Transcriptional control of human p53-regulated genes

p53, the cellular gatekeeper for growth and division

Levine, A. J. (1997) · Cell · doi:10.1016/s0092-8674(00)81871-1 · Cited by 7,693

Surfing the p53 network

Vogelstein, B., Lane, D., & Levine, A. J. (2000) · Nature · doi:10.1038/35042675 · Cited by 6,607 · cited 1×

Profile hidden Markov models

Eddy, S. R. (1998) · Bioinformatics · doi:10.1093/bioinformatics/14.9.755 · Cited by 5,515

Sequence logos: a new way to display consensus sequences

Schneider, T. D., & Stephens, R. M. (1990) · Nucleic Acids Research · doi:10.1093/nar/18.20.6097 · Cited by 3,354

Biological Sequence Analysis

Durbin, R. M., Eddy, S. R., Krogh, A., & Mitchison, G. (1998) · Cambridge University Press eBooks · doi:10.1017/cbo9780511790492 · Cited by 3,255

Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain

Gu, W., & Roeder, R. G. (1997) · Cell · doi:10.1016/s0092-8674(00)80521-8 · Cited by 2,559

Crystal Structure of a p53 Tumor Suppressor-DNA Complex: Understanding Tumorigenic Mutations

Cho, Y., Gorina, S., Jeffrey, P. D., & Pavletich, N. P. (1994) · Science · doi:10.1126/science.8023157 · Cited by 2,559 · cited 1×

Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer

Minucci, S., & Pelicci, P. G. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1779 · Cited by 2,233

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

Yonish-Rouach, E., Resnftzky, D., Lotem, J., Sachs, L., Kimchi, A., & Oren, M. (1991) · Nature · doi:10.1038/352345a0 · Cited by 2,079

Maximum Entropy Modeling of Short Sequence Motifs with Applications to RNA Splicing Signals

Yeo, G. W.-M., & Burge, C. B. (2004) · Journal of Computational Biology · doi:10.1089/1066527041410418 · Cited by 2,042

The roles and mechanisms of G3BP1 in tumour promotion

Zhang, C.-H., Wang, J., Cai, M., Shao, R., Liu, H., & Zhao, W. (2018) · Journal of drug targeting · doi:10.1080/1061186x.2018.1523415 · Cited by 70

The roles of lncRNA in hepatic fibrosis

Peng, H., Wan, L., Liang, J.-J., Zhang, Y., Ai, W., & Wu, J. (2018) · Cell & Bioscience · doi:10.1186/s13578-018-0259-6 · Cited by 71

p53 Superfamily Proteins in Marine Bivalve Cancer and Stress Biology

Walker, C. W., Beneden, R. J. V., Muttray, A. F., Böttger, S. A., Kelley, M. L., Tucker, A. E., & Thomas, W. K. (2011) · Advances in marine biology · doi:10.1016/b978-0-12-385536-7.00001-7 · Cited by 72

TTK/hMps1 Mediates the p53-Dependent Postmitotic Checkpoint by Phosphorylating p53 at Thr18

Huang, Y., Chang, M. D., & Shieh, S.-Y. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01837-08 · Cited by 78

Structures of three distinct activator–TFIID complexesPreprint

Liu, W.-L., Coleman, R. A., Ma, E., Grob, P., Yang, J. L., Zhang, Y., Dailey, G. M., Nogales, E., & Tjian, R. (2009) · Genes & Development · doi:10.1101/gad.1790709 · Cited by 71

Extensive Post-translational Modification of Active and Inactivated Forms of Endogenous p53

DeHart, C. J., Chahal, J. S., Flint, S. J., & Perlman, D. H. (2014) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m113.030254 · Cited by 70

The Enteropathogenic Escherichia coli Effector Cif Induces Delayed Apoptosis in Epithelial Cells

Samba‐Louaka, A., Nougayrède, J., Watrin, C., Oswald, É., & Taieb, F. E. (2009) · Infection and Immunity · doi:10.1128/iai.00860-09 · Cited by 70

Targeted depletion of BMI1 sensitizes tumor cells to P53-mediated apoptosis in response to radiation therapy

Alajez, N. M., Shi, W., Hui, A. B., Yue, S., Ng, R., Lo, K. W., Bastianutto, C., O’Sullivan, B., Gullane, P., & Liu, F. (2009) · Cell Death and Differentiation · doi:10.1038/cdd.2009.85 · Cited by 70

Modulation of the DNA damage response during the life cycle of human papillomaviruses

