Plasticity of dendritic spines: subcompartmentalization of signaling
Open accessAbstract
The ability to induce and study neuronal plasticity in single dendritic spines has greatly advanced our understanding of the signaling mechanisms that mediate long-term potentiation. It is now clear that in addition to compartmentalization by the individual spine, subcompartmentalization of biochemical signals occurs at specialized microdomains within the spine. The spatiotemporal coordination of these complex cascades allows for the concomitant remodeling of the postsynaptic density and actin spinoskeleton and for the regulation of membrane traffic to express functional and structural plasticity. Here, we highlight recent findings in the signaling cascades at spine microdomains as well as the challenges and approaches to studying plasticity at the spine level.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Crowding in the spine head may contribute to diffusional trapping of receptors.
“Based on results from modeling (Renner et al., 2009) it has been suggested that crowding in the spine head may contribute to this phenomenon (Colgan and Yasuda, 2014).”
From Barriers in the brain: resolving dendritic spine morphology and compartmentalization (2014) · cites this paper as Colgan and Yasuda, 2014
Nlg1 is a postsynaptic protein selectively expressed at excitatory synapses which is known to regulate spine formation and synapse stability through binding to presynaptic neurexins.
“Nlg1 is a postsynaptic protein selectively expressed at excitatory synapses which is known to regulate spine formation and synapse stability through binding to presynaptic neurexins [16, 70].”
From Glia-to-neuron transfer of miRNAs via extracellular vesicles: a new mechanism underlying inflammation-induced synaptic alterations (2018) · cites this paper as [16]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Two-photon laser scanning fluorescence microscopy
Denk, W., Strickler, J. H., & Webb, W. W. (1990) · Science · doi:10.1126/science.2321027 · Cited by 9,488 · see citing works
Imaging Intracellular Fluorescent Proteins at Nanometer Resolution
Betzig, E., Patterson, G. H., Sougrat, R., Lindwasser, O. W., Olenych, S. G., Bonifacino, J. S., Davidson, M. W., Lippincott‐Schwartz, J., & Hess, H. F. (2006) · Science · doi:10.1126/science.1127344 · Cited by 8,802 · see citing works
Sub-diffraction-limit imaging by stochastic optical reconstruction microscopy (STORM)
Rust, M. J., Bates, M., & Zhuang, X. (2006) · Nature Methods · doi:10.1038/nmeth929 · Cited by 8,109 · see citing works
Hell, S. W., & Wichmann, J. (1994) · Optics Letters · doi:10.1364/ol.19.000780 · Cited by 6,068 · see citing works
Gustafsson, M. G. L. (2000) · Journal of Microscopy · doi:10.1046/j.1365-2818.2000.00710.x · Cited by 3,786 · see citing works
Structural basis of long-term potentiation in single dendritic spines
Matsuzaki, M., Honkura, N., Ellis-Davies, G. C. R., & Kasai, H. (2004) · Nature · doi:10.1038/nature02617 · Cited by 2,500 · see citing works
Learning induces long-term potentiation in the hippocampus
Whitlock, J. R., Heynen, A. J., Shuler, M. G., & Bear, M. F. (2006) · Science · doi:10.1126/science.1128134 · Cited by 1,913 · see citing works
GEFs and GAPs: Critical Elements in the Control of Small G Proteins
Bos, J. L., Rehmann, H., & Wittinghofer, A. (2007) · Cell · doi:10.1016/j.cell.2007.05.018 · Cited by 1,903 · see citing works
Matsuzaki, M., Ellis-Davies, G. C. R., Nemoto, T., Miyashita, Y., Iino, M., & Kasai, H. (2001) · Nature Neuroscience · doi:10.1038/nn736 · Cited by 1,563 · see citing works
The importance of dendritic mitochondria in the morphogenesis and plasticity of spines and synapses
Li, Z., Okamoto, K.-I., Hayashi, Y., & Sheng, M. (2004) · Cell · doi:10.1016/j.cell.2004.11.003 · Cited by 1,498 · see citing works
Deficient Hippocampal Long-Term Potentiation in α-Calcium-Calmodulin Kinase II Mutant Mice
Silva, A. J., Stevens, C. F., Tonegawa, S., & Wang, Y. (1992) · Science · doi:10.1126/science.1378648 · Cited by 1,472 · see citing works
Structure and function of dendritic spines
Nimchinsky, E. A., Sabatini, B. L., & Svoboda, K. (2002) · Annual Review of Physiology · doi:10.1146/annurev.physiol.64.081501.160008 · Cited by 1,208 · see citing works
Mechanisms of CaMKII action in long-term potentiation
Lisman, J., Yasuda, R., & Raghavachari, S. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3192 · Cited by 1,134 · see citing works
Self-citationStargazin regulates synaptic targeting of AMPA receptors by two distinct mechanisms
Chen, L., Chetkovich, D. M., Petralia, R. S., Sweeney, N. T., Kawasaki, Y., Wenthold, R. J., Bredt, D. S., & Nicoll, R. A. (2000) · Nature · doi:10.1038/35050030 · Cited by 1,111 · see citing works
NMDA receptor-dependent long-term potentiation and long-term depression (LTP/LTD).
Luscher, C., & Malenka, R. C. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005710 · Cited by 1,110 · cited 1× · see citing works
“In a simplified view of LTP signaling, LTP is induced by NMDAR-dependent Ca2+ influx, followed by a transient activation of Ca2+/calmodulin-dependent protein kinase II (CaMKII) (8, 9).”
BackgroundAutophosphorylation at Thr <sup>286</sup> of the α Calcium-Calmodulin Kinase II in LTP and Learning
Giese, K. P., Fedorov, N. B., Filipkowski, R. K., & Silva, A. J. (1998) · Science · doi:10.1126/science.279.5352.870 · Cited by 1,055 · see citing works
Harris, K. M., Jensen, F. E., & Tsao, B. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-07-02685.1992 · Cited by 990 · see citing works
Okamoto, K.-I., Nagai, T., Miyawaki, A., & Hayashi, Y. (2004) · Nature Neuroscience · doi:10.1038/nn1311 · Cited by 854 · see citing works
Characterization of multiple phosphorylation sites on the AMPA receptor GluR1 subunit
Roche, K. W., O'Brien, R. J., Mammen, A. L., Bernhardt, J., & Huganir, R. L. (1996) · Neuron · doi:10.1016/s0896-6273(00)80144-0 · Cited by 812 · see citing works
Structural dynamics of dendritic spines in memory and cognition
Kasai, H., Fukuda, M., Watanabe, S., Hayashi-Takagi, A., & Noguchi, J. (2010) · Trends in Neurosciences · doi:10.1016/j.tins.2010.01.001 · Cited by 804 · see citing works
Lee, H.-K., Takamiya, K., Han, J.-S., Man, H., Kim, C.-H., Rumbaugh, G., Yu, S., Ding, L., He, C., Petralia, R. S., et al. (2003) · Cell · doi:10.1016/s0092-8674(03)00122-3 · Cited by 802 · see citing works
Arc/Arg3.1 interacts with the endocytic machinery to regulate AMPA receptor trafficking
Chowdhury, S., Shepherd, J. D., Okuno, H., Lyford, G., Petralia, R. S., Plath, N., Kuhl, D., Huganir, R. L., & Worley, P. F. (2006) · Neuron · doi:10.1016/j.neuron.2006.08.033 · Cited by 792 · see citing works
Arc/Arg3.1 Mediates Homeostatic Synaptic Scaling of AMPA Receptors
Shepherd, J. D., Rumbaugh, G., Wu, J., Chowdhury, S., Plath, N., Kuhl, D., Huganir, R. L., & Worley, P. F. (2006) · Neuron · doi:10.1016/j.neuron.2006.08.034 · Cited by 779 · see citing works
Recycling Endosomes Supply AMPA Receptors for LTP
Park, M., Penick, E. C., Edwards, J. G., Kauer, J. A., & Ehlers, M. D. (2004) · Science · doi:10.1126/science.1102026 · Cited by 730 · see citing works
Superresolution Imaging of Chemical Synapses in the Brain
Dani, A., Huang, B., Bergan, J. F., Dulac, C. G., & Zhuang, X. (2010) · Neuron · doi:10.1016/j.neuron.2010.11.021 · Cited by 718 · see citing works
NMDA Receptor Subunit Composition Controls Synaptic Plasticity by Regulating Binding to CaMKII
Barria, A., & Malinow, R. (2005) · Neuron · doi:10.1016/j.neuron.2005.08.034 · Cited by 709 · see citing works
Fukazawa, Y., Saitoh, Y., Ozawa, F., Ohta, Y., Mizuno, K., & Inokuchi, K. (2003) · Neuron · doi:10.1016/s0896-6273(03)00206-x · Cited by 695 · see citing works
