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Tracking T cells with tetramers: new tales from new tools
Abstract
To understand the success or failure of immune responses against pathogens or tumours requires the direct measurement of specific lymphocytes. Recently, there has been an explosion of data in this field through the use of several new tools for measuring the number and function of T cells. This has allowed immunologists who study human disease and mouse models of infection and cancer to readily track specific T cells--in both time and space. Although there are common patterns, over time, each host-pathogen relationship seems to develop unique characteristics, as reflected in the quality of the T-cell response.
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“Moreover, this methodology will not identify the proportion of antigen-specific cells that are senescent/exhausted, unless functional measurements are incorporated in tandem or post hoc (Borchers et al. 2014; Klenerman et al. 2002).”
From Is immunosenescence influenced by our lifetime “dose” of exercise? (2016) · cites this paper as Klenerman et al. 2002
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Metadata
- Authors
- Klenerman, P., Cerundolo, V., & Dunbar, P. R.
- Affiliations
- University of Oxford (GB)
- John Radcliffe Hospital (GB)
- Corresponding author
- Klenerman, Paul
- Venue
- Nature Reviews Immunology
- Published
- 2002-04-01
- Volume
- 2
- Issue
- 4
- Pages
- 263-272
- ISSN
- 1474-1733 (ISSN-L)
- 1474-1741
- OpenAlex
- W1974562087
- Cited by
- 190
- References
- 109
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 3 · 2023: 3 · 2022: 3 · 2021: 7 · 2020: 4 · 2019: 3 · 2018: 4 · 2017: 7 · 2016: 4 · 2015: 6 · 2014: 8 · 2013: 6 · 2012: 4
- FWCI
- 1.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Nature reviews. Immunology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust
- Cancer Research UK
- Medical Research Council
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Keywords
- T cell tracking, tetramer, T cell response, host-pathogen interaction, infection, tumor immunology, T cell function, mouse model
- MeSH terms
- Animals, beta 2-Microglobulin, Disease Models, Animal, Humans, Immunity, Cellular, Indicators and Reagents, Neoplasms, Peptides, Receptors, Antigen, T-Cell, T-Lymphocytes, Virus Diseases, Histocompatibility Antigens Class I, Lymphocyte Count, Streptavidin, Macromolecular Substances
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