Transcriptional control of human p53-regulated genes

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Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

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PI3K/Akt-mediated regulation of p53 in cancer

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Human NK Cells Are Alerted to Induction of p53 in Cancer Cells by Upregulation of the NKG2D Ligands ULBP1 and ULBP2

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TRIAP1/PRELI Complexes Prevent Apoptosis by Mediating Intramitochondrial Transport of Phosphatidic Acid

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A tumor suppressive coactivator complex of p53 containing ASC-2 and histone H3-lysine-4 methyltransferase MLL3 or its paralogue MLL4

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NAT10 regulates p53 activation through acetylating p53 at K120 and ubiquitinating Mdm2

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Suprainduction of p53 by disruption of 40S and 60S ribosome biogenesis leads to the activation of a novel G2/M checkpointPreprint

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Tumour suppression by p53: the importance of apoptosis and cellular senescence

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UFMylation maintains tumour suppressor p53 stability by antagonizing its ubiquitination

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p53 Improves Aerobic Exercise Capacity and Augments Skeletal Muscle Mitochondrial DNA Content

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CKIα ablation highlights a critical role for p53 in invasiveness control

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Deconstructing p53 transcriptional networks in tumor suppression

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Translating p53-based therapies for cancer into the clinic

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Berberine exerts nephroprotective effect against cisplatin-induced kidney damage through inhibition of oxidative/nitrosative stress, inflammation, autophagy and apoptosis

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MEG3: an Oncogenic Long Non-coding RNA in Different Cancers

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Crosstalk of Notch with p53 and p63 in cancer growth control

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Recent Advances in p53 Research and Cancer Treatment

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Revisiting tumor patterns and penetrance in germline TP53 mutation carriers: temporal phases of Li–Fraumeni syndrome

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The Long Noncoding RNA MEG3 Contributes to Cisplatin Resistance of Human Lung Adenocarcinoma

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A Common Biological Mechanism in Cancer and Alzheimers Disease?

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Insights into p53 transcriptional function via genome-wide chromatin occupancy and gene expression analysis

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DLEU2, frequently deleted in malignancy, functions as a critical host gene of the cell cycle inhibitory microRNAs miR-15a and miR-16-1

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Nondisruptive p53 Mutations Are Associated with Shorter Survival in Patients with Advanced Non–Small Cell Lung Cancer

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Genistein induces G2/M cell cycle arrest and apoptosis via ATM/p53-dependent pathway in human colon cancer cells

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DNA repair processes are critical mediators of p53-dependent tumor suppression

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Real-time in vivo imaging of p16Ink4a reveals cross talk with p53

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Immunotherapeutic Potential of Anti-Human Endogenous Retrovirus-K Envelope Protein Antibodies in Targeting Breast Tumors

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MicroRNA-149*, a p53-responsive microRNA, functions as an oncogenic regulator in human melanoma

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TP53 Germline Variations Influence the Predisposition and Prognosis of B-Cell Acute Lymphoblastic Leukemia in Children

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The ARTS of p53-dependent mitochondrial apoptosis

Hao, Q., Chen, J., Lu, H., & Zhou, X. Y. (2022) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjac074 · Cited by 182

p53-dependent non-coding RNA networks in chronic lymphocytic leukemia

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Polybromo-associated BRG1-associated factor components BRD7 and BAF180 are critical regulators of p53 required for induction of replicative senescence

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MDM2-Dependent Downregulation of p21 and hnRNP K Provides a Switch between Apoptosis and Growth Arrest Induced by Pharmacologically Activated p53

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Systemic Delivery of a miR34a Mimic as a Potential Therapeutic for Liver Cancer

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TRIM family contribute to tumorigenesis, cancer development, and drug resistance

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p53 and mitochondrial function in neurons

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Limiting the power of p53 through the ubiquitin proteasome pathwayPreprint

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Pro-proliferative FoxM1 is a target of p53-mediated repression

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Psychopharmacology of atypical antipsychotic drugs: From the receptor binding profile to neuroprotection and neurogenesis

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Diverse stresses dramatically alter genome-wide p53 binding and transactivation landscape in human cancer cells

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Cell Death in the Developing Brain after Hypoxia-Ischemia

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Current understanding of the role and targeting of tumor suppressor p53 in glioblastoma multiforme

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Autophagy as initiator or executioner of cell death

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The p53 Family Coordinates Wnt and Nodal Inputs in Mesendodermal Differentiation of Embryonic Stem Cells

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Reactive Oxygen Species Induced p53 Activation: DNA Damage, Redox Signaling, or Both?

