The DOI matches its Crossref record; 122 of the 122 references it cites were found in a registry or an index.
Immunopathology of multiple sclerosis
Abstract
Two decades of clinical experience with immunomodulatory treatments for multiple sclerosis point to distinct immunological pathways that drive disease relapses and progression. In light of this, we discuss our current understanding of multiple sclerosis immunopathology, evaluate long-standing hypotheses regarding the role of the immune system in the disease and delineate key questions that are still unanswered. Recent and anticipated advances in the field of immunology, and the increasing recognition of inflammation as an important component of neurodegeneration, are shaping our conceptualization of disease pathophysiology, and we explore the potential implications for improved healthcare provision to patients in the future.
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“The extensive infiltration and activation of peripheral and resident immune cells in MS suggests these cells are key mediators of lesion formation [77, 210, 278] (Fig. 1j-l).”
From Microglia and monocytes in inflammatory CNS disease: integrating phenotype and function (2022) · cites this paper as [77]
In the citing paper
“In addition to possible antigen-specific T cell-mediated inflammation, non-specific inflammation also contributes to myelin destruction in MS [77].”
From Microglia and monocytes in inflammatory CNS disease: integrating phenotype and function (2022) · cites this paper as [77]
In the citing paper
“Since currently available drugs insufficiently mitigate progression of neurodegeneration independent of the MS subtype (2), there is an urgent unmet clinical need for neuroprotective interventions.”
From MicroRNA-92a–CPEB3 axis protects neurons against inflammatory neurodegeneration (2023) · cites this paper as [2]
In the citing paper
“Both conditions have been characterised by immunological abnormalities and dysfunctional myelination, at least in a subset of individuals [170,171].”
From Vitamin D and Autism Spectrum Disorder: A Literature Review (2016) · cites this paper as [171]
In the citing paper
“Furthermore, work from the past few years demonstrates that microglial gene expression changes during aging and may contribute to risk for AD (3) as well as autoimmune disorders of the central nervous system (CNS) such as multiple sclerosis [MS; reviewed in (4)] and lupus (5), but precisely how these cells contribute to risk for autoimmune disorders or AD remains unclear.”
From The Transcriptional Landscape of Microglial Genes in Aging and Neurodegenerative Disease (2019) · cites this paper as [4]
Citations
Cites
Human gut microbiome viewed across age and geography
Yatsunenko, T., Rey, F. E., Manary, M. J., Trehan, I., Dominguez-Bello, M. G., Contreras, M., Magris, M., Hidalgo, G., Baldassano, R. N., Anokhin, A. P., et al. (2012) · Nature · doi:10.1038/nature11053 · Cited by 7,815
From inflammation to sickness and depression: when the immune system subjugates the brain
Dantzer, R., O'Connor, J. C., Freund, G. G., Johnson, R. W., & Kelley, K. W. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2297 · Cited by 7,395
Integrative analysis of 111 reference human epigenomes
Roadmap Epigenomics Consortium, Kundaje, A., Meuleman, W., Ernst, J., Bilenky, M., Yen, A., Heravi-Moussavi, A., Kheradpour, P., Zhang, Z., Wang, J., et al. (2015) · Nature · doi:10.1038/nature14248 · Cited by 6,368
Compston, A., & Coles, A. J. (2008) · The Lancet · doi:10.1016/s0140-6736(08)61620-7 · Cited by 4,699
Structural and functional features of central nervous system lymphatic vessels
Louveau, A., Smirnov, I., Keyes, T. J., Eccles, J. D., Rouhani, S. J., Peske, J. D., Derecki, N. C., Castle, D., Mandell, J. W., Lee, K. S., et al. (2015) · Nature · doi:10.1038/nature14432 · Cited by 4,413