Anacker, D. C., & Moody, C. A. (2016) · Virus Research · doi:10.1016/j.virusres.2016.11.006 · Cited by 70

Glial Cell AMPA Receptors in Nervous System Health, Injury and Disease

Ceprián, M., & Fulton, D. J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20102450 · Cited by 76

Linking environmental carcinogen exposure to TP53 mutations in human tumours using the human TP53 knock-in (Hupki) mouse model

Kucab, J. E., Phillips, D. H., & Arlt, V. M. (2010) · FEBS Journal · doi:10.1111/j.1742-464x.2010.07676.x · Cited by 70

Direct interaction between p53 and Tid1 proteins affects p53 mitochondrial localization and apoptosis

Trinh, D. L. N., Elwi, A. N., & Kim, S.-W. (2010) · Oncotarget · doi:10.18632/oncotarget.174 · Cited by 69

Systems Analysis of ATF3 in Stress Response and Cancer Reveals Opposing Effects on Pro-Apoptotic Genes in p53 Pathway

Tanaka, Y., Nakamura, A., Morioka, M. S., Inoue, S., Tamamori‐Adachi, M., Yamada, K., Taketani, K., Kawauchi, J., Tanaka, M., Miyoshi, J., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0026848 · Cited by 69

Genome-wide characterization reveals complex interplay between TP53 and TP63 in response to genotoxic stress

McDade, S. S., Patel, D., Moran, M., Campbell, J., Fenwick, K., Kozarewa, I., Orr, N., Lord, C. J., Ashworth, A., & McCance, D. J. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku299 · Cited by 71

Trp53 Inactivation in the Tumor Microenvironment Promotes Tumor Progression by Expanding the Immunosuppressive Lymphoid-like Stromal Network

Guo, G., Marrero, L., Rodrı́guez, P. C., Valle, L. D., Ochoa, A. C., & Cui, Y. R. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-3810 · Cited by 69

Moonlighting proteins in cancer

Min, K., Lee, S., & Baek, S. J. (2015) · Cancer Letters · doi:10.1016/j.canlet.2015.09.022 · Cited by 70

p53-Regulated Networks of Protein, mRNA, miRNA, and lncRNA Expression Revealed by Integrated Pulsed Stable Isotope Labeling With Amino Acids in Cell Culture (pSILAC) and Next Generation Sequencing (NGS) Analyses

Hünten, S., Kaller, M., Drepper, F., Oeljeklaus, S., Bonfert, T., Erhard, F., Dueck, A., Eichner, N., Friedel, C. C., Meister, G., et al. (2015) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m115.050237 · Cited by 70

Radiotherapy-induced salivary dysfunction: Structural changes, pathogenetic mechanisms and therapies

Acauan, M. D., de Figueiredo, M. A. Z., Cherubini, K., Gomes, A. P., & Salum, F. G. (2015) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2015.09.014 · Cited by 71

Coordinated regulation of p53 apoptotic targets BAX and PUMA by SMAR1 through an identical MAR element

Sinha, S., Malonia, S. K., Mittal, S. P. K., Singh, K., Sreenath, K., Kamat, R. H., Mukhopadhyaya, R., Pal, J. K., & Chattopadhyay, S. (2010) · The EMBO Journal · doi:10.1038/emboj.2009.395 · Cited by 67

Activation of Wingless Targets Requires Bipartite Recognition of DNA by TCF

Chang, M. V., Chang, J. L., Gangopadhyay, A., Shearer, A. M., & Cadigan, K. M. (2008) · Current Biology · doi:10.1016/j.cub.2008.10.047 · Cited by 68

Low Levels of p53 Protein and Chromatin Silencing of p53 Target Genes Repress Apoptosis in Drosophila Endocycling Cells

Zhang, B., Mehrotra, S., Ng, W. L., & Calvi, B. R. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004581 · Cited by 71

Mechanisms underlying fibronectin‐induced up‐regulation of P2X4R expression in microglia: distinct roles of PI3K–Akt and MEK–ERK signalling pathways

Tsuda, M., Toyomitsu, E., Kometani, M., Tozaki‐Saitoh, H., & Inoue, K. (2009) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2009.00719.x · Cited by 66

Oxidative stress induced cellular signaling in RPE cells

Klettner, A. (2011) · Frontiers in Bioscience-Scholar · doi:10.2741/275 · Cited by 69

