Immunopathology of multiple sclerosis

Human gut microbiome viewed across age and geography

Yatsunenko, T., Rey, F. E., Manary, M. J., Trehan, I., Dominguez-Bello, M. G., Contreras, M., Magris, M., Hidalgo, G., Baldassano, R. N., Anokhin, A. P., et al. (2012) · Nature · doi:10.1038/nature11053 · Cited by 7,815

From inflammation to sickness and depression: when the immune system subjugates the brain

Dantzer, R., O'Connor, J. C., Freund, G. G., Johnson, R. W., & Kelley, K. W. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2297 · Cited by 7,395

Integrative analysis of 111 reference human epigenomes

Roadmap Epigenomics Consortium, Kundaje, A., Meuleman, W., Ernst, J., Bilenky, M., Yen, A., Heravi-Moussavi, A., Kheradpour, P., Zhang, Z., Wang, J., et al. (2015) · Nature · doi:10.1038/nature14248 · Cited by 6,368

Multiple sclerosis

Compston, A., & Coles, A. J. (2008) · The Lancet · doi:10.1016/s0140-6736(08)61620-7 · Cited by 4,699

Structural and functional features of central nervous system lymphatic vessels

Louveau, A., Smirnov, I., Keyes, T. J., Eccles, J. D., Rouhani, S. J., Peske, J. D., Derecki, N. C., Castle, D., Mandell, J. W., Lee, K. S., et al. (2015) · Nature · doi:10.1038/nature14432 · Cited by 4,413

Meta-Analysis of 74,046 Individuals Identifies 11 New Susceptibility Loci for Alzheimer’s Disease

(EADI), E. A. D. I., Lambert, J.-C., (GERAD), G. A. E. R. I. A. D., Alzheimer's Disease Genetic Consortium (ADGC), (CHARGE), C. F. H. A. A. R. I. G. E., Ibrahim-Verbaas, C. A., Harold, D., Naj, A. C., Sims, R., Bellenguez, C., et al. (2013) · Nature Genetics · doi:10.1038/ng.2802 · Cited by 4,336

T cell exhaustion

Wherry, E. J. (2011) · Nature Immunology · doi:10.1038/ni.2035 · Cited by 4,062

The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3

Bennett, C. L., Christie, J., Ramsdell, F., Brunkow, M., Ferguson, P., Whitesell, L., Kelly, T., Saulsbury, F., Chance, P., & Ochs, H. (2001) · Nature Genetics · doi:10.1038/83713 · Cited by 3,576

B-cell depletion with rituximab in relapsing-remitting multiple sclerosis

Hauser, S. L., Waubant, E., Arnold, D. L., Vollmer, T., Antel, J., Fox, R. J., Bar-Or, A., Panzara, M., Sarkar, N., Agarwal, S., et al. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0706383 · Cited by 2,439

Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors

Gomez Perdiguero, E., Klapproth, K., Schulz, C., Busch, K., Azzoni, E., Crozet, L., Garner, H., Trouillet, C., de Bruijn, M. F., Geissmann, F., et al. (2015) · Nature · doi:10.1038/nature13989 · Cited by 2,339

Genetic and epigenetic fine mapping of causal autoimmune disease variants

Farh, K. K.-H., Marson, A., Zhu, J., Kleinewietfeld, M., Housley, W. J., Beik, S., Shoresh, N., Whitton, H., Ryan, R. J. H., Shishkin, A. A., et al. (2015) · Nature · doi:10.1038/nature13835 · Cited by 1,956

Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson’s disease

International Parkinson's Disease Genomics Consortium (IPDGC), Nalls, M. A., Parkinson's Study Group (PSG) Parkinson's Research: The Organized GENetics Initiative (PROGENI), 23andMe, GenePD, NeuroGenetics Research Consortium (NGRC), Hussman Institute of Human Genomics (HIHG), Investigator, T. A. J. D., (CHARGE), C. F. H. A. A. R. I. G. E., North American Brain Expression Consortium (NABEC), et al. (2014) · Nature Genetics · doi:10.1038/ng.3043 · Cited by 1,895

Prevention of experimental autoimmune encephalomyelitis by antibodies against α4βl integrin

Yednock, T. A., Cannon, C., Fritz, L. C., Sánchez‐Madrid, F., Steinman, L., & Karin, N. (1992) · Nature · doi:10.1038/356063a0 · Cited by 1,737

Uncovering disease-disease relationships through the incomplete interactome

Menche, J., Sharma, A., Kitsak, M., Ghiassian, S. D., Vidal, M., Loscalzo, J., & Barabási, A.-L. (2015) · Science · doi:10.1126/science.1257601 · Cited by 1,546

The relation between inflammation and neurodegeneration in multiple sclerosis brains

Frischer, J. M., Bramow, S., Dal-Bianco, A., Lucchinetti, C. F., Rauschka, H., Schmidbauer, M., Laursen, H., Sorensen, P. S., & Lassmann, H. (2009) · Brain · doi:10.1093/brain/awp070 · Cited by 1,450

Innate immune activation in neurodegenerative disease

Heneka, M. T., Kummer, M. P., & Latz, E. (2014) · Nature Reviews Immunology · doi:10.1038/nri3705 · Cited by 1,437

