Transcriptional control of human p53-regulated genes

p53, the cellular gatekeeper for growth and division

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Surfing the p53 network

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Profile hidden Markov models

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Sequence logos: a new way to display consensus sequences

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Biological Sequence Analysis

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Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain

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Crystal Structure of a p53 Tumor Suppressor-DNA Complex: Understanding Tumorigenic Mutations

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Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer

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Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

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Maximum Entropy Modeling of Short Sequence Motifs with Applications to RNA Splicing Signals

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Definition of a consensus binding site for p53

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The p53 pathway: positive and negative feedback loops

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Hidden Markov Models in Computational Biology

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DNA binding sites: representation and discovery

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Biological sequence analysis

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Assessing computational tools for the discovery of transcription factor binding sites

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A Single Nucleotide Polymorphism in the MDM2 Promoter Attenuates the p53 Tumor Suppressor Pathway and Accelerates Tumor Formation in Humans

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Is a p53-Regulated Inhibitor of G2/M Progression

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The coordinate regulation of the p53 and mTOR pathways in cells

Feng, Z., Zhang, H., Levine, A. J., & Jin, S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502857102 · Cited by 1,235

Applied bioinformatics for the identification of regulatory elements

Wasserman, W. W., & Sandelin, A. (2004) · Nature Reviews Genetics · doi:10.1038/nrg1315 · Cited by 1,233

p53AIP1, a Potential Mediator of p53-Dependent Apoptosis, and Its Regulation by Ser-46-Phosphorylated p53

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A Global Map of p53 Transcription-Factor Binding Sites in the Human Genome

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DNA sequence-dependent deformability deduced from protein–DNA crystal complexes

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Interaction of the p53-Regulated Protein Gadd45 with Proliferating Cell Nuclear Antigen

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Oncogenic Forms of p53 Inhibit p53-Regulated Gene Expression

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Regulation of PTEN Transcription by p53

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A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage

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p53 Activates the CD95 (APO-1/Fas) Gene in Response to DNA Damage by Anticancer Drugs

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Induction of the growth inhibitor IGF-binding protein 3 by p53

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Regulation of p53 activity through lysine methylation

Chuikov, S., Kurash, J. K., Wilson, J. R., Xiao, B., Justin, N., Ivanov, G. S., McKinney, K. M., Tempst, P., Prives, C. L., Gamblin, S. J., et al. (2004) · Nature · doi:10.1038/nature03117 · Cited by 846

p63 and p73 are required for p53-dependent apoptosis in response to DNA damage

Flores, E. R., Tsai, K. Y., Crowley, D. G., Sengupta, S., Yang, A., McKeon, F., & Jacks, T. (2002) · Nature · doi:10.1038/416560a · Cited by 815

Transcriptional Repression of the Anti-apoptoticsurvivin Gene by Wild Type p53

Hoffman, W. H., Biade, S., Zilfou, J. T., Chen, J., & Murphy, M. E. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m106643200 · Cited by 811

A Transcriptionally Active DNA-Binding Site for Human p53 Protein Complexes

Funk, W. D., Pak, D. T. S., Karas, R. H., Wright, W. E., & Shay, J. W. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.6.2866 · Cited by 732

Acetylation of p53 Activates Transcription through Recruitment of Coactivators/Histone Acetyltransferases

Barlev, N. A., Liu, L., Chehab, N. H., Mansfield, K., Harris, K. G., Halazonetis, T. D., & Berger, S. L. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00414-2 · Cited by 710

The ubiquitin ligase COP1 is a critical negative regulator of p53

Dornan, D., Wertz, I. E., Shimizu, H., Arnott, D. P., Frantz, G. D., Dowd, P., Rourke, K. O., Koeppen, H., & Dixit, V. M. (2004) · Nature · doi:10.1038/nature02514 · Cited by 700

The Regulation of Exosome Secretion: a Novel Function of the p53 Protein

Yu, X., Harris, S. L., & Levine, A. J. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-4579 · Cited by 688

NPAT links cyclin E–Cdk2 to the regulation of replication-dependent histone gene transcriptionPreprint

Zhao, J., Kennedy, B. K., Lawrence, B. D., Barbie, D. A., Matera, A. G., Fletcher, J. A., & Harlow, E. (2000) · Genes & Development · doi:10.1101/gad.827700 · Cited by 665

The P53 pathway: what questions remain to be explored?

Levine, A. J., Hu, W., & Feng, Z. (2006) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401910 · Cited by 661

The Regulation of AMPK β1, TSC2, and PTEN Expression by p53: Stress, Cell and Tissue Specificity, and the Role of These Gene Products in Modulating the IGF-1-AKT-mTOR Pathways

Feng, Z., Hu, W., de Stanchina, E., Teresky, A. K., Jin, S., Lowe, S., & Levine, A. J. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-4149 · Cited by 633

Analysis of p53-regulated gene expression patterns using oligonucleotide arraysPreprint

Zhao, R., Gish, K., Murphy, M. E., Yin, Y., Notterman, D. A., Hoffman, W. H., Tom, E., Mack, D. H., & Levine, A. J. (2000) · Genes & Development · doi:10.1101/gad.14.8.981 · Cited by 632

Synergistic activation of transcription by CBP and p53

Gu, W., Shi, X.-L., & Roeder, R. G. (1997) · Nature · doi:10.1038/42972 · Cited by 599

Topological control of p21WAF1/CIP1 expression in normal and neoplastic tissues.