Meta-Analysis of 74,046 Individuals Identifies 11 New Susceptibility Loci for Alzheimer’s Disease
(EADI), E. A. D. I., Lambert, J.-C., (GERAD), G. A. E. R. I. A. D., Alzheimer's Disease Genetic Consortium (ADGC), (CHARGE), C. F. H. A. A. R. I. G. E., Ibrahim-Verbaas, C. A., Harold, D., Naj, A. C., Sims, R., Bellenguez, C., et al. (2013) · Nature Genetics · doi:10.1038/ng.2802 · Cited by 4,336
Wherry, E. J. (2011) · Nature Immunology · doi:10.1038/ni.2035 · Cited by 4,062
Bennett, C. L., Christie, J., Ramsdell, F., Brunkow, M., Ferguson, P., Whitesell, L., Kelly, T., Saulsbury, F., Chance, P., & Ochs, H. (2001) · Nature Genetics · doi:10.1038/83713 · Cited by 3,576
B-cell depletion with rituximab in relapsing-remitting multiple sclerosis
Hauser, S. L., Waubant, E., Arnold, D. L., Vollmer, T., Antel, J., Fox, R. J., Bar-Or, A., Panzara, M., Sarkar, N., Agarwal, S., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0706383 · Cited by 2,439
Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors
Gomez Perdiguero, E., Klapproth, K., Schulz, C., Busch, K., Azzoni, E., Crozet, L., Garner, H., Trouillet, C., de Bruijn, M. F., Geissmann, F., et al. (2015) · Nature · doi:10.1038/nature13989 · Cited by 2,339
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Items 101–200 of 1,003
Groß, C. C., Schulte‐Mecklenbeck, A., Rünzi, A., Kuhlmann, T., Posevitz‐Fejfár, A., Schwab, N., Schneider‐Hohendorf, T., Herich, S., Held, K., Konjević, M., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1524924113 · Cited by 185
Neutrophils and redox stress in the pathogenesis of autoimmune disease
Glennon-Alty, L., Hackett, A. P., Chapman, E. A., & Wright, H. L. (2018) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2018.03.049 · Cited by 189
The Role of Diet in Multiple Sclerosis: Mechanistic Connections and Current Evidence
Sand, I. K. (2018) · Current Nutrition Reports · doi:10.1007/s13668-018-0236-z · Cited by 181
van Nierop, G. P., van Luijn, M. M., Michels, S. S., Melief, M.-J., Janssen, M., Langerak, A. W., Ouwendijk, W. J. D., Hintzen, R. Q., & Verjans, G. M. G. M. (2017) · Acta Neuropathologica · doi:10.1007/s00401-017-1744-4 · Cited by 174
Liver X Receptors: Regulators of Cholesterol Metabolism, Inflammation, Autoimmunity, and Cancer
Bilotta, M. T., Petillo, S., Santoni, A., & Cippitelli, M. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.584303 · Cited by 180
The "Gut Feeling": Breaking Down the Role of Gut Microbiome in Multiple Sclerosis
Freedman, S. N., Shahi, S. K., & Mangalam, A. K. (2018) · Neurotherapeutics · doi:10.1007/s13311-017-0588-x · Cited by 168
Sánchez‐Fernández, A., Skouras, D. B., Dinarello, C. A., & López‐Vales, R. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02578 · Cited by 167
Pericytes regulate vascular immune homeostasis in the CNS
Török, O., Schreiner, B., Schaffenrath, J., Tsai, H.-C., Maheshwari, U., Stifter, S. A., Welsh, C., Amorim, A., Sridhar, S., Utz, S. G., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2016587118 · Cited by 166
Role of Endogenous Lipopolysaccharides in Neurological Disorders
Kalyan, M., Hediyal, T. A., Sonali, S., Vichitra, C., Sunanda, T., Praveenraj, S. S., Ray, B., Gorantla, V. R., Rungratanawanich, W., Mahalakshmi, A. M., et al. (2022) · Cells · doi:10.3390/cells11244038 · Cited by 172
Cunha, M. I., Su, M., Cantuti-Castelvetri, L., Müller, S. A., Schifferer, M., Djannatian, M., Alexopoulos, I., van der Meer, F., Winkler, A., van Ham, T. J., et al. (2020) · Journal of Experimental Medicine · doi:10.1084/jem.20191390 · Cited by 160
When encephalitogenic T cells collaborate with microglia in multiple sclerosis
Dong, Y., & Yong, V. W. (2019) · Nature Reviews Neurology · doi:10.1038/s41582-019-0253-6 · Cited by 169
Chu, F., Shi, M., Lang, Y., Shen, D., Jin, T., Zhu, J., & Cui, L. (2018) · Mediators of Inflammation · doi:10.1155/2018/8168717 · Cited by 164
