, D., Zhang, Y., et al. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116815 · Cited by 21

Efferocytosis: The Janus‐Faced Gatekeeper of Aging and Tumor Fate

Liu, Z., Li, Y., Ren, Y., Chen, J., Weng, S., Zhou, Z., Luo, P., Cheng, Q., Xu, H., Ba, Y., et al. (2025) · Aging Cell · doi:10.1111/acel.14467 · Cited by 21

Intra and inter-organ communication through extracellular vesicles in obesity: functional role of obesesomes and steatosomes

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Extracellular vesicles: innovative cell-free solutions for wound repair

Eerdekens, H., Pirlet, E., Willems, S., Bronckaers, A., & Lins, P. M. P. (2025) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2025.1571461 · Cited by 19

Development of novel fluorescent particles applicable for phagocytosis assays with human macrophages

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p75NTR and DR6 Regulate Distinct Phases of Axon Degeneration Demarcated by Spheroid Rupture

Yu, Y., Gamage, K. K., Cheng, I., Barford, K., Spano, A., Winckler, B., & Deppmann, C. D. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.1867-19.2019 · Cited by 19

Chlorogenic acid‐enriched extract of Ilex kudingcha C.J. Tseng tea inhibits neutrophil recruitment in injured zebrafish by promoting reverse migration via the focal adhesion pathway

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Reactive oxygen mediated apoptosis as a therapeutic approach against opportunistic Candida albicans

Atriwal, T., Chawla, M., Hussain, A., Alajmi, M. F., & Abid, M. (2021) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2020.12.004 · Cited by 18

What’s the deal with efferocytosis and asthma?

Martinez, J., & Cook, D. N. (2021) · Trends in Immunology · doi:10.1016/j.it.2021.08.004 · Cited by 19

Gas6 Ameliorates Inflammatory Response and Apoptosis in Bleomycin-Induced Acute Lung Injury

Kim, B., Lee, Y., Choi, Y. J., Park, E., & Kang, J. L. (2021) · Biomedicines · doi:10.3390/biomedicines9111674 · Cited by 19

Drosophila caspases as guardians of host-microbe interactions

Kietz, C., & Meinander, A. (2022) · Cell Death and Differentiation · doi:10.1038/s41418-022-01038-4 · Cited by 22

Immunogenicity of cancer cells: An overview

Singh, T., Bhattacharya, M., Mavi, A. K., Gulati, A., Rakesh, Sharma, N. K., Gaur, S., & Kumar, U. (2023) · Cellular Signalling · doi:10.1016/j.cellsig.2023.110952 · Cited by 20

From exosomes to mitochondria and myocardial infarction: Molecular insight and therapeutic challenge

Liu, C. X., Zhang, D., Long, K., Qi, W., Pang, L., Li, J., Cheng, K. K. Y., & Cai, Y. (2024) · Pharmacological Research · doi:10.1016/j.phrs.2024.107468 · Cited by 19

Newcastle disease virus infection induces parthanatos in tumor cells via calcium waves

Qu, Y., Wang, S., Jiang, H., Liao, Y., Qiu, X., Tan, L., Song, C., Nair, V., Yang, Z., Sun, Y., et al. (2024) · PLoS Pathogens · doi:10.1371/journal.ppat.1012737 · Cited by 19

Emerging roles of apoptotic microtubules during the execution phase of apoptosis

Ávila, M. O., Fernández-Vega, A., Garrido‐Maraver, J., Paz, M. V., de Lavera, I., de la Mata, M., Cordero, M. D., Alcocer‐Gómez, E., Pavón, A. D., Álvarez-Córdoba, M., et al. (2015) · Cytoskeleton · doi:10.1002/cm.21254 · Cited by 20

Apoptotic Cell Clearance in Drosophila melanogaster

Zheng, Q., Ma, A., Yuan, L., Gao, N., Feng, Q., Franc, N. C., & Xiao, H. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01881 · Cited by 20

A Tolerogenic Artificial APC Durably Ameliorates Experimental Autoimmune Encephalomyelitis by Directly and Selectively Modulating Myelin Peptide–Autoreactive CD4+ and CD8+ T Cells

Wan, X., Pei, W., Shahzad, K. A., Zhang, L., Song, S., Jin, X., Wang, L., Zhao, C., & Shen, C. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1800108 · Cited by 19