El‐Deiry, W. S., Tokino, T., Waldman, T. A., Oliner, J., Velculescu, V. E., Burrell, M., HILL, D. E., Healy, E., Rees, J. L., & Hamilton, S. R. (1995) · PubMed · Cited by 582

Wild-type p53 binds to the TATA-binding protein and represses transcription.

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REDD1, a Developmentally Regulated Transcriptional Target of p63 and p53, Links p63 to Regulation of Reactive Oxygen Species

Ellisen, L. W., Ramsayer, K. D., Johannessen, C. M., Yang, A., Beppu, H., Minda, K., Oliner, J. D., McKeon, F., & Haber, D. A. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00706-2 · Cited by 474

p53 regulates maternal reproduction through LIF

Hu, W., Feng, Z., Teresky, A. K., & Levine, A. J. (2007) · Nature · doi:10.1038/nature05993 · Cited by 456

Transcriptional repression by wild-type p53 utilizes histone deacetylases, mediated by interaction with mSin3aPreprint

Murphy, M. E., Ahn, J., Walker, K. K., Hoffman, W. H., Evans, R. M., Levine, A. J., & George, D. L. (1999) · Genes & Development · doi:10.1101/gad.13.19.2490 · Cited by 455

Transcriptional Regulation by p53 through Intrinsic DNA/Chromatin Binding and Site-Directed Cofactor Recruitment

Espinosa, J. M., & Emerson, B. M. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00283-0 · Cited by 440

p53 Transcriptional Activation Mediated by Coactivators TAF II 40 and TAF II 60

Thut, C. J., Chen, J.-L., Klemm, R. D., & Tjian, R. (1995) · Science · doi:10.1126/science.7809597 · Cited by 439

BID regulation by p53 contributes to chemosensitivity

Sax, J. K., Fei, P., Murphy, M. E., Bernhard, E., Korsmeyer, S. J., & El-Deiry, W. S. (2002) · Nature Cell Biology · doi:10.1038/ncb866 · Cited by 420

Acetylation of p53 augments its site-specific DNA binding both in vitro and in vivo

Luo, J., Li, M., Tang, Y., Laszkowska, M., Roeder, R. G., & Gu, W. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308762101 · Cited by 419

Gain of function of mutant p53: The mutant p53/NF-Y protein complex reveals an aberrant transcriptional mechanism of cell cycle regulation

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Specificity, free energy and information content in protein–DNA interactions

Stormo, G. D., & Fields, D. S. (1998) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(98)01187-6 · Cited by 367

Wild-type p53 transactivates the KILLER/DR5 gene through an intronic sequence-specific DNA-binding site

Takimoto, R., & El-Deiry, W. S. (2000) · Oncogene · doi:10.1038/sj.onc.1203489 · Cited by 360

Pidd, a new death-domain–containing protein, is induced by p53 and promotes apoptosis

Lin, Y., Ma, W., & Benchimol, S. (2000) · Nature Genetics · doi:10.1038/79102 · Cited by 359

Inhibition of Cyclooxygenase-2 Gene Expression by p53

Subbaramaiah, K., Altorki, N. K., Chung, W. J., MESTRE, J. R., Sampat, A., & Dannenberg, A. J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.16.10911 · Cited by 355

p53DINP1, a p53-Inducible Gene, Regulates p53-Dependent Apoptosis

Okamura, S., Arakawa, H., Tanaka, T., Nakanishi, H., Ng, C. C., Taya, Y., Monden, M., & Nakamura, Y. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00284-2 · Cited by 352

The chemokine growth-regulated oncogene 1 (Gro-1) links RAS signaling to the senescence of stromal fibroblasts and ovarian tumorigenesis

Yang, G., Rosen, D. G., Zhang, Z., Bast, R. C., Mills, G. B., Colacino, J. A., Mercado-Uribe, I., & Liu, J. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605752103 · Cited by 341

Activation of the p53 tumor suppressor protein

Vousden, K. H. (2002) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/s0304-419x(02)00035-5 · Cited by 337

PML Is a Direct p53 Target that Modulates p53 Effector Functions

de Stanchina, E., Querido, E., Narita, M., Davuluri, R. V., Pandolfi, P. P., Ferbeyre, G., & Lowe, S. W. (2004) · Molecular Cell · doi:10.1016/s1097-2765(04)00062-0 · Cited by 312

The p53MH algorithm and its application in detecting p53-responsive genes

Hoh, J., Jin, S. V., Parrado, T., Edington, J., Levine, A. J., & Ott, J. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.132268899 · Cited by 295

Regulation of the Human hsp70 Promoter by p53

Agoff, S. N., Hou, J., Linzer, D. I., & Wu, B. (1993) · Science · doi:10.1126/science.8418500 · Cited by 292

p53 Regulates the Expression of the Tumor Suppressor Gene Maspin

Zou, Z., Gao, C., Nagaich, A. K., Connell, T., Saito, S., Moul, J. W., Seth, P. K., Appella, E., & Srivastava, S. K. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.9.6051 · Cited by 277

A functional p53-responsive intronic promoter is contained within the human mdm2 gene

Zauberman, A., Flusberg, D., Haupt, Y., Barak, Y., & Oren, M. (1995) · Nucleic Acids Research · doi:10.1093/nar/23.14.2584 · Cited by 276

A polymorphic microsatellite that mediates induction of PIG3 by p53

Contente, A., Dittmer, A., Koch, M. C., Roth, J., & Dobbelstein, M. (2002) · Nature Genetics · doi:10.1038/ng836 · Cited by 274

Transcriptional Activation by p53 of the Human Type IV Collagenase (Gelatinase A or Matrix Metalloproteinase 2) Promoter

