Cited by 1,921Cancer-related Molecular PathwaysGenomics and Chromatin DynamicsDNA Repair Mechanisms

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Transcriptional control of human p53-regulated genes

Riley, Todd, Sontag, Eduardo, Chen, Patricia, Levine, Arnold·2008·Nature Reviews Molecular Cell Biology

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Abstract

The p53 protein regulates the transcription of many different genes in response to a wide variety of stress signals. Following DNA damage, p53 regulates key processes, including DNA repair, cell-cycle arrest, senescence and apoptosis, in order to suppress cancer. This Analysis article provides an overview of the current knowledge of p53-regulated genes in these pathways and others, and the mechanisms of their regulation. In addition, we present the most comprehensive list so far of human p53-regulated genes and their experimentally validated, functional binding sites that confer p53 regulation.

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Authors: Riley, T., Sontag, E., Chen, P., & Levine, A.
Affiliations: Institute for Advanced Study (US)
Rutgers, The State University of New Jersey (US)
Corresponding author: Riley, Todd
ORCID: Sontag, Eduardo
Chen, Patricia
Levine, Arnold
Venue: Nature Reviews Molecular Cell Biology
Publisher: Springer Science and Business Media LLC
Published: 2008-05
Volume: 9
Issue: 5
Pages: 402-412
ISSN: 1471-0072 (ISSN-L)
1471-0080
DOI: 10.1038/nrm2395
OpenAlex: W1964719993
Cited by: 1,921
References: 201
Citations by year: 2026: 36 · 2025: 45 · 2024: 56 · 2023: 73 · 2022: 85 · 2021: 97 · 2020: 79 · 2019: 92 · 2018: 110 · 2017: 134 · 2016: 131 · 2015: 115 · 2014: 154 · 2013: 143 · 2012: 153
FWCI: 12.97
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Molecular Cell Biology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Keywords: p53, transcriptional regulation, p53 target genes, DNA damage response, DNA repair, cell cycle arrest, senescence, apoptosis, tumor suppression, transcription factor binding sites, stress signaling
MeSH terms: Base Sequence, Binding Sites, Cell Transformation, Neoplastic, DNA Damage, Gene Expression Regulation, Humans, Markov Chains, Molecular Sequence Data, Regulatory Sequences, Nucleic Acid, Transcription, Genetic, Signal Transduction, Genes, p53, Tumor Suppressor Protein p53, Response Elements, Regulatory Elements, Transcriptional

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Transcriptional control of human p53-regulated genes

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