Generation of pathogenic TH17 cells in the absence of TGF-β signalling

Ghoreschi, K., Laurence, A., Yang, X.-P., Tato, C. M., McGeachy, M. J., Konkel, J. E., Ramos, H. L., Wei, L., Davidson, T. S., Bouladoux, N., et al. (2010) · Nature · doi:10.1038/nature09447 · Cited by 1,388

Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis

International Multiple Sclerosis Genetics Consortium (IMSGC) (2013) · Nature Genetics · doi:10.1038/ng.2770 · Cited by 1,386

Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination

Berer, K., Mues, M., Koutrolos, M., Rasbi, Z. A., Boziki, M., Johner, C., Wekerle, H., & Krishnamoorthy, G. (2011) · Nature · doi:10.1038/nature10554 · Cited by 1,251

Interleukin-17 Production in Central Nervous System-Infiltrating T Cells and Glial Cells Is Associated with Active Disease in Multiple Sclerosis

Tzartos, J. S., Friese, M. A., Craner, M. J., Palace, J. A., Newcombe, J., Esiri, M. M., & Fugger, L. H. (2007) · American Journal Of Pathology · doi:10.2353/ajpath.2008.070690 · Cited by 1,225

Homeostasis, Inflammation, and Disease Susceptibility

Kotas, M. E., & Medzhitov, R. (2015) · Cell · doi:10.1016/j.cell.2015.02.010 · Cited by 1,213

RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation

Codarri, L., Gyülvészi, G., Tosevski, V., Hesske, L., Fontana, A., Magnenat, L., Suter, T., & Becher, B. (2011) · Nature Immunology · doi:10.1038/ni.2027 · Cited by 1,191

Variation in the Human Immune System Is Largely Driven by Non-Heritable Influences

Brodin, P., Jojic, V., Gao, T., Bhattacharya, S., Angel, C. J. L., Furman, D., Shen-Orr, S., Dekker, C. L., Swan, G. E., Butte, A. J., et al. (2015) · Cell · doi:10.1016/j.cell.2014.12.020 · Cited by 1,065

IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases

Shen, P., Roch, T., Lampropoulou, V., O’Connor, R. A., Stervbo, U., Hilgenberg, E., Ries, S., Dang, V. D., Jaimes, Y., Daridon, C., et al. (2014) · Nature · doi:10.1038/nature12979 · Cited by 1,048

The anatomical and cellular basis of immune surveillance in the central nervous system

Ransohoff, R. M., & Engelhardt, B. (2012) · Nature reviews. Immunology · doi:10.1038/nri3265 · Cited by 1,029

Pathogen-induced human TH17 cells produce IFN-γ or IL-10 and are regulated by IL-1β

Zielinski, C. E., Mele, F., Aschenbrenner, D., Jarrossay, D., Ronchi, F., Gattorno, M., Monticelli, S., Lanzavecchia, A., & Sallusto, F. (2012) · Nature · doi:10.1038/nature10957 · Cited by 919

Meningeal inflammation is widespread and linked to cortical pathology in multiple sclerosis

Howell, O. W., Reeves, C. A., Nicholas, R., Carassiti, D., Radotra, B., Gentleman, S. M., Serafini, B., Aloisi, F., Roncaroli, F., Magliozzi, R., et al. (2011) · Brain · doi:10.1093/brain/awr182 · Cited by 858

Differential roles of microglia and monocytes in the inflamed central nervous system

Yamasaki, R., Lu, H., Butovsky, O., Ohno, N., Rietsch, A. M., Cialic, R., Wu, P. M., Doykan, C. E., Lin, J., Cotleur, A. C., et al. (2014) · Journal of Experimental Medicine · doi:10.1084/jem.20132477 · Cited by 856

Lymphoid organ development: from ontogeny to neogenesis

Drayton, D. L., Liao, S., Mounzer, R. H., & Ruddle, N. H. (2006) · Nature Immunology · doi:10.1038/ni1330 · Cited by 777

Oxidative damage in multiple sclerosis lesions

Haider, L., Fischer, M. T., Frischer, J., Bauer, J., Höftberger, R., Botond, G., Esterbauer, H., Binder, C., Witztum, J., & Lassmann, H. (2011) · Brain : a journal of neurology · doi:10.1093/brain/awr128 · Cited by 754

Ocrelizumab in relapsing-remitting multiple sclerosis: a phase 2, randomised, placebo-controlled, multicentre trial

Kappos, L., Li, D., Calabresi, P. A., O'Connor, P. W., Bar‐Or, A., Barkhof, F., Yin, M., Leppert, D., Glanzman, R., Tinbergen, J., et al. (2011) · The Lancet · doi:10.1016/s0140-6736(11)61649-8 · Cited by 743

Environmental risk factors and multiple sclerosis: an umbrella review of systematic reviews and meta-analyses

Belbasis, L., Bellou, V., Εvangelou, Ε., Ioannidis, J. P. A., & Tzoulaki, I. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70267-4 · Cited by 715

Epitope spreading initiates in the CNS in two mouse models of multiple sclerosis

McMahon, E. J., Bailey, S. L., Castenada, C. V., Waldner, H., & Miller, S. D. (2005) · Nature Medicine · doi:10.1038/nm1202 · Cited by 694

A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation

Goldmann, T., Wieghofer, P., Müller, P. F., Wolf, Y., Varol, D., Yona, S., Brendecke, S. M., Kierdorf, K., Staszewski, O., Datta, M., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3531 · Cited by 688

