Immunopathology of multiple sclerosis

Human gut microbiome viewed across age and geography

Yatsunenko, T., Rey, F. E., Manary, M. J., Trehan, I., Dominguez-Bello, M. G., Contreras, M., Magris, M., Hidalgo, G., Baldassano, R. N., Anokhin, A. P., et al. (2012) · Nature · doi:10.1038/nature11053 · Cited by 7,815

From inflammation to sickness and depression: when the immune system subjugates the brain

Dantzer, R., O'Connor, J. C., Freund, G. G., Johnson, R. W., & Kelley, K. W. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2297 · Cited by 7,395

Integrative analysis of 111 reference human epigenomes

Roadmap Epigenomics Consortium, Kundaje, A., Meuleman, W., Ernst, J., Bilenky, M., Yen, A., Heravi-Moussavi, A., Kheradpour, P., Zhang, Z., Wang, J., et al. (2015) · Nature · doi:10.1038/nature14248 · Cited by 6,368

Multiple sclerosis

Compston, A., & Coles, A. J. (2008) · The Lancet · doi:10.1016/s0140-6736(08)61620-7 · Cited by 4,699

Structural and functional features of central nervous system lymphatic vessels

Louveau, A., Smirnov, I., Keyes, T. J., Eccles, J. D., Rouhani, S. J., Peske, J. D., Derecki, N. C., Castle, D., Mandell, J. W., Lee, K. S., et al. (2015) · Nature · doi:10.1038/nature14432 · Cited by 4,413

Meta-Analysis of 74,046 Individuals Identifies 11 New Susceptibility Loci for Alzheimer’s Disease

(EADI), E. A. D. I., Lambert, J.-C., (GERAD), G. A. E. R. I. A. D., Alzheimer's Disease Genetic Consortium (ADGC), (CHARGE), C. F. H. A. A. R. I. G. E., Ibrahim-Verbaas, C. A., Harold, D., Naj, A. C., Sims, R., Bellenguez, C., et al. (2013) · Nature Genetics · doi:10.1038/ng.2802 · Cited by 4,336

T cell exhaustion

Wherry, E. J. (2011) · Nature Immunology · doi:10.1038/ni.2035 · Cited by 4,062

The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3

Bennett, C. L., Christie, J., Ramsdell, F., Brunkow, M., Ferguson, P., Whitesell, L., Kelly, T., Saulsbury, F., Chance, P., & Ochs, H. (2001) · Nature Genetics · doi:10.1038/83713 · Cited by 3,576

B-cell depletion with rituximab in relapsing-remitting multiple sclerosis

Hauser, S. L., Waubant, E., Arnold, D. L., Vollmer, T., Antel, J., Fox, R. J., Bar-Or, A., Panzara, M., Sarkar, N., Agarwal, S., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0706383 · Cited by 2,439

Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors

Gomez Perdiguero, E., Klapproth, K., Schulz, C., Busch, K., Azzoni, E., Crozet, L., Garner, H., Trouillet, C., de Bruijn, M. F., Geissmann, F., et al. (2015) · Nature · doi:10.1038/nature13989 · Cited by 2,339

A backpack-based myeloid cell therapy for multiple sclerosis

Kapate, N., Dunne, M., Kumbhojkar, N., Prakash, S., Wang, L., Graveline, A. R., Park, K. S., Suja, V. C., Goyal, J., Clegg, J. R., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2221535120 · Cited by 48

NLRP3 exacerbates EAE severity through ROS-dependent NET formation in the mouse brain

Byun, D. J., Lee, J., Ko, K., & Hyun, Y. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-023-01447-z · Cited by 47

The intricate brain–body interaction in psychiatric and neurological diseases

Gregorio, F. D., & Battaglia, S. (2024) · Advances in Clinical and Experimental Medicine · doi:10.17219/acem/185689 · Cited by 49

Dynamic Response Genes in CD4+ T Cells Reveal a Network of Interactive Proteins that Classifies Disease Activity in Multiple Sclerosis

Hellberg, S., Eklund, D., Gawel, D. R., Köpsén, M., Zhang, H., Nestor, C. E., Kockum, I. S., Olsson, T. P., Skogh, T., Kastbom, A., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.08.036 · Cited by 47

Meningeal Lymphatics: A Review and Future Directions From a Clinical Perspective

Hershenhouse, K. S., Shauly, O., Gould, D. J., & Patel, K. M. (2019) · Neuroscience Insights · doi:10.1177/1179069519889027 · Cited by 47