Bian, J., & Sun, Y. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.11.6330 · Cited by 274

PTGF-β , a type β transforming growth factor (TGF-β) superfamily member, is a p53 target gene that inhibits tumor cell growth via TGF-β signaling pathway

Tan, M., Wang, Y., Guan, K., & Sun, Y. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.1.109 · Cited by 257

PA26, a novel target of the p53 tumor suppressor and member of the GADD family of DNA damage and growth arrest inducible genes

Velasco-Miguel, S., Buckbinder, L., Jean, P., Gelbert, L., Talbott, R. L., Laidlaw, J. L., Seizinger, B. R., & Kley, N. (1999) · Oncogene · doi:10.1038/sj.onc.1202274 · Cited by 252

Regulation of the human p21(waf1/cip1) gene promoter via multiple binding sites for p53 and the vitamin D3 receptor

Saramaki, A. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkj460 · Cited by 252

ASC is a Bax adaptor and regulates the p53–Bax mitochondrial apoptosis pathway

Ohtsuka, T., Ryu, H., Minamishima, Y. A., Macip, S., Sagara, J., Nakayama, K. I., Aaronson, S. A., & Lee, S. W. (2004) · Nature Cell Biology · doi:10.1038/ncb1087 · Cited by 243

p53 alterations in human cancer: more questions than answers

Soussi, T. (2007) · Oncogene · doi:10.1038/sj.onc.1210280 · Cited by 236

Bnip3L is induced by p53 under hypoxia, and its knockdown promotes tumor growth

Fei, P., Wang, W., Kim, S.-H., Wang, S., Burns, T. F., Sax, J. K., Buzzai, M., Dicker, D. T., McKenna, W. G., Bernhard, E. J., et al. (2004) · Cancer Cell · doi:10.1016/j.ccr.2004.10.012 · Cited by 236

p21/CDKN1A Mediates Negative Regulation of Transcription by p53

Löhr, K., Möritz, C., Contente, A., & Dobbelstein, M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212517200 · Cited by 227

A Biophysical Approach to Transcription Factor Binding Site DiscoveryPreprint

Djordjević, M., Sengupta, A. M., & Shraiman, B. I. (2003) · Genome Research · doi:10.1101/gr.1271603 · Cited by 226

Potential role for Cathepsin D in p53-dependent tumor suppression and chemosensitivity

Wu, G. S., Säftig, P., Peters, C., & El‐Deiry, W. S. (1998) · Oncogene · doi:10.1038/sj.onc.1201755 · Cited by 226

Targets and mechanisms for the regulation of translation in malignant transformation

Clemens, M. J. (2004) · Oncogene · doi:10.1038/sj.onc.1207544 · Cited by 225

Adenoviral expression of p53 represses telomerase activity through down-regulation of human telomerase reverse transcriptase transcription.

Kanaya, T., Kyo, S., Hamada, K., Takakura, M., Kitagawa, Y., Harada, H., & Inoue, M. (2000) · PubMed · Cited by 222

NDRG1 Is Necessary for p53-dependent Apoptosis

Stein, S., Thomas, E. K., Herzog, B., Westfall, M. D., Rocheleau, J. V., Jackson, R. S., Wang, M., & Liang, P. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m400386200 · Cited by 220

Silencing of the Novel p53 Target Gene Snk/Plk2 Leads to Mitotic Catastrophe in Paclitaxel (Taxol)-Exposed Cells

Burns, T. F., Fei, P., Scata, K. A., Dicker, D. T., & El‐Deiry, W. S. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.16.5556-5571.2003 · Cited by 220

Comparative Binding of p53 to its Promoter and DNA Recognition Elements

Weinberg, R. L., Veprintsev, D. B., Bycroft, M., & Fersht, A. R. (2005) · Journal of Molecular Biology · doi:10.1016/j.jmb.2005.03.014 · Cited by 211

Direct p53 Transcriptional Repression: In Vivo Analysis of CCAAT-Containing G2/M Promoters

Imbriano, C., Gurtner, A., Cocchiarella, F., Agostino, S. D., Basile, V., Gostissa, M., Dobbelstein, M., Sal, G. D., Piaggio, G., & Mantovani, R. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.9.3737-3751.2005 · Cited by 209

The ferredoxin reductase gene is regulated by the p53 family and sensitizes cells to oxidative stress-induced apoptosis

Liu, G., & Chen, X. (2002) · Oncogene · doi:10.1038/sj.onc.1205862 · Cited by 207

Direct interaction between the transcriptional activation domain of human p53 and the TATA box-binding protein.

Truant, R., Xiao, H., Ingles, C. J., & Greenblatt, J. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53769-8 · Cited by 203

Modeling dependencies in protein-DNA binding sites

Barash, Y., Elidan, G., Friedman, N., & Kaplan, T. (2003) · Research in Computational Molecular Biology · doi:10.1145/640075.640079 · Cited by 203

Differential Transactivation by the p53 Transcription Factor Is Highly Dependent on p53 Level and Promoter Target Sequence

Inga, A., Storici, F., Darden, T. A., & Resnick, M. A. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.24.8612-8625.2002 · Cited by 195

Wild‐type p53 adopts a ‘mutant’‐like conformation when bound to DNA.

Halazonetis, T. D., Davis, L. J., & Kandil, A. N. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb05743.x · Cited by 193

APAF-1 is a transcriptional target of p53 in DNA damage-induced apoptosis.