Abl interconnects oncogenic Met and p53 core pathways in cancer cells

Furlan, A., Stagni, V., Hussain, A., Richelme, S., Conti, F., Prodosmo, A., Destro, A., Roncalli, M. G., Barilà, D., & Maina, F. (2011) · Cell Death and Differentiation · doi:10.1038/cdd.2011.23 · Cited by 73

Mitochondrial p53 mediates a transcription-independent regulation of cell respiration and interacts with the mitochondrial F₁F₀-ATP synthase

Bergeaud, M., Mathieu, L., Guillaume, A., Moll, U. M., Mignotte, B., Floch, N. L., Vayssière, J., & Rincheval, V. (2013) · Cell Cycle · doi:10.4161/cc.25870 · Cited by 74

Nuclear Pore Component Nup98 Is a Potential Tumor Suppressor and Regulates Posttranscriptional Expression of Select p53 Target Genes

Singer, S., Zhao, R., Barsotti, A. M., Ouwehand, A., Fazollahi, M., Coutavas, E. E., Breuhahn, K., Neumann, O., Longerich, T., Pusterla, T., et al. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.09.020 · Cited by 69

Human bladder cancer cells undergo cisplatin-induced apoptosis that is associated with p53-dependent and p53-independent responses

Stravopodis (2009) · International Journal of Oncology · doi:10.3892/ijo_00000353 · Cited by 67

Inverted repeatAluelements in the human lincRNA-p21 adopt a conserved secondary structure that regulates RNA function

Chillón, I., & Pyle, A. M. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw599 · Cited by 67

Decoding p53 tumor suppression: a crosstalk between genomic stability and epigenetic control?

Janic, A., Abad, E., & Amelio, I. (2024) · Cell Death and Differentiation · doi:10.1038/s41418-024-01259-9 · Cited by 72

Phosphorylation of p53 on Ser15 during cell cycle and caused by Topo I and Topo II inhibitors in relation to ATM and Chk2 activation

Zhao, H. L., Traganos, F., & Darżynkiewicz, Z. (2008) · Cell Cycle · doi:10.4161/cc.7.19.6750 · Cited by 66

USP11 regulates p53 stability by deubiquitinating p53

Ke, J., Dai, C., Wu, W.-L., Gao, J., Xia, A.-J., Liu, G., Lv, K., & Wu, C. (2014) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b1400180 · Cited by 69

T-cell intracellular antigens function as tumor suppressor genes

Sánchez-Jiménez, C., Ludeña, M. D., & Izquierdo, J. M. (2015) · Cell Death and Disease · doi:10.1038/cddis.2015.43 · Cited by 65

Long non-coding RNAs in Colorectal Cancer: Progression and Future Directions

Yang, Y. P., Peng, J., Sanjun, C., & Ma, Y. (2017) · Journal of Cancer · doi:10.7150/jca.19794 · Cited by 67

The p53/microRNA Network in Cancer: Experimental and Bioinformatics Approaches

Hünten, S., Siemens, H., Kaller, M., & Hermeking, H. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-94-007-5590-1_5 · Cited by 66

The p53 tumor suppressor protein is a critical regulator of hematopoietic stem cell behavior

Liu, Y., Elf, S., Asai, T., Miyata, Y., Liu, Y., Sashida, G., Huang, G., Giandomenico, S. D., Koff, A., & Nimer, S. D. (2009) · Cell Cycle · doi:10.4161/cc.8.19.9627 · Cited by 67

Wild type p53 reactivation: From lab bench to clinic

Selivanova, G. (2014) · FEBS Letters · doi:10.1016/j.febslet.2014.03.049 · Cited by 68

Gambogic acid triggers DNA damage signaling that induces p53/p21Waf1/CIP1 activation through the ATR-Chk1 pathway

Rong, J., Hu, R., Song, X., Ha, J., Lu, N., Qi, Q., Tao, L., You, Q., & Guo, Q. (2010) · Cancer Letters · doi:10.1016/j.canlet.2010.03.016 · Cited by 65

A Genetic Screen Identifies TCF3/E2A and TRIAP1 as Pathway-Specific Regulators of the Cellular Response to p53 Activation

Andrysík, Z., Kim, J., Tan, A. C., & Espinosa, J. M. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.04.014 · Cited by 68

hSSB1 regulates both the stability and the transcriptional activity of p53

Xu, S., Wu, Y., Chen, Q., Cao, J., Hu, K., Tang, J., Sang, Y., Lai, F., Wang, L., Zhang, R., et al. (2012) · Cell Research · doi:10.1038/cr.2012.162 · Cited by 68