Oligodendrocytes that survive acute coronavirus infection induce prolonged inflammatory responses in the CNS

Pan, R., Zhang, Q., Anthony, S. M., Zhou, Y., Zou, X., Cassell, M. D., & Perlman, S. M. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2003432117 · Cited by 50

Monomethyl Fumarate (MMF, Bafiertam) for the Treatment of Relapsing Forms of Multiple Sclerosis (MS)

Berger, A. A., Sottosanti, E., Winnick, A. A., Izygon, J. J., Berardino, K., Cornett, E. M., Kaye, A. D., Varrassi, G., Viswanath, O., & Urits, I. (2021) · Neurology International · doi:10.3390/neurolint13020022 · Cited by 48

Exercise protects from hippocampal inflammation and neurodegeneration in experimental autoimmune encephalomyelitis

Rizzo, F. R., Guadalupi, L., Sanna, K., Vanni, V., Fresegna, D., Vito, F. D., Musella, A., Caioli, S., Balletta, S., Bullitta, S., et al. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.08.212 · Cited by 48

The role of iron metabolism in the pathogenesis and treatment of multiple sclerosis

Duarte-Silva, E., Meuth, S. G., & Peixoto, C. A. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1137635 · Cited by 46

Emerging roles of 14-3-3γ in the brain disorder

Cho, E., & Park, J. (2020) · BMB Reports · doi:10.5483/bmbrep.2020.53.10.158 · Cited by 46

Unveiling the role of gut-brain axis in regulating neurodegenerative diseases: A comprehensive review

Yadav, H., Jaldhi, Bhardwaj, R., Anamika, A., Bakshi, A., Gupta, S., & Maurya, S. K. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.122022 · Cited by 47

Myelin dysfunction in aging and brain disorders: mechanisms and therapeutic opportunities

Huang, Z., Zhang, Y., Zou, P., Zong, X., & Zhang, Q. (2025) · Molecular Neurodegeneration · doi:10.1186/s13024-025-00861-w · Cited by 49

Genetics of Infectious and Inflammatory Diseases: Overlapping Discoveries from Association and Exome-Sequencing Studies

Langlais, D., Fodil, N., & Gros, P. (2016) · Annual Review of Immunology · doi:10.1146/annurev-immunol-051116-052442 · Cited by 47

Interplay Between the Unfolded Protein Response and Immune Function in the Development of Neurodegenerative Diseases

García-González, P. A., Cabral‐Miranda, F., Hetz, C. A., & Osorio, F. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02541 · Cited by 46

Purinergic receptors in multiple sclerosis pathogenesis

Domercq, M., Zabala, A., & Matute, C. (2018) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2018.11.018 · Cited by 46

Coenzyme Q10 supplementation reduces peripheral oxidative stress and inflammation in interferon-β1a-treated multiple sclerosis

Moccia, M., Capacchione, A., Lanzillo, R., Carbone, F., Micillo, T., Perna, F., Rosa, A. D., Carotenuto, A., Albero, R., Matarese, G., et al. (2019) · Therapeutic Advances in Neurological Disorders · doi:10.1177/1756286418819074 · Cited by 46

Different epigenetic clocks reflect distinct pathophysiological features of multiple sclerosis

Theodoropoulou, E., Alfredsson, L. S., Piehl, F., Marabita, F., & Jagodic, M. (2019) · Epigenomics · doi:10.2217/epi-2019-0102 · Cited by 47

Cell Type-Specific Intralocus Interactions Reveal Oligodendrocyte Mechanisms in MS

Factor, D. C., Barbeau, A. M., Allan, K. C., Hu, L. R., Madhavan, M., Hoang, A. T., Hazel, K. E. A., Hall, P. A., Nisraiyya, S., Najm, F. J., et al. (2020) · Cell · doi:10.1016/j.cell.2020.03.002 · Cited by 48

Gut Microbiota and Neurologic Diseases and Injuries

Patterson, T. T., & Grandhi, R. (2020) · Advances in experimental medicine and biology · doi:10.1007/978-981-15-2385-4_6 · Cited by 46

Evaluating the Effects of Dietary Interventions on Disease Progression and Symptoms of Adults with Multiple Sclerosis: An Umbrella Review

Tredinnick, A. R., & Probst, Y. (2020) · Advances in Nutrition · doi:10.1093/advances/nmaa063 · Cited by 46