Robles, A. I., Bemmels, N. A., Foraker, A. B., & Harris, C. C. (2001) · PubMed · Cited by 190

Transcriptional Activation of the Human Epidermal Growth Factor Receptor Promoter by Human p53

Ludes-Meyers, J. H., Subler, M. A., Shivakumar, C. V., Muñoz, R. M., Jiang, P., Bigger, J. E., Brown, D. R., Deb, S. P., & Deb, S. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.11.6009 · Cited by 185

p53 Upregulates Death Receptor 4 Expression through an Intronic p53 Binding Site

Liu, X., Yue, P., Khuri, F. R., & Sun, S.-Y. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1195 · Cited by 184

Global transcriptional program of p53 target genes during the process of apoptosis and cell cycle progression

Mirza, A., Wu, Q. J., Wang, L., McClanahan, T., Bishop, W. R., Gheyas, F., Ding, W., Hutchins, B., Hockenberry, T., Kirschmeier, P. T., et al. (2003) · Oncogene · doi:10.1038/sj.onc.1206477 · Cited by 183

Autoinhibitory Regulation of p73 by ΔNp73 To Modulate Cell Survival and Death through a p73-Specific Target Element within the ΔNp73 Promoter

Nakagawa, T., Takahashi, M., Ozaki, T., Watanabe, K., Todo, S., Mizuguchi, H., Hayakawa, T., & Nakagawara, A. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.8.2575-2585.2002 · Cited by 177

p53 tagged sites from human genomic DNA

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p53-Mediated Repression of Alpha-Fetoprotein Gene Expression by Specific DNA Binding

Lee, K. C., Crowe, A. J., & Barton, M. C. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.2.1279 · Cited by 175

DNA Damage-Induced Downregulation of Cdc25C Is Mediated by p53 via Two Independent Mechanisms

Clair, S. S., Giono, L. E., Varmeh, S., Resnick‐Silverman, L., Liu, W.-J., Padi, A., Dastidar, J., DaCosta, A., Mattia, M., & Manfredi, J. J. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.11.002 · Cited by 168

p53 Binds and Activates the Xeroderma Pigmentosum DDB2 Gene in Humans but Not Mice

Tan, T., & Chu, G. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.10.3247-3254.2002 · Cited by 167

Analyses of p53 Target Genes in the Human Genome by Bioinformatic and Microarray Approaches

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Human Dkk-1, a gene encoding a Wnt antagonist, responds to DNA damage and its overexpression sensitizes brain tumor cells to apoptosis following alkylation damage of DNA

Shou, J., Ali‐Osman, F., Multani, A. S., Pathak, S., Fedi, P., & Srivenugopal, K. S. (2002) · Oncogene · doi:10.1038/sj.onc.1205138 · Cited by 164

Identification of the interferon regulatory factor 5 gene (IRF-5) as a direct target for p53

Mori, T., Anazawa, Y., Iiizumi, M., Fukuda, S., Nakamura, Y., & Arakawa, H. (2002) · Oncogene · doi:10.1038/sj.onc.1205459 · Cited by 164

Apoptotic threshold is lowered by p53 transactivation of caspase-6

MacLachlan, T. K., & El‐Deiry, W. S. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.132241599 · Cited by 162

Transcriptional Repression by p53 through Direct Binding to a Novel DNA Element

Johnson, R. A., Ince, T. A., & Scotto, K. W. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c100121200 · Cited by 158

p53 Regulates Insulin-Like Growth Factor-I (IGF-I) Receptor Expression and IGF-I-Induced Tyrosine Phosphorylation in an Osteosarcoma Cell Line: Interaction between p53 and Sp1

Ohlsson, C., Kley, N., Werner, H., & LeRoith, D. (1998) · Endocrinology · doi:10.1210/endo.139.3.5832 · Cited by 157

Further characterisation of the p53 responsive element – identification of new candidate genes for trans-activation by p53

Bourdon, J., Chambon, V., Lelong, J., Dessen, P., May, P., Debuire, B., & May, E. (1997) · Oncogene · doi:10.1038/sj.onc.1200804 · Cited by 156

Histone Deacetylase 2 Modulates p53 Transcriptional Activities through Regulation of p53-DNA Binding Activity

Harms, K. L., & Chen, X. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-4397 · Cited by 156

Interaction of p53 with Its Consensus DNA-Binding Site

Wang, Y., Schwedes, J. F., Parks, D., Mann, K., & Tegtmeyer, P. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.4.2157 · Cited by 155

p53 Negatively Regulates cdc2 Transcription via the CCAAT-binding NF-Y Transcription Factor

Yun, J., Chae, H., Choy, H. E., Chung, J., Yoo, H., Han, M.-H., & Shin, D. Y. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.42.29677 · Cited by 155

Cloning and characterization of the promoter region of human focal adhesion kinase gene: nuclear factor kappa B and p53 binding sites

Golubovskaya, V., Kaur, A. S., & Cance, W. G. (2004) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/j.bbaexp.2004.03.002 · Cited by 152

The expression of the KAI1 gene, a tumor metastasis suppressor, is directly activated by p53

Mashimo, T., Watabe, M., Hirota, S., Hosobe, S., Miura, K., Tegtmeyer, P., Rinker-Schaeffer, C. W., & Watabe, K. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.19.11307 · Cited by 150

Efficient Specific DNA Binding by p53 Requires both Its Central and C-Terminal Domains as Revealed by Studies with High-Mobility Group 1 Protein

McKinney, K. M., & Prives, C. L. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.19.6797-6808.2002 · Cited by 149