GRWD1 negatively regulates p53 via the RPL11–MDM2 pathway and promotes tumorigenesis

Kayama, K., Watanabe, S., Takafuji, T., Tsuji, T., Hironaka, K., Matsumoto, M., Nakayama, K. I., Enari, M., Kohno, T., Shiraishi, K., et al. (2016) · EMBO Reports · doi:10.15252/embr.201642444 · Cited by 65

Mesoporous Silica Nanoparticles as an Antitumoral-Angiogenesis Strategy

Setyawati, M. I., & Leong, D. T. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b12524 · Cited by 65

p53 and Cell Cycle Dependent Transcription of kinesin family member 23 (KIF23) Is Controlled Via a CHR Promoter Element Bound by DREAM and MMB Complexes

Fischer, M., Grundke, I., Sohr, S., Quaas, M., Hoffmann, S., Knörck, A., Gumhold, C., & Rother, K. (2013) · PLoS ONE · doi:10.1371/journal.pone.0063187 · Cited by 64

Mechanical insights into the regulation of programmed cell death by p53 via mitochondria

Yamada, K., & Yoshida, K. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2019.02.009 · Cited by 64

Effectiveness of gene delivery systems for pluripotent and differentiated cells

Rapti, K., Stillitano, F., Karakikes, I., Nonnenmacher, M. E., Weber, T., Hulot, J., & Hajjar, R. J. (2015) · Molecular Therapy — Methods & Clinical Development · doi:10.1038/mtm.2014.67 · Cited by 68

Novel regulation of checkpoint kinase 1: Is checkpoint kinase 1 a good candidate for anti‐cancer therapy?

Goto, H., Izawa, I., Li, P., & Inagaki, M. (2012) · Cancer Science · doi:10.1111/j.1349-7006.2012.02280.x · Cited by 68

p63 is an alternative p53 repressor in melanoma that confers chemoresistance and a poor prognosis

Matin, R., Chikh, A., Chong, S. L. P., Mesher, D., Graf, M., Sanzà, P., Senatore, V., Scatolini, M., Moretti, F., Leigh, I. M., et al. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.20121439 · Cited by 66

Centrosomes in the DNA damage response—the hub outside the centre

Mullee, L. I., & Morrison, C. G. (2015) · Chromosome Research · doi:10.1007/s10577-015-9503-7 · Cited by 63

Structural and Drug Targeting Insights on Mutant p53

Gomes, A. S., Ramos, H., Inga, A., Sousa, E., & Saraiva, L. (2021) · Cancers · doi:10.3390/cancers13133344 · Cited by 63

Overlapping and Non-overlapping Functions of Condensins I and II in Neural Stem Cell Divisions

Nishide, K., & Hirano, T. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004847 · Cited by 63

More targets, more pathways and more clues for mutant p53

Garritano, S., Inga, A., Gemignani, F., & Landi, S. (2013) · Oncogenesis · doi:10.1038/oncsis.2013.15 · Cited by 64

SUMO-specific protease 2 in Mdm2-mediated regulation of p53

Jiang, M., Chiu, S.-Y., & Hsu, W. (2010) · Cell Death and Differentiation · doi:10.1038/cdd.2010.168 · Cited by 65

AKR1B10, a Transcriptional Target of p53, Is Downregulated in Colorectal Cancers Associated with Poor Prognosis

Ohashi, T., Idogawa, M., Sasaki, Y., Suzuki, H., & Tokino, T. (2013) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-13-0330-t · Cited by 63

Effect of Temperature Downshift on the Transcriptomic Responses of Chinese Hamster Ovary Cells Using Recombinant Human Tissue Plasminogen Activator Production Culture

Bedoya-López, A., Estrada, K., Sánchez‐Flores, A., Ramı́rez, O. T., Altamirano, C., Segovia, L., Miranda‐Ríos, J., Trujillo‐Roldán, M. A., & Valdez‐Cruz, N. A. (2016) · PLoS ONE · doi:10.1371/journal.pone.0151529 · Cited by 65

The role of the cancer stem cell marker CD271 in DNA damage response and drug resistance of melanoma cells

Redmer, T., Walz, I., Klinger, B., Khouja, S., Welte, Y., Schäfer, R., & Regenbrecht, C. R. A. (2017) · Oncogenesis · doi:10.1038/oncsis.2016.88 · Cited by 63

Glycogen synthase kinase 3 promotes p53 mRNA translation via phosphorylation of RNPC1Preprint