B cell depletion therapy ameliorates autoimmune disease through ablation of IL-6–producing B cells

Barr, T. A., Shen, P., Brown, S. L., Lampropoulou, V., Roch, T., Lawrie, S., Fan, B., O’Connor, R. A., Anderton, S. M., Bar‐Or, A., et al. (2012) · The Journal of Experimental Medicine · doi:10.1084/jem.20111675 · Cited by 673

Interleukin 7 receptor α chain ( IL7R ) shows allelic and functional association with multiple sclerosis

for the Multiple Sclerosis Genetics Group, Gregory, S. G., Schmidt, S., Seth, P., Oksenberg, J. R., Hart, J., Prokop, A., Caillier, S. J., Ban, M., Goris, A., et al. (2007) · Nature Genetics · doi:10.1038/ng2103 · Cited by 657

Mechanisms of neurodegeneration and axonal dysfunction in multiple sclerosis

Friese, M. A., Schattling, B., & Fugger, L. (2014) · Nature Reviews Neurology · doi:10.1038/nrneurol.2014.37 · Cited by 628

Aging-induced type I interferon response at the choroid plexus negatively affects brain function

Baruch, K., Deczkowska, A., David, E., Castellano, J. M., Miller, O., Kertser, A., Berkutzki, T., Barnett-Itzhaki, Z., Bezalel, D., Wyss-Coray, T., et al. (2014) · Science · doi:10.1126/science.1252945 · Cited by 615

The Virome in Mammalian Physiology and Disease

Virgin, H. W. (2014) · Cell · doi:10.1016/j.cell.2014.02.032 · Cited by 603

Persistent infection with Theiler's virus leads to CNS autoimmunity via epitope spreading

Miller, S. D., Vanderlugt, C. L., Begolka, W. S., Pao, W., Yauch, R. L., Neville, K. L., Katz-Levy, Y., Carrizosa, A., & Kim, B. S. (1997) · Nature Medicine · doi:10.1038/nm1097-1133 · Cited by 565

Preferential recruitment of interferon‐γ–expressing T H 17 cells in multiple sclerosis

Kebir, H., Ifergan, I., Alvarez, J. I., Bernard, M., Poirier, J., Arbour, N., Duquette, P., & Prat, A. (2009) · Annals of Neurology · doi:10.1002/ana.21748 · Cited by 551

Identification of T helper type 1–like, Foxp3+ regulatory T cells in human autoimmune disease

Dominguez-Villar, M., Baecher-Allan, C. M., & Hafler, D. A. (2011) · Nature Medicine · doi:10.1038/nm.2389 · Cited by 526

NADPH oxidase expression in active multiple sclerosis lesions in relation to oxidative tissue damage and mitochondrial injury

Fischer, M. T., Sharma, R., Lim, J. L., Haider, L., Frischer, J. M., Drexhage, J., Mahad, D., Bradl, M., van Horssen, J., & Lassmann, H. (2012) · Brain · doi:10.1093/brain/aws012 · Cited by 507

Polarization of the Effects of Autoimmune and Neurodegenerative Risk Alleles in Leukocytes

Raj, T., Rothamel, K., Mostafavi, S., Ye, C., Lee, M. N., Replogle, J. M., Feng, T., Lee, M., Asinovski, N., Frohlich, I., et al. (2014) · Science · doi:10.1126/science.1249547 · Cited by 506

Antiviral immune responses: triggers of or triggered by autoimmunity?

Münz, C., Lünemann, J. D., Getts, M. T., & Miller, S. D. (2009) · Nature reviews. Immunology · doi:10.1038/nri2527 · Cited by 496

Repeated subcutaneous injections of IL12/23 p40 neutralising antibody, ustekinumab, in patients with relapsing-remitting multiple sclerosis: a phase II, double-blind, placebo-controlled, randomised, dose-ranging study

Segal, B. M., Constantinescu, C. S., Raychaudhuri, A., Kim, L., Fidelus-Gort, R., & Kasper, L. H. (2008) · The Lancet Neurology · doi:10.1016/s1474-4422(08)70173-x · Cited by 493

Regulation of astrocyte activation by glycolipids drives chronic CNS inflammation

Mayo, L., Trauger, S. A., Blain, M., Nadeau, M., Patel, B., Alvarez, J. I., Mascanfroni, I. D., Yeste, A., Kivisäkk, P., Kallas, K., et al. (2014) · Nature Medicine · doi:10.1038/nm.3681 · Cited by 488

CD39+Foxp3+ Regulatory T Cells Suppress Pathogenic Th17 Cells and Are Impaired in Multiple Sclerosis

Fletcher, J. M., Lonergan, R. M., Costelloe, L., Kinsella, K., Moran, B., O’Farrelly, C., Tubridy, N. J., & Mills, K. H. G. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901881 · Cited by 476

B cells populating the multiple sclerosis brain mature in the draining cervical lymph nodes

Stern, J. N. H., Yaari, G., Heiden, J. A. V., Church, G. M., Donahue, W. F., Hintzen, R. Q., Huttner, A. J., Laman, J. D., Nagra, R. M., Nylander, A. N., et al. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3008879 · Cited by 450

Molecular changes in neurons in multiple sclerosis: Altered axonal expression of Na v 1.2 and Na v 1.6 sodium channels and Na + /Ca 2 + exchanger