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Unravelling the mechanisms regulating muscle mitochondrial biogenesis

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Fluctuations in p53 Signaling Allow Escape from Cell-Cycle Arrest

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Sirt3 protects in vitro–fertilized mouse preimplantation embryos against oxidative stress–induced p53-mediated developmental arrest

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High Mitochondrial Priming Sensitizes hESCs to DNA-Damage-Induced Apoptosis

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The transcription factor p53: Not a repressor, solely an activator.

Fischer, M., Steiner, L., & Engeland, K. (2014) · Cell Cycle · doi:10.4161/15384101.2014.949083 · Cited by 153

Functional Identification of Tumor-Suppressor Genes through an In Vivo RNA Interference Screen in a Mouse Lymphoma Model

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Chrysin protects against cisplatin-induced colon. toxicity via amelioration of oxidative stress and apoptosis: Probable role of p38MAPK and p53

Khan, R., Khan, A. Q., Qamar, W., Lateef, A., Tahir, M., Rehman, M. U., Ali, F., & Sultana, S. (2011) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2011.11.013 · Cited by 161

Long Noncoding RNA PURPL Suppresses Basal p53 Levels and Promotes Tumorigenicity in Colorectal Cancer

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The non‐apoptotic role of p53 in neuronal biology: enlightening the dark side of the moon

Tedeschi, A., & Giovanni, S. D. (2009) · EMBO Reports · doi:10.1038/embor.2009.89 · Cited by 163

Mechanisms of transcription factor selectivity

Pan, Y., Tsai, C., Ma, B., & Nussinov, R. (2010) · Trends in Genetics · doi:10.1016/j.tig.2009.12.003 · Cited by 160

The Central Nervous System-Restricted Transcription Factor Olig2 Opposes p53 Responses to Genotoxic Damage in Neural Progenitors and Malignant Glioma

Mehta, S. V., Huillard, E., Kesari, S., Maire, C. L., Golebiowski, D., Harrington, E. P., Alberta, J. A., Kane, M., Theisen, M., Ligon, K. L., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.01.035 · Cited by 165

Mage-A Cancer/Testis Antigens Inhibit p53 Function by Blocking Its Interaction with Chromatin

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Deficiency of microRNA miR-34a expands cell fate potential in pluripotent stem cells

Choi, Y. J., Lin, C., Risso, D., Chen, S., Kim, T. A., Tan, M. H., Li, J. B., Wu, Y., Chen, C., Xuan, Z., et al. (2017) · Science · doi:10.1126/science.aag1927 · Cited by 158

Induction of renal fibrotic genes by TGF-β1 requires EGFR activation, p53 and reactive oxygen species

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A Novel Human AlkB Homologue, ALKBH8, Contributes to Human Bladder Cancer Progression

Shimada, K., Nakamura, M., Anai, S., Velasco, M. A. D., Tanaka, M., Tsujikawa, K., Ouji, Y., & Konishi, N. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-3530 · Cited by 164

Exploring the multiple roles of guardian of the genome: P53

Feroz, W., & Sheikh, A. M. A. (2020) · Egyptian Journal of Medical Human Genetics · doi:10.1186/s43042-020-00089-x · Cited by 172

Should mutant TP53 be targeted for cancer therapy?

Wang, Z., Strasser, A., & Kelly, G. L. (2022) · Cell Death and Differentiation · doi:10.1038/s41418-022-00962-9 · Cited by 162

p53 Protein-mediated Regulation of Phosphoglycerate Dehydrogenase (PHGDH) Is Crucial for the Apoptotic Response upon Serine Starvation

Ou, Y., Wang, S.-J., Jiang, L., Zheng, B., & Gu, W. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.616359 · Cited by 156

Homeostatic functions of the p53 tumor suppressor: Regulation of energy metabolism and antioxidant defense

Olovnikov, I. A., Kravchenko, J. E., & Chumakov, P. M. (2008) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2008.11.005 · Cited by 156

Cell cycle progression by the repression of primary cilia formation in proliferating cells

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Aurora-A/SOX8/FOXK1 signaling axis promotes chemoresistance via suppression of cell senescence and induction of glucose metabolism in ovarian cancer organoids and cells

Sun, H., Wang, H., Wang, X., Aoki, Y., Wang, X., Wang, Z., Cheng, X., Wang, Z., & Wang, X. (2020) · Theranostics · doi:10.7150/thno.43811 · Cited by 154

Microglia-derived IL-1β triggers p53-mediated cell cycle arrest and apoptosis in neural precursor cells

Guadagno, J., Swan, P., Shaikh, R., & Cregan, S. P. (2015) · Cell Death and Disease · doi:10.1038/cddis.2015.151 · Cited by 152

Ferredoxin reductase is critical for p53-dependent tumor suppression via iron regulatory protein 2Preprint

Zhang, Y., Qian, Y., Zhang, J., Yan, W., Jung, Y.-S., Chen, M., Huang, E. C., Lloyd, K. C. K., Duan, Y., Wang, J., et al. (2017) · Genes & Development · doi:10.1101/gad.299388.117 · Cited by 153

Targeting MDM2-p53 Interaction for Cancer Therapy: Are We There Yet?