Shamili, F. H., Alibolandi, M., Rafatpanah, H., Abnous, K., Mahmoudi, M., Kalantari, M. R., Taghdisi, S. M., & Ramezani, M. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.02.032 · Cited by 157
Immunological Aspects of Approved MS Therapeutics
Rommer, P. S., Milo, R., Han, M. H., Satyanarayan, S., Sellner, J., Hauer, L., Illés, Z., Warnke, C., Laurent, S. A., Weber, M. S., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01564 · Cited by 161
Mononuclear phagocytes locally specify and adapt their phenotype in a multiple sclerosis model
Locatelli, G., Theodorou, D., Kendirli, A., Jordão, M. J. C., Staszewski, O., Phulphagar, K., Cantuti-Castelvetri, L., Dagkalis, A., Bessis, A., Simons, M., et al. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0212-3 · Cited by 155
Current Evidence for a Role of the Kynurenine Pathway of Tryptophan Metabolism in Multiple Sclerosis
Lovelace, M. D., Varney, B., Sundaram, G., Franco, N. F., Ng, M. L., Pai, S., Lim, C. K., Guillemin, G. J., & Brew, B. J. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00246 · Cited by 161
Nielsen, S., Germanos, R., Weier, M., Pollard, J., Degenhardt, L., Hall, W., Buckley, N., & Farrell, M. (2018) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-018-0814-x · Cited by 153
Therapeutic Potential of ω-3 Polyunsaturated Fatty Acids in Human Autoimmune Diseases
Li, X., Bi, X., Wang, S., Zhang, Z., Li, F., & Zhao, A. Z. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02241 · Cited by 157
Dias, R., Oliveira, H., Fernandes, I., Simal‐Gándara, J., & Pérez-Gregório, R. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1754162 · Cited by 153
Transposable Elements, Inflammation, and Neurological Disease
Saleh, A., Macia, A., & Muotri, A. R. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00894 · Cited by 149
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Diz-Chaves, Y., Mastoor, Z., Spuch, C., González-Matías, L. C., & Mallo, F. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23179583 · Cited by 148
Cross-reactive EBNA1 immunity targets alpha-crystallin B and is associated with multiple sclerosis
Thomas, O. G., Bronge, M., Tengvall, K., Akpinar, B., Nilsson, O. B., Holmgren, E., Hessa, T., Gafvelin, G., Khademi, M., Alfredsson, L. S., et al. (2023) · Science Advances · doi:10.1126/sciadv.adg3032 · Cited by 148
Tostanoski, L. H., Chiu, Y.-C., Gammon, J. M., Simon, T., Andorko, J. I., Bromberg, J. S., & Jewell, C. M. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.08.033 · Cited by 147
Gholamzad, M., Ebtekar, M., Ardestani, M. S., Azimi, M., Mahmodi, Z., Mousavi, M. J., & Aslani, S. (2018) · Inflammation Research · doi:10.1007/s00011-018-1185-0 · Cited by 161
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Scheu, S., Ali, S., Ruland, C., Arolt, V., & Alferink, J. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18112306 · Cited by 150
The contribution of neutrophils to CNS autoimmunity
Pierson, E. R., Wagner, C. A., & Goverman, J. M. (2016) · Clinical Immunology · doi:10.1016/j.clim.2016.06.017 · Cited by 146
P2X7 Receptors Amplify CNS Damage in Neurodegenerative Diseases
Illés, P. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21175996 · Cited by 145
Aso, K., Kono, M., Kanda, M., Kudo, Y., Sakiyama, K., Hisada, R., Karino, K., Ueda, Y., Nakazawa, D., Fujieda, Y., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-36594-x · Cited by 143
The Gut Microbiome and Multiple SclerosisPreprint
Ochoa‐Repáraz, J., Kirby, T. O., & Kasper, L. H. (2018) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a029017 · Cited by 143
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Wu, X., Tian, J., & Wang, S. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01112 · Cited by 148
Unique and shared inflammatory profiles of human brain endothelia and pericytes
