The DOI matches its Crossref record; 122 of the 122 references it cites were found in a registry or an index.
Immunopathology of multiple sclerosis
Abstract
Two decades of clinical experience with immunomodulatory treatments for multiple sclerosis point to distinct immunological pathways that drive disease relapses and progression. In light of this, we discuss our current understanding of multiple sclerosis immunopathology, evaluate long-standing hypotheses regarding the role of the immune system in the disease and delineate key questions that are still unanswered. Recent and anticipated advances in the field of immunology, and the increasing recognition of inflammation as an important component of neurodegeneration, are shaping our conceptualization of disease pathophysiology, and we explore the potential implications for improved healthcare provision to patients in the future.
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“The extensive infiltration and activation of peripheral and resident immune cells in MS suggests these cells are key mediators of lesion formation [77, 210, 278] (Fig. 1j-l).”
From Microglia and monocytes in inflammatory CNS disease: integrating phenotype and function (2022) · cites this paper as [77]
In the citing paper
“In addition to possible antigen-specific T cell-mediated inflammation, non-specific inflammation also contributes to myelin destruction in MS [77].”
From Microglia and monocytes in inflammatory CNS disease: integrating phenotype and function (2022) · cites this paper as [77]
In the citing paper
“Since currently available drugs insufficiently mitigate progression of neurodegeneration independent of the MS subtype (2), there is an urgent unmet clinical need for neuroprotective interventions.”
From MicroRNA-92a–CPEB3 axis protects neurons against inflammatory neurodegeneration (2023) · cites this paper as [2]
In the citing paper
“Both conditions have been characterised by immunological abnormalities and dysfunctional myelination, at least in a subset of individuals [170,171].”
From Vitamin D and Autism Spectrum Disorder: A Literature Review (2016) · cites this paper as [171]
In the citing paper
“Furthermore, work from the past few years demonstrates that microglial gene expression changes during aging and may contribute to risk for AD (3) as well as autoimmune disorders of the central nervous system (CNS) such as multiple sclerosis [MS; reviewed in (4)] and lupus (5), but precisely how these cells contribute to risk for autoimmune disorders or AD remains unclear.”
From The Transcriptional Landscape of Microglial Genes in Aging and Neurodegenerative Disease (2019) · cites this paper as [4]
Citations
Cites
Human gut microbiome viewed across age and geography
Yatsunenko, T., Rey, F. E., Manary, M. J., Trehan, I., Dominguez-Bello, M. G., Contreras, M., Magris, M., Hidalgo, G., Baldassano, R. N., Anokhin, A. P., et al. (2012) · Nature · doi:10.1038/nature11053 · Cited by 7,815
From inflammation to sickness and depression: when the immune system subjugates the brain
Dantzer, R., O'Connor, J. C., Freund, G. G., Johnson, R. W., & Kelley, K. W. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2297 · Cited by 7,395
Integrative analysis of 111 reference human epigenomes
Roadmap Epigenomics Consortium, Kundaje, A., Meuleman, W., Ernst, J., Bilenky, M., Yen, A., Heravi-Moussavi, A., Kheradpour, P., Zhang, Z., Wang, J., et al. (2015) · Nature · doi:10.1038/nature14248 · Cited by 6,368
Compston, A., & Coles, A. J. (2008) · The Lancet · doi:10.1016/s0140-6736(08)61620-7 · Cited by 4,699