Receptor tyrosine kinase EphA2 is regulated by p53-family proteins and induces apoptosis

Dohn, M. R., Jiang, J., & Chen, X. (2001) · Oncogene · doi:10.1038/sj.onc.1204816 · Cited by 147

Differential regulation of plasminogen activator and inhibitor gene transcription by the tumor suppressor p53

Kunz, C., Pebler, S., Otte, J., & von der Ahe, D. (1995) · Nucleic Acids Research · doi:10.1093/nar/23.18.3710 · Cited by 145

p53 Suppresses the Activation of the Bcl-2 Promoter by the Brn-3a POU Family Transcription Factor

Budhram-Mahadeo, V., Morris, P. J., Smith, M. D., Midgley, C. A., Boxer, L. M., & Latchman, D. S. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.21.15237 · Cited by 144

Differential Recognition of Response Elements Determines Target Gene Specificity forp53 and p63

Osada, M., Park, H. L., Nagakawa, Y., Yamashita, K., Fomenkov, A. I., Kim, M. S., Wu, G., Nomoto, S., Trink, B., & Sidransky, D. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.14.6077-6089.2005 · Cited by 140

Upregulation of Major Histocompatibility Complex Class I on Liver Cells by Hepatitis C Virus Core Protein via p53 and TAP1 Impairs Natural Killer Cell Cytotoxicity

Herzer, K., Falk, C. S., Encke, J., Eichhorst, S. T., Ulsenheimer, A., Seliger, B., & Krammer, P. H. (2003) · Journal of Virology · doi:10.1128/jvi.77.15.8299-8309.2003 · Cited by 134

The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase

Passer, B. J., Nancy-Portebois, V., Amzallag, N., Prieur, S., Cans, C., de Climens, A. R., Fiucci, G., Bouvard, V., Tuynder, M., Susini, L., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0530298100 · Cited by 134

Negative regulation of Rb expression by the p53 gene product.

Shiio, Y., Yamamoto, T., & Yamaguchi, N. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.12.5206 · Cited by 133

A conserved intronic response element mediates direct p53-dependent transcriptional activation of both the human and murine bax genes

Thornborrow, E. C., Patel, S., Mastropietro, A. E., Schwartzfarb, E. M., & Manfredi, J. J. (2002) · Oncogene · doi:10.1038/sj.onc.1205069 · Cited by 132

Transcriptional activation of the human proliferating-cell nuclear antigen promoter by p53.

Morris, G. F., Bischoff, J. R., & Mathews, M. B. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.2.895 · Cited by 131

p53 oligomerization and DNA looping are linked with transcriptional activation.

Stenger, J. E., Tegtmeyer, P., Mayr, G. A., Reed, M. J., Wang, Y., Wang, P., Hough, P. V. C., & Mastrangelo, I. A. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06947.x · Cited by 130

Dual-specificity phosphatase 5 (DUSP5) as a direct transcriptional target of tumor suppressor p53

Ueda, K., Arakawa, H., & Nakamura, Y. (2003) · Oncogene · doi:10.1038/sj.onc.1206845 · Cited by 125

p53 tumor suppressor protein regulates the levels of huntingtin gene expression

Feng, Z., Jin, S. V., Zupnick, A., Hoh, J., de Stanchina, E., Lowe, S. W., Prives, C. L., & Levine, A. J. (2005) · Oncogene · doi:10.1038/sj.onc.1209021 · Cited by 125

Identification of Novel p53 Target Genes in Ionizing Radiation Response

Jen, K., & Cheung, V. G. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1039 · Cited by 119

Comparative Genome Analysis Identifies the Vitamin D Receptor Gene as a Direct Target of p53-Mediated Transcriptional Activation

Maruyama, R., Aoki, F., Toyota, M., Sasaki, Y., Akashi, H., Mita, H., Suzuki, H., Akino, K., Ohe-Toyota, M., Maruyama, Y., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-2562 · Cited by 114

Functional Interaction between p53, the TATA-Binding Protein (TBP), and TBP-Associated Factors In Vivo

Farmer, G., Colgan, J. D., Nakatani, Y., Manley, J. L., & Prives, C. L. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.8.4295 · Cited by 113

Identification of the mismatch repair genes PMS2 and MLH1 as p53 target genes by using serial analysis of binding elements

Chen, J., & Sadowski, I. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407069102 · Cited by 111

p53 and c-Jun Functionally Synergize in the Regulation of the DNA Repair Gene hMSH2 in Response to UV

Scherer, S. J., Maier, S. M., Seifert, M., Hanselmann, R. G., Zang, K. D., Müller‐Hermelink, H. K., Angel, P. E., Welter, C., & Schartl, M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m006990200 · Cited by 107

CSR, a scavenger receptor-like protein with a protective role against cellular damage causedby UV irradiation and oxidative stress

Han, H. J. (1998) · Human Molecular Genetics · doi:10.1093/hmg/7.6.1039 · Cited by 106

Profile of gene expression regulated by induced p53: connection to the TGF‐β family

Kannan, K., Amariglio, N., Rechavi, G., & Givol, D. (2000) · FEBS Letters · doi:10.1016/s0014-5793(00)01291-6 · Cited by 104

p53 Regulates Caveolin Gene Transcription, Cell Cholesterol, and Growth by a Novel Mechanism

Bist, A., Fielding, C. J., & Fielding, P. E. (2000) · Biochemistry · doi:10.1021/bi991721h · Cited by 104

The Phosphatase MKP1 Is a Transcriptional Target of p53 Involved in Cell Cycle Regulation