Role of AMPA Receptor Cycling in Synaptic Transmission and Plasticity
Lüscher, C., Xia, H., Beattie, E. C., Carroll, R. C., von Zastrow, M., Malenka, R. C., & Nicoll, R. A. (1999) · Neuron · doi:10.1016/s0896-6273(00)81119-8 · Cited by 692 · see citing works
Activation of CaMKII in single dendritic spines during long-term potentiation
Lee, S.-J. R., Escobedo-Lozoya, Y., Szatmari, E. M., & Yasuda, R. (2009) · Nature · doi:10.1038/nature07842 · Cited by 685 · see citing works
Self-citationUnusual spectral energy distribution of a galaxy previously reported to be at redshift 6.68
Chen, H., Lanzetta, K. M., Pascarelle, S. M., & Yahata, N. (2000) · RePEc: Research Papers in Economics · Cited by 680 · see citing works
Shen, K., & Meyer, T. (1999) · Science · doi:10.1126/science.284.5411.162 · Cited by 673 · see citing works
Spacek, J., & Harris, K. M. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-01-00190.1997 · Cited by 599 · see citing works
The interaction between Stargazin and PSD-95 regulates AMPA receptor surface trafficking
Bats, C., Groc, L., & Choquet, D. (2007) · Neuron · doi:10.1016/j.neuron.2007.01.030 · Cited by 590 · see citing works
Regulation of AMPA receptor trafficking and synaptic plasticity
Anggono, V., & Huganir, R. L. (2012) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2011.12.006 · Cited by 588 · see citing works
Local, persistent activation of Rho GTPases during plasticity of single dendritic spines
Murakoshi, H., Wang, H., & Yasuda, R. (2011) · Nature · doi:10.1038/nature09823 · Cited by 564 · see citing works
Self-citationAllison, D. W., Gelfand, V. I., Spector, I., & Craig, A. M. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-07-02423.1998 · Cited by 556 · see citing works
Regulation of AMPA receptor lateral movements
Borgdorff, A. J., & Choquet, D. (2002) · Nature · doi:10.1038/nature00780 · Cited by 542 · see citing works
Cheng, D., Hoogenraad, C. C., Rush, J., Ramm, E., Schlager, M. A., Duong, D. M., Xu, P., Wijayawardana, S. R., Hanfelt, J., Nakagawa, T., et al. (2006) · Molecular & Cellular Proteomics · doi:10.1074/mcp.d500009-mcp200 · Cited by 510 · see citing works
New insights into the regulation and cellular functions of the ARP2/3 complex
Rotty, J. D., Wu, C., & Bear, J. E. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3492 · Cited by 502 · see citing works
AMPA Receptor Incorporation into Synapses during LTP: The Role of Lateral Movement and Exocytosis
Makino, H., & Malinow, R. (2009) · Neuron · doi:10.1016/j.neuron.2009.08.035 · Cited by 501 · see citing works
Plasticity-induced growth of dendritic spines by exocytic trafficking from recycling endosomes
Park, M., Salgado, J. M., Ostroff, L., Helton, T. D., Robinson, C. G., Harris, K. M., & Ehlers, M. D. (2006) · Neuron · doi:10.1016/j.neuron.2006.09.040 · Cited by 493 · see citing works
The Subspine Organization of Actin Fibers Regulates the Structure and Plasticity of Dendritic Spines
Honkura, N., Matsuzaki, M., Noguchi, J., Ellis-Davies, G. C. R., & Kasai, H. (2008) · Neuron · doi:10.1016/j.neuron.2008.01.013 · Cited by 490 · see citing works
Glutamate Receptor Exocytosis and Spine Enlargement during Chemically Induced Long-Term Potentiation
Kopec, C. D., Li, B., Wei, W., Boehm, J., & Malinow, R. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.3918-05.2006 · Cited by 486 · see citing works
Myosin Vb mobilizes recycling endosomes and AMPA receptors for postsynaptic plasticity
Wang, Z., Edwards, J. G., Riley, N., Provance, D. W., Karcher, R., Li, X.-D., Davison, I. G., Ikebe, M., Mercer, J. A., Kauer, J. A., et al. (2008) · Cell · doi:10.1016/j.cell.2008.09.057 · Cited by 470 · see citing works
Lledo, P. M., Hjelmstad, G. O., Mukherji, S., Soderling, T. R., Malenka, R. C., & Nicoll, R. A. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.24.11175 · Cited by 456 · see citing works
Role of ampa receptor endocytosis in synaptic plasticity
Carroll, R. C., Beattie, E. C., von Zastrow, M., & Malenka, R. C. (2001) · Nature Reviews Neuroscience · doi:10.1038/35072500 · Cited by 448 · see citing works
Unusual spectral energy distribution of a galaxy previously reported to be at redshift 6.68
Chen, H., Lanzetta, K. M., Pascarelle, S., & Yahata, N. (2000) · Nature · doi:10.1038/35046031 · Cited by 447 · see citing works
Nanoscale Scaffolding Domains within the Postsynaptic Density Concentrate Synaptic AMPA Receptors
MacGillavry, H. D., Song, Y., Raghavachari, S., & Blanpied, T. A. (2013) · Neuron · doi:10.1016/j.neuron.2013.03.009 · Cited by 442 · see citing works
The Spread of Ras Activity Triggered by Activation of a Single Dendritic Spine
Harvey, C. D., Yasuda, R., Zhong, H., & Svoboda, K. (2008) · Science · doi:10.1126/science.1159675 · Cited by 434 · see citing works
Self-citationSchwenk, J., Harmel, N., Brechet, A., Zolles, G., Berkefeld, H., Müller, C. S., Bildl, W., Baehrens, D., Hüber, B., Kulik, A., et al. (2012) · Neuron · doi:10.1016/j.neuron.2012.03.034 · Cited by 433 · see citing works
Structural plasticity of dendritic spines
Bosch, M., & Hayashi, Y. (2012) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2011.09.002 · Cited by 415 · see citing works
Elias, G. M., Funke, L., Stein, V., Grant, S., Bredt, D., & Nicoll, R. (2006) · Neuron · doi:10.1016/j.neuron.2006.09.012 · Cited by 413 · see citing works
CaMKII Triggers the Diffusional Trapping of Surface AMPARs through Phosphorylation of Stargazin
Opazo, P., Labrecque, S., Tigaret, C. M., Frouin, A., Wiseman, P. W., Koninck, P. D., & Choquet, D. (2010) · Neuron · doi:10.1016/j.neuron.2010.06.007 · Cited by 403 · see citing works
Verde, E. R., Lee‐Osbourne, J., Worley, P. F., Malinow, R., & Cline, H. T. (2006) · Neuron · doi:10.1016/j.neuron.2006.09.031 · Cited by 403 · see citing works
Korobova, F., & Svitkina, T. (2010) · Molecular Biology of the Cell · doi:10.1091/mbc.e09-07-0596 · Cited by 399 · see citing works
Barría, A., Derkach, V. A., & Soderling, T. R. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.52.32727 · Cited by 392 · see citing works
Organization and dynamics of PDZ-domain-related supramodules in the postsynaptic density
Feng, W., & Zhang, M. (2009) · Nature reviews. Neuroscience · doi:10.1038/nrn2540 · Cited by 387 · see citing works
Leonard, A. S., Lim, I. A., Hemsworth, D. E., Horne, M. C., & Hell, J. W. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.6.3239 · Cited by 385 · see citing works
Dynamics and Regulation of Clathrin Coats at Specialized Endocytic Zones of Dendrites and Spines
Blanpied, T. A., Scott, D. B., & Ehlers, M. (2002) · Neuron · doi:10.1016/s0896-6273(02)00979-0 · Cited by 366 · see citing works
Strack, S., McNeill, R. B., & Colbran, R. J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001471200 · Cited by 356 · see citing works
The postsynaptic density proteins Homer and Shank form a polymeric network structure
Hayashi, M. K., Tang, C., Verpelli, C., Narayanan, R., Stearns, M. H., Xu, R.-M., Li, H., Sala, C., & Hayashi, Y. (2009) · Cell · doi:10.1016/j.cell.2009.01.050 · Cited by 356 · see citing works
A GIT1/PIX/Rac/PAK Signaling Module Regulates Spine Morphogenesis and Synapse Formation through MLC
Zhang, H., Webb, D. J., Asmussen, H., Niu, S., & Horwitz, A. F. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.3553-04.2005 · Cited by 354 · see citing works
GTPase Networks in Membrane Traffic
Mizuno-Yamasaki, E., Rivera-Molina, F. E., & Novick, P. (2012) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-052810-093700 · Cited by 352 · see citing works
Regulation of AMPA receptor extrasynaptic insertion by 4.1N, phosphorylation and palmitoylation
Lin, D.-T., Makino, Y., Sharma, K., Hayashi, T., Neve, R., Takamiya, K., & Huganir, R. L. (2009) · Nature Neuroscience · doi:10.1038/nn.2351 · Cited by 347 · see citing works