Implication of Neuronal Versus Microglial P2X4 Receptors in Central Nervous System Disorders

Duveau, A., Bertin, É., & Boué‐Grabot, É. (2020) · Neuroscience Bulletin · doi:10.1007/s12264-020-00570-y · Cited by 48

Mechanistic underpinning of an inside–out concept for autoimmunity in multiple sclerosis

Hart, B. A. ‘., Luchicchi, A., Schenk, G. J., Stys, P. K., & Geurts, J. J. G. (2021) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.51401 · Cited by 46

Acting centrally or peripherally: A renewed interest in the central nervous system penetration of disease-modifying drugs in multiple sclerosis

Correale, J. D., Halfón, M. J., Jack, D. L., Rubstein, A., & Villa, A. M. (2021) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2021.103264 · Cited by 48

Neutrophil-to-lymphocyte ratio and monocyte-to-lymphocyte ratio are associated with a 2-year relapse in patients with multiple sclerosis

Huang, W.-C., Lin, H., Yang, Y., Hsu, C.-W., Chen, N.-C., Tsai, W., Cheng, B., & Tsai, N. (2022) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2022.103514 · Cited by 46

COVID-19 and Multiple Sclerosis: Predisposition and Precautions in Treatment

Sadeghmousavi, S., & Rezaei, N. (2020) · SN Comprehensive Clinical Medicine · doi:10.1007/s42399-020-00504-9 · Cited by 45

Mindfulness Meditation: Impact on Attentional Control and Emotion Dysregulation.

Prakash, R. S. (2021) · PubMed Central · doi:10.1093/arclin/acab053 · Cited by 45

Restoration of metal homeostasis: a potential strategy against neurodegenerative diseases

Zhang, Y., Li, X., Ren, K., Peng, J., & Luo, X. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.101931 · Cited by 46

The Role of Gut Microbiome in the Pathogenesis of Multiple Sclerosis and Related Disorders

Dunalska, A., Saramak, K., & Szejko, N. (2023) · Cells · doi:10.3390/cells12131760 · Cited by 45

Immunotherapy for Type 1 Diabetes: Why Do Current Protocols Not Halt the Underlying Disease Process?

Kolb, H., & von Herrath, M. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.10.009 · Cited by 47

Immunomodulation in multiple sclerosis: promises and pitfalls

Dendrou, C. A., & Fugger, L. H. (2017) · Current Opinion in Immunology · doi:10.1016/j.coi.2017.08.013 · Cited by 46

The relevance of ceramides and their synthesizing enzymes for multiple sclerosis

Kurz, J., Brunkhorst, R., Foerch, C., Blum, L., Henke, M., Gabriel, L. A., Ulshöfer, T., Ferreirós, N., Parnham, M. J., Geißlinger, G., et al. (2018) · Clinical Science · doi:10.1042/cs20180506 · Cited by 46

Comprehensive Analysis of TCR-β Repertoire in Patients with Neurological Immune-mediated Disorders

Sousa, A. D. P. A., Johnson, K. R., Ohayon, J. M., Zhu, J., Muraro, P. A., & Jacobson, S. (2019) · Scientific Reports · doi:10.1038/s41598-018-36274-7 · Cited by 45

Strategies for Neuroprotection in Multiple Sclerosis and the Role of Calcium

Enders, M., Heider, T., Ludwig, A., & Küerten, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21051663 · Cited by 45

Therapeutic aspects of the Axl/Gas6 molecular system

Stasi, R. D., Rosa, L. D., & D’Andrea, L. D. (2020) · Drug Discovery Today · doi:10.1016/j.drudis.2020.09.022 · Cited by 46

Neutrophil‐to‐lymphocyte ratio and CRP as biomarkers in multiple sclerosis: A systematic review

Olsson, A., Gustavsen, S., Lauridsen, K. G., Hasselbalch, I. C., Sellebjerg, F. T., Søndergaard, H. B., & Oturai, A. B. (2021) · Acta Neurologica Scandinavica · doi:10.1111/ane.13401 · Cited by 47

Selected Clostridia Strains from The Human Microbiota and their Metabolite, Butyrate, Improve Experimental Autoimmune Encephalomyelitis