Structural and functional features of central nervous system lymphatic vessels
Louveau, A., Smirnov, I., Keyes, T. J., Eccles, J. D., Rouhani, S. J., Peske, J. D., Derecki, N. C., Castle, D., Mandell, J. W., Lee, K. S., et al. (2015) · Nature · doi:10.1038/nature14432 · Cited by 4,413
Meta-Analysis of 74,046 Individuals Identifies 11 New Susceptibility Loci for Alzheimer’s Disease
(EADI), E. A. D. I., Lambert, J.-C., (GERAD), G. A. E. R. I. A. D., Alzheimer's Disease Genetic Consortium (ADGC), (CHARGE), C. F. H. A. A. R. I. G. E., Ibrahim-Verbaas, C. A., Harold, D., Naj, A. C., Sims, R., Bellenguez, C., et al. (2013) · Nature Genetics · doi:10.1038/ng.2802 · Cited by 4,336
Wherry, E. J. (2011) · Nature Immunology · doi:10.1038/ni.2035 · Cited by 4,062
Bennett, C. L., Christie, J., Ramsdell, F., Brunkow, M., Ferguson, P., Whitesell, L., Kelly, T., Saulsbury, F., Chance, P., & Ochs, H. (2001) · Nature Genetics · doi:10.1038/83713 · Cited by 3,576
B-cell depletion with rituximab in relapsing-remitting multiple sclerosis
Hauser, S. L., Waubant, E., Arnold, D. L., Vollmer, T., Antel, J., Fox, R. J., Bar-Or, A., Panzara, M., Sarkar, N., Agarwal, S., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0706383 · Cited by 2,439
Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors
Gomez Perdiguero, E., Klapproth, K., Schulz, C., Busch, K., Azzoni, E., Crozet, L., Garner, H., Trouillet, C., de Bruijn, M. F., Geissmann, F., et al. (2015) · Nature · doi:10.1038/nature13989 · Cited by 2,339
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Items 501–600 of 1,003
Effects of disease-modifying therapy on peripheral leukocytes in patients with multiple sclerosis
Schweitzer, F., Laurent, S. A., Fink, G. R., Barnett, M. H., Hartung, H., & Warnke, C. (2020) · Journal of Neurology · doi:10.1007/s00415-019-09690-6 · Cited by 40
Encephalitogenic and Regulatory CD8 T Cells in Multiple Sclerosis and Its Animal Models
Mockus, T. E., Munie, A. N., Atkinson, J., & Segal, B. M. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.2000797 · Cited by 38
Mandolesi, G., Rizzo, F. R., Balletta, S., Bassi, M. S., Gilio, L., Guadalupi, L., Nencini, M., Moscatelli, A., Ryan, C. P., Licursi, V., et al. (2021) · Cells · doi:10.3390/cells10020330 · Cited by 38
Spaas, J., Franssen, W. M. A., Keytsman, C., Blancquaert, L., Vanmierlo, T., Bogie, J. F. J., Broux, B., Hellings, N., van Horssen, J., Posa, D. K., et al. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02306-9 · Cited by 38
Li, G., Yamasaki, R., Fang, M., Masaki, K., Ochi, H., Matsushita, T., & Kira, J. (2018) · Scientific Reports · doi:10.1038/s41598-018-20390-5 · Cited by 40
Post‐mortem multiple sclerosis lesion pathology is influenced by single nucleotide polymorphisms
Fransen, N. L., Crusius, J. B. A., Smolders, J., Mizee, M. R., van Eden, C. G., Luchetti, S., Remmerswaal, E. B. M., Hamann, J., Mason, M. R. J., & Huitinga, I. (2020) · Brain Pathology · doi:10.1111/bpa.12760 · Cited by 37
MIF contribution to progressive brain diseases
Matejuk, A., Benedek, G., Bucala, R., Matejuk, S., Offner, H., & Vandenbark, A. A. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02993-6 · Cited by 40
Nogo-A Antibodies for Progressive Multiple Sclerosis
Ineichen, B. V., Plattner, P. S., Good, N., Martinꝉ, R., Linnebank, M., & Schwab, M. E. (2017) · CNS Drugs · doi:10.1007/s40263-017-0407-2 · Cited by 37
Innate lymphoid cells in autoimmunity and chronic inflammatory diseases
Xiong, T., & Turner, J. (2018) · Seminars in Immunopathology · doi:10.1007/s00281-018-0670-4 · Cited by 37