Hudmon, A., Schulman, H., Kim, J., Maltez, J. M., Tsien, R. W., & Pitt, G. S. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200505155 · Cited by 345 · see citing works
Pettit, D. L., Perlman, S., & Malinow, R. (1994) · Science · doi:10.1126/science.7997883 · Cited by 329 · see citing works
Okamoto, K.-I., Narayanan, R., Lee, S. H., Murata, K., & Hayashi, Y. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0701656104 · Cited by 328 · see citing works
ADF/cofilin-mediated actin dynamics regulate AMPA receptor trafficking during synaptic plasticity
Gu, J., Lee, C. W., Fan, Y., Komlos, D., Tang, X., Sun, C., Yu, K., Hartzell, H. C., Chen, G., Bamburg, J. R., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2634 · Cited by 325 · see citing works
Synaptic Plasticity and AMPA Receptor Trafficking
Malenka, R. C. (2003) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1300.001 · Cited by 324 · see citing works
LTP requires a reserve pool of glutamate receptors independent of subunit type
Granger, A. J., Shi, Y., Lu, W., Cerpas, M., & Nicoll, R. A. (2013) · Nature · doi:10.1038/nature11775 · Cited by 313 · see citing works
Phosphorylation of WAVE1 regulates actin polymerization and dendritic spine morphology
Kim, Y., Sung, J. Y., Ceglia, I., Lee, K.-W., Ahn, J.-H., Halford, J. M., Kim, A. M., Kwak, S. P., Park, J. B., Ho Ryu, S., et al. (2006) · Nature · doi:10.1038/nature04976 · Cited by 307 · see citing works
Petrini, E. M., Lü, J., Cognet, L., Lounis, B., Ehlers, M., & Choquet, D. (2009) · Neuron · doi:10.1016/j.neuron.2009.05.025 · Cited by 296 · see citing works
Changes in Synaptic Morphology Accompany Actin Signaling during LTP
Chen, L. Y., Rex, C. S., Casale, M. S., Gall, C. M., & Lynch, G. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.0164-07.2007 · Cited by 296 · see citing works
Syntaxin-4 defines a domain for activity-dependent exocytosis in dendritic spines
Kennedy, M. J., Davison, I. G., Robinson, C. G., & Ehlers, M. D. (2010) · Cell · doi:10.1016/j.cell.2010.02.042 · Cited by 294 · see citing works
Strack, S., Choi, S., Lovinger, D. M., & Colbran, R. J. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.21.13467 · Cited by 293 · see citing works
Synaptopodin-deficient mice lack a spine apparatus and show deficits in synaptic plasticity
Deller, T., Körte, M., Chabanis, S., Drakew, A., Schwegler, H., Stefani, G. G., Zúñiga, A., Schwarz, K., Bonhoeffer, T., Zeller, R., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1832384100 · Cited by 291 · see citing works
Organization of the core structure of the postsynaptic density
Chen, X., Winters, C. A., Azzam, R. N., Li, X., Galbraith, J. A., Leapman, R. D., & Reese, T. S. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0800897105 · Cited by 290 · see citing works
Optical Control of Protein Activity by Fluorescent Protein Domains
Zhou, X. X., Chung, H. K., Lam, A. J., & Lin, M. Z. (2012) · Science · doi:10.1126/science.1226854 · Cited by 289 · see citing works
Wheeler, D. G., Groth, R. D., Ma, H., Barrett, C. F., Owen, S. F., Safa, P., & Tsien, R. W. (2012) · Cell · doi:10.1016/j.cell.2012.03.041 · Cited by 287 · see citing works
Kim, M. J., Futai, K., Jo, J., Hayashi, Y., Cho, K., & Sheng, M. (2007) · Neuron · doi:10.1016/j.neuron.2007.09.007 · Cited by 278 · see citing works
Lu, J., Helton, T. D., Blanpied, T. A., Rácz, B., Newpher, T. M., Weinberg, R. J., & Ehlers, M. D. (2007) · Neuron · doi:10.1016/j.neuron.2007.06.041 · Cited by 273 · see citing works
Cooney, J. R., Hurlburt, J. L., Selig, D. K., Harris, K. M., & Fiala, J. C. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-06-02215.2002 · Cited by 269 · see citing works
Autophosphorylated CaMKIIα Acts as a Scaffold to Recruit Proteasomes to Dendritic Spines
Bingol, B., Wang, C.-F., Arnott, D., Cheng, D., Peng, J., & Sheng, M. (2010) · Cell · doi:10.1016/j.cell.2010.01.024 · Cited by 268 · see citing works
Frost, N. A., Shroff, H., Kong, H., Betzig, E., & Blanpied, T. A. (2010) · Neuron · doi:10.1016/j.neuron.2010.05.026 · Cited by 263 · see citing works
Motor protein–dependent transport of AMPA receptors into spines during long-term potentiation
Correia, S. S., Bassani, S., Brown, T. C., Lisé, M.-F., Backos, D. S., El-Husseini, A., Passafaro, M., & Esteban, J. A. (2008) · Nature Neuroscience · doi:10.1038/nn2063 · Cited by 260 · see citing works
Patterson, M. A., Szatmari, E. M., & Yasuda, R. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0913875107 · Cited by 259 · see citing works
Self-citationSteiner, P., Higley, M. J., Xu, W., Czervionke, B. L., Malenka, R. C., & Sabatini, B. L. (2008) · Neuron · doi:10.1016/j.neuron.2008.10.014 · Cited by 259 · see citing works
Otmakhov, N., Tao-Cheng, J.-H., Carpenter, S., Asrican, B., Dosemeci, A., Reese, T. S., & Lisman, J. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.2350-04.2004 · Cited by 258 · see citing works
Role of the CaMKII/NMDA Receptor Complex in the Maintenance of Synaptic Strength
Sanhueza, M., Fernandez-Villalobos, G., Stein, I. S., Kasumova, G., Zhang, P., Bayer, K. U., Otmakhov, N., Hell, J. W., & Lisman, J. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.1250-11.2011 · Cited by 248 · see citing works
Ashby, M. C., De La Rue, S. A., Ralph, G. S., Uney, J., Collingridge, G. L., & Henley, J. M. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.1042-04.2004 · Cited by 244 · see citing works
Regulation of AMPA receptor surface diffusion by PSD-95 slots
Opazo, P., Sainlos, M., & Choquet, D. (2012) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2011.10.010 · Cited by 234 · see citing works
LTP Requires a Unique Postsynaptic SNARE Fusion Machinery
Jurado, S., Goswami, D., Zhang, Y., Molina, A. J. M., Südhof, T. C., & Malenka, R. C. (2013) · Neuron · doi:10.1016/j.neuron.2012.11.029 · Cited by 232 · see citing works
Rocca, D. L., Martin, S., Jenkins, E. L., & Hanley, J. (2008) · Nature Cell Biology · doi:10.1038/ncb1688 · Cited by 228 · see citing works
Saneyoshi, T., Wayman, G. A., Fortin, D. A., Davare, M. A., Hoshi, N., Nozaki, N., Natsume, T., & Soderling, T. R. (2008) · Neuron · doi:10.1016/j.neuron.2007.11.016 · Cited by 228 · see citing works
Transsynaptic Signaling by Activity-Dependent Cleavage of Neuroligin-1
Peixoto, R. T., Kunz, P. A., Kwon, H., Mabb, A. M., Sabatini, B. L., Philpot, B. D., & Ehlers, M. (2012) · Neuron · doi:10.1016/j.neuron.2012.07.006 · Cited by 224 · see citing works
Holbro, N., Grunditz, Å., & Oertner, T. G. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0905110106 · Cited by 223 · see citing works
A WAVE-1 and WRP Signaling Complex Regulates Spine Density, Synaptic Plasticity, and Memory
Soderling, S. H., Guire, E. S., Kaech, S., White, J., Zhang, F., Schutz, K., Langeberg, L. K., Banker, G., Raber, J., & Scott, J. D. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.3209-06.2006 · Cited by 217 · see citing works
Kuriu, T., Inoue, A., Bito, H., Sobue, K., & Okabe, S. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0522-06.2006 · Cited by 206 · see citing works
Real-Time Imaging of Discrete Exocytic Events Mediating Surface Delivery of AMPA Receptors
Yudowski, G. A., Puthenveedu, M. A., Leonoudakis, D., Panicker, S., Thorn, K. S., Beattie, E. C., & von Zastrow, M. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.2465-07.2007 · Cited by 197 · see citing works
The WRP component of the WAVE-1 complex attenuates Rac-mediated signalling
Soderling, S. H., Binns, K. L., Wayman, G. A., Davee, S. M., Ong, S. H., Pawson, T. J., & Scott, J. D. (2002) · Nature Cell Biology · doi:10.1038/ncb886 · Cited by 194 · see citing works
Actin in membrane trafficking.