Zhang, M., Zhang, J., Chen, X., Cho, S.-J., & Chen, X. (2013) · Genes & Development · doi:10.1101/gad.221739.113 · Cited by 65

CerS6 Is a Novel Transcriptional Target of p53 Protein Activated by Non-genotoxic Stress

Fekry, B., Jeffries, K. A., Esmaeilniakooshkghazi, A., Ogretmen, B., Krupenko, S. A., & Krupenko, N. I. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.716902 · Cited by 59

Potential anticancer properties and mechanisms of thymoquinone in osteosarcoma and bone metastasis

Homayoonfal, M., Asemi, Z., & Yousefi, B. (2022) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-022-00320-0 · Cited by 64

The NLRP 3 inflammasome affects DNA damage responses after oxidative and genotoxic stress in dendritic cells

Licandro, G., Khor, H. L., Beretta, O., Lai, J., Derks, H., Laudisi, F., Conforti‐Andreoni, C., Qian, H. L., Teng, G. G., Ricciardi‐Castagnoli, P., et al. (2013) · European Journal of Immunology · doi:10.1002/eji.201242918 · Cited by 63

Polo-like kinase 4 transcription is activated via CRE and NRF1 elements, repressed by DREAM through CDE/CHR sites and deregulated by HPV E7 protein

Fischer, M., Quaas, M., Wintsche, A., Müller, G. A., & Engeland, K. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt849 · Cited by 66

Aging and vascular dysfunction: beneficial melatonin effects

Rodella, L. F., Favero, G., Rossini, C., Foglio, E., Bonomini, F., Reiter, R. J., & Rezzani, R. (2011) · AGE · doi:10.1007/s11357-011-9336-z · Cited by 62

Chemokine receptor CXCR 2 is transactivated by p53 and induces p38‐mediated cellular senescence in response to DNA damage

Guo, H., Liu, Z., Xu, B., Hu, H., Wei, Z., Liu, Q., Zhang, X., Ding, X., Wang, Y., Zhao, M., et al. (2013) · Aging Cell · doi:10.1111/acel.12138 · Cited by 63

RECQL4 and p53 potentiate the activity of polymerase γ and maintain the integrity of the human mitochondrial genome

Gupta, S., De, S., Srivastava, V. K., Hussain, M., Kumari, J., Muniyappa, K., & Sengupta, S. (2013) · Carcinogenesis · doi:10.1093/carcin/bgt315 · Cited by 65

A Single Recombinant Adenovirus Expressing p53 and p21-targeting Artificial microRNAs Efficiently Induces Apoptosis in Human Cancer Cells

Idogawa, M., Sasaki, Y., Suzuki, H., Mita, H., Imai, K., Shinomura, Y., & Tokino, T. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-2396 · Cited by 62

Pneumococcal Pneumolysin Induces DNA Damage and Cell Cycle Arrest

Rai, P., He, F., Kwang, J., Engelward, B. P., & Chow, V. T. K. (2016) · Scientific Reports · doi:10.1038/srep22972 · Cited by 65

Chronic polycyclic aromatic hydrocarbon exposure causes DNA damage and genomic instability in lung epithelial cells

Bai, H., Wu, M., Zhang, H., & Tang, G. (2017) · Oncotarget · doi:10.18632/oncotarget.20891 · Cited by 69

Role and mechanisms of autophagy, ferroptosis, and pyroptosis in sepsis-induced acute lung injury

Shen, Y., He, Y., Pan, Y., Liu, L., Liu, Y., & Jia, J. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1415145 · Cited by 66

RITA can induce cell death in p53-defective cells independently of p53 function via activation of JNK/SAPK and p38

Weilbacher, A., Gutekunst, M., Oren, M., Aulitzky, W. E., & van der Kuip, H. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.284 · Cited by 62

p63 the guardian of human reproduction

Amelio, I., Grespi, F., Annicchiarico‐Petruzzelli, M., & Melino, G. (2012) · Cell Cycle · doi:10.4161/cc.22819 · Cited by 61

Differential regulation of the proapoptotic multidomain protein Bak by p53 and p73 at the promoter level

Graupner, V., Alexander, E., Overkamp, T., Rothfuss, O. C., Laurenzi, V. D., Gillissen, B. F., Daniel, P. T., Schulze‐Osthoff, K., & Eßmann, F. (2011) · Cell Death and Differentiation · doi:10.1038/cdd.2010.179 · Cited by 60