Nag, S. A., Zhang, X., Srivenugopal, K. S., Wang, M.-H., Wang, W., & Zhang, R. (2014) · Current Medicinal Chemistry · doi:10.2174/09298673113206660325 · Cited by 156

The regulation of cellular metabolism by tumor suppressor p53

Liang, Y., Liu, J., & Feng, Z. (2013) · Cell & Bioscience · doi:10.1186/2045-3701-3-9 · Cited by 154

TGF-β1/p53 signaling in renal fibrogenesis

Higgins, S. P., Tang, Y., Higgins, C. E., Mian, B. M., Zhang, W., Czekay, R., Samarakoon, R., Conti, D. J., & Higgins, P. J. (2017) · Cellular Signalling · doi:10.1016/j.cellsig.2017.11.005 · Cited by 153

Another fork in the road—life or death decisions by the tumour suppressor p53

Carvajal, L. A., & Manfredi, J. J. (2013) · The EMBO Reports · doi:10.1038/embor.2013.25 · Cited by 149

Kaempferol protects against doxorubicin-induced cardiotoxicity in vivo and in vitro

Xiao, J., Sun, G., Sun, B., Wu, Y., He, L., Wang, X., Chen, R., Cao, L., Ren, X., & Sun, X. (2011) · Toxicology · doi:10.1016/j.tox.2011.11.018 · Cited by 149

Glioblastoma Models Reveal the Connection between Adult Glial Progenitors and the Proneural Phenotype

Lei, L., Sonabend, A. M., Guarnieri, P., Soderquist, C. R., Ludwig, T. E., Rosenfeld, S. A., Bruce, J. N., & Canoll, P. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020041 · Cited by 149

The Toll-like receptor gene family is integrated into human DNA damage and p53 networks

Menendez, D., Shatz, M., Azzam, K., Garantziotis, S., Fessler, M. B., & Resnick, M. A. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1001360 · Cited by 148

A gene expression signature distinguishes normal tissues of sporadic and radiation-induced papillary thyroid carcinomas

Dom, G., Tarabichi, M., Unger, K., Thomas, G. A., Oczko‐Wojciechowska, M., Ti, B., Jarząb, B., Dumont, J.-E., Detours, V., & Maenhaut, C. (2012) · British Journal of Cancer · doi:10.1038/bjc.2012.302 · Cited by 147

Toward Cochlear Therapies

Wang, J., & Puel, J. (2018) · Physiological Reviews · doi:10.1152/physrev.00053.2017 · Cited by 150

Different mechanisms of arsenic related signaling in cellular proliferation, apoptosis and neo-plastic transformation

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Trial Watch: Targeting ATM–CHK2 and ATR–CHK1 pathways for anticancer therapy

Manic, G., Obrist, F., Sistigu, A., & Vitale, I. (2015) · Molecular & Cellular Oncology · doi:10.1080/23723556.2015.1012976 · Cited by 152

The importance of p53 pathway genetics in inherited and somatic cancer genomes

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A Large Scale shRNA Barcode Screen Identifies the Circadian Clock Component ARNTL as Putative Regulator of the p53 Tumor Suppressor Pathway

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Ubiquitin-binding domains and their role in the DNA damage response

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TGF-β1 → SMAD/p53/USF2 → PAI-1 transcriptional axis in ureteral obstruction-induced renal fibrosis

Samarakoon, R., Overstreet, J. M., Higgins, S. P., & Higgins, P. J. (2011) · Cell and Tissue Research · doi:10.1007/s00441-011-1181-y · Cited by 146

p53 Isoforms and Their Implications in Cancer

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Regulation of Embryonic and Induced Pluripotency by Aurora Kinase-p53 Signaling

Lee, D., Su, J., Ang, Y.-S., Carvajal‐Vergara, X., Mulero‐Navarro, S., Pereira, C., Gingold, J. A., Wang, H.-L., Zhao, R., Sevilla, A., et al. (2012) · Cell stem cell · doi:10.1016/j.stem.2012.05.020 · Cited by 138

The pro-longevity gene FoxO3 is a direct target of the p53 tumor suppressor

Renault, V. M., Thekkat, P. U., Hoang, K., White, J. L., Brady, C. A., Brož, D. K., Venturelli, O. S., Johnson, T. M., Oskoui, P. R., Xuan, Z., et al. (2011) · Oncogene · doi:10.1038/onc.2011.35 · Cited by 139

