Cited by 2,215Multiple Sclerosis Research StudiesPsoriasis: Treatment and PathogenesisNeuroinflammation and Neurodegeneration Mechanisms

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Immunopathology of multiple sclerosis

Dendrou, Calliope A., Fugger, Lars, Friese, Manuel A.·2015·Nature Reviews Immunology

DOI 10.1038/nri3871

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Abstract

Two decades of clinical experience with immunomodulatory treatments for multiple sclerosis point to distinct immunological pathways that drive disease relapses and progression. In light of this, we discuss our current understanding of multiple sclerosis immunopathology, evaluate long-standing hypotheses regarding the role of the immune system in the disease and delineate key questions that are still unanswered. Recent and anticipated advances in the field of immunology, and the increasing recognition of inflammation as an important component of neurodegeneration, are shaping our conceptualization of disease pathophysiology, and we explore the potential implications for improved healthcare provision to patients in the future.

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Authors: Dendrou, C. A., Fugger, L., & Friese, M. A.
Affiliations: John Radcliffe Hospital (GB)
Aarhus University Hospital (DK)
University Medical Center Hamburg-Eppendorf (DE)
Corresponding author: Fugger, Lars
ORCID: Dendrou, Calliope A.
Fugger, Lars
Friese, Manuel A.
Venue: Nature Reviews Immunology
Publisher: Springer Science and Business Media LLC
Published: 2015-08-07
Volume: 15
Issue: 9
Pages: 545-558
ISSN: 1474-1733 (ISSN-L)
1474-1741
DOI: 10.1038/nri3871
OpenAlex: W1828576284
Cited by: 2,215
References: 122
Citations by year: 2026: 117 · 2025: 177 · 2024: 243 · 2023: 230 · 2022: 252 · 2021: 272 · 2020: 257 · 2019: 216 · 2018: 201 · 2017: 159 · 2016: 83 · 2015: 5
FWCI: 21.94
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Immunology (publishedVersion)
PubMed (publishedVersion)
Funders: Wellcome Trust (100308/Z/12/Z, 100308)
Alan and Babette Sainsbury Charitable Fund
Topics: Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: multiple sclerosis, immunopathology, genetic susceptibility, environmental triggers, neuroinflammation, neurodegeneration, immunomodulatory therapy, recurrence, disease progression
MeSH terms: Environmental Exposure, Humans, Inflammation, Multiple Sclerosis, Autoimmunity, Genetic Predisposition to Disease

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