Yan, L., Jiang, B., Niu, Y., Wang, H., Li, E., Yan, Y., Sun, H., Duan, Y., Chang, S., Chen, G., et al. (2018) · Cell Death Discovery · doi:10.1038/s41420-018-0091-0 · Cited by 37
IL-21 and IL-21-producing T cells are involved in multiple sclerosis severity and progression
Gharibi, T., Hosseini, A., Marofi, F., Oraei, M., Jahandideh, S., Abdollahpour‐Alitappeh, M., Hashemi, V., Motallebnezhad, M., Babaloo, Z., & Baradaran, B. (2019) · Immunology Letters · doi:10.1016/j.imlet.2019.09.003 · Cited by 38
CNS-localized myeloid cells capture living invading T cells during neuroinflammation
Wasser, B., Luchtman, D. W., Löffel, J. T., Robohm, K., Birkner, K., Stroh, A., Vogelaar, C. F., Zipp, F., & Bittner, S. (2020) · The Journal of Experimental Medicine · doi:10.1084/jem.20190812 · Cited by 38
Plasma Exchange or Immunoadsorption in Demyelinating Diseases: A Meta-Analysis
Lipphardt, M., Wallbach, M., & Koziolek, M. J. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9051597 · Cited by 38
Multifaceted Involvement of Microglia in Gray Matter Pathology in Multiple Sclerosis
Tsouki, F., & Williams, A. (2021) · Stem Cells · doi:10.1002/stem.3374 · Cited by 39
Gut-Brain Axis and Neurological Disorders-How Microbiomes Affect our Mental Health
Bhatia, N. Y., Jalgaonkar, M. P., Hargude, A. B., Sherje, A. P., Oza, M. J., & Doshi, G. (2022) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527321666220822172039 · Cited by 38
PET imaging in multiple sclerosis
Faria, D. D. P., Copray, S. C. V. M., Buchpiguel, C. A., Dierckx, R., & de Vries, E. F. J. (2014) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-014-9544-2 · Cited by 40
Zhen, M., Xu, Y. M., Wang, C., & Bai, C. (2024) · Advanced Functional Materials · doi:10.1002/adfm.202409319 · Cited by 36
Schroeder, A. R., Loth, M., Luo, C., Yao, S., Yan, H., Zhang, D., Piya, S., Plowey, E. D., Hu, W., Clemenceau, J. R. V., et al. (2025) · Nature Methods · doi:10.1038/s41592-025-02770-8 · Cited by 37
Pericytes modulate myelination in the central nervous system
de Azevedo, P. O., Sena, I. F. G., Andreotti, J. P., Tavares, J. C., Alves-Filho, J. C., Cunha, T. M., Cunha, F. Q., Mintz, A., & Birbrair, A. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.26348 · Cited by 36
Cognitive function predicts work disability among multiple sclerosis patients
Kavaliūnas, A., Tinghög, P., Friberg, E., Olsson, T. P., Alexanderson, K. A. E., Hillert, J. A., & Karrenbauer, V. D. (2019) · Multiple Sclerosis Journal - Experimental Translational and Clinical · doi:10.1177/2055217318822134 · Cited by 36
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Ikram, M. A., Ullah, R., Khan, A., & Kim, M. O. (2020) · Cells · doi:10.3390/cells9061464 · Cited by 36
Distinct Functional Connectivity Signatures of Impaired Social Cognition in Multiple Sclerosis
Golde, S., Heine, J., Pöttgen, J., Mantwill, M., Lau, S., Wingenfeld, K., Otte, C., Penner, I., Engel, A. K., Heesen, C., et al. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.00507 · Cited by 36
Molecular imaging of the urokinase plasminogen activator receptor: opportunities beyond cancer
Baart, V. M., Houvast, R. D., de Geus‐Oei, L., Quax, P. H. A., Kuppen, P. J. K., Vahrmeijer, A. L., & Sier, C. F. M. (2020) · EJNMMI Research · doi:10.1186/s13550-020-00673-7 · Cited by 36
Cognitive impairment in multiple sclerosis: lessons from cerebrospinal fluid biomarkers
Filippo, M. D., Gaetani, L., Salvadori, N., Chipi, E., Gentili, L., Borrelli, A., & Parnetti, L. (2020) · Neural Regeneration Research · doi:10.4103/1673-5374.286949 · Cited by 37
Contributions of T cells in multiple sclerosis: what do we currently know?