Smyth, L. C. D., Rustenhoven, J., Park, T., Schweder, P. M., Jansson, D., Heppner, P. A., O’Carroll, S. J., Mee, E. W., Faull, R. L. M., Curtis, M. A., et al. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1167-8 · Cited by 138
Lesion stage-dependent causes for impaired remyelination in MS
Heß, K., Starost, L. J., Kieran, N. W., Thomas, C., Vincenten, M. C. J., Antel, J. P., Martino, G., Huitinga, I., Healy, L. M., & Kuhlmann, T. (2020) · Acta Neuropathologica · doi:10.1007/s00401-020-02189-9 · Cited by 144
Gao, H., Danzi, M. C., Choi, C. S., Taherian, M., Hansen, C. D., Ellman, D. G., Madsen, P. M., Bixby, J. L., Lemmon, V., Lambertsen, K. L., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2016.11.083 · Cited by 140
Multiple sclerosis: molecular pathogenesis and therapeutic intervention
Boutitah-Benyaich, I., Eixarch, H., Villacieros‐Álvarez, J., Hervera, A., Cobo‐Calvo, Á., Montalbán, X., & Espejo, C. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02415-4 · Cited by 149
Resolution of inflammation during multiple sclerosis
Ruiz, F., Vigne, S., & Pot, C. (2019) · Seminars in Immunopathology · doi:10.1007/s00281-019-00765-0 · Cited by 136
Proinflammatory CD20+ T cells in the pathogenesis of multiple sclerosis
von Essen, M. R., Ammitzbøll, C., Hansen, R. H., Petersen, E. R., McWilliam, O. H., Marquart, H. V., Damm, P., & Sellebjerg, F. T. (2018) · Brain · doi:10.1093/brain/awy301 · Cited by 132
Magliozzi, R., Howell, O. W., Durrenberger, P. F., Aricò, E., James, R., Cruciani, C., Reeves, C., Roncaroli, F., Nicholas, R. S., & Reynolds, R. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1650-x · Cited by 131
Anti-CD20 therapies for multiple sclerosis: current status and future perspectives
Margoni, M., Preziosa, P., Filippi, M., & Rocca, M. A. (2021) · Journal of Neurology · doi:10.1007/s00415-021-10744-x · Cited by 135
Bäcker‐Koduah, P., Paul, F., & Dörr, J.-M. (2017) · The EPMA Journal · doi:10.1007/s13167-017-0120-8 · Cited by 134
Regulatory T Cell Plasticity and Stability and Autoimmune Diseases
Qiu, R., Zhou, L., Ma, Y., Zhou, L., Liang, T., Shi, L., Long, J., & Yuan, D. (2018) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-018-8721-0 · Cited by 132
Identification of early neurodegenerative pathways in progressive multiple sclerosis
Kaufmann, M., Schaupp, A.-L., Sun, R., Coscia, F., Dendrou, C. A., Cortés, A., Kaur, G., Evans, H. G., Mollbrink, A., Navarro, J. F., et al. (2022) · Nature Neuroscience · doi:10.1038/s41593-022-01097-3 · Cited by 130
Self-citationThe role of TGF-β superfamily signaling in neurological disorders
Kashima, R., & Hata, A. (2017) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmx124 · Cited by 130
Type I/II Interferon Balance in the Regulation of Brain Physiology and Pathology
Deczkowska, A., Baruch, K., & Schwartz, M. (2016) · Trends in Immunology · doi:10.1016/j.it.2016.01.006 · Cited by 131
Cellular architecture of evolving neuroinflammatory lesions and multiple sclerosis pathology
Kukanja, P., Langseth, C. M., Rubio Rodríguez-Kirby, L. A., Agirre, E., Zheng, C., Raman, A., Yokota, C., Avenel, C., Tiklová, K., Guerreiro-Cacais, A. O., et al. (2024) · Cell · doi:10.1016/j.cell.2024.02.030 · Cited by 124
Inflammasome Proteins As Biomarkers of Multiple Sclerosis
Keane, R. W., Dietrich, W. D., & Vaccari, J. P. D. R. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.00135 · Cited by 130
Li, R., Rezk, A., Ghadiri, M., Luessi, F., Zipp, F., Li, H., Giacomini, P. S., Antel, J. P., & Bar‐Or, A. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1601649 · Cited by 122
Musella, A., Gentile, A., Rizzo, F. R., Vito, F. D., Fresegna, D., Bullitta, S., Vanni, V., Guadalupi, L., Bassi, M. S., Buttari, F., et al. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00238 · Cited by 126
Fard, M. T., & Stough, C. K. K. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00056 · Cited by 124