Calvo‐Barreiro, L., Eixarch, H., Cornejo, T., Costa, C., Castillo, M., Mestre, L., Guaza, C., Martínez‐Cuesta, M. C., Tanoue, T., Honda, K., et al. (2021) · Neurotherapeutics · doi:10.1007/s13311-021-01016-7 · Cited by 45

Microglial Nox2 Plays a Key Role in the Pathogenesis of Experimental Autoimmune Encephalomyelitis

Hu, C.-F., Wu, S., Lin, G., Shieh, C.-C. K., Hsu, C.-S., Chen, J.-W., Chen, S., Hong, J., & Chen, S.-J. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.638381 · Cited by 45

Intermediate uveitis associated with MS

Abraham, A., Nicholson, L. B., Dick, A. D., Rice, C. M., & Atan, D. (2020) · Neurology Neuroimmunology & Neuroinflammation · doi:10.1212/nxi.0000000000000909 · Cited by 44

Pregnancy and multiple sclerosis: from molecular mechanisms to clinical application

Gold, S. M., & Voskuhl, R. R. (2016) · Seminars in Immunopathology · doi:10.1007/s00281-016-0584-y · Cited by 44

A population-based cohort study suggests an increased risk of multiple sclerosis incidence in patients with type 2 diabetes mellitus

Hou, W., Li, C., Chang, H.-H., Sun, Y., & Tsai, C.-C. (2017) · Journal of Epidemiology · doi:10.1016/j.je.2016.06.006 · Cited by 44

Is there a change of paradigm towards more effective treatment early in the course of apparent high-risk MS?

Fernández, Ó. (2017) · Multiple Sclerosis and Related Disorders · doi:10.1016/j.msard.2017.07.003 · Cited by 44

Gut–CNS-Axis as Possibility to Modulate Inflammatory Disease Activity—Implications for Multiple Sclerosis

Fleck, A.-K., Schuppan, D., Wiendl, H., & Klotz, L. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18071526 · Cited by 47

Macrophage galactose-type lectin (MGL) is induced on M2 microglia and participates in the resolution phase of autoimmune neuroinflammation

Ilarregui, J. M., Kooij, G., Rodríguez, E., van der Pol, S. M. A., Koning, N., Kalay, H., van der Horst, J. C., van Vliet, S. J., García-Vallejo, J. J., de Vries, H. E., et al. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1522-4 · Cited by 45

Gas6 Inhibits Toll-Like Receptor-Mediated Inflammatory Pathways in Mouse Microglia via Axl and Mer

Gilchrist, S. E., Goudarzi, S., & Hafizi, S. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.576650 · Cited by 46

CNS endothelial derived extracellular vesicles are biomarkers of active disease in multiple sclerosis

Mazzucco, M. R., Mannheim, W., Shetty, S. V., & Linden, J. R. (2022) · Fluids and Barriers of the CNS · doi:10.1186/s12987-021-00299-4 · Cited by 44

The role of the BTLA-HVEM complex in the pathogenesis of autoimmune diseases

Wojciechowicz, K., Spodzieja, M., Lisowska, K. A., & Wardowska, A. (2022) · Cellular Immunology · doi:10.1016/j.cellimm.2022.104532 · Cited by 45

Increased Type I interferon signaling and brain endothelial barrier dysfunction in an experimental model of Alzheimer’s disease

Jana, A., Wang, X., Leasure, J. W., Magana, L., Wang, L., Kim, Y.-M., Dodiya, H., Toth, P. T., Sisodia, S. S., & Rehman, J. (2022) · Scientific Reports · doi:10.1038/s41598-022-20889-y · Cited by 43

The cerebrospinal fluid in multiple sclerosis: far beyond the bands

Domingues, R. B., Fernandes, G. B. P., Leite, F. B. V. D. M., Tilbery, C. P., Thomaz, R. B., Silva, G. S., Mangueira, C. L. P., & Soares, C. A. S. (2017) · Einstein (São Paulo) · doi:10.1590/s1679-45082017rw3706 · Cited by 43

Astrocytes and Inflammatory T Helper Cells: A Dangerous Liaison in Multiple Sclerosis

Kunkl, M., Amormino, C., Tedeschi, V., Fiorillo, M. T., & Tuosto, L. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.824411 · Cited by 49

Inflammasomes in neurodegenerative diseases

Wang, Q., Yang, S., Zhang, X., Zhang, S., Chen, L., Wang, W., Chen, N., & Yan, J. (2024) · Translational Neurodegeneration · doi:10.1186/s40035-024-00459-0 · Cited by 47