Arneth, B. M. (2020) · Journal of Neurology · doi:10.1007/s00415-020-10275-x · Cited by 36
Choi, J. H., Oh, J., Lee, M. J., Ko, S., Nah, S.-Y., & Cho, I. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.12.004 · Cited by 36
The emerging roles of absent in melanoma 2 (AIM2) inflammasome in central nervous system disorders
Li, Y.-K., Chen, J., & Wang, F. (2021) · Neurochemistry International · doi:10.1016/j.neuint.2021.105122 · Cited by 36
MiR‐142‐3p regulates synaptopathy‐driven disease progression in multiple sclerosis
Vito, F. D., Musella, A., Fresegna, D., Rizzo, F. R., Gentile, A., Bassi, M. S., Gilio, L., Buttari, F., Procaccini, C., Colamatteo, A., et al. (2021) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12765 · Cited by 38
Pomegranate (Punica granatum L.) Attenuates Neuroinflammation Involved in Neurodegenerative Diseases
Alami, M., Benchagra, L., Boulbaroud, S., Ramchoun, M., Khalil, A., Fülöp, T., & Berrougui, H. (2022) · Foods · doi:10.3390/foods11172570 · Cited by 38
Kap, Y. S., Bus‐Spoor, C., van Driel, N., Dubbelaar, M. L., Grit, C., Kooistra, S. M., Fagrouch, Z. C., Verschoor, E. J., Bauer, J., Eggen, B. J. L., et al. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1800822 · Cited by 36
Straeten, F. A., Zhu, J. K., Börsch, A., Zhang, B., Li, K., Lu, I., Groß, C. C., Heming, M., Li, X., Rubin, R., et al. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02667-9 · Cited by 38
Yan, M., Sun, Z., Zhang, S., Yang, G., Jiang, X. Y., Wang, G., Li, R., Wang, Q., & Tian, X. (2024) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2024.110988 · Cited by 38
piRNA associates with immune diseases
Jiang, M., Hong, X., Gao, Y., Kho, A. T., Tantisira, K. G., & Li, J. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01724-5 · Cited by 36
Xia, X., Liang, Z., Xu, G., Wei, F., Yang, J., Zhu, X., Zhou, C., Ye, J., Hu, Q., Zhao, Z., et al. (2025) · Analytical Chemistry · doi:10.1021/acs.analchem.4c05388 · Cited by 36
Aghaie, T., Jazayeri, M. H., Avan, A., Anissian, A., & Salari, A. (2019) · IUBMB Life · doi:10.1002/iub.2045 · Cited by 35
A narrative review of psoriasis and multiple sclerosis: links and risks
Silfvast‐Kaiser, A., Homan, K. B., & Mansouri, B. (2019) · Psoriasis Targets and Therapy · doi:10.2147/ptt.s186637 · Cited by 35
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Yin, J.-J., He, Y., An, J., Miao, Q., Sui, R., Wang, Q., Yu, J., Xiao, B., & Ma, C. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00572 · Cited by 35
Goulding, D. S., Vogel, R. C., Pandya, C. D., Shula, C., Gensel, J. C., Mangano, F. T., Goto, J., & Miller, B. A. (2020) · Journal of Neurosurgery Pediatrics · doi:10.3171/2019.12.peds19625 · Cited by 35
Lee, M. J., Choi, J. H., Oh, J., Lee, Y. H., In, J.-G., Chang, B., Nah, S.-Y., & Cho, I. (2020) · Journal of Ginseng Research · doi:10.1016/j.jgr.2020.09.001 · Cited by 36
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Rubio-Ramos, A., Labat‐de‐Hoz, L., Correas, I., & Alonso, M. A. (2021) · Cells · doi:10.3390/cells10051065 · Cited by 35
Chatzikonstantinou, S., Poulidou, V., Arnaoutoglou, M., Kazis, D. A., Heliopoulos, I., Grigoriadis, N., & Boziki, M. K. (2021) · Cells · doi:10.3390/cells10113217 · Cited by 35
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Rodriguez-Mogeda, C., Rodríguez‐Lorenzo, S., Attia, J. V. D., van Horssen, J., Witte, M. E., & de Vries, H. E. (2022) · Biomolecules · doi:10.3390/biom12060800 · Cited by 36
Bashir, Y., & Khan, A. U. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.1030694 · Cited by 35
Morandi, E., Tănăsescu, R., Tarlinton, R. E., Constantin‐Teodosiu, D., & Gran, B. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2018.03092 · Cited by 35
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Penesová, A., Dean, Z., Kollár, B., Havranová, A., Imrich, R., Vlček, M., & Rádiková, Ž. (2018) · Physiological Research · doi:10.33549/physiolres.933694 · Cited by 35
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Monaghan, K. L., & Wan, E. C. K. (2020) · Cells · doi:10.3390/cells9030611 · Cited by 35
Tonev, D. G., & Momchilova, A. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242417223 · Cited by 34
Thomé, R., de Carvalho, A. C., da Costa, T. A., Ishikawa, L. L. W., Fraga‐Silva, T. F. D. C., Sartori, A., de Oliveira, A. L. R., & Verinaud, L. M. C. (2016) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12561 · Cited by 34
Kulkarni, A., Ganesan, P., & O’Donnell, L. A. (2016) · Clinical Medicine Insights Pathology · doi:10.4137/cpath.s40497 · Cited by 35
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Suescun, J., Chandra, S., & Schiess, M. C. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-813832-8.00013-3 · Cited by 34
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Rádiková, Ž., Penesová, A., Vlček, M., Havranová, A., Siváková, M., Šiarnik, P., Žitňanová, I., Imrich, R., Turčáni, P., & Kollár, B. (2020) · Lipids in Health and Disease · doi:10.1186/s12944-020-01221-x · Cited by 34
Martinez, B., & Peplow, P. V. (2020) · Neural Regeneration Research · doi:10.4103/1673-5374.280307 · Cited by 34
Alcohol and multiple sclerosis: an immune system-based review.