CTLA4 as Immunological Checkpoint in the Development of Multiple Sclerosis
Gerdes, L. A., Held, K., Beltrán, E., Berking, C., Prinz, J. C., Junker, A., Tietze, J. K., Ertl-Wagner, B. B., Straube, A. M., Kümpfel, T., et al. (2016) · Annals of Neurology · doi:10.1002/ana.24715 · Cited by 125
High-dimensional single-cell analysis reveals the immune signature of narcolepsy
Hartmann, F. J., Bernard‐Valnet, R., Queriault, C., Mrdjen, D., Weber, L. M., Galli, E., Krieg, C., Robinson, M. D., Nguyen, X., Dauvilliers, Y. A., et al. (2016) · The Journal of Experimental Medicine · doi:10.1084/jem.20160897 · Cited by 124
Kooij, G., Troletti, C. D., Leuti, A., Norris, P. C., Riley, I. R., Albanese, M., Ruggieri, S., Libreros, S., van der Pol, S. M. A., Hof, B. V. H., et al. (2019) · Haematologica · doi:10.3324/haematol.2019.219519 · Cited by 123
Parnell, G. P., & Booth, D. R. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00425 · Cited by 128
Thinking outside the box: non-canonical targets in multiple sclerosis
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Sex differences in autoimmune disorders of the central nervous system
Gold, S. M., Willing, A., Leypoldt, F., Paul, F., & Friese, M. A. (2018) · Seminars in Immunopathology · doi:10.1007/s00281-018-0723-8 · Cited by 122
Self-citationA Fungal World: Could the Gut Mycobiome Be Involved in Neurological Disease?
Forbes, J. D., Bernstein, C. N., Tremlett, H. L., Domselaar, G. V., & Knox, N. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.03249 · Cited by 122
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Fresegna, D., Bullitta, S., Musella, A., Rizzo, F. R., Vito, F. D., Guadalupi, L., Caioli, S., Balletta, S., Sanna, K., Dolcetti, E., et al. (2020) · Cells · doi:10.3390/cells9102290 · Cited by 121
Maleki, A. F., & Rivest, S. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00355 · Cited by 120
Pretreatment Cancer-Related Cognitive Impairment—Mechanisms and Outlook
Olson, B. G., & Marks, D. L. (2019) · Cancers · doi:10.3390/cancers11050687 · Cited by 122
Ruiz-Ballesteros, A. I., Meza-Meza, M. R., Vizmanos-Lamotte, B., Parra‐Rojas, I., & la Cruz-Mosso, U. D. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21249626 · Cited by 115
Diaz, G. M., Hupperts, R., Fraussen, J., & Somers, V. A. (2018) · Autoimmunity Reviews · doi:10.1016/j.autrev.2018.07.001 · Cited by 118
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NADPH oxidases as drug targets and biomarkers in neurodegenerative diseases: What is the evidence?
Sorce, S., Stocker, R., Seredenina, T. S., Holmdahl, R., Aguzzi, A., Chiò, A., Depaulis, A., Heitz, F., Olofsson, P., Olsson, T. P., et al. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.08.006 · Cited by 113
LaMothe, R. A., Kolte, P. N., Vo, T., Ferrari, J. D., Gelsinger, T. C., Wong, J., Chan, V., Ahmed, S., Srinivasan, A., Deitemeyer, P., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00281 · Cited by 113
Myelin-specific CD8+ T cells exacerbate brain inflammation in CNS autoimmunity
Wagner, C. A., Roqué, P. J., Mileur, T. R., Liggitt, D., & Goverman, J. M. (2019) · Journal of Clinical Investigation · doi:10.1172/jci132531 · Cited by 112
Praveenraj, S. S., Sonali, S., Anand, N., Hediyal, T. A., Vichitra, C., Kalyan, M., Kanna, P. V., Chandana, K. A., Paneyala, S., Mahalakshmi, A. M., et al. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-02990-5 · Cited by 116
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Engler, J. B., Kursawe, N., Solano, M. E., Patas, K., Wehrmann, S., Heckmann, N., Lühder, F., Reichardt, H. M., Arck, P., Gold, S. M., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1617115114 · Cited by 115
Self-citationThe Choroid Plexus Functions as a Niche for T-Cell Stimulation Within the Central Nervous System