Magnetic resonance imaging of stem cell–macrophage interactions with ferumoxytol and ferumoxytol‐derived nanoparticles

Nejadnik, H., Tseng, J., & Daldrup-Link, H. E. (2019) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.1552 · Cited by 19

Auranofin, a thioredoxin reductase inhibitor, causes platelet death through calcium overload

Harper, M. T. (2017) · Platelets · doi:10.1080/09537104.2017.1378809 · Cited by 20

Efferocytosis of Apoptotic Neutrophils Enhances Control of Mycobacterium tuberculosis in HIV-Coinfected Macrophages in a Myeloperoxidase-Dependent Manner

Andersson, A.-M., Larsson, M., Stendahl, O. I., & Blomgran, R. (2019) · Journal of Innate Immunity · doi:10.1159/000500861 · Cited by 19

Ischemic Conditioning Promotes Transneuronal Survival and Stroke Recovery via CD36-Mediated Efferocytosis

Ju, H., Kim, I., Pavlova, I., Mu, S., Park, K. W., Minkler, J., Madkoor, A., Wang, W., Wang, X., Wu, Z., et al. (2025) · Circulation Research · doi:10.1161/circresaha.124.325428 · Cited by 21

Contribution of leukocytes to the induction and resolution of the acute inflammatory response in chickens

Juan More, B., Karuppannan, A. K., & Barreda, D. R. (2017) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2017.04.018 · Cited by 18

Research progress of radiation induced bystander and abscopal effects in normal tissue

Hu, S., & Shao, C. (2020) · Radiation Medicine and Protection · doi:10.1016/j.radmp.2020.04.001 · Cited by 18

Caspases help to spread the message via extracellular vesicles

Hill, C., Dellar, E. R., & Baena-López, L. A. (2022) · FEBS Journal · doi:10.1111/febs.16418 · Cited by 17

The small molecule raptinal can simultaneously induce apoptosis and inhibit PANX1 activity

Santavanond, J. P., Chiu, Y., Tixeira, R., Liu, Z., Yap, J. K. Y., Chen, K. W., Li, C., Lu, Y., Roncero-Carol, J., Hoijman, E., et al. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-06513-z · Cited by 18

Transforming growth factor‐β released by apoptotic white blood cells during red blood cell storage promotes transfusion‐induced alloimmunomodulation

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Cytotoxicity of benzophenone-3, an organic ultraviolet filter, caused by increased intracellular Zn2+ levels in rat thymocytes.

Utsunomiya, H., Hiraishi, R., Kishimoto, K., Hamada, S., Abe, S., Bekki, Y., & Kamemura, N. (2019) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2018.10.029 · Cited by 16

A 17-kDa Fragment of Lactoferrin Associates With the Termination of Inflammation and Peptides Within Promote Resolution

Lutaty, A., Soboh, S., Schif‐Zuck, S., Zeituni-Timor, O., Rostoker, R., Podolska, M. J., Schauer, C., i, M. H., Munoz, L. E., & Ariel, A. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00644 · Cited by 18

Pathogenesis of Chronic Allograft Dysfunction Progress to Renal Fibrosis

Yang, C., Qi, R., & Yang, B. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-8871-2_6 · Cited by 18

Immunologic basis for development of keratoconjunctivitis sicca in systemic autoimmune diseases: Role of innate immune sensors

Stern, M. E., Theofilopoulos, A. N., Steven, P., Niederkorn, J. Y., Fox, R. I., Calonge, M., Scheid, C., & Pflugfelder, S. C. (2024) · The Ocular Surface · doi:10.1016/j.jtos.2024.02.003 · Cited by 17

Cardiolipin’s multifaceted role in immune response: a focus on interacting proteins

Chai, Z., Zhou, Y., Hossain, S., Huynh, K., Hajimirzaei, S., Zhang, Y., Qi, J., Zhang, G., Li, Z., & Wei, Y. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1680326 · Cited by 17

Functional miR-142a-3p Induces Apoptosis and Macrophage Polarization by Targeting tnfaip2 and glut3 in Grass Carp (Ctenopharyngodon idella)

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Physiological Roles of Apoptotic Cell Clearance: Beyond Immune Functions

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