Craner, M. J., Newcombe, J., Black, J. A., Hartle, C., Cuzner, M. L., & Waxman, S. G. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402765101 · Cited by 446

A molecular basis for the association of the HLA-DRB1 locus, citrullination, and rheumatoid arthritis

Scally, S. W., Petersen, J., Law, S. C., Dudek, N. L., Nel, H. J., Loh, K. L., Wijeyewickrema, L. C., Eckle, S. B. G., van Heemst, J., Pike, R. N., et al. (2013) · Journal of Experimental Medicine · doi:10.1084/jem.20131241 · Cited by 429

Pathology of Demyelinating Diseases

Popescu, B. F. G., & Lucchinetti, C. F. (2011) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-011811-132443 · Cited by 426

Autoimmune encephalopathies

Leypoldt, F., Armangué, T., & Dalmau, J. O. (2014) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12553 · Cited by 424

Orchestrated leukocyte recruitment to immune-privileged sites: absolute barriers versus educational gates

Shechter, R., London, A., & Schwartz, M. (2013) · Nature reviews. Immunology · doi:10.1038/nri3391 · Cited by 422

BACH2 represses effector programs to stabilize Treg-mediated immune homeostasis

Roychoudhuri, R., Hirahara, K., Mousavi, K., Clever, D. C., Klebanoff, C. A., Bonelli, M. M., Sciumè, G., Zare, H., Vahedi, G., Dema, B., et al. (2013) · Nature · doi:10.1038/nature12199 · Cited by 412

Acid-sensing ion channel-1 contributes to axonal degeneration in autoimmune inflammation of the central nervous system

Friese, M. A., Craner, M. J., Etzensperger, R., Vergo, S. B., Wemmie, J. A., Welsh, M. J., Vincent, A. C., & Fugger, L. H. (2007) · Nature Medicine · doi:10.1038/nm1668 · Cited by 408

TNF receptor 1 genetic risk mirrors outcome of anti-TNF therapy in multiple sclerosis

Gregory, A., Dendrou, C. A., Attfield, K. E., Haghikia, A., Xifara, D. K., Butter, F., Poschmann, G., Kaur, G., Lambert, L., Leach, O. A., et al. (2012) · Nature · doi:10.1038/nature11307 · Cited by 395

Meningeal inflammation plays a role in the pathology of primary progressive multiple sclerosis.

Choi, S. R., Howell, O. W., Carassiti, D., Magliozzi, R., Gveric, D., Muraro, P. A., Nicholas, R., Roncaroli, F., & Reynolds, R. (2012) · Brain · doi:10.1093/brain/aws189 · Cited by 386

Compromised CD4+ CD25high regulatory T‐cell function in patients with relapsing‐remitting multiple sclerosis is correlated with a reduced frequency of FOXP3‐positive cells and reduced FOXP3 expression at the single‐cell level

Venken, K., Hellings, N., Thewissen, M. M., Somers, V. A., Hensen, K., Rummens, J., Medaer, R., Hupperts, R., & Stinissen, P. (2007) · Immunology · doi:10.1111/j.1365-2567.2007.02690.x · Cited by 376

Inhibition of Microglial Phagocytosis Is Sufficient To Prevent Inflammatory Neuronal Death

Neher, J. J., Neniskyte, U., Zhao, J.-W., Bal-Price, A., Tolkovsky, A. M., & Brown, G. C. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003600 · Cited by 373

Super-enhancers delineate disease-associated regulatory nodes in T cells

Vahedi, G., Kanno, Y., Furumoto, Y., Jiang, K., Parker, S. C. J., Erdos, M. R., Davis, S. R., Roychoudhuri, R., Restifo, N. P., Gadina, M., et al. (2015) · Nature · doi:10.1038/nature14154 · Cited by 369

Brain atrophy in clinically early relapsing–remitting multiple sclerosis

Chard, D. T., Griffin, C. M., Parker, G. J. M., Kapoor, R., Thompson, A. J., & Miller, D. H. (2002) · Brain · doi:10.1093/brain/awf025 · Cited by 366

Time course and localization patterns of interleukin-1β messenger rna expression in brain and pituitary after peripheral administration of lipopolysaccharide

Quan, N., Whiteside, M., & Herkenham, M. (1998) · Neuroscience · doi:10.1016/s0306-4522(97)00350-3 · Cited by 335

Analysis of regulatory CD8 T cells in Qa-1-deficient mice

Hu, D., Ikizawa, K., Lu, L., Sanchirico, M. E., Shinohara, M. L., & Cantor, H. (2004) · Nature Immunology · doi:10.1038/ni1063 · Cited by 330

Microglial displacement of inhibitory synapses provides neuroprotection in the adult brain

Chen, Z., Jalabi, W., Hu, W., Park, H.-J., Gale, J. T., Kidd, G. J., Bernatowicz, R., Gossman, Z. C., Chen, J. T., Dutta, R., et al. (2014) · Nature Communications · doi:10.1038/ncomms5486 · Cited by 319

Cytokine signals propagate through the brain

Vitković, L., Konsman, J. P., Bockaert, J., Dantzer, R., Homburger, V., & Jacque, C. (2000) · Molecular Psychiatry · doi:10.1038/sj.mp.4000813 · Cited by 306

Functional inflammatory profiles distinguish myelin-reactive T cells from patients with multiple sclerosis