Strominger, I., Elyahu, Y., Berner, O., Reckhow, J. D., Mittal, K., Nemirovsky, A., & Monsonego, A. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01066 · Cited by 116
Planas, R., Santos, R. G., Ojer, P. T., Cruciani, C., Lutterotti, A., Faigle, W., Schaeren‐Wiemers, N., Espejo, C., Eixarch, H., Pinilla, C., et al. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aat4301 · Cited by 115
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Laumet, G. O., Ma, J., Robison, A. J., Kumari, S., Heijnen, C. J., & Kavelaars, A. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00216 · Cited by 117
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Kalafatakis, I., & Karagogeos, D. (2021) · Biomolecules · doi:10.3390/biom11071058 · Cited by 126
Cai, Y., Zhang, Y., Leng, S., Ma, Y., Jiang, Q., Wen, Q., Ju, S., & Hu, J. (2024) · Neurobiology of Disease · doi:10.1016/j.nbd.2024.106426 · Cited by 120
Vitamin D and Autism Spectrum Disorder: A Literature Review
Mazahery, H., Camargo, C., Conlon, C., Beck, K., Kruger, M., & Von Hurst, P. (2016) · Nutrients · doi:10.3390/nu8040236 · Cited by 110
Early versus later treatment start in multiple sclerosis: a register‐based cohort study
Chalmer, T. A., Baggesen, L. M., Nørgaard, M., Koch‐Henriksen, N., Magyari, M., Sørensen, P. S., & the Danish Multiple Sclerosis Group (2018) · European Journal of Neurology · doi:10.1111/ene.13692 · Cited by 110
Curley, C. T., Sheybani, N., Bullock, T. N. J., & Price, R. J. (2017) · Theranostics · doi:10.7150/thno.21225 · Cited by 111
Achievements and obstacles of remyelinating therapies in multiple sclerosis
Stangel, M., Kuhlmann, T., Matthews, P. M., & Kilpatrick, T. J. (2017) · Nature Reviews Neurology · doi:10.1038/nrneurol.2017.139 · Cited by 116
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Lückel, C., Picard, F. S. R., Raifer, H., Carrascosa, L. C., Guralnik, A., Zhang, Y., Klein, M., Bittner, S., Steffen, F., Moos, S., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-13731-z · Cited by 106
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Carstensen, M., Stilund, M., Petersen, T., Møller, H. J., Petersen, E. L., & Christensen, T. (2017) · Immunology and Cell Biology · doi:10.1111/imcb.1025 · Cited by 105
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Levi, I., Gurevich, M., Perlman, G., Magalashvili, D., Menascu, S., Bar, N., Godneva, A., Zahavi, L., Chermon, D., Kosower, N., et al. (2021) · Cell Reports Medicine · doi:10.1016/j.xcrm.2021.100246 · Cited by 99
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Kaufmann, M., Evans, H. G., Schaupp, A.-L., Engler, J. B., Kaur, G., Willing, A., Kursawe, N., Schubert, C., Attfield, K. E., Fugger, L. H., et al. (2021) · Med · doi:10.1016/j.medj.2021.01.006 · Cited by 95
Self-citation
Metadata
- Authors
- Dendrou, C. A., Fugger, L., & Friese, M. A.
- Affiliations
- John Radcliffe Hospital (GB)
- Aarhus University Hospital (DK)
- University Medical Center Hamburg-Eppendorf (DE)
- Corresponding author
- Fugger, Lars
- Venue
- Nature Reviews Immunology
- Published
- 2015-08-07
- Volume
- 15
- Issue
- 9
- Pages
- 545-558
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W1828576284
- Cited by
- 2,215
- References
- 122
- Citations by year
- 2026: 117 · 2025: 177 · 2024: 243 · 2023: 230 · 2022: 252 · 2021: 272 · 2020: 257 · 2019: 216 · 2018: 201 · 2017: 159 · 2016: 83 · 2015: 5
- FWCI
- 21.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust (100308/Z/12/Z, 100308)
- Alan and Babette Sainsbury Charitable Fund
- Topics
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- multiple sclerosis, immunopathology, genetic susceptibility, environmental triggers, neuroinflammation, neurodegeneration, immunomodulatory therapy, recurrence, disease progression
- MeSH terms
- Environmental Exposure, Humans, Inflammation, Multiple Sclerosis, Autoimmunity, Genetic Predisposition to Disease
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