How mutations shape p53 interactions with the genome to promote tumorigenesis and drug resistance

Stiewe, T., & Haran, T. E. (2018) · Drug Resistance Updates · doi:10.1016/j.drup.2018.05.001 · Cited by 143

Transcriptional Regulation by Wild-Type and Cancer-Related Mutant Forms of p53Preprint

Pfister, N. T., & Prives, C. L. (2016) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a026054 · Cited by 146

E3 ubiquitin ligase TRIM32 negatively regulates tumor suppressor p53 to promote tumorigenesis

Liu, J., Zhang, C., Wang, X. L., Ly, P., Белый, В. А., Xu-Monette, Z. Y., Young, K. H., Hu, W., & Feng, Z. (2014) · Cell Death and Differentiation · doi:10.1038/cdd.2014.121 · Cited by 139

Beneficial effects of Chrysin against Methotrexate-induced hepatotoxicity via attenuation of oxidative stress and apoptosis

Ali, N., Rashid, S., Nafees, S., Hasan, S. K., & Sultana, S. (2013) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-013-1830-4 · Cited by 136

A dp53/JNK-dependant feedback amplification loop is essential for the apoptotic response to stress in Drosophila

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A miR‐34a‐SIRT6 axis in the squamous cell differentiation network

Lefort, K., Brooks, Y., Ostano, P., Cario, M., Calpini, V., Guinea‐Viniegra, J., Albinger‐Hegyi, A., Hoetzenecker, W., Kolfschoten, I., Wagner, E. F., et al. (2013) · The EMBO Journal · doi:10.1038/emboj.2013.156 · Cited by 138

Immunomodulatory Function of the Tumor Suppressor p53 in Host Immune Response and the Tumor Microenvironment

Cui, Y. R., & Guo, G. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17111942 · Cited by 137

p53 regulates a non-apoptotic death induced by ROS

Montero, J., Dutta, C., van Bodegom, D., Weinstock, D. M., & Letai, A. G. (2013) · Cell Death and Differentiation · doi:10.1038/cdd.2013.52 · Cited by 138

Cellular senescence and cancer chemotherapy resistance

Gordon, R. R., & Nelson, P. S. (2012) · Drug Resistance Updates · doi:10.1016/j.drup.2012.01.002 · Cited by 138

Targeted Quantitation of Site-Specific Cysteine Oxidation in Endogenous Proteins Using a Differential Alkylation and Multiple Reaction Monitoring Mass Spectrometry Approach

Held, J. M., Danielson, S. R., Behring, J. B., Atsriku, C., Britton, D. J., Puckett, R., Schilling, B., Campisi, J., Benz, C. C., & Gibson, B. W. (2010) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m900643-mcp200 · Cited by 135

The Guardian of the Genome Revisited: p53 Downregulates Genes Required for Telomere Maintenance, DNA Repair, and Centromere Structure

Toufektchan, E., & Toledo, F. (2018) · Cancers · doi:10.3390/cancers10050135 · Cited by 144

Current status of biodosimetry based on standard cytogenetic methods

Pinto, M. M. P. D. L., Santos, N. F., & Amaral, A. (2010) · Radiation and Environmental Biophysics · doi:10.1007/s00411-010-0311-3 · Cited by 133

Molecular Mechanisms of Neonatal Brain Injury

Thornton, C., Rousset, C. I., Kichev, A., Miyakuni, Y., Vontell, R., Baburamani, A. A., Fleiss, B., Gressèns, P., & Hagberg, H. (2012) · Neurology Research International · doi:10.1155/2012/506320 · Cited by 132

Tumor suppressor p53 and its gain-of-function mutants in cancer

Liu, J., Zhang, C., & Feng, Z. (2013) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmt144 · Cited by 133

p53 Attenuates Lipopolysaccharide-Induced NF-κB Activation and Acute Lung Injury

Liu, G., Park, Y.-J., Tsuruta, Y., Lorne, E., & Abraham, E. H. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803526 · Cited by 133

Analysis Transcriptional control of human p53-regulated genes

Riley, T., Sontag, E. D., Chen, P., & Levine, A. (2008)

Transcriptional repression mediated by the p53 tumour suppressor

Ho, J., & Benchimol, S. (2003) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401191 · Cited by 203

p53 Function and Dysfunction in Human Health and Diseases

D’Orazi, G. (2023) · Biomolecules · doi:10.3390/biom13030506 · Cited by 19

The Regulation of p53 Protein Function by Phosphorylation

MacLaine, N. J., & Hupp, T. (2010) · Molecular biology intelligence unit · doi:10.1007/978-1-4419-8231-5_4 · Cited by 2

Transcriptional regulation by p53: one protein, many possibilities

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