Li, M., Zhou, J.-Y., Ge, Y., Matherly, L. H., & Wu, G. S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m307149200 · Cited by 103

MCG10, a Novel p53 Target Gene That Encodes a KH Domain RNA-Binding Protein, Is Capable of Inducing Apoptosis and Cell Cycle Arrest in G2-M

Zhu, J., & Chen, X. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.15.5602-5618.2000 · Cited by 99

Direct Transcriptional Activation of Human Caspase-1 by Tumor Suppressor p53

Gupta, S., Radha, V., Furukawa, Y., & Swarup, G. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.c100025200 · Cited by 98

p53 binds and represses the HBV enhancer: an adjacent enhancer element can reverse the transcription effect of p53

Ori, A., Zauberman, A., Doitsh, G., Paran, N., Oren, M., & Shaul, Y. (1998) · The EMBO Journal · doi:10.1093/emboj/17.2.544 · Cited by 97

p73 is transcriptionally regulated by DNA damage, p53, and p73

Chen, X., Zheng, Y., Zhu, J., Jiang, J., & Wang, J. (2001) · Oncogene · doi:10.1038/sj.onc.1204149 · Cited by 96

Gene expression profiling of isogenic cells with different TP53 gene dosage reveals numerous genes that are affected by TP53 dosage and identifies CSPG2 as a direct target of p53

Yoon, H., Liyanarachchi, S., Wright, F. A., Davuluri, R. V., Lockman, J. C., de la Chapelle, A., & Pellegata, N. S. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.242597299 · Cited by 95

Decoy Receptor 2 ( DcR2 ) Is a p53 Target Gene and Regulates Chemosensitivity

Liu, X., Yue, P., Khuri, F. R., & Sun, S. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0939 · Cited by 95

p53 and its homologues, p63 and p73, induce a replicative senescence through inactivation of NF-Y transcription factor

Jung, M.-S., Yun, J., Chae, H., Kim, J., Kim, S., Choi, T.-S., & Shin, D. Y. (2001) · Oncogene · doi:10.1038/sj.onc.1204748 · Cited by 93

p53-mediated repression of DNA methyltransferase 1 expression by specific DNA binding.

Peterson, E. J., Bögler, O., & Taylor, S. M. (2003) · PubMed · Cited by 92

Staf50 is a novel p53 target gene conferring reduced clonogenic growth of leukemic U-937 cells

Obad, S., Brunnström, H., Vallon-Christersson, J., Borg, Å., Drott, K., & Gullberg, U. (2004) · Oncogene · doi:10.1038/sj.onc.1207524 · Cited by 90

p53 is a NF‐Y‐ and p21‐independent, Sp1‐dependent repressor of cyclin B1 transcription

Innocente, S. A., & Lee, J. M. (2005) · FEBS Letters · doi:10.1016/j.febslet.2004.12.073 · Cited by 86

Positive and negative regulation of ΔN-p63 promoter activity by p53 and ΔN-p63-α contributes to differential regulation of p53 target genes

Harmes, D. C., Bresnick, E., Lubin, E. A., Watson, J. K., Heim, K. E., Curtin, J. C., Suskind, A. M., Lamb, J., & DiRenzo, J. (2003) · Oncogene · doi:10.1038/sj.onc.1207129 · Cited by 85

A Genomic Map of p53 Binding Sites Identifies Novel p53 Targets Involved in an Apoptotic Network

Miled, C., Pontoglio, M., Garbay, S., Yaniv, M., & Weitzman, J. B. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-4232 · Cited by 85

The Tumor Suppressor Protein p53 Requires a Cofactor to Activate Transcriptionally the Human BAX Promoter

Thornborrow, E. C., & Manfredi, J. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m011643200 · Cited by 85

Cloning of P2XM, a novel human P2X receptor gene regulated by p53.

Urano, T., Nishimori, H., Han, H., Furuhata, T., Kimura, Y., Nakamura, Y., & Tokino, T. (1997) · PubMed · Cited by 83

Transcriptional activation of the human stress-inducible transcriptional repressor ATF3 gene promoter by p53

Zhang, C., Gao, C., Kawauchi, J., Hashimoto, Y., Tsuchida, N., & Kitajima, S. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)02382-3 · Cited by 81

p53 Stimulates Transcription from the Human Transforming Growth Factor α Promoter: a Potential Growth-Stimulatory Role for p53

Shin, T. H., Paterson, A. J., & Kudlow, J. E. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.9.4694 · Cited by 78

Endogenous Endothelial Cell Nitric-oxide Synthase Modulates Apoptosis in Cultured Breast Cancer Cells and Is Transcriptionally Regulated by p53

Mortensen, K., Skouv, J., HOUGAARD, D. M., & Larsson, L. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.53.37679 · Cited by 78

RGC32, a novel p53-inducible gene, is located on centrosomes during mitosis and results in G2/M arrest

Saigusa, K., Imoto, I., Tanikawa, C., Aoyagi, M., Ohno, K., Nakamura, Y., & Inazawa, J. (2006) · Oncogene · doi:10.1038/sj.onc.1210148 · Cited by 77

DNA Damage Promotes Histone Deacetylase 4 Nuclear Localization and Repression of G2/M Promoters, via p53 C-terminal Lysines

Basile, V., Mantovani, R., & Imbriano, C. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m507712200 · Cited by 77

BLIMP1 regulates cell growth through repression of p53 transcription

Yan, J., Jiang, J., Lim, C. A., Wu, Q., Ng, H., & Chin, K.-C. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605562104 · Cited by 75