Cao, Y., Goods, B. A., Raddassi, K., Nepom, G. T., Kwok, W. W., Love, J. C., & Hafler, D. A. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aaa8038 · Cited by 306

Memory Inflation during Chronic Viral Infection Is Maintained by Continuous Production of Short-Lived, Functional T Cells

Snyder, C. M., Cho, K. S., Bonnett, E. L., van Dommelen, S. L. H., SHELLAM, G. R., & Hill, A. B. (2008) · Immunity · doi:10.1016/j.immuni.2008.07.017 · Cited by 300

Treatment of progressive multiple sclerosis: what works, what does not, and what is needed

Feinstein, A., Freeman, J. A., & Lo, A. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70231-5 · Cited by 296

The Genetic Architecture of the Human Immune System: A Bioresource for Autoimmunity and Disease Pathogenesis

Roederer, M., Quaye, L., Mangino, M., Beddall, M. H., Mahnke, Y., Chattopadhyay, P., Tosi, I., Napolitano, L., Terranova Barberio, M., Menni, C., et al. (2015) · Cell · doi:10.1016/j.cell.2015.02.046 · Cited by 296

Antigen-Specific Tolerance by Autologous Myelin Peptide–Coupled Cells: A Phase 1 Trial in Multiple Sclerosis

Lutterotti, A., Yousef, S., Sputtek, A., Stürner, K. H., Stellmann, J., Breiden, P., Reinhardt, S., Schulze, C., Bester, M., Heesen, C., et al. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3006168 · Cited by 282

Cell-specific protein phenotypes for the autoimmune locus IL2RA using a genotype-selectable human bioresource

Dendrou, C. A., Plagnol, V., Fung, E., Yang, J. H. M., Downes, K., Cooper, J. D., Nutland, S., Coleman, G., Himsworth, M., Hardy, M., et al. (2009) · Nature Genetics · doi:10.1038/ng.434 · Cited by 274

Natural Naive CD4+CD25+CD127low Regulatory T Cell (Treg) Development and Function Are Disturbed in Multiple Sclerosis Patients: Recovery of Memory Treg Homeostasis during Disease Progression

Venken, K., Hellings, N., Broekmans, T., Hensen, K., Rummens, J., & Stinissen, P. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.9.6411 · Cited by 272

IL-17 and GM-CSF Expression Are Antagonistically Regulated by Human T Helper Cells

Noster, R., Riedel, R., Mashreghi, M., Radbruch, H., Harms, L., Haftmann, C., Chang, H., Radbruch, A., & Zielinski, C. E. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3008706 · Cited by 244

Expansion and Functional Relevance of High-Avidity Myelin-Specific CD4+ T Cells in Multiple Sclerosis

Bielekova, B., Sung, M., Kadom, N., Simon, R. M., McFarland, H. F., & Martinꝉ, R. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.6.3893 · Cited by 241

Intersection of population variation and autoimmunity genetics in human T cell activation

Ye, C. J., Feng, T., Kwon, H.-K., Raj, T., Wilson, M. T., Asinovski, N., McCabe, C., Lee, M. H., Frohlich, I., Paik, H.-I., et al. (2014) · Science · doi:10.1126/science.1254665 · Cited by 236

A virus-induced molecular mimicry model of multiple sclerosis

Olson, J. K., Croxford, J. L., Calenoff, M. A., Canto, M. C. D., & Miller, S. D. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13032 · Cited by 227

Treatment of multiple sclerosis with Copolymer-1 (Copaxone®): implicating mechanisms of Th1 to Th2/Th3 immune-deviation

Miller, A., Shapiro, S., Gershtein, R., Kinarty, A., Rawashdeh, H., Honigman, S., & Lahat, N. (1998) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(98)00191-x · Cited by 225

Immunoglobulin class-switched B cells form an active immune axis between CNS and periphery in multiple sclerosis

Palanichamy, A., Apeltsin, L., Kuo, T. C., Sirota, M., Wang, S., Pitts, S. J., Sundar, P. D., Telman, D., Zhao, L., Derstine, M., et al. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3008930 · Cited by 225

Therapeutic Induction of Regulatory, Cytotoxic CD8+ T Cells in Multiple Sclerosis

Tennakoon, D. K., Mehta, R. S., Ortega, S. B., Bhoj, V. G., Racke, M. K., & Karandikar, N. J. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.176.11.7119 · Cited by 207

Functional epistasis on a common MHC haplotype associated with multiple sclerosis

Gregersen, J. W., Kranc, K. R., Ke, X., Svendsen, P., Madsen, L. S., Thomsen, A. R., Cardon, L. R., Bell, J. I., & Fugger, L. H. (2006) · Nature · doi:10.1038/nature05133 · Cited by 207

TRPM4 cation channel mediates axonal and neuronal degeneration in experimental autoimmune encephalomyelitis and multiple sclerosis

Schattling, B., Steinbach, K., Thies, E., Kruse, M., Menigoz, A., Ufer, F., Flockerzi, V., Brück, W., Pongs, O., Vennekens, R., et al. (2012) · Nature Medicine · doi:10.1038/nm.3015 · Cited by 205

Non-myeloablative autologous haematopoietic stem cell transplantation expands regulatory cells and depletes IL-17 producing mucosal-associated invariant T cells in multiple sclerosis