Lanzetti, L. (2007) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2007.04.017 · Cited by 193 · see citing works
Synaptopodin Regulates Plasticity of Dendritic Spines in Hippocampal Neurons
Vlachos, A., Korkotian, E., Schoenfeld, E., Copanaki, E., Deller, T., & Segal, M. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5528-08.2009 · Cited by 181 · see citing works
Neuroligin-1–dependent competition regulates cortical synaptogenesis and synapse number
Kwon, H., Kozorovitskiy, Y., Oh, W., Peixoto, R. T., Akhtar, N., Saulnier, J. L., Gu, C., & Sabatini, B. L. (2012) · Nature Neuroscience · doi:10.1038/nn.3256 · Cited by 181 · see citing works
Chemical Two-Photon Uncaging: a Novel Approach to Mapping Glutamate Receptors
Pettit, D. L., Wang, S. S. ‐., Gee, K. R., & Augustine, G. J. (1997) · Neuron · doi:10.1016/s0896-6273(00)80361-x · Cited by 180 · see citing works
Interactions between the NR2B Receptor and CaMKII Modulate Synaptic Plasticity and Spatial Learning
Zhou, Y., Takahashi, E., Li, W., Halt, A., Wiltgen, B., Ehninger, D., Li, G.-D., Hell, J. W., Kennedy, M. B., & Silva, A. J. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.4486-07.2007 · Cited by 179 · see citing works
Park, E., Na, M., Choi, J., Kim, S., Lee, J.-R., Yoon, J., Park, D., Sheng, M., & Kim, E. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301052200 · Cited by 175 · see citing works
Kim, I. H., Racz, B., Wang, H., Burianek, L., Weinberg, R., Yasuda, R., Wetsel, W. C., & Soderling, S. H. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.0035-13.2013 · Cited by 172 · see citing works
Self-citationTARP Phosphorylation Regulates Synaptic AMPA Receptors through Lipid Bilayers
Sumioka, A., Yan, D., & Tomita, S. (2010) · Neuron · doi:10.1016/j.neuron.2010.04.035 · Cited by 167 · see citing works
PICK1 is a calcium‐sensor for NMDA‐induced AMPA receptor trafficking
Hanley, J. G., & Henley, J. M. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600801 · Cited by 162 · see citing works
Enoki, R., Hu, Y.-L., Hamilton, D. C., & Fine, A. (2009) · Neuron · doi:10.1016/j.neuron.2009.02.026 · Cited by 158 · see citing works
Yasuda, R. (2006) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2006.08.012 · Cited by 157 · see citing works
Self-citationKim, J., Jung, S.-Y., Lee, Y. K., Park, S., Choi, J.-S., Lee, C. J., Kim, H.-S., Choi, Y.-B., Scheiffele, P., Bailey, C. H., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803448105 · Cited by 153 · see citing works
Neurexin-Neuroligin Adhesions Capture Surface-Diffusing AMPA Receptors through PSD-95 Scaffolds
Mondin, M., Labrousse, V. F., Hosy, E., Heine, M., Tessier, B., Levet, F., Poujol, C., Blanchet, C., Choquet, D., & Thoumine, O. R. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.6439-10.2011 · Cited by 150 · see citing works
Evidence That Long-Term Potentiation Occurs within Individual Hippocampal Synapses during Learning
Fedulov, V., Rex, C. S., Simmons, D. A., Palmer, L. C., Gall, C. M., & LYNCH, G. S. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.2003-07.2007 · Cited by 150 · see citing works
Activity-driven postsynaptic translocation of CaMKII
Merrill, M. A., Chen, Y., Strack, S., & Hell, J. W. (2005) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2005.10.003 · Cited by 148 · see citing works
Long-term potentiation: Peeling the onion
Nicoll, R. A., & Roche, K. W. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.02.010 · Cited by 146 · see citing works
Izeddin, I., Specht, C. G., Lelek, M., Darzacq, X., Triller, A., Zimmer, C., & Dahan, M. (2011) · PLoS ONE · doi:10.1371/journal.pone.0015611 · Cited by 140 · see citing works
Brown, T. C., Correia, S. S., Petrok, C. N., & Esteban, J. A. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4258-07.2007 · Cited by 138 · see citing works
Postsynaptic Complexin Controls AMPA Receptor Exocytosis during LTP
Ahmad, M., Polepalli, J. S., Goswami, D., Yang, X., Kaeser-Woo, Y. J., Südhof, T. C., & Malenka, R. C. (2012) · Neuron · doi:10.1016/j.neuron.2011.11.020 · Cited by 133 · see citing works
Structural plasticity with preserved topology in the postsynaptic protein network
Blanpied, T. A., Kerr, J. M., & Ehlers, M. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711669105 · Cited by 133 · see citing works
Regulation of spine and synapse formation by activity-dependent intracellular signaling pathways
Saneyoshi, T., Fortin, D. A., & Soderling, T. R. (2010) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2009.09.013 · Cited by 133 · see citing works
Nanoscopy of living brain slices with low light levels
Testa, I., Urban, N. T., Jakobs, S., Eggeling, C., Willig, K. I., & Hell, S. W. (2012) · Neuron · doi:10.1016/j.neuron.2012.07.028 · Cited by 131 · see citing works
Subcellular Dynamics of Type II PKA in Neurons
Zhong, H., Sia, G.-M., Sato, T., Gray, N. W., Mao, T., Khuchua, Z. A., Huganir, R. L., & Svoboda, K. (2009) · Neuron · doi:10.1016/j.neuron.2009.03.013 · Cited by 125 · see citing works
Spatial organization of cofilin in dendritic spines
Rácz, B., & Weinberg, R. J. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2005.11.025 · Cited by 121 · see citing works
Intersubunit capture of regulatory segments is a component of cooperative CaMKII activation
Chao, L. H., Pellicena, P., Deindl, S., Barclay, L. A., Schulman, H., & Kuriyan, J. (2010) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1751 · Cited by 119 · see citing works
A role for the spine apparatus in LTP and spatial learning
Jedlička, P., Vlachos, A., Schwarzacher, S. W., & Deller, T. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.02.033 · Cited by 116 · see citing works
Tangential synaptic distribution of NMDA and AMPA receptors in rat neocortex
Kharazia, V. N., & Weinberg, R. J. (1997) · Neuroscience Letters · doi:10.1016/s0304-3940(97)00846-x · Cited by 104 · see citing works
The dynamic cytoskeleton: backbone of dendritic spine plasticity
Dent, E. W., Merriam, E. B., & Hu, X. (2010) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2010.08.013 · Cited by 103 · see citing works
A Subtype-Specific Function for the Extracellular Domain of Neuroligin 1 in Hippocampal LTP
Shipman, S. L., & Nicoll, R. A. (2012) · Neuron · doi:10.1016/j.neuron.2012.07.024 · Cited by 101 · see citing works
Yoshimura, Y., Shinkawa, T., Taoka, M., Kobayashi, K., Isobe, T., & Yamauchi, T. (2002) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.6320 · Cited by 94 · see citing works
Lü, W., Isozaki, K., Roche, K. W., & Nicoll, R. A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016289107 · Cited by 92 · see citing works
Kerr, J. M., & Blanpied, T. A. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.2927-11.2012 · Cited by 91 · see citing works
The Spine Apparatus, Synaptopodin, and Dendritic Spine Plasticity