CCRL2 regulates M1/M2 polarization during EAE recovery phase

Mazzon, C., Zanotti, L., Wang, L., Prete, A. D., Fontana, E., Salvi, V., Poliani, P. L., & Sozzani, S. (2016) · Journal of Leukocyte Biology · doi:10.1189/jlb.3ma0915-444rr · Cited by 43

Interleukin-33 deficiency exacerbated experimental autoimmune encephalomyelitis with an influence on immune cells and glia cells

Xiao, Y., Lai, L., Chen, H., Shi, J., Zeng, F., Li, J., Feng, H., Mao, J., Zhang, F., Wu, N., et al. (2018) · Molecular Immunology · doi:10.1016/j.molimm.2018.08.026 · Cited by 44

Immune Signatures of Prodromal Multiple Sclerosis in Monozygotic Twins

Gerdes, L. A., Janoschka, C., Eveslage, M., Mannig, B., Wirth, T., Schulte‐Mecklenbeck, A., Lauks, S., Glau, L., Groß, C. C., Tolosa, E., et al. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2003339117 · Cited by 43

Ellagic acid ameliorates neuroinflammation and demyelination in experimental autoimmune encephalomyelitis: Involvement of NLRP3 and pyroptosis

Kiasalari, Z., Afshin‐Majd, S., Baluchnejadmojarad, T., Azadi-Ahmadabadi, E., Esmaeil-Jamaat, E., Fahanik‐Babaei, J., Fakour, M., Fereidouni, F., Ghasemi-Tarie, R., Jalalzade-Ogvar, S., et al. (2020) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2020.101891 · Cited by 43

Piperine Improves Experimental Autoimmune Encephalomyelitis (EAE) in Lewis Rats Through its Neuroprotective, Anti-inflammatory, and Antioxidant Effects

Nasrnezhad, R., Halalkhor, S., Sadeghi, F., & Pourabdolhossein, F. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02497-5 · Cited by 45

Lymphotoxin-alpha expression in the meninges causes lymphoid tissue formation and neurodegeneration

Bates, R. E. J., Browne, E., Schalks, R., Jacobs, H., Tan, L. Y., Parekh, P., Magliozzi, R., Calabrese, M., Mazarakis, N. D., & Reynolds, R. (2022) · Brain · doi:10.1093/brain/awac232 · Cited by 42

Crosstalk between dendritic cells and regulatory T cells: Protective effect and therapeutic potential in multiple sclerosis

Li, R., Li, H., Yang, X., Hu, H., Liu, P., & Liu, H. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.970508 · Cited by 42

Bidirectional Communication Between the Brain and Other Organs: The Role of Extracellular Vesicles

Zhou, W., Zhao, L., Mao, Z., Wang, Z., Zhang, Z., & Li, M. (2023) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-023-01345-5 · Cited by 42

EBV Infection and Multiple Sclerosis: Lessons from a Marmoset Model

Hart, B. A. ‘., Kap, Y. S., Morandi, E., Laman, J. D., & Gran, B. (2016) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2016.10.007 · Cited by 43

Emerging Biosensing Technologies for Neuroinflammatory and Neurodegenerative Disease Diagnostics

Abreu, C. M., Soares-dos-Reis, R., Melo, P., Relvas, J. B., Guimarães, J., Sá, M. J., Cruz, A., & Pinto, I. M. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00164 · Cited by 42

Pharmacological Inhibition of STAT3 by Stattic Ameliorates Clinical Symptoms and Reduces Autoinflammation in Myeloid, Lymphoid, and Neuronal Tissue Compartments in Relapsing–Remitting Model of Experimental Autoimmune Encephalomyelitis in SJL/J Mice

Alhazzani, K., Ahmad, S. F., Al-Harbi, N. O., Attia, S. M., Bakheet, S. A., Sarawi, W. S., Alqarni, S. A., Algahtani, M., & Nadeem, A. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13070925 · Cited by 42

Systematic Review of the Socioeconomic Consequences in Patients With Multiple Sclerosis With Different Levels of Disability and Cognitive Function

Kavaliūnas, A., Karrenbauer, V. D., Binzer, S., & Hillert, J. A. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2021.737211 · Cited by 42

Quercetin as a possible complementary therapy in multiple sclerosis: Anti-oxidative, anti-inflammatory and remyelination potential properties

