Cited by 134Neuroscience and Neuropharmacology ResearchGenetics and Neurodevelopmental DisordersMemory and Neural Mechanisms

Plasticity of dendritic spines: subcompartmentalization of signaling

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Colgan, Lesley A., Yasuda, Ryohei·2014·Annual Review of Physiology

Abstract

The ability to induce and study neuronal plasticity in single dendritic spines has greatly advanced our understanding of the signaling mechanisms that mediate long-term potentiation. It is now clear that in addition to compartmentalization by the individual spine, subcompartmentalization of biochemical signals occurs at specialized microdomains within the spine. The spatiotemporal coordination of these complex cascades allows for the concomitant remodeling of the postsynaptic density and actin spinoskeleton and for the regulation of membrane traffic to express functional and structural plasticity. Here, we highlight recent findings in the signaling cascades at spine microdomains as well as the challenges and approaches to studying plasticity at the spine level.

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  1. [140]Harris KM Jensen FE Tsao B Three-dimensional structure of dendritic spines and synapses in rat hippocampus (CA1) at postnatal day 15 and adult ages: implications for the maturation of synaptic physiology and long-term potentiation J. Neurosci 1992 12 2685 705 1613552 PMC6575840

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Authors
Colgan, L. A., & Yasuda, R.
Affiliations
Max Planck Florida Institute for Neuroscience (US)
Venue
Annual Review of Physiology
Published
2014-02-10
Volume
76
Issue
1
Pages
365-385
ISSN
  • 0066-4278 (ISSN-L)
  • 1545-1585
OpenAlex
W2109779479
Cited by
124
References
153
Citations by year
2026: 2 · 2025: 6 · 2024: 12 · 2023: 7 · 2022: 7 · 2021: 7 · 2020: 12 · 2019: 11 · 2018: 8 · 2017: 12 · 2016: 17 · 2015: 13 · 2014: 8 · 2013: 2
FWCI
1.36
Type
journal article
Language
en
Open access
Locations
  • Annual Review of Physiology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • Max Planck Digital Library (submittedVersion)
  • MPG.PuRe (Max Planck Society) (submittedVersion)
Funders
  • National Institute of Mental Health (R01MH080047, R01MH095090)
  • National Institute of Neurological Disorders and Stroke (R01NS068410)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
dendritic spines, synaptic plasticity, long-term potentiation, postsynaptic density, actin cytoskeleton, membrane trafficking, signaling pathways
MeSH terms
Actins, Animals, Cell Membrane, Cytoskeleton, Humans, Neuronal Plasticity, Synapses, Signal Transduction, Dendritic Spines

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