Cisplatin Hypersensitivity of Testicular Germ Cell Tumors Is Determined by High Constitutive Noxa Levels Mediated by Oct-4

Gutekunst, M., Mueller, T., Weilbacher, A., Dengler, M. A., Bedke, J., Kruck, S., Oren, M., Aulitzky, W. E., & van der Kuip, H. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-2876 · Cited by 61

Real-time in vivo imaging of p16Ink4a gene expression: a new approach to study senescence stress signaling in living animals

Ohtani, N., Yamakoshi, K., Takahashi, A., & Hara, E. (2010) · Cell Division · doi:10.1186/1747-1028-5-1 · Cited by 62

T-Type Ca2+ Channel Inhibition Induces p53-Dependent Cell Growth Arrest and Apoptosis through Activation of p38-MAPK in Colon Cancer Cells

Dziegielewska, B., Brautigan, D. L., Larner, J. M., & Dziegielewski, J. (2013) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-13-0485 · Cited by 64

Cellular senescence and protein degradation

Deschênes‐Simard, X., Lessard, F., Gaumont‐Leclerc, M., Bardeesy, N. M., & Ferbeyre, G. (2014) · Cell Cycle · doi:10.4161/cc.29335 · Cited by 66

Targeting the MDM2-p53 pathway in dedifferentiated liposarcoma

Traweek, R. S., Cope, B. M., Roland, C. L., Keung, E. Z.-Y., Nassif, E. F., & Erstad, D. J. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.1006959 · Cited by 64

The Dual MEK/FLT3 Inhibitor E6201 Exerts Cytotoxic Activity against Acute Myeloid Leukemia Cells Harboring Resistance-Conferring FLT3 Mutations

Zhang, W., Borthakur, G. M., Chen, G., Chen, Y., Mu, H., Ruvolo, V. R., Nomoto, K., Zhao, N., Konopleva, M. Y., & Andreeff, M. (2016) · Cancer Research · doi:10.1158/0008-5472.can-15-1580 · Cited by 60

Transcriptome analysis of genes expressed in the earthworm Eisenia fetida in response to cadmium exposure

Chai, L., Yang, Y., Yang, H., Zhao, Y., & Wang, H. (2019) · Chemosphere · doi:10.1016/j.chemosphere.2019.124902 · Cited by 60

Mutant p53 Drives Cancer Metastasis via RCP-Mediated Hsp90α Secretion

Zhang, S., Wang, C., Ma, B., Xu, M., Xu, S., Liu, J., Tian, Y., Fu, Y., & Luo, Y. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107879 · Cited by 61

Adrenocortical stem and progenitor cells: Implications for adrenocortical carcinoma

Simon, D. P., & Hammer, G. D. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.12.006 · Cited by 62

p53 Interaction with JMJD3 Results in Its Nuclear Distribution during Mouse Neural Stem Cell Differentiation

Solá, S., Xavier, J. M., dos Santos, D. M., Aranha, M. M., Morgado, A. L., Jepsen, K., & Rodrigues, C. M. P. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018421 · Cited by 61

Making sense of ubiquitin ligases that regulate p53

Jain, A. K., & Barton, M. C. (2010) · Cancer Biology & Therapy · doi:10.4161/cbt.10.7.13445 · Cited by 60

Illuminating p53 function in cancer with genetically engineered mouse models

Garcia, P. B., & Attardi, L. D. (2014) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2013.12.014 · Cited by 65

ARF and p53 Coordinate Tumor Suppression of an Oncogenic IFN-β-STAT1-ISG15 Signaling Axis

Forys, J. T., Kuzmicki, C. E., Saporita, A. J., Winkeler, C. L., Maggi, L. B., & Weber, J. D. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.03.026 · Cited by 61

Rap2b, a novel p53 target, regulates p53-mediated pro-survival function

Zhang, X., He, Y., Lee, K. H., Dubois, W., Li, Z., Wu, X., Kovalchuk, A. L., Zhang, W., & Huang, J. L. (2013) · Cell Cycle · doi:10.4161/cc.24364 · Cited by 59

Ninjurin1, a target of p53, regulates p53 expression and p53-dependent cell survival, senescence, and radiation-induced mortality

Cho, S.-J., Rossi, A., Jung, Y.-S., Yan, W., Liu, G., Zhang, J., Zhang, M., & Chen, X. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1221242110 · Cited by 61

Interrogating the Roles of Post-Translational Modifications of Non-Histone Proteins

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