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The multifaceted biology of plasmacytoid dendritic cells

Open access
Swiecki, Melissa, Colonna, Marco·2015·Nature Reviews Immunology

Abstract

Plasmacytoid dendritic cells (pDCs) are a unique DC subset that specializes in the production of type I interferons (IFNs). pDCs promote antiviral immune responses and have been implicated in the pathogenesis of autoimmune diseases that are characterized by a type I IFN signature. However, pDCs can also induce tolerogenic immune responses. In this Review, we summarize recent progress in the field of pDC biology, focusing on the molecular mechanisms that regulate the development and functions of pDCs, the pathways involved in their sensing of pathogens and endogenous nucleic acids, their functions at mucosal sites, and their roles in infection, autoimmunity and cancer.

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Metadata

Authors
Swiecki, M., & Colonna, M.
Venue
Nature Reviews Immunology
Published
2015-07-10
Volume
15
Issue
8
Pages
471-485
ISSN
  • 1474-1733 (ISSN-L)
  • 1474-1741
OpenAlex
W1652582743
Cited by
1,131
References
16
FWCI
6.56
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: The multifaceted biology of plasmacytoid dendritic cells. https://app.cochat.ai/papers/10.1038/nri3865
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Swiecki, M., & Colonna, M. (2015). The multifaceted biology of plasmacytoid dendritic cells. Nature Reviews Immunology. https://doi.org/10.1038/nri3865

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Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.