Segal, M., Vlachos, A., & Korkotian, E. (2010) · The Neuroscientist · doi:10.1177/1073858409355829 · Cited by 91 · see citing works
Atomic Force Microscopy Reveals Drebrin Induced Remodeling of F-Actin with Subnanometer Resolution
Sharma, S., Grintsevich, E. E., Phillips, M. L., Reisler, E., & Gimzewski, J. K. (2010) · Nano Letters · doi:10.1021/nl104159v · Cited by 91 · see citing works
Structural studies on the regulation of Ca2+/calmodulin dependent protein kinase II
Stratton, M. M., Chao, L. H., Schulman, H., & Kuriyan, J. (2013) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2013.04.002 · Cited by 89 · see citing works
Tatavarty, V., Kim, E., Rodionov, V., & Yu, J. H. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007724 · Cited by 87 · see citing works
Chen, L., El-Husseini, A., Tomita, S., Bredt, D. S., & Nicoll, R. A. (2003) · Molecular Pharmacology · doi:10.1124/mol.64.3.703 · Cited by 68 · see citing works
A network of networks: cytoskeletal control of compartmentalized function within dendritic spines
Frost, N. A., Kerr, J. M., Lu, H. E., & Blanpied, T. A. (2010) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2010.06.009 · Cited by 65 · see citing works
RNA Binding Proteins Accumulate at the Postsynaptic Density with Synaptic Activity
Zhang, G., Neubert, T. A., & Jordan, B. A. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.2463-11.2012 · Cited by 60 · see citing works
Interactions between drebrin and Ras regulate dendritic spine plasticity
Biou, V., Brinkhaus, H., Malenka, R. C., & Matus, A. I. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06269.x · Cited by 60 · see citing works
Deconstructing signal transduction pathways that regulate the actin cytoskeleton in dendritic spines
Penzes, P., & Cahill, M. E. (2012) · Cytoskeleton · doi:10.1002/cm.21015 · Cited by 57 · see citing works
Optical super-resolution microscopy in neurobiology
Sigrist, S. J., & Sabatini, B. L. (2011) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2011.10.014 · Cited by 56 · see citing works
Orth, C. B., Vlachos, A., Turco, D. D., Burbach, G. J., Haas, C. A., Mundel, P. H., Feng, G., Frotscher, M., & Deller, T. (2005) · The Journal of Comparative Neurology · doi:10.1002/cne.20539 · Cited by 56 · see citing works
Santamaria, F., Gonzalez, J., Augustine, G. J., & Raghavachari, S. (2010) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1000780 · Cited by 53 · see citing works
Merrill, M. A., Malik, Z. A., Akyol, Z., Bartos, J. A., Leonard, A. S., Hudmon, A., Shea, M. A., & Hell, J. W. (2007) · Biochemistry · doi:10.1021/bi0623025 · Cited by 51 · see citing works
Drebrin a content correlates with spine head size in the adult mouse cerebral cortex
Kobayashi, C., Aoki, C. J., Kojima, N., Yamazaki, H., & Shirao, T. (2007) · The Journal of Comparative Neurology · doi:10.1002/cne.21408 · Cited by 43 · see citing works
The excitatory postsynaptic density is a size exclusion diffusion environment
Renner, M. L., Cognet, L., Lounis, B., Triller, A., & Choquet, D. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.07.022 · Cited by 43 · see citing works
Microdomains in Forebrain Spines: an Ultrastructural Perspective
Rácz, B., & Weinberg, R. J. (2012) · Molecular Neurobiology · doi:10.1007/s12035-012-8345-y · Cited by 37 · see citing works
Studying Signal Transduction in Single Dendritic SpinesPreprint
Yasuda, R. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005611 · Cited by 32 · see citing works
Self-citationThe role of endosomal-recycling in long-term potentiation
Kelly, E. E., Horgan, C. P., McCaffrey, M. W., & Young, P. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0516-2 · Cited by 27 · see citing works
Synaptopodin and the spine apparatus organelle-regulators of different forms of synaptic plasticity?
Vlachos, A. (2012) · Annals of Anatomy · doi:10.1016/j.aanat.2011.10.014 · Cited by 26 · see citing works
The Rabs: A family at the root of metazoan evolution
Stenmark, H. (2012) · BMC Biology · doi:10.1186/1741-7007-10-68 · Cited by 21 · see citing works
Flagged first, then by citations
1 of the 153 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- [140]Harris KM Jensen FE Tsao B Three-dimensional structure of dendritic spines and synapses in rat hippocampus (CA1) at postnatal day 15 and adult ages: implications for the maturation of synaptic physiology and long-term potentiation J. Neurosci 1992 12 2685 705 1613552 PMC6575840
Cited by
Sorted by citations
Zeng, M., Shang, Y., Araki, Y., Guo, T., Huganir, R. L., & Zhang, M. (2016) · Cell · doi:10.1016/j.cell.2016.07.008 · Cited by 598 · see citing works
Long-Term Potentiation: From CaMKII to AMPA Receptor Trafficking
Herring, B. E., & Nicoll, R. A. (2016) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021014-071753 · Cited by 425 · see citing works
Prada, I., Gabrielli, M., Turola, E., Iorio, A., D’Arrigo, G., Parolisi, R., De Luca, M., Pacifici, M., Bastoni, M., Lombardi, M., et al. (2018) · Acta Neuropathologica · doi:10.1007/s00401-017-1803-x · Cited by 312 · see citing works
Araki, Y., Zeng, M., Zhang, M., & Huganir, R. L. (2015) · Neuron · doi:10.1016/j.neuron.2014.12.023 · Cited by 271 · see citing works
Plasticity of Spine Structure: Local Signaling, Translation and Cytoskeletal Reorganization
Nakahata, Y., & Yasuda, R. (2018) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2018.00029 · Cited by 209 · see citing works
Self-citationBDNF signaling during the lifetime of dendritic spines
Zagrebelsky, M., Tacke, C., & Korte, M. (2020) · Cell and Tissue Research · doi:10.1007/s00441-020-03226-5 · Cited by 147 · see citing works
TAOK2 Kinase Mediates PSD95 Stability and Dendritic Spine Maturation through Septin7 Phosphorylation
Yadav, S., Osés-Prieto, J. A., Peters, C. J., Zhou, J., Pleasure, S. J., Burlingame, A. L., Jan, L. Y., & Jan, Y. N. (2017) · Neuron · doi:10.1016/j.neuron.2016.12.006 · Cited by 139 · see citing works
Docosahexaenoic acid (DHA): a modulator of microglia activity and dendritic spine morphology
Chang, P. K.-Y., Khatchadourian, A., McKinney, R. A., & Maysinger, D. (2015) · Journal of Neuroinflammation · doi:10.1186/s12974-015-0244-5 · Cited by 124 · see citing works
Cui, Y., Cao, K., Lin, H., Cui, S., Shen, C., Wen, W., Mo, H., Dong, Z., Bai, S., Yang, L., et al. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.00102 · Cited by 119 · see citing works
Positioning of AMPA Receptor-Containing Endosomes Regulates Synapse Architecture
da Silva, M. E., Adrian, M., Schätzle, P., Lipka, J., Watanabe, T., Cho, S., Futai, K., Wierenga, C. J., Kapitein, L. C., & Hoogenraad, C. C. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.09.062 · Cited by 122 · see citing works
Assembly of Excitatory Synapses in the Absence of Glutamatergic Neurotransmission