Abrahamsson, S., Angelini, D. F., Dubinsky, A. N., Morel, E., Oh, U., Jones, J., Carassiti, D., Reynolds, R., Salvetti, M., Calabresi, P. A., et al. (2013) · Brain · doi:10.1093/brain/awt182 · Cited by 200

Absence of Epstein-Barr virus in the brain and CSF of patients with multiple sclerosis

Sargsyan, S. A., Shearer, A. J., Ritchie, A. M., Burgoon, M. P., Anderson, S. W., Hemmer, B., Stadelmann, C., Gattenlöhner, S., Owens, G. P., Gilden, D., et al. (2010) · Neurology · doi:10.1212/wnl.0b013e3181d865a1 · Cited by 200

Increased frequency of CD4+ CD25+ regulatory T cells in the cerebrospinal fluid but not in the blood of multiple sclerosis patients

Feger, U., Luther, C., Poeschel, S., Melms, A., Tolosa, E., & Wiendl, H. (2007) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2006.03271.x · Cited by 199

T Cell-Mediated Autoimmune Disease Due to Low-Affinity Crossreactivity to Common Microbial Peptides

Harkiolaki, M., Holmes, S. L., Svendsen, P., Gregersen, J. W., Jensen, L. T., McMahon, R. M., Friese, M. A., van Boxel, G., Etzensperger, R., Tzartos, J. S., et al. (2009) · Immunity · doi:10.1016/j.immuni.2009.01.009 · Cited by 198

Dendritic Cells Ameliorate Autoimmunity in the CNS by Controlling the Homeostasis of PD-1 Receptor+ Regulatory T Cells

Yogev, N., Frommer, F., Lukas, D., Kautz-Neu, K., Karram, K., Ielo, D., von Stebut, E., Probst, H.-C., van den Broek, M., Riethmacher, D., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.05.025 · Cited by 197

Multiple sclerosis-associated IL2RA polymorphism controls GM-CSF production in human TH cells

Hartmann, F. J., Khademi, M., Aram, J., Ammann, S., Kockum, I. S., Constantinescu, C. S., Gran, B., Piehl, F., Olsson, T. P., Deak, L. C., et al. (2014) · Nature Communications · doi:10.1038/ncomms6056 · Cited by 186

Opposing effects of HLA class I molecules in tuning autoreactive CD8+ T cells in multiple sclerosis

Friese, M. A., Jakobsen, K. B., Friis, L. S., Etzensperger, R., Craner, M. J., McMahon, R. M., Jensen, L. T., Huygelen, V., Jones, E. Y., Bell, J. I., et al. (2008) · Nature Medicine · doi:10.1038/nm.1881 · Cited by 184

A virus-induced molecular mimicry model of multiple sclerosis

Olson, J. K., Croxford, J. L., Calenoff, M. A., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci200113032 · Cited by 176

Viral infection triggers central nervous system autoimmunity via activation of CD8+ T cells expressing dual TCRs

Ji, Q., Perchellet, A., & Goverman, J. M. (2010) · Nature Immunology · doi:10.1038/ni.1888 · Cited by 167

From classic to spontaneous and humanized models of multiple sclerosis: Impact on understanding pathogenesis and drug development

Ben‐Nun, A., Kaushansky, N., Kawakami, N., Krishnamoorthy, G., Berer, K., Liblau, R., Hohlfeld, R., & Wekerle, H. (2014) · Journal of Autoimmunity · doi:10.1016/j.jaut.2014.06.004 · Cited by 165

CD 8 + MAIT cells infiltrate into the CNS and alterations in their blood frequencies correlate with IL ‐18 serum levels in multiple sclerosis

Willing, A., Leach, O. A., Ufer, F., Attfield, K. E., Steinbach, K., Kursawe, N., Piédavent, M., & Friese, M. A. (2014) · European Journal of Immunology · doi:10.1002/eji.201344160 · Cited by 165

Shift work at young age is associated with increased risk for multiple sclerosis

Hedström, A. K., Åkerstedt, T., Hillert, J. A., Olsson, T. P., & Alfredsson, L. S. (2011) · Annals of Neurology · doi:10.1002/ana.22597 · Cited by 161

A combined post-mortem magnetic resonance imaging and quantitative histological study of multiple sclerosis pathology

Kolasinski, J., Stagg, C. J., Chance, S. A., DeLuca, G. C., Esiri, M. M., Chang, E.-H., Palace, J. A., McNab, J. A., Jenkinson, M., Miller, K. L., et al. (2012) · Brain · doi:10.1093/brain/aws242 · Cited by 160

Soluble IL7Rα potentiates IL-7 bioactivity and promotes autoimmunity

Lundström, W., Highfill, S. L., Walsh, S. T. R., Beq, S., Morse, E., Kockum, I. S., Alfredsson, L. S., Olsson, T. P., Hillert, J. A., & Mackall, C. L. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1222303110 · Cited by 159

In Active Relapsing-Remitting Multiple Sclerosis, Effector T Cell Resistance to Adaptive T regs Involves IL-6–Mediated Signaling

Schneider, A., Long, S. A., Cerosaletti, K. M., Ni, C., Samuels, P. L., Kita, M., & Buckner, J. H. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3004970 · Cited by 157

IL‐10 suppressor activity and ex vivo Tr1 cell function are impaired in multiple sclerosis