Javanbakht, P., Yazdi, F. R., Taghizadeh, F., Khadivi, F., Hamidabadi, H. G., Kashani, I. R., Zarini, D., & Mojaverrostami, S. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e21741 · Cited by 44

Neuroinflammation — using big data to inform clinical practice

Dendrou, C. A., McVean, G., & Fugger, L. H. (2016) · Nature Reviews Neurology · doi:10.1038/nrneurol.2016.171 · Cited by 43

Activity of NaV1.2 promotes neurodegeneration in an animal model of multiple sclerosis

Schattling, B., Fazeli, W., Engeland, B., Liu, Y., Lerche, H., Isbrandt, D., & Friese, M. A. (2016) · JCI Insight · doi:10.1172/jci.insight.89810 · Cited by 41

IL-12p35 Inhibits Neuroinflammation and Ameliorates Autoimmune Encephalomyelitis

Choi, J. K., Dambuza, I. M., He, C., Yu, C., Uche, A. N., Mattapallil, M. J., Caspi, R. R., & Egwuagu, C. E. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01258 · Cited by 43

Targeting P2X4 and P2X7 receptors in multiple sclerosis

Domercq, M., & Matute, C. (2019) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2019.03.010 · Cited by 43

The Potential of Computational Modeling to Predict Disease Course and Treatment Response in Patients with Relapsing Multiple Sclerosis

Pappalardo, F., Russo, G. L., Pennisi, M. A., Palumbo, G. A. P., Sgroi, G., Motta, S., & Maimone, D. (2020) · Cells · doi:10.3390/cells9030586 · Cited by 42

Nano and Microparticle Emerging Strategies for Treatment of Autoimmune Diseases: Multiple Sclerosis and Type 1 Diabetes

Kwiatkowski, A. J., Stewart, J. M., Cho, J. J., Avram, D., & Keselowsky, B. G. (2020) · Advanced Healthcare Materials · doi:10.1002/adhm.202000164 · Cited by 43

Regionally diverse astrocyte subtypes and their heterogeneous response to EAE

Borggrewe, M., Grit, C., Vainchtein, I. D., Brouwer, N., Wesseling, E. M., Laman, J. D., Eggen, B. J. L., Kooistra, S. M., & Boddeke, E. (2020) · Glia · doi:10.1002/glia.23954 · Cited by 41

Th17 Cells in Viral Infections—Friend or Foe?

Paiva, I. A., Badolato-Corrêa, J., Familiar-Macedo, D., & de‐Oliveira‐Pinto, L. M. (2021) · Cells · doi:10.3390/cells10051159 · Cited by 41

Role of the PD‐1/PD‐L1 Signaling in Multiple Sclerosis and Experimental Autoimmune Encephalomyelitis: Recent Insights and Future Directions

Mi, Y., Han, J., Zhu, J., & Jin, T. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02495-7 · Cited by 44

Fecal microbiota transplantation for the management of autoimmune diseases: Potential mechanisms and challenges

Liu, X., Liu, M., Zhao, M., Li, P., Gao, C., Fan, X., Cai, G., Lu, Q., & Chen, X. (2023) · Journal of Autoimmunity · doi:10.1016/j.jaut.2023.103109 · Cited by 41

Opportunities for Translation from the Bench: Therapeutic Intervention of the JAK/STAT Pathway in Neuroinflammatory Diseases

Liu, Y., Gibson, S. A., Benveniste, E. N., & Qin, H. (2015) · Critical Reviews in Immunology · doi:10.1615/critrevimmunol.2016015517 · Cited by 43

Atf6α deficiency suppresses microglial activation and ameliorates pathology of experimental autoimmune encephalomyelitis

Ta, H. M., Le, T. M., Ishii, H., Takarada‐Iemata, M., Hattori, T., Hashida, K., Yamamoto, Y., Mori, K., Takahashi, R., Kitao, Y., et al. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13714 · Cited by 40

Viruses and Multiple Sclerosis: From Mechanisms and Pathways to Translational Research Opportunities

Mentis, A. A., Dardiotis, E., Grigoriadis, N., Petinaki, E., & Hadjigeorgiou, G. M. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0530-6 · Cited by 40

Immunophenotype and Transcriptome Profile of Patients With Multiple Sclerosis Treated With Fingolimod: Setting Up a Model for Prediction of Response in a 2-Year Translational Study

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Farnesol induces protection against murine CNS inflammatory demyelination and modifies gut microbiome

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