Sando, R. C., Bushong, E. A., Zhu, Y., Huang, M., Considine, C., Phan, S., Ju, S., Uytiepo, M., Ellisman, M. H., & Maximov, A. (2017) · Neuron · doi:10.1016/j.neuron.2017.03.047 · Cited by 108 · see citing works
An Integrated Approach to Neuro-development, Neuroplasticity and Cognitive Improvement
Drigas, A. S., Karyotaki, M., & Skianis, C. A. (2018) · International Journal of Recent Contributions from Engineering Science & IT (iJES) · doi:10.3991/ijes.v6i3.9034 · Cited by 104 · see citing works
Dendritic Spine Elimination: Molecular Mechanisms and Implications
Stein, I. S., & Zito, K. (2018) · The Neuroscientist · doi:10.1177/1073858418769644 · Cited by 102 · see citing works
Grienberger, C., Chen, X., & Konnerth, A. (2014) · Trends in Neurosciences · doi:10.1016/j.tins.2014.11.002 · Cited by 97 · see citing works
Plasticity of dendritic spines: Molecular function and dysfunction in neurodevelopmental disorders
Nishiyama, J. (2019) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12899 · Cited by 92 · see citing works
Unraveling the cellular and molecular mechanisms of repetitive magnetic stimulation
Müller‐Dahlhaus, F., & Vlachos, A. (2013) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2013.00050 · Cited by 91 · see citing works
Mirror trends of plasticity and stability indicators in primate prefrontal cortex
García‐Cabezas, M. Á., Joyce, M. K. P., John, Y. J., Zikopoulos, B., & Barbas, H. (2017) · European Journal of Neuroscience · doi:10.1111/ejn.13706 · Cited by 86 · see citing works
Synapse-type-specific plasticity in local circuits
Larsen, R. S., & Sjöström, P. J. (2015) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2015.08.001 · Cited by 86 · see citing works
Ng, L. H. L., Huang, Y., Han, L., Chang, R. C.-C., Chan, Y. S., & Lai, C. S. W. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0321-5 · Cited by 82 · see citing works
Dittmer, P. J., Wild, A. R., Dell’Acqua, M. L., & Sather, W. A. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.03.056 · Cited by 77 · see citing works
Control of dendritic spine morphological and functional plasticity by small GTPases.
Woolfrey, K. M., & Srivastava, D. P. (2016) · Neural Plasticity · doi:10.1155/2016/3025948 · Cited by 76 · see citing works
Calcium, Reactive Oxygen Species, and Synaptic Plasticity
Hidalgo, C., & Arias‐Cavieres, A. (2016) · Physiology · doi:10.1152/physiol.00038.2015 · Cited by 72 · see citing works
Proteomics of the Synapse – A Quantitative Approach to Neuronal Plasticity
Dieterich, D. C., & Kreutz, M. R. (2015) · Molecular & Cellular Proteomics · doi:10.1074/mcp.r115.051482 · Cited by 73 · see citing works
Dendritic mitoflash as a putative signal for stabilizing long-term synaptic plasticity
Fu, Z.-X., Tan, X., Fang, H., Lau, P.-M., Wang, X., Cheng, H., & Bi, G. (2017) · Nature Communications · doi:10.1038/s41467-017-00043-3 · Cited by 71 · see citing works
A Neuronal Culture System to Detect Prion Synaptotoxicity
Fang, C., Imberdis, T., Garza, M. C., Wille, H., & Harris, D. A. (2016) · PLoS Pathogens · doi:10.1371/journal.ppat.1005623 · Cited by 67 · see citing works
Tjia, M., Yu, X., Jammu, L. S., Lu, J., & Zuo, Y. (2017) · Frontiers in Neural Circuits · doi:10.3389/fncir.2017.00043 · Cited by 66 · see citing works
Barriers in the brain: resolving dendritic spine morphology and compartmentalization
Adrian, M., Kusters, R., Wierenga, C. J., Storm, C., Hoogenraad, C. C., & Kapitein, L. C. (2014) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2014.00142 · Cited by 62 · see citing works
“Based on results from modeling (Renner et al., 2009) it has been suggested that crowding in the spine head may contribute to this phenomenon (Colgan and Yasuda, 2014).”
Input transformation by dendritic spines of pyramidal neurons
Araya, R. (2014) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2014.00141 · Cited by 58 · see citing works
CNS Neurons Deposit Laminin α5 to Stabilize Synapses
Omar, M. H., Campbell, M. K., Xiao, X., Zhong, Q., Brunken, W. J., Miner, J. H., Greer, C. A., & Koleske, A. J. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.10.028 · Cited by 59 · see citing works
Wu, Q., Sun, M., Bernard, L. P., & Zhang, H. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.782490 · Cited by 59 · see citing works
LTP enhances synaptogenesis in the developing hippocampus
Watson, D. J., Ostroff, L. E., Cao, G., Parker, P. H., Smith, H., & Harris, K. M. (2015) · Hippocampus · doi:10.1002/hipo.22536 · Cited by 54 · see citing works
Paradoxical signaling regulates structural plasticity in dendritic spines
Rangamani, P., Levy, M. G., Khan, S., & OSTER, G. F. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1610391113 · Cited by 51 · see citing works
Brain–immune interaction mechanisms: Implications for cognitive dysfunction in psychiatric disorders
Zhao, F., Li, B., Yang, W., Ge, T., & Cui, R. (2022) · Cell Proliferation · doi:10.1111/cpr.13295 · Cited by 47 · see citing works
Jedlička, P., & Deller, T. (2016) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2016.07.023 · Cited by 46 · see citing works
A Caged Enkephalin Optimized for Simultaneously Probing Mu and Delta Opioid Receptors
Banghart, M. R., He, X. J., & Sabatini, B. L. (2017) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.7b00485 · Cited by 46 · see citing works
The actin-modulating protein synaptopodin mediates long-term survival of dendritic spines
Yap, K. A. F., Drakew, A., Smilović, D., Rietsche, M., Paul, M. H., Vukšić, M., Turco, D. D., & Deller, T. (2020) · eLife · doi:10.7554/elife.62944 · Cited by 44 · see citing works
Structural plasticity of dendritic secretory compartments during LTP-induced synaptogenesis
Kulik, Y. D., Watson, D. J., Cao, G., Kuwajima, M., & Harris, K. M. (2019) · eLife · doi:10.7554/elife.46356 · Cited by 45 · see citing works
Neuhofer, D., & Kalivas, P. W. (2018) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2018.02.007 · Cited by 40 · see citing works
Kanjhan, R., Noakes, P. G., & Bellingham, M. C. (2015) · Neural Plasticity · doi:10.1155/2016/3423267 · Cited by 40 · see citing works
Mechanical Principles Governing the Shapes of Dendritic Spines
Alimohamadi, H., Bell, M. K., Halpain, S., & Rangamani, P. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.657074 · Cited by 41 · see citing works
Bosch, C., Muhaisen, A., Pujadas, L., Soriano, E., & Martı́nez, A. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00138 · Cited by 34 · see citing works
Jung, G., Kim, E., Cicvaric, A., Sase, S., Gröger, M., Höger, H., Sialana, F. J., Berger, J., Monje, F. J., & Lübec, G. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13119 · Cited by 35 · see citing works
Rac1 is a downstream effector of PKCα in structural synaptic plasticity
Tu, X., Yasuda, R., & Colgan, L. A. (2020) · Scientific Reports · doi:10.1038/s41598-020-58610-6 · Cited by 31 · see citing works