Fahim, M., Zadeh, A. R., Shoureshi, P., Ghadimi, K., Cheshmavar, M., Sheikhinia, N., & Afzali, M. (2020) · PubMed Central · Cited by 34
Pennati, A., Nylen, E. A., Duncan, I. D., & Galipeau, J. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.2840-19.2020 · Cited by 34
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Vuotto, C., Battistini, L., Caltagirone, C., & Borsellino, G. (2020) · The Neuroscientist · doi:10.1177/1073858420918826 · Cited by 37
Al‐Mazroua, H. A., Nadeem, A., Ansari, M. A., Attia, S. M., Bakheet, S. A., Albekairi, T. H., Ali, N., Alasmari, F. F., Algahtani, M., Alsaad, A. M. S., et al. (2022) · Molecular Immunology · doi:10.1016/j.molimm.2022.02.017 · Cited by 34
Zveik, O., Fainstein, N., Rechtman, A., Haham, N., Ganz, T., Lavon, I., Brill, L., & Vaknin‐Dembinsky, A. (2022) · Glia · doi:10.1002/glia.24165 · Cited by 35
Epigenetic Regulation of Ferroptosis in Central Nervous System Diseases
Lan, T., Sun, T., Wei, C., Cheng, T., Yang, F., Zhang, J.-N., & Li, Q. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03267-1 · Cited by 35
Stanisavljević, S., Lukić, J., Momčilović, M. B., Miljković, M., Jevtić, B., Kojić, M., Golić, N., Stojković, M. M., & Miljković, D. M. (2016) · Beneficial Microbes · doi:10.3920/bm2015.0159 · Cited by 34
Zhang, J., Li, Z., Hu, X., Su, Q., He, C., Liu, J., Ren, H., Qian, M., Liu, J., Cui, S., et al. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.12.001 · Cited by 34
Rajasundaram, S. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00402 · Cited by 37
Quinn, J., & Axtell, R. C. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19103233 · Cited by 36
Musella, A., Gentile, A., Guadalupi, L., Rizzo, F. R., Vito, F. D., Fresegna, D., Bruno, A., Dolcetti, E., Vanni, V., Vitiello, L., et al. (2020) · Cells · doi:10.3390/cells9051290 · Cited by 34
Unique Bioactives from Zombie Fungus (Cordyceps) as Promising Multitargeted Neuroprotective Agents
Sharma, H., Sharma, N., & An, S. S. A. (2023) · Nutrients · doi:10.3390/nu16010102 · Cited by 35
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Neamţu, M., Bild, V., Vasincu, A., Arcan, O. D., Bulea, D., Ababei, D. C., Rusu, R.-N., Macadan, I., Sciucă, A. M., & Neamțu, A. (2024) · Current Issues in Molecular Biology · doi:10.3390/cimb46040220 · Cited by 35
Liu, X., Li, Y., Huang, L., Kuang, Y., Wu, X., Ma, X., Zhao, B., & Lan, J. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1450704 · Cited by 39
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Turner, T.-A. J., Lehman, P., Ghimire, S., Shahi, S. K., & Mangalam, A. K. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2387794 · Cited by 33
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Bianchini, E., Biasi, S. D., Simone, A. M., Ferraro, D., Sola, P., Cossarizza, A., & Pinti, M. (2017) · Immunology Letters · doi:10.1016/j.imlet.2017.01.009 · Cited by 33
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Solouki, S., August, A., & Huang, W. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2019.05.008 · Cited by 37
N’diaye, M., Brauner, S., Flytzani, S., Kular, L., Warnecke, A., Adzemovic, M. Z., Piket, E., Min, J.-H., Edwards, W., Mela, F., et al. (2019) · Journal of Clinical Investigation · doi:10.1172/jci125857 · Cited by 33
Chen, J., Martindale, J. L., Abdelmohsen, K., Kumar, G., Fortina, P. M., Gorospe, M., Rostami, A. M., & Yu, S. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.1900769 · Cited by 34
Wang, Z., Zheng, G., Li, G., Wang, M., Ma, Z., Li, H., Wang, X., & Yi, H. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.15928 · Cited by 33
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Dziedzic, A., Saluk, J., Miller, E. D., Niemcewicz, M., & Bijak, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041804 · Cited by 33