Martínez‐Forero, I., García‐Muñoz, R., Martinez‐Pasamar, S., Inogés, S., de Cerio, A. L.-D., Palacios, R., Sepulcre, J., Moreno, B., Gonzalez, Z., Fernández-Díez, B., et al. (2008) · European Journal of Immunology · doi:10.1002/eji.200737271 · Cited by 141

High‐throughput sequencing of TCR repertoires in multiple sclerosis reveals intrathecal enrichment of EBV‐reactive CD8+ T cells

Lossius, A., Johansen, J. N., Vartdal, F., Robins, H. S., Benth, J. Š., Holmøy, T., & Olweus, J. (2014) · European Journal of Immunology · doi:10.1002/eji.201444662 · Cited by 135

MHC class I–restricted myelin epitopes are cross-presented by Tip-DCs that promote determinant spreading to CD8+ T cells

Ji, Q., Castelli, L., & Goverman, J. M. (2013) · Nature Immunology · doi:10.1038/ni.2513 · Cited by 124

Relapsing–Remitting Central Nervous System Autoimmunity Mediated by GFAP-Specific CD8 T Cells

Sasaki, K., Bean, A., Shah, S., Schutten, E., Huseby, P. G., Peters, B., Shen, Z. T., Vanguri, V. K., Liggitt, D., & Huseby, E. S. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1302911 · Cited by 118

Cervical cord lesion load is associated with disability independently from atrophy in MS

KEARNEY, H. F., Altmann, D. R., Samson, R. S., Yiannakas, M. C., Wheeler‐Kingshott, C. A. M. G., Ciccarelli, O., & Miller, D. H. (2014) · Neurology · doi:10.1212/wnl.0000000000001186 · Cited by 113

Interferon beta induces T-helper 2 immune deviation in MS

Kozovska, M., Hong, J., Zang, Y. C. Q., Li, S., Rivera, V. M., Killian, J. M., & Zhang, J. Z. (1999) · Neurology · doi:10.1212/wnl.53.8.1692 · Cited by 111

A case‐control study of multiple sclerosis

Operskalski, E. A., Visscher, B. R., Malmgren, R. M., & Detels, R. (1989) · Neurology · doi:10.1212/wnl.39.6.825 · Cited by 107

Intracerebral Human Regulatory T Cells: Analysis of CD4+CD25+FOXP3+ T Cells in Brain Lesions and Cerebrospinal Fluid of Multiple Sclerosis Patients

Fritzsching, B., Haas, J., König, F. B., Kunz, P., Fritzsching, E., Pöschl, J. M. B., Krammer, P. H., Brück, W., Suri‐Payer, E., & Wildemann, B. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017988 · Cited by 106

Increased PK11195-PET binding in normal-appearing white matter in clinically isolated syndrome

Giannetti, P., Politis, M., Su, P., Turkheimer, F., Malik, O., Shiva Keihaninejad, A., Wu, K., Waldman, A. D., Reynolds, R., Nicholas, R. S., et al. (2014) · Brain · doi:10.1093/brain/awu331 · Cited by 106

Therapies for multiple sclerosis: translational achievements and outstanding needs

Haghikia, A., Hohlfeld, R., Gold, R., & Fugger, L. H. (2013) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2013.03.004 · Cited by 105

Selecting causal genes from genome-wide association studies via functionally coherent subnetworks

Taşan, M., Musso, G. A., Hao, T., Vidal, M., MacRae, C. A., & Roth, F. P. (2014) · Nature Methods · doi:10.1038/nmeth.3215 · Cited by 102

Investigation of the KIR4.1 potassium channel as a putative antigen in patients with multiple sclerosis: a comparative study

Brickshawana, A., Hinson, S. R., Romero, M. F., Lucchinetti, C. F., Guo, Y. X., Buttmann, M., McKeon, A. B., Pittock, S. J., Chang, M.-H., Chen, A., et al. (2014) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70141-3 · Cited by 83

Neuroantigen-specific CD8+ regulatory T-cell function is deficient during acute exacerbation of multiple sclerosis

Baughman, E. J., Mendoza, J. P., Ortega, S. B., Ayers, C. L., Greenberg, B. M., Frohman, E. M., & Karandikar, N. J. (2011) · Journal of Autoimmunity · doi:10.1016/j.jaut.2010.12.003 · Cited by 80

IFN-β Treatment Requires B Cells for Efficacy in Neuroautoimmunity

Schubert, R. D., Hu, Y., Kumar, G., Szeto, S., Abraham, P., Winderl, J., Guthridge, J. M., Pardo, G., Dunn, J., Steinman, L., et al. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1402029 · Cited by 73

Neuromyelitis Optica and Asian Phenotype of Multiple Sclerosis

Kira, J. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1444.002 · Cited by 64

Thymic involution and proliferative T-cell responses in multiple sclerosis

Duszczyszyn, D. A., Williams, J. L., Mason, H., Lapierre, Y., Antel, J. P., & Haegert, D. G. (2010) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2010.02.005 · Cited by 61

IL17 and IFNγ production by peripheral blood mononuclear cells from clinically isolated syndrome to secondary progressive multiple sclerosis

Frisullo, G., Nociti, V., Iorio, R., Patanella, A. K., Marti, A., Caggiula, M., Massimiliano Mirabella, A., Tonali, P. A., & Batocchi, A. P. (2008) · Cytokine · doi:10.1016/j.cyto.2008.08.007 · Cited by 61