Self-citationMiyamoto, T., Kim, D., Knox, J. A., Johnson, E., & Mucke, L. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.666529 · Cited by 33 · see citing works
Semaphorin3F Drives Dendritic Spine Pruning Through Rho-GTPase Signaling
Duncan, B. W., Mohan, V., Wade, S. D., Truong, Y. K.-N., Kampov-Polevoi, A., Temple, B. R. S., & Maness, P. F. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02373-2 · Cited by 33 · see citing works
Loss of SynDIG1 Reduces Excitatory Synapse Maturation But Not Formation In Vivo
Chenaux, G., Matt, L., Hill, T. C., Kaur, I., Liu, X.-B., Kirk, L. M., Speca, D. J., McMahon, S. A., Zito, K., Hell, J. W., et al. (2016) · eNeuro · doi:10.1523/eneuro.0130-16.2016 · Cited by 32 · see citing works
Cell-Autonomous Regulation of Dendritic Spine Density by PirB
Vidal, G. S., Djurisic, M. R., Brown, K., Sapp, R. W., & Shatz, C. J. (2016) · eNeuro · doi:10.1523/eneuro.0089-16.2016 · Cited by 31 · see citing works
Sancho, L., & Bloodgood, B. L. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.07.070 · Cited by 30 · see citing works
Brain is modulated by neuronal plasticity during postnatal development
Kourosh‐Arami, M., Hosseini, N., & Komaki, A. (2021) · The Journal of Physiological Sciences · doi:10.1186/s12576-021-00819-9 · Cited by 30 · see citing works
Calcium signaling in postsynaptic mitochondria: mechanisms, dynamics, and role in ATP production
Feofilaktova, T., Kushnireva, L., Segal, M., & Korkotian, E. (2025) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2025.1621070 · Cited by 25 · see citing works
Racing to learn: statistical inference and learning in a single spiking neuron with adaptive kernels
Afshar, S., George, L., Tapson, J. C., André, V. S., & Hamilton, T. J. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00377 · Cited by 25 · see citing works
MARK/Par1 Kinase Is Activated Downstream of NMDA Receptors through a PKA-Dependent Mechanism
Bernard, L. P., & Zhang, H. (2015) · PLoS ONE · doi:10.1371/journal.pone.0124816 · Cited by 24 · see citing works
Zhu, Y., Uytiepo, M., Bushong, E. A., Haberl, M. G., Beutter, E., Scheiwe, F., Zhang, W., Chang, L., Luu, D., Chui, B., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2021.108953 · Cited by 22 · see citing works
Tazerart, S., Blanchard, M. G., Miranda‐Rottmann, S., Mitchell, D. E., Pina, B. N., Thomas, C. I., Kamasawa, N., & Araya, R. (2022) · The Journal of Physiology · doi:10.1113/jp282303 · Cited by 20 · see citing works
Triggering signaling pathways using F-actin self-organization
Colin, A., Bonnemay, L., Gayrard, C., Gautier, J. J., & Gueroui, Z. (2016) · Scientific Reports · doi:10.1038/srep34657 · Cited by 22 · see citing works
Xie, X., Mahmood, S. R., Gjorgjieva, T., & Percipalle, P. (2020) · Nucleus · doi:10.1080/19491034.2020.1742066 · Cited by 22 · see citing works
Zhuravskaya, A., Yap, K., Hamid, F., & Makeyev, E. V. (2024) · Genome biology · doi:10.1186/s13059-024-03305-8 · Cited by 21 · see citing works
POSH regulates assembly of the NMDAR/PSD-95/Shank complex and synaptic function
Yao, M., Meng, M., Yang, X., Wang, S., Zhang, H., Zhang, F., Shi, L., Zhang, Y., Zhang, X., & Xu, Z. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110642 · Cited by 21 · see citing works
Szatmari, E. M., Moran, C., Cohen, S. J., Jacob, A., Parra-Bueno, P., Kamasawa, N., Guerrero‐Given, D., Klein, M., Stackman, R. W., & Yasuda, R. (2020) · eNeuro · doi:10.1523/eneuro.0111-20.2020 · Cited by 18 · see citing works
Self-citationKim, T., Yamamoto, Y., & Tanaka-Yamamoto, K. (2017) · Nature Communications · doi:10.1038/s41467-017-00518-3 · Cited by 19 · see citing works
Park, E., Tjia, M., Zuo, Y., & Chen, L. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.3028-17.2018 · Cited by 18 · see citing works
A glutamate receptor C-tail recruits CaMKII to suppress retrograde homeostatic signaling
Perry, S., Han, Y., Qiu, C., Chien, C., Goel, P., Nishimura, S., Sajnani, M. R., Schmid, A., Sigrist, S. J., & Dickman, D. K. (2022) · Nature Communications · doi:10.1038/s41467-022-35417-9 · Cited by 20 · see citing works
Ji, J. X., Moquin, A., Bertorelle, F., Chang, P. K. ‐., Antoine, R., Luo, J. X. X., McKinney, R. A., & Maysinger, D. (2019) · Nanotoxicology · doi:10.1080/17435390.2018.1543468 · Cited by 18 · see citing works
c-Abl Deficiency Provides Synaptic Resiliency Against Aβ-Oligomers
Gutiérrez, D. A., Vargas, L. M., Chandía-Cristi, A., de la Fuente, C., Leal, N. R., & Alvarez, A. R. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00526 · Cited by 18 · see citing works
Smirnov, M. S., Evans, P. R., Garrett, T. R., Yan, L., & Yasuda, R. (2017) · PLoS ONE · doi:10.1371/journal.pone.0170586 · Cited by 16 · see citing works
Self-citationStrategies to dissect microglia-synaptic interactions during aging and in Alzheimer's disease
Heuer, S. E., Bloss, E. B., & Howell, G. R. (2024) · Neuropharmacology · doi:10.1016/j.neuropharm.2024.109987 · Cited by 15 · see citing works
Verbich, D., Becker, D., Vlachos, A., Mundel, P. H., Deller, T., & McKinney, R. A. (2016) · Acta Neuropathologica Communications · doi:10.1186/s40478-016-0311-x · Cited by 15 · see citing works
Wnt-related SynGAP1 is a neuroprotective factor of glutamatergic synapses against Aβ oligomers
Codocedo, J. F., Montecinos-Oliva, C., & Inestrosa, N. C. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00227 · Cited by 14 · see citing works
Blockage of Drp1 phosphorylation at Ser579 protects neurons against Aβ1‑42‑induced degeneration
Xu, D., Yang, P. C., Yang, Z., Li, Q.-G., Ouyang, Y., Yu, T., Shangguan, J.-H., Wan, Y., Jiang, L., Qu, X.-H., et al. (2021) · Molecular Medicine Reports · doi:10.3892/mmr.2021.12296 · Cited by 14 · see citing works
Polarity proteins: Shaping dendritic spines and memory
Voglewede, M. M., & Zhang, H. (2022) · Developmental Biology · doi:10.1016/j.ydbio.2022.05.007 · Cited by 13 · see citing works
Reassessing synaptic adhesion pathways
Lim, D., Kim, D., Um, J. W., & Ko, J. (2022) · Trends in Neurosciences · doi:10.1016/j.tins.2022.04.004 · Cited by 13 · see citing works
Birefringence Changes of Dendrites in Mouse Hippocampal Slices Revealed with Polarizing Microscopy
Koike‐Tani, M., Tominaga, T., Oldenbourg, R., & Tani, T. (2020) · Biophysical Journal · doi:10.1016/j.bpj.2020.03.016 · Cited by 13 · see citing works
Biophysical Modeling of Synaptic Plasticity
Lee, C. T., Bell, M. K., Bonilla-Quintana, M., & Rangamani, P. (2024) · Annual Review of Biophysics · doi:10.1146/annurev-biophys-072123-124954 · Cited by 12 · see citing works
Vallejo, D., Lindsay, C. B., González-Billault, C. E., & Inestrosa, N. C. (2021) · Journal of Neurochemistry · doi:10.1111/jnc.15448 · Cited by 12 · see citing works
Cortical Synaptic Reorganization Under Chronic Arsenic Exposure