Identification of SCN3B as a novel p53-inducible proapoptotic gene

Adachi, K., Toyota, M., Sasaki, Y., Yamashita, T., Ishida, S., Ohe-Toyota, M., Maruyama, R., Hinoda, Y., Saito, T., Imai, K., et al. (2004) · Oncogene · doi:10.1038/sj.onc.1208067 · Cited by 74

Proteomics for the early detection and treatment of hepatocellular carcinoma

Feng, J.-T., Shang, S., & Beretta, L. (2006) · Oncogene · doi:10.1038/sj.onc.1209551 · Cited by 74

Transcriptional repression by p53 involves molecular interactions distinct from those with the TATA box binding protein

Farmer, G. (1996) · Nucleic Acids Research · doi:10.1093/nar/24.21.4281 · Cited by 74

The human BTG2/TIS21/PC3 gene: genomic structure, transcriptional regulation and evaluation as a candidate tumor suppressor gene

Duriez, C., Falette, N., Audoynaud, C., Moyret-Lalle, C., Bensaad, K., Courtois, S., Wang, Q., Soussi, T., & Puisieux, A. (2002) · Gene · doi:10.1016/s0378-1119(01)00825-3 · Cited by 73

A positive feedback mechanism in the transcriptional activation of Apaf-1 by p53 and the coactivator Zac-1

Rozenfeld-Granot, G., Krishnamurthy, J., Kannan, K., Toren, A., Amariglio, N., Givol, D., & Rechavi, G. (2002) · Oncogene · doi:10.1038/sj.onc.1205218 · Cited by 72

p53CSV, a Novel p53-Inducible Gene Involved in the p53-Dependent Cell-Survival Pathway

Park, W.-R., & Nakamura, Y. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-3339 · Cited by 72

Physical and functional interactions between members of the tumour suppressor p53 and the Sp families of transcription factors: importance for the regulation of genes involved in cell-cycle arrest and apoptosis

Koutsodontis, G., Vasilaki, E., Chou, W., Papakosta, P., & Kardassis, D. (2005) · Biochemical Journal · doi:10.1042/bj20041980 · Cited by 70

p53 negatively regulates the expression of FAT10, a gene upregulated in various cancers

Zhang, D. W., Jeang, K.-T., & Lee, C. G. L. (2006) · Oncogene · doi:10.1038/sj.onc.1209220 · Cited by 70

Transcriptional activation of the human S100A2 promoter by wild‐type p53

Tan, M., Heizmann, C. W., Guan, K., Schäfer, B. W., & Sun, Y. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)00135-0 · Cited by 70

Caspase-1 activator Ipaf is a p53-inducible gene involved in apoptosis

Sadasivam, S., Gupta, S., Radha, V., Batta, K., Kundu, T. K., & Swarup, G. (2004) · Oncogene · doi:10.1038/sj.onc.1208201 · Cited by 65

p53 and Apoptosis: It's Not Just in the Nucleus Anymore

Manfredi, J. J. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00106-0 · Cited by 63

Identification of a p53 Response Element in the Promoter Region of the hMSH2 Gene Required for Expression in A2780 Ovarian Cancer Cells

Warnick, C. T., Dabbas, B., Ford, C. D., & Strait, K. A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103088200 · Cited by 61

Transcriptional Regulation of Mitotic Checkpoint Gene MAD1 by p53

Chun, A. C. S., & Jin, D. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m307185200 · Cited by 60

Divergent Regulation of the Growth-promoting GeneIEX-1 by the p53 Tumor Suppressor and Sp1

Im, H., Pittelkow, M. R., & Kumar, R. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m109414200 · Cited by 58

Repression of hsp90β Gene by p53 in UV Irradiation-induced Apoptosis of Jurkat Cells

Zhang, Y., Wang, J., Chen, L., Zhang, Y., Cheng, X.-K., Heng, F.-Y., Wu, N., & Shen, Y. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m314213200 · Cited by 58

Dynamics of the p53 Acetylation Pathway

Gu, W., Luo, J., Brooks, C. L., Nikolaev, A. Y., & Li, M. (2004) · Novartis Foundation symposium · doi:10.1002/0470862637.ch14 · Cited by 57

Identification of fractalkine, a CX3C-type chemokine, as a direct target of p53.

Shiraishi, K., Fukuda, S., Mori, T., Matsuda, K., Yamaguchi, T., Tanikawa, C., Ogawa, M., Nakamura, Y., & Arakawa, H. (2000) · PubMed · Cited by 57

The second intron of the human galectin‐3 gene has a strong promoter activity down‐regulated by p53

Raimond, J., Rouleux‐Bonnin, F., Monsigny, M. L. P., & Legrand, A. (1995) · FEBS Letters · doi:10.1016/0014-5793(95)00310-6 · Cited by 57

p53 down‐regulates matrix metalloproteinase‐1 by targeting the communications between AP‐1 and the basal transcription complex

Sun, Y., Zeng, X., Wenger, L., Firestein, G. S., & Cheung, H. S. (2004) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20044 · Cited by 57

Chromatin Immunoprecipitation-Based Screen To Identify Functional Genomic Binding Sites for Sequence-Specific Transactivators

Hearnes, J. M., Mays, D. J., Schavolt, K. L., Tang, L., Jiang, X. J., & Pietenpol, J. A. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.22.10148-10158.2005 · Cited by 57