Unbiased identification of target antigens of CD8+ T cells with combinatorial libraries coding for short peptides

Siewert, K., Malotka, J., Kawakami, N., Wekerle, H., Hohlfeld, R., & Dornmair, K. (2012) · Nature Medicine · doi:10.1038/nm.2720 · Cited by 60

Differential diagnosis of Mendelian and mitochondrial disorders in patients with suspected multiple sclerosis

Weisfeld‐Adams, J. D., Sand, I. K., Honce, J. M., & LUBLIN, F. D. (2015) · Brain · doi:10.1093/brain/awu397 · Cited by 59

Clonally expanded mitochondrial DNA deletions within the choroid plexus in multiple sclerosis

Campbell, G. R., Kraytsberg, Y., Krishnan, K. J., Ohno, N., Ziabreva, I., Reeve, A. K., Trapp, B. D., Newcombe, J., Reynolds, R., Lassmann, H., et al. (2012) · Acta Neuropathologica · doi:10.1007/s00401-012-1001-9 · Cited by 53

Nonapoptotic and Extracellular Activity of Granzyme B Mediates Resistance to Regulatory T Cell (Treg) Suppression by HLA-DR−CD25hiCD127lo Tregs in Multiple Sclerosis and in Response to IL-6

Bhela, S., Kempsell, C., Manohar, M., Dominguez‐Villar, M., Griffin, R. L., Bhatt, P. M., Kivisakk-Webb, P., Fuhlbrigge, R. C., Kupper, T. S., Weiner, H. L., et al. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1303257 · Cited by 50

Hematopoietic mobilization

Mattoscio, M., Nicholas, R. S., Sormani, M. P., Malik, O., Lee, J. S., Waldman, A. D., Dazzi, F., & Muraro, P. A. (2015) · Neurology · doi:10.1212/wnl.0000000000001454 · Cited by 30

Cytokine Secretion Pattern in Treatment of Lymphocytes of Multiple Sclerosis Patients with Fumaric Acid Esters

Zoghi, S., Amirghofran, Z., Nikseresht, A., Ashjazadeh, N., Kamali‐Sarvestani, E., & Rezaei, N. (2011) · Immunological Investigations · doi:10.3109/08820139.2011.569626 · Cited by 27

HLA-E restricted CD8 + T cell subsets are phenotypically altered in multiple sclerosis patients

Pannemans, K., Broux, B., Goris, A., Dubois, B., Broekmans, T., Wijmeersch, B. V., Geraghty, D. E., Stinissen, P., & Hellings, N. (2013) · Multiple Sclerosis Journal · doi:10.1177/1352458513509703 · Cited by 23

Expression and regulation of the LIM-class homeobox generlim-1 in neuronal progenitors of the rat cerebellum

Hayes, W. P., Yangco, N., Chin, H. R., Mill, J. F., Pu, L. P., Taira, M., Dawid, I. B., & Gallo, V. (2001) · Journal of Neuroscience Research · doi:10.1002/1097-4547(20010201)63:3 · Cited by 7

The Microbiota-Gut-Brain Axis

Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286

Multiple sclerosis

Filippi, M., Bar-Or, A., Piehl, F., Preziosa, P., Solari, A., Vukusic, S., & Rocca, M. A. (2018) · Nature Reviews Disease Primers · doi:10.1038/s41572-018-0041-4 · Cited by 1,562

Interactions between genetic, lifestyle and environmental risk factors for multiple sclerosis

Olsson, T. P., Barcellos, L. F., & Alfredsson, L. S. (2016) · Nature Reviews Neurology · doi:10.1038/nrneurol.2016.187 · Cited by 1,263

CNS lymphatic drainage and neuroinflammation are regulated by meningeal lymphatic vasculature.

Louveau, A., Herz, J., Alme, M. N., Salvador, A. F., Dong, M. Q., Viar, K. E., Herod, S. G., Knopp, J., Setliff, J. C., Lupi, A. L., et al. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0227-9 · Cited by 956

Multiple Sclerosis: Mechanisms and Immunotherapy

Baecher-Allan, C., Kaskow, B. J., & Weiner, H. L. (2018) · Neuron · doi:10.1016/j.neuron.2018.01.021 · Cited by 938

Update on immunopathogenesis and immunotherapy in multiple sclerosis

Hemmer, B., & Selter (2013) · ImmunoTargets and Therapy · doi:10.2147/itt.s31813 · Cited by 33

Pathophysiology and Treatment of Multiple Sclerosis: A Review

Dayinta, C. P. T. (2024) · Zenodo (CERN European Organization for Nuclear Research) · doi:10.5281/zenodo.10572077

The Immune Response in Multiple Sclerosis

Murúa, S. R., Farez, M., & Quintana, F. J. (2021) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-052920-040318 · Cited by 378

Immunologic Aspects of Multiple Sclerosis

Boppana, S., Huang, H., Ito, K., & Dhib-Jalbut, S. S. (2011) · Mount Sinai Journal of Medicine A Journal of Translational and Personalized Medicine · doi:10.1002/msj.20249 · Cited by 40

Immunopathogenesis and immunotherapy of multiple sclerosis

Hemmer, B., Nessler, S., Zhou, D., Kieseier, B. C., & Hartung, H. (2006) · Nature Clinical Practice Neurology · doi:10.1038/ncpneuro0154 · Cited by 259