Kim, G., Kim, W., Lim, S., Lee, H., Koo, J., Nam, K.-H., Kim, S., Park, S., & Choi, J. (2021) · Advanced Science · doi:10.1002/advs.202004973 · Cited by 33
Groppa, S., González‐Escamilla, G., Eshaghi, A., Meuth, S. G., & Ciccarelli, O. (2021) · Brain Communications · doi:10.1093/braincomms/fcab237 · Cited by 34
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Zapata-Acevedo, J. F., Perez, V. G., Cabezas-Pérez, R., Losada-Barragán, M., Vargas-Sánchez, K., & González-Reyes, R. E. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23126788 · Cited by 36
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Schwarz, K., & Schmitz, F. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24021639 · Cited by 36
Therapeutic application of apoptosis signal-regulating kinase 1 inhibitors
Fujisawa, T. (2017) · Advances in Biological Regulation · doi:10.1016/j.jbior.2017.10.004 · Cited by 33
Beliën, J., Swinnen, S., D’hondt, R., Verdú de Juan, L., Dedoncker, N., Matthys, P., Bauer, J., Vens, C., Moylett, S., & Dubois, B. (2024) · Nature Communications · doi:10.1038/s41467-024-49312-y · Cited by 32
“Alto-gether, we provide a rationale for CHIT1 as an early biomarker for faster disability progression in MS. Multiplesclerosis(MS)isachronicautoimmunedisorderofthecentral nervous system (CNS) characterized by considerable interindividual heterogeneity in terms of disease onset and severity 1 .”
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Mathy, N. W., Burleigh, O., Kochvar, A. P., Whiteford, E. R., Behrens, M., Marta, P., Tian, C., Gong, A., Drescher, K. M., Steyger, P. S., et al. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-020-02051-5 · Cited by 34
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Archie, S. R., Sharma, S., Burks, E., & Abbruscato, T. J. (2022) · NeuroToxicology · doi:10.1016/j.neuro.2022.02.002 · Cited by 33
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Boziki, M. K., Pοlyzos, S. A., Deretzi, G., Kazakos, E. I., Katsinelos, P., Doulberis, M., Kotronis, G., Giartza‐Taxidou, E., Laskaridis, L., Tzivras, D., et al. (2017) · Neurochemistry International · doi:10.1016/j.neuint.2017.12.003 · Cited by 32
Ouyang, S., Zeng, Q., Tang, N., Guo, H., Tang, R., Yin, W., Wang, A., Tang, H., Zhou, J., Xie, H., et al. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1701204 · Cited by 32
Musella, A., Fresegna, D., Rizzo, F. R., Gentile, A., Vito, F. D., Caioli, S., Guadalupi, L., Bruno, A., Dolcetti, E., Buttari, F., et al. (2020) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2020.1709823 · Cited by 33
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Metadata
- Authors
- Dendrou, C. A., Fugger, L., & Friese, M. A.
- Affiliations
- John Radcliffe Hospital (GB)
- Aarhus University Hospital (DK)
- University Medical Center Hamburg-Eppendorf (DE)
- Corresponding author
- Fugger, Lars
- Venue
- Nature Reviews Immunology
- Published
- 2015-08-07
- Volume
- 15
- Issue
- 9
- Pages
- 545-558
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W1828576284
- Cited by
- 2,215
- References
- 122
- Citations by year
- 2026: 117 · 2025: 177 · 2024: 243 · 2023: 230 · 2022: 252 · 2021: 272 · 2020: 257 · 2019: 216 · 2018: 201 · 2017: 159 · 2016: 83 · 2015: 5
- FWCI
- 21.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust (100308/Z/12/Z, 100308)
- Alan and Babette Sainsbury Charitable Fund
- Topics
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- multiple sclerosis, immunopathology, genetic susceptibility, environmental triggers, neuroinflammation, neurodegeneration, immunomodulatory therapy, recurrence, disease progression
- MeSH terms
- Environmental Exposure, Humans, Inflammation, Multiple Sclerosis, Autoimmunity, Genetic Predisposition to Disease
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