Niño, S. A., Vázquez-Hernández, N., Arévalo-Villalobos, J. I., Chi-Ahumada, É., Martín-Amaya-Barajas, F. L., Díaz-Cintra, S. Y., Martel‐Gallegos, G., González‐Burgos, I., & Jiménez-Capdeville, M. E. (2021) · Neurotoxicity Research · doi:10.1007/s12640-021-00409-y · Cited by 12 · see citing works
Probing Single Synapses via the Photolytic Release of Neurotransmitters
Mitchell, D. E., Martineau, É., Tazerart, S., & Araya, R. (2019) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2019.00019 · Cited by 12 · see citing works
Mikuni, T., & Uchigashima, M. (2020) · European Journal of Neuroscience · doi:10.1111/ejn.14734 · Cited by 11 · see citing works
Koike‐Tani, M., Tominaga, T., Oldenbourg, R., & Tani, T. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/523571 · Cited by 10 · see citing works
Urban, B. E., Xiao, L., Dong, B., Chen, S., Kozorovitskiy, Y., & Zhang, H. F. (2017) · Journal of Biophotonics · doi:10.1002/jbio.201700171 · Cited by 9 · see citing works
Loss of the polarity protein Par3 promotes dendritic spine neoteny and enhances learning and memory
Voglewede, M. M., Ozsen, E. N., Ivak, N. A., Bernabucci, M., Tang, R., Sun, M., Pang, Z. P., & Zhang, H. (2024) · iScience · doi:10.1016/j.isci.2024.110308 · Cited by 7 · see citing works
Rho GTPase signaling and mDia facilitate endocytosis via presynaptic actin
Oevel, K., Hohensee, S., Kumar, A., Rosas-Brugada, I., Bartolini, F., Soykan, T., & Haucke, V. (2023) · eLife · doi:10.7554/elife.92755 · Cited by 11 · see citing works
Tu, G., Jiang, N., Chen, W., Liu, L., Hu, M., & Liao, B. (2024) · Reviews in the Neurosciences · doi:10.1515/revneuro-2024-0058 · Cited by 9 · see citing works
Urban, P., Tabar, V. R., Bokota, G., Denkiewicz, M., Basu, S., & Plewczyński, D. (2019) · Journal of Computational Biology · doi:10.1089/cmb.2018.0155 · Cited by 7 · see citing works
Subcellular partitioning of protein kinase activity revealed by functional kinome profiling
Wegman‐Points, L., Alganem, K., Imami, A. S., Mathis, V., Creeden, J. F., McCullumsmith, R. E., & Yuan, L. (2022) · Scientific Reports · doi:10.1038/s41598-022-21026-5 · Cited by 6 · see citing works
Chen, Y.-C., Tsai, F., & Chen, M. (2020) · Behavioural Neurology · doi:10.1155/2020/4163274 · Cited by 6 · see citing works
Physical Activity Dynamically Regulates the Hippocampal Proteome along the Dorso-Ventral Axis
Frey, S., Schieweck, R., Forné, I., Imhof, A., Straub, T., Popper, B., & Kiebler, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21103501 · Cited by 5 · see citing works
Chen, Y. (2014) · FEBS Letters · doi:10.1016/j.febslet.2014.10.023 · Cited by 5 · see citing works
Majumder, P., Chatterjee, B., Akter, K., Ahsan, A., Tan, S. J., Huang, C., Chu, J.-F., & Shen, C.-K. J. (2025) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-024-00684-5 · Cited by 5 · see citing works
Analysis of the mechanism of synaptic integration focusing on the charge held in the spine
Tsubo, T. (2021) · Biophysics and Physicobiology · doi:10.2142/biophysico.bppb-v18.036 · Cited by 4 · see citing works
Rho GTPase signaling and mDia facilitate endocytosis via presynaptic actin
Oevel, K., Hohensee, S., Kumar, A., Rosas-Brugada, I., Bartolini, F., Soykan, T., & Haucke, V. (2024) · eLife · doi:10.7554/elife.92755.3 · Cited by 3 · see citing works
Postsynaptic Stability and Variability Described by a Stochastic Model of Endosomal Trafficking
Kim, T., & Tanaka, K. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00072 · Cited by 3 · see citing works
Icariin rescues developmental BPA exposure induced spatial memory deficits in rats
Li, D., Ai, S., Huang, C., Liu, Z., & Wang, H.-L. (2023) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2023.116776 · Cited by 3 · see citing works
Oh, D.-R., Kim, Y. K. S. Y., Mun, B. Y., Ko, H., Kim, Y., Kim, M., Oh, K., Hong, J., & Bae, D. (2025) · Metabolic Brain Disease · doi:10.1007/s11011-025-01608-8 · Cited by 3 · see citing works
Paradoxical Signaling Regulates Structural Plasticity in Dendritic Spines
Rangamani, P., Levy, M., Khan, S., & OSTER, G. F. (2016) · Biophysical Journal · doi:10.1016/j.bpj.2015.11.2003 · Cited by 3 · see citing works
Astrocyte subdomains respond independently in vivoPreprint
López-Hidalgo, M. A., Kellner, V., & Schummers, J. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/675769 · Cited by 3 · see citing works
Spine apparatus modulates Ca 2+ in spines through spatial localization of sources and sinksPreprint
Mesa, M. H., García, G. C., Hoerndli, F. J., McCabe, K. J., & Rangamani, P. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.09.22.558941 · Cited by 3 · see citing works
Comparing Neural and Digital Circuits on Achieving Basic Functions Necessary for Data Processing
Tsubo, T. (2023) · European Journal of Biophysics · doi:10.11648/j.ejb.20231102.11 · Cited by 2 · see citing works
Endolysosome dysfunction in HAND
Hasler, W. A., Rezagholizadeh, N., & Chen, X. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-99744-7.00034-1 · Cited by 2 · see citing works
Spine apparatus modulates Ca2+ in spines through spatial localization of sources and sinks
Mesa, M. H., García, G. C., Hoerndli, F. J., McCabe, K. J., & Rangamani, P. (2025) · The Journal of Physiology · doi:10.1113/jp286859 · Cited by 2 · see citing works
CaMKII: A Master Functional and Structural Molecule in Synaptic Plasticity and Memory
Sanhueza, M., & Fernandez, G. (2015) · Springer eBooks · doi:10.1007/978-3-319-24364-1_3 · Cited by 2 · see citing works
- Authors
- Colgan, L. A., & Yasuda, R.
- Affiliations
- Max Planck Florida Institute for Neuroscience (US)
- Venue
- Annual Review of Physiology
- Publisher
- Annual Reviews
- Published
- 2014-02-10
- Volume
- 76
- Issue
- 1
- Pages
- 365-385
- ISSN
- 0066-4278 (ISSN-L)
- 1545-1585
- PMC
- PMC4142713
- OpenAlex
- W2109779479
- Cited by
- 124
- References
- 153
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 12 · 2023: 7 · 2022: 7 · 2021: 7 · 2020: 12 · 2019: 11 · 2018: 8 · 2017: 12 · 2016: 17 · 2015: 13 · 2014: 8 · 2013: 2
- FWCI
- 1.36
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Annual Review of Physiology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Max Planck Digital Library (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Funders
- National Institute of Mental Health (R01MH080047, R01MH095090)
- National Institute of Neurological Disorders and Stroke (R01NS068410)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- dendritic spines, synaptic plasticity, long-term potentiation, postsynaptic density, actin cytoskeleton, membrane trafficking, signaling pathways
- MeSH terms
- Actins, Animals, Cell Membrane, Cytoskeleton, Humans, Neuronal Plasticity, Synapses, Signal Transduction, Dendritic Spines
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review