AMID is a p53-inducible gene downregulated in tumors

Wu, M., Xu, L., Su, T., Tian, Y., Zhai, Z., & Shu, H. (2004) · Oncogene · doi:10.1038/sj.onc.1207909 · Cited by 56

p53RFP, a p53-inducible RING-finger protein, regulates the stability of p21WAF1

Ng, C.-C., Arakawa, H., Fukuda, S., Kondoh, H., & Nakamura, Y. (2003) · Oncogene · doi:10.1038/sj.onc.1206586 · Cited by 54

Translational control of gene expression: Role of IRESs and consequences for cell transformation and angiogenesis

Prats, A., & Prats, H. (2002) · Progress in nucleic acid research and molecular biology · doi:10.1016/s0079-6603(02)72075-8 · Cited by 53

Additive effect between NF-κB subunits and p53 protein for transcriptional activation of human p53 promoter

Benoît, V., Hellin, A., Huygen, S., GIELEN, J. E., Bours, V., & Merville, M.-P. (2000) · Oncogene · doi:10.1038/sj.onc.1203831 · Cited by 52

BCL6 is regulated by p53 through a response element frequently disrupted in B-cell non-Hodgkin lymphoma

Margalit, O., Amram, H. W., Amariglio, N., Simon, A. J., Shaklai, S., Granot, G., Minsky, N., Shimoni, A., Harmelin, A., Givol, D., et al. (2005) · Blood · doi:10.1182/blood-2005-04-1629 · Cited by 52

Regulation of the c-met Proto-oncogene Promoter by p53

Seol, D., Chen, Q., Smith, M. L., & Zarnegar, R. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.6.3565 · Cited by 51

Upregulation of the Elongation Factor-1α Gene by p53 in Association With Death of an Erythroleukemic Cell Line

Kato, M. V., Sato, H., Nagayoshi, M., & Ikawa, Y. (1997) · Blood · doi:10.1182/blood.v90.4.1373 · Cited by 51

p53 Represses CAAT Enhancer-binding Protein (C/EBP)-dependent Transcription of the Albumin Gene

Kubicka, S., Kühnel, F., Zender, L., Rudolph, K. L., Plümpe, J., Manns, M. P., & Trautwein, C. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.45.32137 · Cited by 50

p53-dependent Transcriptional Regulation of theAPC Promoter in Colon Cancer Cells Treated with DNA Alkylating Agents

Jaiswal, A. S., & Narayan, S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101298200 · Cited by 50

Identification of the p53 family-responsive element in the promoter region of the tumor suppressor gene hypermethylated in cancer 1

Britschgi, C., Rizzi, M., Grob, T. J., Tschan, M. P., Hügli, B., Reddy, V. A., Andres, A. ‐., Torbett, B. E., Tobler, A., & Fey, M. F. (2005) · Oncogene · doi:10.1038/sj.onc.1209240 · Cited by 50

IL-6 Rescues Enterocytes from Hemorrhage Induced Apoptosisin Vivoandin Vitroby abcl-2Mediated Mechanism

Rollwagen, F. M., Yu, Z.-Y., Li, Y., & Pacheco, N. D. (1998) · Clinical Immunology and Immunopathology · doi:10.1006/clin.1998.4600 · Cited by 49

Multiple response elements and differential p53 binding control Perp expression during apoptosis.

Reczek, E. E., Flores, E. R., Tsay, A. S., Attardi, L. D., & Jacks, T. (2003) · PubMed · Cited by 49

Cyclin K as a Direct Transcriptional Target of the p53 Tumor Suppressor

Mori, T., Anazawa, Y., Matsui, K., Fukuda, S., Nakamura, Y., & Arakawa, H. (2002) · Neoplasia · doi:10.1038/sj.neo.7900235 · Cited by 48

Repression of New p53 Targets Revealed by ChIP on Chip Experiments

Ceribelli, M., Alcalay, M., Viganò, M., & Mantovani, R. (2006) · Cell Cycle · doi:10.4161/cc.5.10.2777 · Cited by 48

Negative Regulation of Chk2 Expression by p53 Is Dependent on the CCAAT-binding Transcription Factor NF-Y

Matsui, T., Katsuno, Y., Inoue, T., Fujita, F., Joh, T., Niida, H., Murakami, H., Itoh, M., & Nakanishi, M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403232200 · Cited by 47

Caspase 10 Levels are Increased Following DNA Damage in a p53-Dependent Manner

Rikhof, B., Corn, P. G., & El‐Deiry, W. S. (2003) · Cancer Biology & Therapy · doi:10.4161/cbt.2.6.626 · Cited by 43

Receptor protein tyrosine kinase DDR is up‐regulated by p53 protein

Sakuma, S., Saya, H., Tada, M., Nakao, M., Fujiwara, T., Roth, J. A., Sawamura, Y., Shinohe, Y., & Abe, H. (1996) · FEBS Letters · doi:10.1016/s0014-5793(96)01234-3 · Cited by 39

The Bradykinin Type 2 Receptor Is a Target for p53-mediated Transcriptional Activation

Saifudeen, Z. R., Du, H., Dipp, S., & El-Dahr, S. S. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m909810199 · Cited by 38

E2FBP1/DRIL1, an AT-rich interaction domain-family transcription factor, is regulated by p53.

Ma, K., Araki, K., Ichwan, S. J. A., Suganuma, T., Tamamori‐Adachi, M., & Ikeda, M. (2003) · PubMed · Cited by 38

Down-regulation of fibronectin gene expression by the p53 tumor suppressor protein.

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Genomic Structure and Chromosomal Localization of GML (GPI-Anchored Molecule-like Protein), a Gene Induced by p53

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